82 results about "Brain development" patented technology

The invention discloses a nutritional composition for promoting neurodevelopment and application, and provides a nutritional composition for promoting neurodevelopment, which comprises the following necessary components: a sialylated substance component comprising one or more of N-acetylneuraminic acid, sialylated oligosaccharide, sialylated protein and sialylated lipid; the whey protein component comprises alpha-lactalbumin; and a peptide component from casein, including a hydrolysate of casein; the nutritional composition comprises a sialylated substance component, a whey protein component and a casein-derived peptide component, and the mass ratio of the sialylated substance component, the whey protein component and the casein-derived peptide component in the nutritional composition is (0.5-10): (300-1): (100-0.5). The nutritional composition provided by the invention can promote brain development and cognitive functions, and can significantly promote neurodevelopment by scientifically matching the sialylated substance component, the whey protein component and the peptide component from casein.

The invention belongs to the technical field of nutritious food, and particularly discloses a composition for promoting brain development and application thereof. The composition for promoting brain development provided by the invention comprises bifidobacterium longum subsp. Infantis i18 and sn-2 site docosahexaenoic acid. According to the composition provided by the invention, all the components have a synergistic effect, so that the accumulation of DHA in cerebral cortex and hippocampus can be remarkably improved, and the purpose of promoting brain development is achieved. The composition is suitable for health food, formula milk powder or fermented milk and other products for improving cognition and promoting brain development.

The invention belongs to the technical field of microbial engineering, discloses a composition for promoting infant brain development and application thereof, and provides a composition containing lactobacillus paracasei N1115, breast milk oligosaccharide and whey protein powder, the composition can promote infant brain and nerve development, all the components have a synergistic effect, and the effect of promoting infant brain and nerve development is achieved. The conversion from latent TGF-beta in the whey protein powder to activated TGF-beta is activated, so that the aims of promoting neurodevelopment, improving memory and promoting brain development of infants are fulfilled. The preparation method is suitable for preparing milk powder, cheese, yoghourt, plant-based yoghourt and derivative products or other foods for promoting brain development of infants.

The invention relates to a nutritional composition comprising non-digestible oligosaccharides for infants and / or young children. The invention further relates to the use of said nutritional composition for improving the brain function, in particular social recognition.

The invention discloses a brain abnormal development trajectory identification method and system, and belongs to the technical field of magnetic resonance image analysis, and the method comprises the following steps: obtaining T1 weighted magnetic resonance images of a plurality of healthy individuals, and carrying out the offset correction of the structure index of each brain region in the images, a generalized additive position-scale-shape model of the healthy crowd is constructed; generating a norm development trajectory curve and a normal change range thereof; obtaining a T1 weighted magnetic resonance image of a to-be-evaluated individual, and selecting a target brain region of the to-be-evaluated individual; obtaining various offset corrected structure indexes of the target brain region of the individual to be evaluated; obtaining a mean value and a standard deviation of each structure index at the position of the brain region corresponding to the same-age healthy population of the individual to be evaluated; and generating a recognition report of the abnormal brain development trajectory of the to-be-evaluated individual. The problem that it is difficult to accurately, clearly and visually reflect the abnormal recognition condition of the brain trajectory of the individual to be evaluated and the position of the corresponding abnormal brain region is solved.

The invention discloses a brain development characteristic evolution analysis system and method based on multi-mode brain image data. The system comprises a brain development map construction module, a data acquisition module, a data processing module and an evolution matching evaluation module. The method comprises the following steps: collecting demographic information and multi-modal brain image data of multi-age healthy people, constructing a structure, and connecting and activating a three-dimensional group brain development map; the method comprises the following steps: processing individual data by adopting the same process, obtaining a multi-modal brain feature vector in a unified brain region space, mapping the multi-modal brain feature vector to a corresponding group map space, calculating a deviation amount and combining a stability weight to obtain a fusion deviation index, identifying an abnormal brain region according to the fusion deviation index, calculating an abnormal proportion and a risk change rate, and realizing brain development feature evolution analysis. According to the method, group evolution priori and individual multi-modal data are fused, brain development can be dynamically and accurately evaluated, and the problems of static detection, group individual disjunction, insufficient multi-modal fusion and the like are solved.

