113 results about "Brain development" patented technology

The present invention relates to a kit of nutrient blend compositions for young individuals, in particular children between 0 and 66 months of age, each of these compositions having age-specific ingredients. The kit of nutrient blend compositions is particularly intended to promote myelination of a targeted brain region, in particular of the social brain, of children at a specific age and brain development stage.

The invention discloses a white matter fiber bundle structure-function connection coupling method based on a distance function. The method comprises the steps that brain imaging data are collected and preprocessed; extracting white matter fiber bundle structure attributes and function signals of the preprocessed brain imaging data; constructing a structure connection matrix and an individualized function connection matrix according to the white matter fiber bundle structure attributes and the function signals; measuring the connection weight similarity between corresponding columns of the structure connection matrix and the function connection matrix through a distance function, and carrying out white matter fiber bundle structure-function connection coupling according to the connection weight similarity; through the method, the relationship of the white matter fiber bundle structure and function of the brain can be quantified, and the method is suitable for brain structure and function analysis based on the white matter fiber bundle and research on brain development and mental diseases.

The invention discloses a comprehensive evaluation method and system for a child brain growth and development state, and relates to the technical field of child growth and development health. Multi-dimensional data of child brain growth and development are comprehensively collected, and a child development database is established; based on the collected multi-dimensional data, extracting features for evaluating the growth and development state of the brain of the child, determining the standard value of each feature, and generating a feature sequence table; and respectively carrying out structural analysis, functional analysis and behavior analysis on the children by combining the relevant features of the feature sequence table and the standard value of each feature. According to the method, by collecting multi-dimensional data related to child brain growth and development, the key field of child brain development can be comprehensively covered, deviation or omission possibly brought by single-dimensional evaluation is avoided, deep analysis is performed on the collected data, key features are extracted and standardized processing is performed, and the accuracy of child brain development is improved. The quality and comparability of the data are further improved, the comprehensiveness of the evaluation result is improved, and the credibility of the evaluation result is enhanced.

The invention discloses a nutritional composition for promoting neurodevelopment and application, and provides a nutritional composition for promoting neurodevelopment, which comprises the following necessary components: a sialylated substance component comprising one or more of N-acetylneuraminic acid, sialylated oligosaccharide, sialylated protein and sialylated lipid; the whey protein component comprises alpha-lactalbumin; and a peptide component from casein, including a hydrolysate of casein; the nutritional composition comprises a sialylated substance component, a whey protein component and a casein-derived peptide component, and the mass ratio of the sialylated substance component, the whey protein component and the casein-derived peptide component in the nutritional composition is (0.5-10): (300-1): (100-0.5). The nutritional composition provided by the invention can promote brain development and cognitive functions, and can significantly promote neurodevelopment by scientifically matching the sialylated substance component, the whey protein component and the peptide component from casein.

The present invention relates to the use of a nutritional composition for non-therapeutic purposes of improving brain development, promoting neural and / or cognitive development. The nutritional composition comprises medium and long-chain fatty acid triglycerides and human milk oligosaccharides, and the mass ratio of the medium and long-chain fatty acid triglycerides to the human milk oligosaccharides is 1:1 to 9:1. In this composition, the medium and long-chain fatty acid triglycerides and the human milk oligosaccharides have a synergistic effect in terms of the said use, significantly improving the effect of the composition in improving brain development, promoting neural and / or cognitive development. This composition can be used for preventing or improving brain developmental retardation, nervous system and / or cognitive developmental retardation; at the same time, it can also be used for preventing or improving impaired learning ability, impaired mental behavior, impaired memory or reduced attention span, etc., and has good application prospects.

The invention provides a neural developmental disorder prediction model construction method, system and device and a medium, and the method comprises the steps: obtaining the clinical information of a child patient, the clinical information comprises severity of developmental retardation / dyspepsia, complexity of syndromic neurodevelopmental disorder, autism spectrum disorder, epilepsy, attention deficit hyperactivity disorder, head circumference deformity, brain development deformity, hearing / visual function impairment and related ear-eye development deformity; applying logistic regression analysis to screen out predictive factors significantly related to the positive diagnosis rate of third-generation whole exon genome sequencing in the clinical information; constructing a neural developmental disorder prediction model based on binary logistic regression according to the prediction factor; and verifying the neurodevelopmental disorder prediction model by applying data of the internal verification group and the external verification group so as to evaluate the prediction efficiency of the neurodevelopmental disorder prediction model, so that the probability of obtaining positive diagnosis after the child patient receives trio-WES detection can be accurately evaluated, and the prediction efficiency is remarkably improved.

