27 results about "Primate" patented technology

The invention relates to a touch fluid neuron specific tracing imaging agent, a preparation method and application, and belongs to the technical field of nuclear medicine imaging, the tracing imaging agent is composed of a nerve tracer agent horseradish peroxidase (HRP), zirconium-89 isotope chelated by deferoxamine and a pharmaceutically acceptable carrier, the effective tracking window of the tracer agent is prolonged to 120 hours, and the effective tracking window of the tracer agent is prolonged to 120 hours. The multi-stage synaptic transfer period of the fluid touching neuron can be completely covered; the spatial resolution is improved by 5-8 times compared with that of traditional FDG-PET, and a fluid touching neuron cluster can be accurately presented; the in-vitro serum stability is excellent, the radiochemical purity is still larger than or equal to 80.5% within 120 hours, PET / MRI bimodal imaging can be adapted, drug administration is conducted through lateral ventricle minimally invasive injection, the probe is suitable for various animal models such as mice, rats and non-human primates, in-vivo dynamic tracing of sympathetic fluid neuron trans-synapses can be achieved on the premise that no tissue damage exists, and the probe has a good application prospect. And a key technical tool is provided for neural circuit analysis, neuroscience basic research and preclinical research of neurodegenerative diseases.

The invention relates to a barcoding method to assess transduction efficiency of AAV vectors, in particular in vivo in rodent and non-human primate.

The invention discloses a sperm genome methylation detection method for safety evaluation of biological breeding crops by using primates and application, and relates to the technical field of safety evaluation of crops, the sperm genome methylation detection method comprises the following steps: dividing non-human primates into three groups, collecting sperms after long-term feeding, and extracting DNA (Deoxyribose Nucleic Acid); carrying out whole genome sequencing and quality control after bisulfite treatment; the epigenetic safety of crops is comprehensively evaluated by analyzing the methylation level of a whole genome and a functional region and functional enrichment of a differential methylation region and related genes thereof; according to the sperm genome methylation detection method for evaluating the safety of the biologically bred crops by utilizing the primates and the application, by utilizing a high-resolution WGBS technology, subtle epigenetic changes which are difficult to find by traditional toxicology can be detected, and the sperm genome methylation detection method has important significance in cross-generation reproduction effect evaluation, and has a wide application prospect. A food safety evaluation system can be perfected, and a more scientific and reliable safety interpretation basis can be established.

This application relates to a modular non-human primate rearing cage, belonging to the technical field of animal husbandry. It includes a cage frame, a resource supply system, a hygiene and cleaning system, an activity and enrichment system, and a connection and management system. The cage frame includes a cage base, a cage top, and cage side frames. The resource supply system includes a food supply device and a water supply device detachably installed on the cage frame. The connection and management system includes a connecting channel on the cage side frames and a connecting cage door movably installed on the cage side frames for changing the opening and closing state of the connecting channel. The activity and enrichment system includes a lookout component installed on the cage side frames, a climbing component located between the lookout component and the cage base, and multiple monitoring units installed on the cage top frame. This application can improve the husbandry and management efficiency of non-human primates.

This disclosure relates to the fields of computer vision and wildlife monitoring technology, and specifically to a method and system for identifying Tibetan macaques in the wild based on deep learning. First, a face detection model is used to detect and crop faces from raw wild images. The detection model is initialized with pre-trained weights and fine-tuned by freezing the backbone network. Then, an individual identification model is constructed to output classification results. During training, a joint loss function is used, combining Focal Loss to suppress easily classified samples and guide attention to difficult-to-classify samples. Supervised contrastive loss is used to enhance the discriminative power of the feature space. Simultaneously, an adaptive hybrid enhancement strategy and a hierarchical Dropout regularization mechanism are introduced to effectively address the problems of small sample sizes, class imbalance, and overfitting in complex wild environments. This disclosure enables high-precision identification of Tibetan macaques, providing an efficient technical means for long-term ecological monitoring of wild primates.

The invention provides a targeting reagent for preparing fragile X syndrome animals and application of the targeting reagent. The invention discloses a target which is matched with non-human primates and is suitable for gene modification, namely a third exon and / or a fourth exon of an FMR1 gene, a target reagent is prepared by targeting the target, and a fragile X syndrome animal model with typical disease symptoms can be obtained by implementing down-regulation.

