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Systems and methods for providing an LGD with a collimated backlight and a non-Lambertian diffuser are described. An LCD system includes: an illumination source for producing light; a collimating waveguide optically connected to the illumination source, the collimating waveguide including a top surface, an incident end and a plurality of substantially parallel optical elements for redirecting light from the incident end to, and through, the top surface by total internal reflection (TR), each of the plurality of substantially parallel optical elements including a first facet that is nonparallel to the top surface and a mirrored second facet that is nonparallel to the top surface; a reflector optically connected to the light source and optically connected to the collimating waveguide, the reflector (1) at least partially surrounding the illumination source, and (2) reflecting light from said illumination source to said incident end by direct reflection; a liquid crystal display optically connected to the collimating waveguide; and a non-Lambertian diffuser optically connected to the liquid crystal display for directing light from said liquid crystal display. The light from the reflector is directly incident upon the incident end. The systems and methods provide advantages in that the light from the LCD is bright and homogenous.

In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.

Drospirenone for Hormone Replacement Therapy A pharmaceutical composition comprising as a first active ingredient an estrogen, such as estradiol or estradiol valerate, in sufficient amounts to treat disorders and symptoms associated with deficient endogenous levels of estrogen in women, and as a second active ingredient 6beta,7beta; 15beta; 16beta-dimethylene-3-oxo-17alpha-preg-4-ene-21,17-carbolactone (drospirenone, DRSP) in sufficient amounts to protect the endometrium from the adverse effects of estrogen is useful for, amongst others, treating peri-menopausal, menopausal and post-menopausal women. This composition may be used for hormone replacement therapy and may be administered as a multi-phased pharmaceutical preparation. This combination therapy may comprise continuous, sequential or interrupted administration, or combinations thereof, of DRSP and estrogen, each optionally in micronized form.

Systems and methods for providing an LCD backlight are described. An LCD backlight system includes: a beam bending and viewing film including a first side including a surface diffuser and a second side including a plurality of substantially parallel optical elements, each of the plurality of substantially parallel optical elements including a first facet that includes a refractive surface and a second facet that includes a total internal reflection surface. The systems and methods provide advantages in that light from the LCD backlight is bright and homogenous.

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

In certain aspects, the present invention provides compositions and methods for decreasing FSH levels in a patient. The patient may, for example, be diagnosed with an FSH-related disorder or desire to delay or inhibit germ cell maturation.

In certain aspects, the present invention provides compositions and methods for treating or preventing breast cancer in humans.

In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma.

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

In certain aspects, the present invention provides methods for dosing a patient with an activin-ActRIIa antagonist and methods for managing patients treated with an activin-ActRIIa anatagonist. In certain aspects, the methods involve measuring one or more hematologic parameters in a patient.

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

A pharmaceutical composition comprising as a first active ingredient an estrogen, such as estradiol or estradiol valerate, in sufficient amounts to treat disorders and symptoms associated with deficient endogenous levels of estrogen in women, and as a second active ingredient 6beta,7beta; 15beta; 16beta-dimethylene-3-oxo-17alpha-preg-4-ene-21,17-carbolactone (drospirenone, DRSP) in sufficient amounts to protect the endometrium from the adverse effects of estrogen is useful for, amongst others, treating peri-menopausal, menopausal and post-menopausal women. This composition may be used for hormone replacement therapy and may be administered as a multi-phased pharmaceutical preparation. This combination therapy may comprise continuous, sequential or interrupted administration, or combinations thereof, of DRSP and estrogen, each optionally in micronized form.

In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma. Methods for dosing a patient with an ActRIIb antagonist are also provided.

In certain aspects, the present invention provides methods for dosing a patient with an ActRIIb antagonist and methods for managing patients treated with an ActRIIb anatagonist. In certain aspects, the methods involve measuring one or more hematologic parameters in a patient.

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

A method for segmenting an image comprising: determining an initial estimation of a boundary between at least two components in a region of an image to be segmented; providing image data from the region of the image to be segmented, the image data representing gray level values of a plurality of image elements of the components; modelling the image data on a mixture of at least two statistical distributions, each statistical distribution having more than one parameter, and each component being associated with certain weights of the statistical distributions in the mixture; estimating the parameters of the statistical distributions in the mixture; for each component, estimating the weights of the statistical distributions in the mixture based on the estimated parameters and the image data of each image element; and optimizing the initial estimation of the boundary between the components based on the estimated parameters and estimated weights.

A fuel cell with a gas diffusion media having a hydrophobic layer adjacent a flow field plate and a hydrophilic layer adjacent the membrane electrode assembly of the fuel cell. The two layers enable balanced humidification of reactant gas along with a basis for managing capillary water addition into the gas diffusion media. The combination of balanced moisture flux (via the hydrophobic layer) and the retention of water (via the hydrophilic layer) for humidifying reactant gas sustains hydration of the proton exchange membrane while preserving the catalyst at full activity.

A method for the treatment of fly ash to remove carbon and other matter. The resulting treated fly ash has a fine particle size and low carbon content and is useful in cementitious compositions. Other useful by-products, such as commerial grade cenopheres, can also be recovered.

In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma.