106results about How to "Improve bone strength" patented technology

In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.

An orthopaedic implant system includes an orthopaedic implant implantable at a selected location within a corporeal body. The implant includes a first structural material and a second structural material. The first structural material is non-resorbable relative to the corporeal body and is different relative to the second structural material. The implant is an internal fixation device.

An orthopaedic screw having a plurality of regions, at least one of which may be porous. The orthopaedic screw includes a head, a tip and at least one thread. The porosity of the screw of the present invention can vary within the part or region, including changes in pore shape, size and density. These characteristics can vary along the length of the screw axis and / or radially (from the outer diameter to the axis). The orthopaedic screw may further include at least one solid region formed of any implantable polymer, reinforced polymer or metal.

In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma.

This invention provides substituted acylanilide compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter alia, a muscle wasting disease and / or disorder or a bone-related disease and / or disorder.

In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.

A stem-like bone implant includes longitudinal structural members and tension cables that provide curvature control and support, and rigidity against bending and buckling. The longitudinal structural members and tension cables may become an integral part of a composite regenerated bone having a substantially increased strength over natural bone. The flexibility of the implant is controlled by specifically varying the structural geometry of certain portions of the implant, and by adjusting the tension in the tension cables before, during and after the implantation operation to thereby adjust the stiffness of the implant. The tension cables may be adjusted to produce asymmetric or non-uniform levels of tension in the longitudinal structural members.

In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma. Methods for dosing a patient with an ActRIIb antagonist are also provided.

This invention provides SARM compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter alia, a muscle wasting disease and / or disorder or a bone-related disease and / or disorder.

In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma.

This invention provides SARM compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter-alia, muscle wasting diseases and / or disorders, bone-related diseases and / or disorders, diabetes, cardiovascular disease, renal disease and others.

In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma.

Composite materials comprising a water-soluble compound adsorbed onto a basic inorganic material and a bio-degradable polymer which yields acidic degradation products, methods of producing same, and methods of use thereof are described, wherein the composite materials are designed so as to provide controlled release of the water soluble molecule.

This invention provides SARM compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter-alia, muscle wasting diseases and / or disorders, bone-related diseases and / or disorders, diabetes, cardiovascular disease, renal disease and others.

This invention provides new compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter alia, prostate cancer, muscle wasting diseases and / or disorders or a bone-related diseases and / or disorders.

The invention discloses child development formula milk powder. DHA, phosphatidylserine and choline are combined to facilitate child brain development, lutein is added for protecting child eyesight, the components are reasonably combined with substances such as raw milk, various vitamins, mineral substances and dietary fiber (fructo-oligose and galactooligosaccharide) to give play to the synergistic effect, the effect of promoting comprehensive development of the brain, eyesight and the whole body of children of 3-7 years old is achieved, and the milk powder is good in taste and comprehensive in nutrient. The invention further provides a preparation method of the child development formula milk powder. The child development formula milk powder is obtained through the steps of raw milk inspection and acceptance, milk purification, pre-pasteurization, dosing, preheating, homogenizing, sterilization, condensation, spray drying, cooling and the like in sequence, the steps are simple, the process is easy to control, the nutritional ingredient losses are small, the method is applicable to preparing child formula milk powder, and the obtained milk powder is applicable to children of 3-7 years old.

A fixing member for an implant which comprises a tube or a pillar made of an hydroxyapatite ceramics at least one part of which is a ceramics porous article consisting essentially of a hydroxyapatite formed by agitation foaming, in which a number of approximately spherical pores mutually contact having pore structures communicated three-dimensionally opened at the contact area and having an averaged porosity of from 65% to 85%. A method for fixing an implant comprising a step of inserting an implant whose at least one part of the periphery is integrated with a hydroxyapatite ceramics into an implant insertion site of an alveolar bone or a gnathic bone. A method for fixing an implant, a fixing member for the implant and an implant composite in order to reinforce an implant insertion site by compensating or regenerating an alveolar bone or a gnathic bone on an implant treatment in dentistry or in oral surgery is obtained.

Disclosed are methods for improving bone health, strength and formation in an infant who may be susceptible to developing bone health issues from conception through adolescence. The methods include administration of a nutritional formulation including at least one LCPUFA to a woman during pregnancy and optionally during lactation and breastfeeding of an infant.

In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density and strength. In certain embodiments, the present invention provides ALK3 polypeptides, including ALK3-Fc fusion proteins.

