13 results about "Bioaccumulation" patented technology

The invention discloses application of ursolic acid in resisting fish ichthyophthiriasis. The ursolic acid has a remarkable killing effect on ichthyophthirius multifilis in an in-vitro stage, and the 4-hour half effective insecticidal concentration (4h-EC50) of the ursolic acid on a grazing body is 0.3774 mg / L; and the 22-hour half effective insecticidal concentration (22h-EC 50) on the capsule is 4.931 mg / L. An acute toxicity test shows that the 96-hour median lethal concentration (96h-LC50) of ursolic acid to goldfish is 9.358 mg / L, the therapeutic index (TI = 96h-LC50 / 4h-EC50) is up to 24.8, and the safety of ursolic acid is remarkably superior to that of a traditional medicine. Ursolic acid used in the invention is a plant-derived active component, has the characteristics of high environmental compatibility and low biological accumulation, meets the development requirements of green fishery, and has an industrialization basis for being developed into eco-friendly aquatic products.

A method for detecting the extent of microplastic accumulation in bivalve organisms in extreme deep-sea environments is provided. This method is performed through sampling of biological communities to represent the community structure of that biological bed layer, then morphological characterization statistics are conducted to classify the age stage data of individual bivalves, multivariate factor analysis is used to obtain the individual bivalves with the greatest degree of contribution in each classified age stage, subsequently tissue-specific microplastic extraction is performed, the morphology of seafloor microplastics is restored and streamlined identification of full-size microplastics is considered, carbon-14 dating is used to trace the duration of microplastic adsorption by each individual bivalve, dynamic accumulation curves for seafloor bivalves are constructed by connecting each bivalve's survival duration, and finally this is scaled up to the entire bivalve bed to derive the microplastic accumulation rate and historical accumulation of the entire extreme ecosystem.

Systems and methods are provided for comprehensive in vivo nanotoxicity testing, as well as fabrication methods of chips used for nanotoxicity testing. A three-dimensional (3D)-printed, automated microfluidic chip can be configured for in vivo nanotoxicity testing, and the chip can allow for multi-route (e.g., waterborne and / or foodborne) exposure of marine organisms to small materials (e.g., plastics such as microplastics and / or nanoplastics (NPLs), or metals), providing real-time, in situ monitoring of bioaccumulation and oxygen consumption.

Disclosed are methods for remediating soil having persistent and bioaccumulative contaminants, and more particularly, methods for remediating soil having perfluoro and polyfluoroalkyl substances (PFAS) and other halogen-containing contaminants by rapid electrothermal mineralization.

This application relates to the technical field of environmental monitoring and data analysis, and particularly to a screening method for priority-controlled OPEs based on surface water concentration data. According to the organophosphate ester flame retardants (OPEs) exposure database, the monitoring data of each OPE compound within a specified time period is obtained. For each OPE compound, based on the monitoring data, the quantitative data of environmental persistence, bioaccumulation, and toxicity effects are respectively obtained, and the exposure potential index and hazard potential index are obtained through principal component analysis; the exposure potential index and hazard potential index are processed to obtain the priority control index; based on the priority control index, sorting is carried out to screen OPE compounds that meet the preset conditions, and the screening results are determined as the priority control targets. This application can simultaneously identify key pollutants with high exposure risks and high hazard risks, reveal the main risk drivers of different OPEs, and effectively support the screening and priority control decision-making of emerging pollutants.

The invention discloses a lake water environment optimal control pollutant identification method, and belongs to the field of environmental analysis, ecotoxicology and water environment risk assess.The method comprises the steps that lake deposition column samples are collected for high-resolution mass spectrum non-targeted analysis to establish a pollutant time sequence database; the substances with the occurrence abundance in the continuous increasing trend are screened through time sequence trend statistical analysis; integrating environment durability, mobility, biological accumulation potential and biological toxicity multi-dimensional risk indexes, performing risk weighting calculation through a toxicity priority index model, and outputting risk index sorting in combination with relative abundance; chemical structure identification is performed on the high-risk substances to determine a priority control pollutant list. According to the method, the risk-driven identification of unknown, historically accumulated and composite high-risk pollutants in the lake water environment is realized, and a key technical means is provided for the construction of a regional new pollutant list.

This invention discloses a chromium (VI)-resistant Enterococcus faecium, its isolation method, and its applications in the field of microbial technology. This chromium (VI)-resistant Enterococcus faecium, classified and named Enterococcus faecium, was deposited on October 24, 2025, at the China General Microbiological Culture Collection Center (CGMCC), with accession number CGMCC NO.36330. The chromium (VI)-resistant Enterococcus faecium isolated by this invention can survive in high-concentration chromium (VI) environments and has a strong adsorption effect on hexavalent chromium, reducing the residue and bioaccumulation of hexavalent chromium in feed, thereby mitigating its toxicity to poultry.