The invention provides a composition for synergistically promoting brain development. The invention provides a composition. The composition is composed of 2 '-FL and 3'-SL in a mass ratio of (2.5: 1)-(15: 1). The invention further provides food and medicine containing the composition, application of the composition in preparation of food or medicine for promoting brain development, application of the food or medicine for promoting brain development and a method for promoting brain development.

A nutritional composition comprising digestible carbohydrates, protein and lipid, wherein the lipid is in the form of lipid globules which are at least partly coated on the surface with phospholipids, for increasing myelination in the brain of an infant who has delayed brain development or is at risk of having delayed brain development.

The invention belongs to the technical field of nutritious food, and particularly discloses a composition for promoting brain development and application thereof. The composition for promoting brain development provided by the invention comprises bifidobacterium longum subsp. Infantis i18 and sn-2 site docosahexaenoic acid. According to the composition provided by the invention, all the components have a synergistic effect, so that the accumulation of DHA in cerebral cortex and hippocampus can be remarkably improved, and the purpose of promoting brain development is achieved. The composition is suitable for health food, formula milk powder or fermented milk and other products for improving cognition and promoting brain development.

The invention belongs to the technical field of microbial engineering, discloses a composition for promoting infant brain development and application thereof, and provides a composition containing lactobacillus paracasei N1115, breast milk oligosaccharide and whey protein powder, the composition can promote infant brain and nerve development, all the components have a synergistic effect, and the effect of promoting infant brain and nerve development is achieved. The conversion from latent TGF-beta in the whey protein powder to activated TGF-beta is activated, so that the aims of promoting neurodevelopment, improving memory and promoting brain development of infants are fulfilled. The preparation method is suitable for preparing milk powder, cheese, yoghourt, plant-based yoghourt and derivative products or other foods for promoting brain development of infants.

The present invention discloses a brain development atlas and image processing system based on fetal magnetic resonance imaging, which belongs to the field of medical imaging technology, and specifically comprises: an image acquisition module, which is used to regularly acquire and preprocess nuclear magnetic resonance image data; an image segmentation module, which is used to segment the fetal brain image in the nuclear magnetic resonance image, obtain brain parameters, and identify brain sub-regions; a three-dimensional reconstruction module, which is used to detect whether the fetal brain image is qualified, use a slice-volume registration algorithm to perform three-dimensional reconstruction of the fetal brain image, segment and extract the three-dimensional brain tissue structure, perform cortical reconstruction on the segmentation result, and generate the three-dimensional structure of the fetal brain tissue; an atlas generation module, which is used to obtain a cross-sectional image of the three-dimensional structure of the fetal brain tissue from a preset angle, and arrange the cross-sectional images in chronological order to generate a fetal brain development atlas; the present invention improves the recognition efficiency and accuracy of fetal development information.

The invention relates to a nutritional composition comprising non-digestible oligosaccharides for infants and / or young children. The invention further relates to the use of said nutritional composition for improving the brain function, in particular social recognition.

The invention belongs to the technical field of nutritional compositions, and discloses a breast milk oligosaccharide-containing composition for promoting brain metabolism and relieving diarrhea and application of the breast milk oligosaccharide-containing composition, and the breast milk oligosaccharide-containing composition contains breast milk oligosaccharide consisting of 2 '-fucosyllactose, 3'-sialic acid lactose and 6 '-sialic acid lactose in a specific weight ratio. The composition disclosed by the invention is used for preparing products with the functions of promoting brain development or metabolism and relieving diarrhea. The composition prepared by the invention can be used for preparing formula milk powder, yoghourt and various metabiotics preparations with corresponding effects.