The invention discloses multifunctional medical biological bone cement. The multifunctional medical biological bone cement is prepared from the following raw materials in percentage by mass: 5%-15% of polyacrylic acid microspheres, 20% of bioactive glass, 64.9%-74.9% of calcium phosphate bone cement and 0.1% of nanometer alendronate sodium microspheres, wherein the sum of the mass percentages of the raw materials is 100%. The multifunctional medical biological bone cement has the function of water absorption self-expansion; the using amount of the bone cement can be reduced, and further the leakage of the bone cement is reduced; the multifunctional medical biological bone cement has relatively good tissue compatibility, can be used for inducing the formation of new bones and enhancing the strength of vertebral bodies, is degradable in vivo without in vivo foreign matter residues; and meanwhile, the controlled-release alendronate sodium has the effects of resisting osteoporosis, reducing the absorption of bones and furthering enhancing the vertebral bodies. Therefore, the multifunctional medical biological bone cement has the advantages of little consumption, promotion of bone formation and bone absorption resistance when applied to vertebroplasty.

The invention discloses a method for improving quality of strong aromatic dry distilled grain, comprising the steps of pretreating the materials, piling and fermenting, taking out of a pit, stirring the mixed grains, getting wine and steaming grains, getting out of a steamer and proportioning water, reducing temperature and mixing the rice flour, entering the pit and sealing the pit. The method is characterized in that new measures about a pit mud maintenance in contact with the dry grains and about a prevention of mixed bacteria infection are carried out by not crushing part of the materials for wine making, increasing the mixed grain amount and reducing the use quantity of bran shells, thereby improving acidity of fermented grain for pit entry and water retention property of the fermented grain, and greatly improving the quality of the dry distilled grain. The method improves the quality of dry grains, improves the high-quality yield of the dry distilled grain by about 35%, improves the high-quality yield of the wet grain by above 10% and improves wine yield by above 3% so that the whole pit can brew high-quality wine. The invention has simple technology, easy operation, low production cost, good wine quality and easy implementation, thereby providing reliable guarantee for large-area application of technical reform in strong aromatic wine production enterprise.

The invention relates to the field of medical food and discloses an aquatic collagen peptide food used for adjuvant therapy of osteoporosis and arthritis. Every 100g of the food contains multiple nutritional ingredients as follows: 9-11g of cod skin collagen protein peptide powder, 4-6g of squid skin collagen protein peptide powder, 2-3g of whey protein powder, 2-3g of soybean protein powder, 9-11g of MCT fat, 2-3g of soybean oil, 58-62g of carbohydrate and other vitamins and microelements. The aquatic collagen peptide food takes cod skin collagen protein peptide powder, squid skin collagen protein peptide powder and whey protein powder as main raw materials and has relatively high digestive absorptivity, and collagen protein peptide can promote bone formation and reinforce a bone collagen structure at low calcium level, so that bone strength is improved; bone metabolism can be improved, and ossification can be enhanced; and bone diseases such as the osteoporosis, hyperostosis and swelling and pain of bone joints can be prevented.

The invention provides an electromagnet field and ultrasonic wave combined device for remedying osteoprosis. The device comprises a power system, a signal generator powered by the power system, at least an electromagnet field treatment head and an ultrasonic wave treatment head driven by the signal generator. The electromagnet field generating device of the invention can wholly remedy the osteoprosis, enhance the density of human body bones, change the electric and chemical environment of a bone tissue, and influence and correct the growth, the restoration and the maintenance of the bone tissue; the ultrasonic wave emitting device has low density of a radiation bone or a fracture part, can promote the growth of the bone tissue, shorten the healing time of bone injury caused by the osteoprosis, and improve the curative ratio of bone disconnection. The above comprehensive treatment proposal from the whole to the part is applied in remedying the osteoprosis and promoting the rehabilitation of the osteoporosis bone injury. The device of the invention has the advantages that the operation is convenient, and the comprehensive remedy effect is good, and the device is suitable for various constituents and crowds.

Methods of using an injectable or implantable rod-shaped formulation for delivery of osteogenic proteins to treat osteoporotic and / or osteopenic bone are disclosed. The formulation comprises hyaluronic acid derivatives and osteogenic proteins, and optional excipients and active ingredients such as a bone resorption inhibitor.

This invention provides pharmaceutical uses for 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3. This compound is characterized by high bone calcium mobilization activity demonstrating preferential activity on bone. This results in a novel therapeutic agent for the treatment and prophylaxis of diseases where bone formation is desired, particularly osteoporosis. This compound also increases both breaking strength and crushing strength of bones evidencing use in conjunction with bone replacement surgery such as hip and knee replacements, as well as use by normal subjects when high bone mass is desired.