2 results about "Adeno associate virus" patented technology

Disclosed herein are nucleic acid molecules and compositions of preparing recombinant adeno-associated viruses (rAAV) and uses thereof. Specifically, two-plasmid systems are provided for efficient rAAV production.

Provided herein are pharmaceutical compositions comprising an adeno-associated virus (AAV). In some aspects, a pharmaceutical composition comprises from about 5 mM to about 20 mM of a Tris buffer, from about 100 mM to about 250 mM of sodium chloride, from about 0.001% (w / v) to about 0.01% (w / v) of Pluronic F68, and has a pH of from 7.0 to 9.0. Also provided are methods of making a pharmaceutical composition comprising the AAV, methods of treating a VEGF-associated condition in a subject, and methods of storing the AAV composition.