The invention discloses a brain abnormal development trajectory identification method and system, and belongs to the technical field of magnetic resonance image analysis, and the method comprises the following steps: obtaining T1 weighted magnetic resonance images of a plurality of healthy individuals, and carrying out the offset correction of the structure index of each brain region in the images, a generalized additive position-scale-shape model of the healthy crowd is constructed; generating a norm development trajectory curve and a normal change range thereof; obtaining a T1 weighted magnetic resonance image of a to-be-evaluated individual, and selecting a target brain region of the to-be-evaluated individual; obtaining various offset corrected structure indexes of the target brain region of the individual to be evaluated; obtaining a mean value and a standard deviation of each structure index at the position of the brain region corresponding to the same-age healthy population of the individual to be evaluated; and generating a recognition report of the abnormal brain development trajectory of the to-be-evaluated individual. The problem that it is difficult to accurately, clearly and visually reflect the abnormal recognition condition of the brain trajectory of the individual to be evaluated and the position of the corresponding abnormal brain region is solved.

The invention belongs to the technical field of microorganisms, and particularly relates to lactobacillus helveticus YM1922 for promoting brain development, improving concentration and nourishing nerves as well as a metabolite, a complex flora, a metabolite and application. The lactobacillus helveticus YM1922 is preserved in the China General Microbiological Culture Collection Center on September 10, 2024, and the preservation number of the lactobacillus helveticus YM1922 is CGMCC No. 31928. Fermentation metabolites of the strain can promote secretion of brain-derived neurotrophic factors, and thalli can inhibit production of intestinal tract D-gluconic acid in intestinal tracts. Therefore, the strain and the metabolite thereof have application potentials of promoting brain development, improving cognitive level, improving concentration and nourishing nerves, and can be prepared into products for playing corresponding roles.

The invention discloses a brain development characteristic evolution analysis system and method based on multi-mode brain image data. The system comprises a brain development map construction module, a data acquisition module, a data processing module and an evolution matching evaluation module. The method comprises the following steps: collecting demographic information and multi-modal brain image data of multi-age healthy people, constructing a structure, and connecting and activating a three-dimensional group brain development map; the method comprises the following steps: processing individual data by adopting the same process, obtaining a multi-modal brain feature vector in a unified brain region space, mapping the multi-modal brain feature vector to a corresponding group map space, calculating a deviation amount and combining a stability weight to obtain a fusion deviation index, identifying an abnormal brain region according to the fusion deviation index, calculating an abnormal proportion and a risk change rate, and realizing brain development feature evolution analysis. According to the method, group evolution priori and individual multi-modal data are fused, brain development can be dynamically and accurately evaluated, and the problems of static detection, group individual disjunction, insufficient multi-modal fusion and the like are solved.

The invention provides an intelligence-promoting healthy fish sausage and a preparation method thereof, the intelligence-promoting healthy fish sausage comprises the following raw materials in parts by weight: 50-60 parts of fish meat or minced fillet, 1-5 parts of starch, 5-20 parts of water and 0.1-5 parts of a brain-benefiting raw material combination, the brain-benefiting raw material combination is added into the fish sausage, and the adding sequence of the brain-benefiting raw material combination is after high-speed chopping and mixing and before ligation. The brain-benefiting raw material composition can be ensured not to be damaged and loss of the brain-benefiting raw material composition can be reduced to the greatest extent, substances contained in the brain-benefiting raw material composition can promote brain and retina development, enhance intelligence and memory and improve blood fat and blood circulation, a sufficient material basis is provided for brain development, and the body of an eater becomes healthier.

A use of a nutritional composition in promoting the bidirectional development of the gut and brain via the gut-brain axis. The nutritional composition comprises the following essential components: docosahexaenoic acid, eicosatetraenoic acid, galactooligosaccharide, 1,3-dioleic acid-2-palmitic acid triglyceride, lutein, nucleotide, lactoferrin, casein phosphopeptide, and probiotics. By combining and strengthening multiple functional active components, the gut health and brain cognitive development of the organism can be bidirectionally promoted by means of the microbiota-gut-brain axis. In particular, the present application can promote the regulation of flora in the gut of the organism, increase the abundance of beneficial bacteria, and decrease the abundance of harmful bacteria related to brain development diseases. The content of butyric acid in the gut can be increased, and the contents of acetic acid and propionic acid are decreased to promote brain and cognitive development.