A use of a nutritional composition in promoting the bidirectional development of the gut and brain via the gut-brain axis. The nutritional composition comprises the following essential components: docosahexaenoic acid, eicosatetraenoic acid, galactooligosaccharide, 1,3-dioleic acid-2-palmitic acid triglyceride, lutein, nucleotide, lactoferrin, casein phosphopeptide, and probiotics. By combining and strengthening multiple functional active components, the gut health and brain cognitive development of the organism can be bidirectionally promoted by means of the microbiota-gut-brain axis. In particular, the present application can promote the regulation of flora in the gut of the organism, increase the abundance of beneficial bacteria, and decrease the abundance of harmful bacteria related to brain development diseases. The content of butyric acid in the gut can be increased, and the contents of acetic acid and propionic acid are decreased to promote brain and cognitive development.

The present invention provides a kind of composition containing bird's nest acid, phospholipid and polyunsaturated fatty acid and preparation method thereof, composition, when not adding any additives, bird's nest acid is dispersed in DHA grease in functional ingredients, while solving the problem that DHA is easily oxidized, promotes brain development, regulates immunity, promotes the absorption and utilization of minerals in the intestine and the effects of beauty and skin care. Phospholipids can prevent the sedimentation of bird's nest acid in ω 3 polyunsaturated fatty acid grease, and are phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol or phosphatidylserine. Not only can the sedimentation of bird's nest acid be prevented, but also the growth of nerve cells can be supported, thereby improving the absorption rate of DHA in the brain. Especially PS, itself can not only nourish the brain, enhance brain function, but also relieve mental stress and improve cognition, and is called "brain nutrient".

The present application belongs to the field of functional substance research, and particularly relates to a nutritional composition for promoting brain development and use thereof. The nutritional composition provided by the present application comprises essential active ingredients shown in (i) and (ii) as follows: (i) lysophosphatidylethanolamine; (ii) 3'-SL; wherein the essential active ingredient shown in (i) at least comprises lysophosphatidylethanolamine with a fatty acid chain with a length of 14-22 carbon atoms connected at the sn-1 position, and in the nutritional composition, the mass ratio of the essential active ingredient shown in (i) to the essential active ingredient shown in (ii) is 1:(1-450). The combination of lysophosphatidylethanolamine and breast milk oligosaccharide 3'-SL can effectively promote the overall development of the body, especially the brain development, and improve the relative gene expression amount of brain-derived neurotrophic factor and glial cell-derived neurotrophic factor in brain tissue, thereby effectively assisting the improvement of cognitive ability.

The present invention presents a driver with a route that provides the brain with stimulation for improving cognitive function and promoting brain development.　A route search device 1 comprises: a route search unit 112 that searches for a plurality of routes from the current location of a vehicle 10 to the destination thereof; a driving difficulty calculation unit 113 that calculates a driving difficulty on the basis of the travel environment of a route; an estimation unit 116 that estimates the driver's level of concentration on the basis of the recognition results of a first recognition unit 114, which recognizes the driver's facial expressions, and a second recognition unit 115, which recognizes the driver's biological information; a provisional total driving load value calculation unit 117 that calculates a provisional total driving load value, in a case where the destination is reached, on the basis of the driving difficulty and an arbitrarily determined degree of concentration; an actual driving load value calculation unit 118 that calculates an actual driving load value on the basis of the driver's level of concentration while traveling the route and the driving difficulty; and a control unit 119 that re-searches for a route on the basis of an estimated total driving load value at a destination arrival time calculated on the basis of the actual driving load value, and the estimated total driving load value.

The present invention provides a nutritional composition comprising at least one lactose-N-fucose pentasaccharide, in particular lactose-N-fucose pentasaccharide-I (LNFP-I) or a combination of lactose-N-fucose pentasaccharide-I (LNFP-I), lactose-N-fucose pentasaccharide-II (LNFP-II) and lactose-N-fucose pentasaccharide-III (LNFP-III), for use in improving brain development and / or cognitive development in a subject. There is also provided a nutritional composition comprising at least one lactose-N-fucopentasaccharide, in particular lactose-N-fucopentasaccharide-I (LNFP-I) or a combination of lactose-N-fucopentasaccharide-I (LNFP-I), lactose-N-fucopentasaccharide-II (LNFP-II) and lactose-N-fucopentasaccharide-III (LNFP-III), and Bifidobacterium bifidobacterium.

A fusion model-based quantitative assessment system for infant brain development includes a posture estimation module, a coordinate preprocessing module, a feature extraction module, a decision tree classification module, a graph convolution classification module, a multidimensional index analysis module, and a result visualization module. The posture estimation module receives an infant movement video as input, the posture estimation module output is connected to the coordinate preprocessing module input, the coordinate preprocessing module output is connected to the feature extraction module input, the feature extraction module output is connected to the decision tree classification module input, the decision tree classification module first output is connected to the graph convolution classification module input, the decision tree classification module second output and the graph convolution classification module output are connected to the multidimensional index analysis module input, and the multidimensional index analysis module output is connected to the result visualization module input. The present invention performs multidimensional and precise quantitative assessment of infant brain development, while providing interpretable results to assist physicians in conducting targeted treatment.