This invention discloses a neural microprobe for bimodal functional localization and precise electrical stimulation of deep brain nuclei in non-human primates. It comprises a basal layer, a conductive metal layer, and an insulating layer. The conductive layer includes a set of detection sites and stimulation sites. This invention employs a dry etching process on the back of the silicon basal layer using two insulating layers with opposite stresses, balancing the stress differences between the different materials. This overcomes the technological challenges of extending silicon microprobes and solves the problems of probe bending and low mechanical stress caused by the large aspect ratio of silicon probes in non-human primates. The detection sites acquire bimodal signals using modified nanomaterials and polymer anti-interference ion-exchange membranes as localization markers for functional localization. The detection sites are arranged between the positive and negative electrodes of the electrical stimulation, controlling the stimulation range to be near the detection sites, thus achieving precise electrical stimulation. This invention provides a new research method and means for deep brain stimulation therapy of diseases such as Parkinson's disease.

The invention relates to the field of medicines, in particular to a construction method of an Alzheimer's disease non-human primate model. A small dose of thiamine antagonist pyrithiamine is given to the chronic abdominal cavity to induce chronic thiamine metabolic disorder, so that the non-human primate marmoset Alzheimer disease model capable of reflecting the Alzheimer disease course is established, and the method has the advantages of simplicity in operation, small animal injury and the like; therefore, the method is beneficial to further basic clinical transformation research and the like, and has more important scientific significance and economic value.

The present application relates to the field of animal experiment equipment, and specifically discloses a primate hand action testing machine, which comprises a box body, a first channel, a second channel, a first opening and a second opening. A storage assembly composed of a base and guide rods of different structures is placed in the first channel. A liftable movable tray is arranged in the second channel. An activity evaluation device capable of being used in cooperation with the hand action testing machine is also disclosed, which comprises a cage body, a seat body, a climbing rod, a first flexible column and a second flexible column. Food is placed on the first channel, the second channel and the guide rods to test the simple grabbing and fine finger movement of the animal, thereby achieving the effect of testing the hand action. The first flexible column flexibly connects the cage body and the seat body, and the second flexible column flexibly connects the climbing rod and the front and rear grilles. The pressure change of the pressure point of the pressure sensor can be used to evaluate the activity of the animal in the cage.

This utility model belongs to the field of animal disease prevention, specifically an animal blood collection device, including a tray. A support plate is fixedly connected to the bottom of the tray near the rear side. A locking block is engaged on the outer side of the support plate. A wall is fixedly connected to one side of the locking block, and a window is opened on the surface of the wall. After aligning the locking block with the support plate, a pin passes through the inside of the sleeve and the mounting ring, while a positioning post passes through the inside of the pin, so that the tray is vertically mounted on the front side of the window, which facilitates disassembly and assembly and fixation of the device in front of the window, improving the adaptability and stability of the device. Secondly, by enticing the forelimbs of primates to be placed on the surface of the tray, the closing limiting ring is rotated and the tension spring on the side of the tray pulls the buckle. The buckle rotates on the front side of the tray, so that the buckle engages with the surface of the locking post. The test tube to be used is placed through three fixing clips on the side of the tray, and blood is collected through a needle, improving the user's work efficiency and safety.

Disclosed are an antibody targeting the monkeypox virus, an antigen-binding fragment thereof, and a use thereof. The antibody or the antigen-binding fragment thereof comprises a heavy chain variable region and a light chain variable region. The antibody or the antigen-binding fragment thereof of the present invention targets A35R of humans and non-human primates.

The invention belongs to the technical field of regenerative medicine, and discloses an organoid culture method derived from neural stem cells in subventricular regions of human and non-human primates. By optimizing a culture medium formula and regulating and controlling transcription factors, the organoid is successfully induced to be differentiated into the neuron precursor for expressing the CRABP1. The cell expresses TAC3, the limitation of the prior art in simulation of special neuropedigree and complex brain structure of primates is overcome, and a breakthrough in-vitro model is provided for research on neurodevelopment and nervous system diseases and drug development. The established system not only can provide a new tool for researching the development law and disease mechanism of the primate nervous system, but also can provide a reliable experimental platform and a transplantable cell source for developing targeted drugs, constructing advanced disease models and developing cell replacement therapy.

The application discloses a non-human primate cage door locking device, which comprises a cage door, a T-shaped bolt lock and a locking structure. The cage door is provided with a plurality of cylindrical sleeves. The T-shaped bolt lock comprises a lock core part and a handle part. The lock core part is a horizontal circular rod in the axial direction, and the handle part is a vertical circular rod in the axial direction. The top end of the handle part is welded at the midpoint of the lock core part. The two ends of the lock core part are respectively inserted into the cylindrical sleeves. The T-shaped bolt lock can move left and right relative to the cage door. A through hole is formed in the T-shaped bolt lock. One end of the locking structure penetrates through the through hole and is detachably mounted on the T-shaped bolt lock. The non-human primate cage door locking device has the advantages of simple structure, easy operation, low cost, easy manufacturing, difficult learning of the opening and closing mode by monkeys, prevention of the monkeys from opening and closing the cage door by themselves, great improvement of the working efficiency of non-human primate cage production personnel and solution to the difficult problems in the intensive feeding of non-human primates.