This invention discloses a total phenolic amine from bee pollen, its preparation method, and its application in alleviating zearalenone (ZEA) toxicity, belonging to the field of agricultural technology. The total phenolic amines extracted from bee pollen by this invention can reduce the bioaccumulation of ZEA and alleviate organ pathological damage; it can inhibit lipid peroxidation by activating the Nrf2 / GPX4 signaling pathway, upregulate BTB core protein, and restore the integrity of the barrier function; furthermore, TPP can regulate sex hormone balance, reverse the ZEA-induced decrease in testosterone levels and abnormal increase in estradiol, thereby comprehensively alleviating the toxic effects of ZEA.

This invention discloses a four-dimensional Raman monitoring system and dynamic quantitative method for environmental microplastics in vivo, belonging to the field of environmental ecological monitoring and analysis technology. The system includes a confocal spectroscopy acquisition module, a controller, and a data processing module. It acquires the three-dimensional coordinates of live samples through coordinated spatial scanning and simultaneously acquires Raman signals to construct four-dimensional spectral data. A multidimensional convolutional instance segmentation network is used to process the four-dimensional Raman spectral data, identifying and classifying endogenous biological matrices and exogenous multi-mixed microplastics in vivo, outputting voxel-level semantic classification results, and then quantitatively calculating the absolute retention volume and abundance of microplastics in the organism. This invention overcomes the shortcomings of existing technologies in label-free quantification under complex biological backgrounds, achieving in-situ accurate identification of mixed microplastics in vivo, and providing a standardized quantitative monitoring method for assessing the bioaccumulation, metabolic patterns, and ecotoxicological effects of environmental microplastics.

This invention relates to a miniature flexible temperature sensor for use in living organisms, its fabrication method, and its applications. The miniature flexible temperature sensor comprises a thermosensitive conductive layer polymerized in situ from acrylamide, glycerol, choline chloride, and lipoic acid, and a flexible encapsulation layer made of a flexible biocompatible material. The fabrication method includes mixing acrylamide, glycerol, and choline chloride to obtain a deep eutectic solvent; adding lipoic acid to the deep eutectic solvent to obtain a homogeneous solution; injecting the homogeneous solution into a mold made of the flexible biocompatible material to obtain a material to be cured; and subjecting the material to be cured to ultraviolet light curing to obtain the miniature flexible temperature sensor. Its advantages include good biocompatibility, reducing the potential bioaccumulation risk of traditional conductive polymers or nanomaterials; high sensitivity, good repeatability, linearity, and resolution; a thermosensitive layer thickness of 1–2 mm, suitable for non-invasive monitoring on the body surface and multi-point temperature detection in confined biological spaces; and a simple fabrication method with no leakage risk.

The invention relates to a flame retardant chemical export trade dynamic early warning system based on environmental exposure and health toxicological harmfulness. The system comprises a data acquisition module, a data preprocessing module, a QSAR prediction module, a database management module, a regulation supervision matching module, an early warning list generation module, a priority management and control directory compiling module and a user interaction module. Four types of QSAR prediction models (R is greater than or equal to 0.85 and Q is greater than or equal to 0.70) of physical and chemical safety, toxicity, degradability and bioaccumulation are constructed, more than 15 kinds of hazard data of more than 1000 kinds of flame retardants are integrated, trade supervision laws and regulations of more than 30 countries / regions in the world are matched, a dynamic early warning list updated each month is generated, and a priority control material list is compiled based on a comprehensive scoring algorithm. According to the method, the problem of export limitation caused by lack of flame retardant environmental hazard data and foreign green technical barriers is solved, and risk early warning and accurate management and control of flame retardant export trade are realized.

This invention belongs to the field of environmental and human health technology, and discloses a PM... 2.5 An alveolar microresponsive system carrying insoluble particles and a model for evaluating its relative bioefficacy. This alveolar microresponsive system establishes an alveolar microresponsive system by carrying insoluble PM... 2.5 A model for the bioaccumulation and relative bioavailability of -M, derived from lung surfactant extraction and PM2.5. 2.5 The process of incubating and extracting adsorbed substances from M, screening adsorbent layer lipids and proteomes, and assembling microreaction system models revealed the properties of water-insoluble PM. 2.5 The accumulation and absorption characteristics of PM2.5 particles in the alveoli; lipidomics and proteomics analyses clarified the composition of insoluble PM2.5 particles in the alveoli. 2.5 A degradation and transformation microreaction system consisting of -M and alveolar fluid was constructed, and a non-water-soluble PM2.5 was first constructed based on the microreaction system. 2.5 - Model for calculating alveolar turnover rate after M respiratory exposure and the amount of water-insoluble PM in alveoli 2.5 -M bioefficacy assessment model.

The present invention relates to an in-vitro model of the human gut microbiome, the model comprising a culture of the gut microbiome, wherein the model has a cumulative enzymatic coverage of more than 85% of the gut microbiome of a healthy human. The model facilitates metabolic modeling and enables a better understanding of the structure and function of the human gut microbiome as well as of modifications of xenobiotics by intrinsic gut microbiota, such as biotransformation and bioaccumulation. It can further be used to study the effects of variations in nutritional conditions. Importantly, the invention can also be used for diagnosing a disease, such as a gastrointestinal disorder, a proliferative disease, a metabolic disorder, a cardiovascular disease, an immunological disease, and an infectious disease.