The utility model discloses a lamplight game board for exercising hand-eye coordination, which comprises a base, a cavity with an opening at the top is arranged on the base, a plurality of game lamp beads which are annularly arranged are mounted at the edge of the cavity, one of the game lamp beads is a target lamp bead, a slapping button is arranged on the outer side of the target lamp bead in the cavity, and the slapping button is arranged on the outer side of the target lamp bead in the cavity. A cavity is formed in the base, an audible device and a plurality of arranged level lamp beads are installed in the middle of the cavity, a game panel is installed on the base, first through holes for exposing game lamp beads, the level lamp beads and a slapping key are formed in the game panel, the game lamp beads are regularly lightened during game, and when a target lamp bead is lightened, the slapping key is pressed to complete challenge. The children's eye and hand cooperation ability can be exercised, and the children's eye and hand cooperation ability training device has important significance for children's body and brain development.

The present invention relates to a kit of nutrient blend compositions for young individuals, in particular children aged between 0 and 66 months, each one of the compositions having age-specific ingredients. The kit of nutrient blend compositions is specifically aimed at promoting myelination of targeted brain regions, in particular the social brain, of children at specific ages and stages of brain development.

A quantitative assessment system for infant brain development based on a graph convolutional network includes a posture estimation module, a sequence preprocessing module, a feature extraction module, a graph convolution classification module, a multidimensional indicator analysis module, and a result visualization module. The posture estimation module receives an infant movement video as input, the posture estimation module output is connected to the sequence preprocessing module input, the sequence preprocessing module output is connected to the feature extraction module input, the feature extraction module output is connected to the graph convolution classification module input, the graph convolution classification module output is connected to the multidimensional indicator analysis module input, and the multidimensional indicator analysis module output is connected to the result visualization module input. The system output can output multiple abnormality categories and includes interpretable visualization results, thereby assisting physicians in targeted treatment intervention.

The invention relates to the technical field of food, and particularly discloses DHA algal oil PS lutein ester gel candies capable of promoting brain development and improving eyesight and a preparation method thereof.The DHA algal oil PS lutein ester gel candies capable of promoting brain development and improving eyesight are of a three-layer sandwich structure, the slow-release capsule comprises an outer-layer rubber sheet, a middle slow-release layer and an inner core active layer from outside to inside, the outer-layer rubber skin is prepared from gelatin, glycerol, sorbitol liquid, pectin, stevioside, edible essence and water; the middle slow-release layer comprises beeswax, medium chain triglyceride and phospholipid; the inner core active layer is prepared from DHA algal oil, phosphatidylserine, lutein ester oil, (3R, 3 'S)-dihydroxy-beta-carotene oil, starch acetate, a blueberry powder solid beverage and citric acid. The DHA algal oil phosphatidylserine lutein ester gel candy can promote brain development, improve learning and memory, improve concentration, prevent blue light, prevent myopia, improve myopia and relieve asthenopia.

The present application relates to the technical field of biotechnology, and particularly discloses a composition, a preparation method thereof and application in improving brain health. The present application finds that when oat green extract and sialic acid are combined in a specific ratio, the composition can simultaneously have the effects of promoting brain development and improving cognitive impairment in the elderly, and further proposes a composition comprising: oat green extract and sialic acid; the mass ratio of the oat green extract and the sialic acid is (0.7-41.5):(1-14). The composition of the present application can simultaneously promote brain development and improve cognitive impairment in the elderly, and provides an effective new solution capable of acting throughout the entire life cycle for improving brain health.

The present invention provides a fucosylated human milk oligosaccharide (HMO) for use in improving brain development and / or social emotional development in a subject wherein the fucosylated HMO is 3-fucosyllactose (3-FL), and wherein the subject is an infant, a young child, or a child.

The application relates to the technical field of image processing, in particular to an MRI image feature extraction method for dynamic evaluation of child brain development, which comprises the following steps: determining a cerebrospinal fluid coefficient of a child brain; dividing an MRI image into a cerebrospinal fluid region and a residual brain region based on the cerebrospinal fluid coefficient of the child brain of each pixel point; determining a white matter coefficient of each pixel point in the residual brain region according to the gray value of each pixel point in the decayed weighted image of each pixel point in different gradient directions, and the gray value of each pixel point in the first weighted image and the second weighted image in the residual brain region; segmenting the white matter region and the gray matter region of the residual brain region based on the white matter coefficient, and extracting image features in the white matter region and the gray matter region. In this way, the accuracy and reliability of the segmentation result of different tissue regions in the child brain MRI image are improved.

