3 results about "Cells bone" patented technology

The application provides a targeted pathological B cell temperature-sensitive hydrogel bone repair material and a preparation method and application thereof, and belongs to the technical field of bone repair biomaterials. The targeted pathological B cell bone repair material HPCH / B3-Cu-Zn-MBGs temperature-sensitive hydrogel provided by the application is prepared by mixing hydroxypropyl chitin HPCH and B3-Cu-Zn-MBGs, and the mass ratio of the hydroxypropyl chitin HPCH and the B3-Cu-Zn-MBGs is 5:1-1:1. The HPCH / B3-Cu-Zn-MBGs provided by the application significantly improves joint swelling, reduces arthritis index, and reduces the clinical symptoms of RA through the comprehensive action thereof.

This invention discloses a bio-barrier membrane with guided bone regeneration (GBR) function and its construction method, belonging to the technical field of bone tissue regeneration and repair materials. The bio-barrier membrane is a composite structure formed by a decellularized periosteum and an extracellular matrix (ECM) cross-linked layer. Specifically, it is prepared by in-situ cross-linking of the decellularized periosteum with an acidic ECM solution. This bio-barrier membrane is a bilayer composite membrane that mimics the natural periosteum, synergistically exerting barrier, osteoconduction, and osteoinduction effects, significantly improving bone repair and regeneration.