The invention discloses a bone filling
adhesive which has good
biocompatibility and is convenient to
implant, and a preparation method of the bone filling
adhesive as well as application of the bone filling
adhesive. The bone filling adhesive is characterized by being made from
PLGA (poly(lactic-co-
glycolic acid)),
ethyl acetate,
biological glue, a
phosphate buffer and
distilled water serving as raw materials according to the ratio, wherein
ethyl acetate can be replaced by
acetone or
dichloromethane, the bone filling adhesive is prepared by the steps of dissolving
PLGA intoethyl acetate or
acetone or
dichloromethane, and dissolving the
biological glue into the
phosphate buffer. The bone filling adhesive is added into a
solvent, and after being dissolved, the bone filling adhesive is implanted in an injection manner. The bone filling adhesive has the beneficial effects that when bone fractures are treated, the bone filling adhesive is added into the
solvent and the mixture is implanted in an injection manner by utilizing good biodegradability and
biocompatibility of the
PLGA and the
biological glue, and the implantation manner is accurate, convenient and fast; the bone filling adhesive is capable of promoting and adjusting growth and differentiation of subperiosteal
peripheral cells, accelerating formation of bone matrixes and a mineralizing biological mechanism, quickly healing the bone fractures and quickly fixing and supporting
bone fracture parts; and the bone filling adhesive can be proliferated and disintegrated into bone generating cells, has good
bone conduction property and is absorbed into
bone fracture areas to form calluses and further repair the bone fractures.