The application relates to the cross field of biomedical engineering and artificial intelligence, and discloses a personalized brain power development training method based on electroencephalogram signals. The method comprises the following steps: collecting resting state and task state multi-channel electroencephalogram signals of a subject, constructing a functional connection matrix after pretreatment, identifying individualized weak connection target points through difference operation and cluster analysis; matching a neural feedback training protocol from a preset paradigm library based on the target points, and generating a feedback signal by extracting a target point synchronicity feature in real time during training to guide the subject to actively enhance the weak connection; updating the model after each training and dynamically optimizing subsequent parameters to form a closed-loop regulation. The application improves working memory and attention through individualized targeted training, induces neural plasticity, and realizes efficient and accurate brain power development.

The invention discloses a nutritional composition for promoting brain development and application thereof, and relates to the technical field of biological medicines. The compound composition is selected from a composition A (melatonin + uridylic acid + inositol), a composition B (melatonin + uridylic acid) and a composition C (uridylic acid + inositol). Experiments prove that the combination B can significantly improve elevated anxiety behaviors and learning and memory ability caused by rhythm disorder, the combination C can significantly improve open field anxiety behaviors caused by rhythm disorder, and the combination A can significantly relieve anxiety behaviors (including elevated and open field) and spatial learning and memory ability disorder caused by rhythm disorder at the same time. The active components in the compound composition disclosed by the invention are remarkable in synergistic effect, high in safety and good in biocompatibility, and can be used for preparing medicines, food additives or feed additives for improving rhythm disorder related brain dysplasia.

The invention belongs to the technical field of medical image processing, and particularly relates to a functional magnetic resonance image data denoising method, system and device and a medium, and the method comprises the steps: obtaining child brain functional magnetic resonance original time sequence image data, child brain development prior map data, historical same-age denoising standard data and physiological movement synchronous collection data; brain tissue region segmentation and region-of-interest positioning are completed, positioning results of different brain regions are obtained, and time sequence signal features and space structure features of the different brain regions are extracted; constructing a children brain functional magnetic resonance multi-dimensional adaptive denoising model, generating a brain region noise type thermodynamic diagram, and generating a brain region hierarchical differential denoising strategy through a signal-noise separation algorithm to obtain denoised functional magnetic resonance image data; and generating a de-noising quality evaluation report and updating the parameter weight of the multi-dimensional adaptive de-noising model. Therefore, the problems of low denoising accuracy and the like in the prior art are solved.

This invention discloses a highly absorbable, non-allergenic DHA brain-boosting oral liquid specifically designed for students of all ages, belonging to the field of functional nutritional beverage technology for teenagers. This invention uses high-purity Schizochytrium algae oil DHA and perilla seed active molecules as the core brain-boosting matrix, innovatively configuring a grade-specific ingredient system. The formula is customized for the physical condition and brain function needs of students at different grade levels: kindergarten, primary school, junior high school, high school, and university. Through a small-molecule cell-wall breaking extraction process, the nutrients are directly absorbed into the bloodstream and quickly converted into "brain gold" in the brain. This formula strictly avoids eight major food allergens, ensuring safety for all ages. It also specifically addresses sub-health issues related to learning across all grade levels, including early childhood brain development and emotional well-being, exam preparation efficiency and fatigue reduction for students preparing for higher education, and cognitive development and mental sustainability for university students. The product comes in standardized packaging of 50ml / vial and 15 vials / box, with a customized sweet taste tailored to different grade levels, making it highly acceptable to students. It has no side effects and is suitable for long-term healthy consumption by all school students, effectively improving brain efficiency and learning status across all grade levels, with broad market application prospects.

The invention belongs to the field of nutrient substance research, and particularly relates to a nutrient composition for improving brain development. The nutritional composition provided by the invention comprises necessary active ingredients shown in the following (i) and (ii): (i) lactose-N-neotetraose, (ii) 1, 2-diacyl-sn-glycerol-3-phosphorylcholine, and (iii) 1, 2-diacyl-sn-glycerol-3-phosphorylcholine. The nutritional composition comprises lactose-N-neotetraose and 1, 2-diacyl-sn-glycerol-3-phosphorylcholine, and in the nutritional composition, the mass ratio of the lactose-N-neotetraose to the 1, 2-diacyl-sn-glycerol-3-phosphorylcholine is 1: (0.010-2.5). The research shows that the combination of the lactose-N-neotetraose and the 1, 2-diacyl-sn-glycerol-3-phosphorylcholine can be used for improving offspring brain immune disorder and / or nervous system dysplasia caused by maternal immune activation, and the lactose-N-neotetraose and the 1, 2-diacyl-sn-glycerol-3-phosphorylcholine have a synergistic interaction effect.