The present invention provides a kind of composition containing bird's nest acid, phospholipid and polyunsaturated fatty acid and preparation method thereof, composition, when not adding any additives, bird's nest acid is dispersed in DHA grease in functional ingredients, while solving the problem that DHA is easily oxidized, promotes brain development, regulates immunity, promotes the absorption and utilization of minerals in the intestine and the effects of beauty and skin care. Phospholipids can prevent the sedimentation of bird's nest acid in ω 3 polyunsaturated fatty acid grease, and are phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol or phosphatidylserine. Not only can the sedimentation of bird's nest acid be prevented, but also the growth of nerve cells can be supported, thereby improving the absorption rate of DHA in the brain. Especially PS, itself can not only nourish the brain, enhance brain function, but also relieve mental stress and improve cognition, and is called "brain nutrient".

The present application belongs to the field of functional substance research, and particularly relates to a nutritional composition for promoting brain development and use thereof. The nutritional composition provided by the present application comprises essential active ingredients shown in (i) and (ii) as follows: (i) lysophosphatidylethanolamine; (ii) 3'-SL; wherein the essential active ingredient shown in (i) at least comprises lysophosphatidylethanolamine with a fatty acid chain with a length of 14-22 carbon atoms connected at the sn-1 position, and in the nutritional composition, the mass ratio of the essential active ingredient shown in (i) to the essential active ingredient shown in (ii) is 1:(1-450). The combination of lysophosphatidylethanolamine and breast milk oligosaccharide 3'-SL can effectively promote the overall development of the body, especially the brain development, and improve the relative gene expression amount of brain-derived neurotrophic factor and glial cell-derived neurotrophic factor in brain tissue, thereby effectively assisting the improvement of cognitive ability.

The present invention presents a driver with a route that provides the brain with stimulation for improving cognitive function and promoting brain development.　A route search device 1 comprises: a route search unit 112 that searches for a plurality of routes from the current location of a vehicle 10 to the destination thereof; a driving difficulty calculation unit 113 that calculates a driving difficulty on the basis of the travel environment of a route; an estimation unit 116 that estimates the driver's level of concentration on the basis of the recognition results of a first recognition unit 114, which recognizes the driver's facial expressions, and a second recognition unit 115, which recognizes the driver's biological information; a provisional total driving load value calculation unit 117 that calculates a provisional total driving load value, in a case where the destination is reached, on the basis of the driving difficulty and an arbitrarily determined degree of concentration; an actual driving load value calculation unit 118 that calculates an actual driving load value on the basis of the driver's level of concentration while traveling the route and the driving difficulty; and a control unit 119 that re-searches for a route on the basis of an estimated total driving load value at a destination arrival time calculated on the basis of the actual driving load value, and the estimated total driving load value.

The invention provides a fucosylated human milk oligosaccharide (HMO) for use in improving brain development and / or vision development in a subject, wherein: a) the fucosylated HMO is lacto-N-fucopentaose-I (LNFP-I) and the subject is an infant up to 12 months old; and / or b) the fucosylated HMO is A-tetrasaccharide, wherein the subject is an infant, a young child or a child.

The present invention provides a nutritional composition comprising at least one lactose-N-fucose pentasaccharide, in particular lactose-N-fucose pentasaccharide-I (LNFP-I) or a combination of lactose-N-fucose pentasaccharide-I (LNFP-I), lactose-N-fucose pentasaccharide-II (LNFP-II) and lactose-N-fucose pentasaccharide-III (LNFP-III), for use in improving brain development and / or cognitive development in a subject. There is also provided a nutritional composition comprising at least one lactose-N-fucopentasaccharide, in particular lactose-N-fucopentasaccharide-I (LNFP-I) or a combination of lactose-N-fucopentasaccharide-I (LNFP-I), lactose-N-fucopentasaccharide-II (LNFP-II) and lactose-N-fucopentasaccharide-III (LNFP-III), and Bifidobacterium bifidobacterium.