The invention relates to the field of medicines, in particular to a construction method of an Alzheimer's disease non-human primate model. A small dose of thiamine antagonist pyrithiamine is given to the chronic abdominal cavity to induce chronic thiamine metabolic disorder, so that the non-human primate marmoset Alzheimer disease model capable of reflecting the Alzheimer disease course is established, and the method has the advantages of simplicity in operation, small animal injury and the like; therefore, the method is beneficial to further basic clinical transformation research and the like, and has more important scientific significance and economic value.

This invention discloses a non-human primate visual-spatial working memory testing cage. This invention uses a non-human primate visual-spatial working memory testing cage to measure the learning, discrimination, and reversal abilities, or cognitive and memory abilities, of non-human primates, providing a more comprehensive evaluation of changes in animal brain function and behavior. It can provide a model evaluation tool for central nervous system diseases such as Alzheimer's disease and stroke, and offer new methods for disease research and new drug development.

The utility model relates to the technical field of animal experiments, in particular to a small non-human primate fixing plate which comprises a plate body and a plurality of bandage structures, and the plate body is provided with a plurality of through hole structures for the bandage structures to penetrate through. The perforated structures are at least arranged in the first area, the second area and the third area of the plate body, and at least two perforated structures which are arranged left and right and have a preset interval are arranged in each area. The fixing device is free of metal materials, the bandage structure and the plate body are simple and convenient to connect, the length between the two bandages is flexible to adjust, the fixing device has better adaptive capacity for different animals, rapid adjustment and fixing can be achieved during fixing, meanwhile, the trunk or the four limbs cannot be pressed, and the fixing device is convenient to use. And the use of the experimental animal in the medical, examination or transportation process can be met, and meanwhile, the advantages of safety and comfort are achieved.

The invention discloses a programmable bionic 4D printing intelligent gripper with electrogenerated repair and visual feedback functions, and belongs to the field of structural design and manufacturing of intelligent grippers, the bionic design of the gripper is derived from a toe-facing efficient enveloping mechanism and color changing characteristics of the foot of a tree-dwelling chameleon and a primate phalanx structure; the main body structure of the gripper is two groups of driving structures which cooperatively move in opposite directions and are formed by four bionic fingers, each finger comprises three active driving units including a near section, a middle section and a far section, the main body structure of the gripper is formed by a shape memory polymer, and a conductive network formed by a conductive polymer is arranged in the main body structure; differentiated electric excitation is applied to a plurality of independently designed conductive contacts, so that the conductive network of the middle layer generates Joule heat, and the Joule heat generated when the conductive network is electrified can realize one or more of the following functions: electro-induced damage repair, visual feedback, programmable selective driving and self-adaptive rigidity dynamic adjustment.

The application belongs to the technical field of biological medicine, and particularly discloses a construction method of a glaucoma non-human primate model, which comprises the following steps: injecting emulsified silicone oil into the anterior chamber of a non-human primate; and detecting after 7-8 weeks, i.e. obtaining the glaucoma non-human primate model. Compared with a traditional model, the animal model of the application does not need to repeatedly use expensive modeling instruments, nor does it need to repeatedly damage the animals by modeling multiple times. The reagent used is low in cost and easy to obtain, the modeling time is short, and the animal model can greatly save manpower, material resources and time cost, and reduce the overall preclinical development cost of new drugs.

The techniques described herein generally relate to methods and compositions for the regulated and controllable expression of transgenes in subjects, such as primate subjects.

The invention discloses application of a reagent for detecting abundance of intestinal flora markers in preparation of a non-human primate chronic enteritis in-vitro diagnosis product. According to the invention, cynomolgus monkeys are used as non-human primates, metagenome sequencing is carried out on bacterial components in feces of healthy individuals and chronic enteritis infected persons, the abundance of bacteria is obtained, 17 specific species of florae are found through screening operation as microbial markers, and a chronic enteritis risk prediction model is constructed. Experiments prove that the chronic enteritis risk prediction model is high in prediction sensitivity and good in specificity, chronic enteritis patients and healthy individuals can be effectively distinguished in multiple samples, and the accuracy is 97% or above, so that the flora can be used as a chronic enteritis detection marker for detecting chronic enteritis. A reagent for detecting the abundance of the intestinal flora marker can be used for preparing a non-human primate chronic enteritis in-vitro diagnosis product, so that a foundation is laid for research on non-human primate chronic enteritis diseases.