The present application belongs to the technical field of nutrient research, and particularly relates to a nutrient composition for promoting brain development and use thereof. The nutrient composition provided by the present application comprises two necessary components: i) lysophosphatidyl ethanolamine; and ii) docosahexaenoic acid; and the mass ratio of the lysophosphatidyl ethanolamine to the docosahexaenoic acid in the nutrient composition is 1:(10-2100). The combination of lysophosphatidyl ethanolamine and docosahexaenoic acid can effectively promote the overall growth and development of the body, especially the brain development, increase the expression levels of brain-derived neurotrophic factor and glial cell-derived neurotrophic factor in brain tissue, and effectively assist the improvement of cognitive ability.

The utility model relates to the technical field of building block sets, in particular to a preschool brain development building block set made of environment-friendly materials, which comprises a building block loading box, a side plate and a multi-shape building block component, and the multi-shape building block component comprises a sliding rod, a first building block placing plate and a second building block placing plate. Through the multi-shape building block assembly and the multi-shape building block sleeve, one end of the building block loading box is fixedly connected with the guide rail rod, through classification and arrangement of building blocks, the shape, the function, the theme and other characteristics of different building blocks can be known more deeply, the classification awareness of the building blocks is strengthened, and the building blocks can be stored more conveniently by participating in the arrangement and storage process of the building blocks. The children can develop good self-care habits and order feelings, the first building block placing plate and the second building block placing plate can be stretched and contracted easily and conveniently, and the children can expand the storage space and clearly see building block sets in different shapes only by slightly pulling the building block sets with the first building block placing plate and the second building block placing plate.

The invention discloses a fetal brain development assessment method and a computer program product, and belongs to the field of medical image analysis. The method comprises the following steps: firstly, acquiring a brain image of a fetus, and then segmenting the brain image by using a segmentation model trained based on a multi-gestational-age sample and a loss function adjusted along with gestational ages to obtain a brain segmentation result; calculating a brain development index of the fetus based on the segmentation result; estimating the gestational age of the fetus by using a gestational age estimation model, wherein the gestational age estimation model comprises a segmentation model serving as a generator and a discriminator obtained through adversarial training; acquiring a normal brain development index range of the corresponding gestational age from a reference database based on the estimated gestational age; and finally, comparing the calculated brain development index with a normal range to obtain a fetal brain development evaluation result.

The present disclosure provides compositions and methods for providing a health benefit to a growing animal comprising administering a food composition to the animal, wherein the food composition includes a brain development blend. The brain development blend generally comprises DHA, EPA, taurine, choline, thiamine, riboflavin, pantothenic acid, niacin, pyridoxine, vitamin B12, and folic acid.

A nutritional composition for promoting brain development. The nutritional composition comprises the following essential components: docosahexaenoic acid, arachidonic acid, galactooligosaccharide, 1,3-dioleoyl-2-palmitoyl triglyceride, lutein, nucleotides, lactoferrin, and casein phosphopeptides. The nutritional composition and food containing same can effectively promote brain structure development and neural network formation. Specifically, on the brain structure, the brain weight can be particularly increased, and the maturation of the white matter region is promoted, and the beneficial development of lipid composition in the brain can also be promoted. Furthermore, in the neural network formation, related protein expression of neural network key components such as synapses and myelin sheaths can be promoted, thereby facilitating nerve cell activity and neural signal transmission, and further facilitating cognitive and neurobehavioral development.

The invention relates to the modelling of a disorder called tubulinopathy, which refers to a wide range of cortical developmental malformations (CDM) resulting from defects in genes encoding tubulin proteins that regulate neuronal migration during brain development, by knocking out the tubulin gamma 1 (Tubg1) gene in zebrafish (Danio rerio) embryos using CRISPR / Cas9 technology. The transgenic animal in question allows the investigation of the phenotype and molecular pathological mechanisms of CDMs resulting from the deficiency of the Tubg1 protein during the developmental process. In the invention, the region located in the third exon of the Tubg1 gene in zebrafish is targeted and knocked out with a guide RNA having the nucleotide sequence SEQ ID NO: 1.