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Application of rare earth 1-hydroxyethylidene-1,1-diphosphonic acid tetrasodium salt

A technology of hydroxyethylidene bisphosphonate and hydroxyethylidene bisphosphonate, applied in the field of medicine, can solve the problems of high price, inability to be widely used, increased risk of endometrial cancer and ovarian cancer, etc., and has broad application prospects. Effect

Inactive Publication Date: 2015-11-25
HAINAN NORMAL UNIV
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Problems solved by technology

[0003] The current anti-osteoporosis drugs are unsatisfactory. Estrogen replacement therapy (ERT) is currently the most important method for the prevention and treatment of postmenopausal osteoporosis, but recent studies have shown that ERT is prone to breast cancer, uterine Increased risk of endometrial and ovarian cancer
In addition, the most common osteoporosis drugs used clinically are mostly expensive and cannot be widely used, so finding other drugs to prevent and treat osteoporosis is an active field of current research work

Method used

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  • Application of rare earth 1-hydroxyethylidene-1,1-diphosphonic acid tetrasodium salt

Examples

Experimental program
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Effect test

Embodiment Construction

[0017] 1. In vitro test

[0018] Rare earth hydroxyethylidene diphosphonate (lanthanum hydroxyethylidene diphosphonate, cerium hydroxyethylidene diphosphonate, praseodymium hydroxyethylidene diphosphonate, neodymium hydroxyethylidene diphosphonate, promethium hydroxyethylidene diphosphonate, Samarium hydroxyethylidene diphosphonate, europium hydroxyethylidene diphosphonate, and gadolinium hydroxyethylidene diphosphonate) were prepared in PBS (phosphate buffer saline) to prepare 10 mg / mL stock solutions, and diluted to 1000 μg / mL before use. 100 μg / mL.

[0019] Experimental procedure: Take the primary cultured rat osteoblasts (OB) in 2×10 4 cells / mL were inoculated in a 96-well plate with a volume of 90 μL per well in CO 2 Cultivate in the incubator for 24h. After the cells adhere to the wall, add 10 μL of PBS solution of rare earth hydroxyethylidene bisphosphonate to make the final concentration of rare earth hydroxyethylidene bisphosphonate 100 μg / mL, 10 μg / mL, and after ...

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Abstract

The invention discloses application of a rare earth 1-hydroxyethylidene-1,1-diphosphonic acid tetrasodium salt. The rare earth 1-hydroxyethylidene-1,1-diphosphonic acid tetrasodium salt is applicable to preparation of an anti-osteoporosis drug. The anti-osteoporosis drug has an obvious function of treating the symptoms that the osteoblast activity and the bone biomechanical strength of an osteoporosis model rat are reduced, is free from obvious toxic and side effects, and has a broad application prospect.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of a rare earth hydroxyethylidene bisphosphonate in the preparation of anti-osteoporosis drugs. Background technique [0002] Osteoporosis (OP) is a systemic skeletal disease characterized by decreased bone mass and degeneration of bone microstructure, resulting in increased bone fragility and susceptibility to fracture. Osteoporosis is a global health problem, second only to cardiovascular disease in severity, and its incidence rate has jumped to the sixth place among common diseases and frequently-occurring diseases in the world. my country lists osteoporosis as one of the geriatric diseases that the country focuses on. [0003] The current anti-osteoporosis drugs are unsatisfactory. Estrogen replacement therapy (ERT) is currently the most important method for the prevention and treatment of postmenopausal osteoporosis, but recent studies have shown that ERT...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/663A61P19/10
Inventor 朱林华朱甜戴春燕沈梅朱祺东
Owner HAINAN NORMAL UNIV
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