The application relates to the technical field of non-human primate habitat assessment. A non-human primate habitat assessment method and system based on multi-source data fusion are provided, wherein the method comprises the following steps: based on an attention guide mechanism, mechanism feature groups and deep space feature groups are interactively corrected to generate a collaborative feature set and a spatial attention weight graph; a spatial self-adaptive weighted fusion of the collaborative feature set is performed through a preset gate fusion unit to generate a habitat suitability prediction graph and a gate fusion weight graph; based on the habitat suitability prediction graph and a spatialized true value labeling graph, a triple constraint joint optimization strategy is adopted for model training to output an optimized model; based on the optimized model, the spatial attention weight graph and the gate fusion weight graph, an interpretable habitat assessment is performed to output an assessment report, so that the technical effects of improving habitat feature capturing capability, enhancing multi-source data fusion accuracy and ensuring that the assessment result conforms to ecological laws are achieved.

The invention belongs to the technical field of biological detection, and particularly relates to a primate eyeball flaking method. The invention provides a primate eyeball flaking method by changing a cutting step in a material taking process. According to the method, the optic disc center and the macular center in the flaking sample can be ensured to be parallel, the optic disc center and the macular center are in the same visual field during sample detection, the yield of the macular flaking is improved, the loss rate of the macular flaking is reduced, the flaking cost is reduced, and the flaking efficiency is remarkably improved.

The utility model discloses a device for testing the exploration behavior of a primate, which relates to the technical field of animal testing devices and comprises a testing panel and a shading box, a window is arranged on the testing panel, a baffle is hinged to the position corresponding to the window, a photoelectric sensor is arranged at the position of the window, and the primate to be tested is placed in the shading box. Primate animals can actively find a light source in a dark environment, due to the exploration instinct of the animals and the behavior of pushing away the baffle to explore the light source, light source signals at the window are recorded through the photoelectric sensor and are recorded by an external computer, and therefore data such as the number of times and duration of pushing away the baffle by the primate animals are obtained; automatic acquisition of primate exploration behavior data is realized, the acquisition is very convenient, manpower is saved, and the data is objective and reliable.

1. Name of the design product: animal training rod. 2. Use of the design product: used in the laboratory for the breeder to learn the skill of training monkeys and other primates. 3. Design points of the design product: in shape. 4. Picture or photo best indicating the design points: perspective view 1.

The utility model discloses postoperative rehabilitation equipment for a non-human primate experimental animal. The postoperative rehabilitation equipment comprises a side plate, a first plate and a head isolation plate, the side plates are fixed to the periphery of the head isolation plate and the first plate and used for forming a closed space, and the body of the experimental animal is located in the closed space. The head isolation plate comprises a rotating neck plate and a fixed plate connected to the periphery of the rotating neck plate, the rotating neck plate is configured to rotate around the axis, a neck moving opening is formed in the rotating neck plate and used for containing the neck of the experimental animal and is away from the neck of the experimental animal by a preset distance, and the experimental animal rotates around the axis of the experimental animal. The head of the experimental animal is located above the head isolation plate, and the hands of the experimental animal cannot make contact with the head. By means of the device, it can be guaranteed that primate experimental animals move freely, meanwhile, the primate experimental animals are effectively prevented from making contact with head wounds with hands or feet, and therefore the postoperative infection risk is remarkably reduced, and wound healing is promoted.

The present application belongs to the field of image processing, and particularly relates to a method and system for extracting primate motor brain function activation area based on MPI, which is used to solve the problems of low detection rate of subtle activation and weak or lost network connection in functional connectivity research in the prior art. The method comprises: making a subject target perform a preset action and continuously collecting brain images in time sequence to obtain brain MPI data; based on the brain MPI data, image reconstruction is performed to obtain a two-dimensional brain time sequence image sequence; comparing a reference brain anatomical diagram, frontal lobe images and occipital lobe images are extracted based on the two-dimensional brain time sequence image sequence of the subject target; the correlation of the signal intensity of each position of the frontal lobe images and the occipital lobe images with the preset action performed by the subject target is calculated respectively to obtain corresponding motor function activation areas. The advantage of the method is that the change of functional CBV with time can be directly monitored, and the activation of the brain area is more clearly and accurately displayed.

The invention provides a fragile X syndrome animal model as well as construction and application thereof. The invention discloses a target which is matched with non-human primates and is suitable for gene modification: a third exon and / or a fourth exon of an FMR1 gene, and a fragile X syndrome animal model can be obtained by targeting the target and implementing down regulation. The animal model is stable and controllable in state, easy to observe, capable of presenting typical disease symptoms compared with animal models of other species of genes and good in application prospect.