A fusion model-based quantitative assessment system for infant brain development includes a posture estimation module, a coordinate preprocessing module, a feature extraction module, a decision tree classification module, a graph convolution classification module, a multidimensional index analysis module, and a result visualization module. The posture estimation module receives an infant movement video as input, the posture estimation module output is connected to the coordinate preprocessing module input, the coordinate preprocessing module output is connected to the feature extraction module input, the feature extraction module output is connected to the decision tree classification module input, the decision tree classification module first output is connected to the graph convolution classification module input, the decision tree classification module second output and the graph convolution classification module output are connected to the multidimensional index analysis module input, and the multidimensional index analysis module output is connected to the result visualization module input. The present invention performs multidimensional and precise quantitative assessment of infant brain development, while providing interpretable results to assist physicians in conducting targeted treatment.

The utility model discloses a lamplight game board for exercising hand-eye coordination, which comprises a base, a cavity with an opening at the top is arranged on the base, a plurality of game lamp beads which are annularly arranged are mounted at the edge of the cavity, one of the game lamp beads is a target lamp bead, a slapping button is arranged on the outer side of the target lamp bead in the cavity, and the slapping button is arranged on the outer side of the target lamp bead in the cavity. A cavity is formed in the base, an audible device and a plurality of arranged level lamp beads are installed in the middle of the cavity, a game panel is installed on the base, first through holes for exposing game lamp beads, the level lamp beads and a slapping key are formed in the game panel, the game lamp beads are regularly lightened during game, and when a target lamp bead is lightened, the slapping key is pressed to complete challenge. The children's eye and hand cooperation ability can be exercised, and the children's eye and hand cooperation ability training device has important significance for children's body and brain development.

The present invention relates to a kit of nutrient blend compositions for young individuals, in particular children aged between 0 and 66 months, each one of the compositions having age-specific ingredients. The kit of nutrient blend compositions is specifically aimed at promoting myelination of targeted brain regions, in particular the social brain, of children at specific ages and stages of brain development.

A quantitative assessment system for infant brain development based on a graph convolutional network includes a posture estimation module, a sequence preprocessing module, a feature extraction module, a graph convolution classification module, a multidimensional indicator analysis module, and a result visualization module. The posture estimation module receives an infant movement video as input, the posture estimation module output is connected to the sequence preprocessing module input, the sequence preprocessing module output is connected to the feature extraction module input, the feature extraction module output is connected to the graph convolution classification module input, the graph convolution classification module output is connected to the multidimensional indicator analysis module input, and the multidimensional indicator analysis module output is connected to the result visualization module input. The system output can output multiple abnormality categories and includes interpretable visualization results, thereby assisting physicians in targeted treatment intervention.

The invention relates to the technical field of food, and particularly discloses DHA algal oil PS lutein ester gel candies capable of promoting brain development and improving eyesight and a preparation method thereof.The DHA algal oil PS lutein ester gel candies capable of promoting brain development and improving eyesight are of a three-layer sandwich structure, the slow-release capsule comprises an outer-layer rubber sheet, a middle slow-release layer and an inner core active layer from outside to inside, the outer-layer rubber skin is prepared from gelatin, glycerol, sorbitol liquid, pectin, stevioside, edible essence and water; the middle slow-release layer comprises beeswax, medium chain triglyceride and phospholipid; the inner core active layer is prepared from DHA algal oil, phosphatidylserine, lutein ester oil, (3R, 3 'S)-dihydroxy-beta-carotene oil, starch acetate, a blueberry powder solid beverage and citric acid. The DHA algal oil phosphatidylserine lutein ester gel candy can promote brain development, improve learning and memory, improve concentration, prevent blue light, prevent myopia, improve myopia and relieve asthenopia.

The present application relates to the technical field of biotechnology, and particularly discloses a composition, a preparation method thereof and application in improving brain health. The present application finds that when oat green extract and sialic acid are combined in a specific ratio, the composition can simultaneously have the effects of promoting brain development and improving cognitive impairment in the elderly, and further proposes a composition comprising: oat green extract and sialic acid; the mass ratio of the oat green extract and the sialic acid is (0.7-41.5):(1-14). The composition of the present application can simultaneously promote brain development and improve cognitive impairment in the elderly, and provides an effective new solution capable of acting throughout the entire life cycle for improving brain health.

The present invention provides a fucosylated human milk oligosaccharide (HMO) for use in improving brain development and / or social emotional development in a subject wherein the fucosylated HMO is 3-fucosyllactose (3-FL), and wherein the subject is an infant, a young child, or a child.