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Wanted immunogenicity is typically related with vaccines, where the injection of an antigen (the vaccine) provokes an immune response against the pathogen (virus, bacteria...) aiming at protecting the organism.
Porcine epidemic diarrhea virus and porcine delta coronavirus bivalent attenuated live vaccine and preparation method thereof
PendingCN122163785Aimprove matchgood cross protectionPowder deliveryAntiviralsEpidemic diarrheaGenotype
The application discloses a porcine epidemic diarrhea virus and porcine delta coronavirus double vaccine and a preparation method thereof. The double attenuated live vaccine is prepared from a PEDV G2a genotype weak strain CH / HBXT-P240 / 2018 (the preservation number is CGMCC NO:45213), a PEDV G2b genotype weak strain CH / HNPJ-P240 / 2017 (the preservation number is CGMCC NO:5212) and a PDCoV weak strain CH / XJYN-P240 / 2016 (the preservation number is CGMCC NO:45211) as seed viruses for vaccine preparation, virus proliferation is carried out in combination with a cell suspension culture process, and the double vaccine is prepared through vaccine preparation and freeze-drying. The vaccine has strong immunogenicity, good cross-protection effect and high safety, can prevent piglet diarrhea caused by two kinds of coronaviruses at the same time, and is suitable for immune prevention and control in large-scale farms.
Owner:LANZHOU VETERINARY RESEARCH INSTITUTE CHINESE ACADEMY OF AGRICULTURAL SCIENCES(LANZHOU BRANCH CENTER OF CHINA ANIMAL HEALTH & EPIDEMIOLOGY CENTER)