46 results about "Brain development" patented technology

The invention belongs to the technical field of nutritious food, and particularly discloses a composition for promoting brain development and application thereof. The composition for promoting brain development provided by the invention comprises bifidobacterium longum subsp. Infantis i18 and sn-2 site docosahexaenoic acid. According to the composition provided by the invention, all the components have a synergistic effect, so that the accumulation of DHA in cerebral cortex and hippocampus can be remarkably improved, and the purpose of promoting brain development is achieved. The composition is suitable for health food, formula milk powder or fermented milk and other products for improving cognition and promoting brain development.

The invention discloses a brain abnormal development trajectory identification method and system, and belongs to the technical field of magnetic resonance image analysis, and the method comprises the following steps: obtaining T1 weighted magnetic resonance images of a plurality of healthy individuals, and carrying out the offset correction of the structure index of each brain region in the images, a generalized additive position-scale-shape model of the healthy crowd is constructed; generating a norm development trajectory curve and a normal change range thereof; obtaining a T1 weighted magnetic resonance image of a to-be-evaluated individual, and selecting a target brain region of the to-be-evaluated individual; obtaining various offset corrected structure indexes of the target brain region of the individual to be evaluated; obtaining a mean value and a standard deviation of each structure index at the position of the brain region corresponding to the same-age healthy population of the individual to be evaluated; and generating a recognition report of the abnormal brain development trajectory of the to-be-evaluated individual. The problem that it is difficult to accurately, clearly and visually reflect the abnormal recognition condition of the brain trajectory of the individual to be evaluated and the position of the corresponding abnormal brain region is solved.

The invention discloses a brain development characteristic evolution analysis system and method based on multi-mode brain image data. The system comprises a brain development map construction module, a data acquisition module, a data processing module and an evolution matching evaluation module. The method comprises the following steps: collecting demographic information and multi-modal brain image data of multi-age healthy people, constructing a structure, and connecting and activating a three-dimensional group brain development map; the method comprises the following steps: processing individual data by adopting the same process, obtaining a multi-modal brain feature vector in a unified brain region space, mapping the multi-modal brain feature vector to a corresponding group map space, calculating a deviation amount and combining a stability weight to obtain a fusion deviation index, identifying an abnormal brain region according to the fusion deviation index, calculating an abnormal proportion and a risk change rate, and realizing brain development feature evolution analysis. According to the method, group evolution priori and individual multi-modal data are fused, brain development can be dynamically and accurately evaluated, and the problems of static detection, group individual disjunction, insufficient multi-modal fusion and the like are solved.

The present application belongs to the field of functional substance research, and particularly relates to a nutritional composition for promoting brain development and use thereof. The nutritional composition provided by the present application comprises essential active ingredients shown in (i) and (ii) as follows: (i) lysophosphatidylethanolamine; (ii) 3'-SL; wherein the essential active ingredient shown in (i) at least comprises lysophosphatidylethanolamine with a fatty acid chain with a length of 14-22 carbon atoms connected at the sn-1 position, and in the nutritional composition, the mass ratio of the essential active ingredient shown in (i) to the essential active ingredient shown in (ii) is 1:(1-450). The combination of lysophosphatidylethanolamine and breast milk oligosaccharide 3'-SL can effectively promote the overall development of the body, especially the brain development, and improve the relative gene expression amount of brain-derived neurotrophic factor and glial cell-derived neurotrophic factor in brain tissue, thereby effectively assisting the improvement of cognitive ability.

The present invention relates to a kit of nutrient blend compositions for young individuals, in particular children aged between 0 and 66 months, each one of the compositions having age-specific ingredients. The kit of nutrient blend compositions is specifically aimed at promoting myelination of targeted brain regions, in particular the social brain, of children at specific ages and stages of brain development.

The present application relates to the technical field of biotechnology, and particularly discloses a composition, a preparation method thereof and application in improving brain health. The present application finds that when oat green extract and sialic acid are combined in a specific ratio, the composition can simultaneously have the effects of promoting brain development and improving cognitive impairment in the elderly, and further proposes a composition comprising: oat green extract and sialic acid; the mass ratio of the oat green extract and the sialic acid is (0.7-41.5):(1-14). The composition of the present application can simultaneously promote brain development and improve cognitive impairment in the elderly, and provides an effective new solution capable of acting throughout the entire life cycle for improving brain health.

The present invention provides a fucosylated human milk oligosaccharide (HMO) for use in improving brain development and / or social emotional development in a subject wherein the fucosylated HMO is 3-fucosyllactose (3-FL), and wherein the subject is an infant, a young child, or a child.

The application relates to the technical field of image processing, in particular to an MRI image feature extraction method for dynamic evaluation of child brain development, which comprises the following steps: determining a cerebrospinal fluid coefficient of a child brain; dividing an MRI image into a cerebrospinal fluid region and a residual brain region based on the cerebrospinal fluid coefficient of the child brain of each pixel point; determining a white matter coefficient of each pixel point in the residual brain region according to the gray value of each pixel point in the decayed weighted image of each pixel point in different gradient directions, and the gray value of each pixel point in the first weighted image and the second weighted image in the residual brain region; segmenting the white matter region and the gray matter region of the residual brain region based on the white matter coefficient, and extracting image features in the white matter region and the gray matter region. In this way, the accuracy and reliability of the segmentation result of different tissue regions in the child brain MRI image are improved.

The application relates to the cross field of biomedical engineering and artificial intelligence, and discloses a personalized brain power development training method based on electroencephalogram signals. The method comprises the following steps: collecting resting state and task state multi-channel electroencephalogram signals of a subject, constructing a functional connection matrix after pretreatment, identifying individualized weak connection target points through difference operation and cluster analysis; matching a neural feedback training protocol from a preset paradigm library based on the target points, and generating a feedback signal by extracting a target point synchronicity feature in real time during training to guide the subject to actively enhance the weak connection; updating the model after each training and dynamically optimizing subsequent parameters to form a closed-loop regulation. The application improves working memory and attention through individualized targeted training, induces neural plasticity, and realizes efficient and accurate brain power development.

The invention belongs to the technical field of medical image processing, and particularly relates to a functional magnetic resonance image data denoising method, system and device and a medium, and the method comprises the steps: obtaining child brain functional magnetic resonance original time sequence image data, child brain development prior map data, historical same-age denoising standard data and physiological movement synchronous collection data; brain tissue region segmentation and region-of-interest positioning are completed, positioning results of different brain regions are obtained, and time sequence signal features and space structure features of the different brain regions are extracted; constructing a children brain functional magnetic resonance multi-dimensional adaptive denoising model, generating a brain region noise type thermodynamic diagram, and generating a brain region hierarchical differential denoising strategy through a signal-noise separation algorithm to obtain denoised functional magnetic resonance image data; and generating a de-noising quality evaluation report and updating the parameter weight of the multi-dimensional adaptive de-noising model. Therefore, the problems of low denoising accuracy and the like in the prior art are solved.

This invention discloses a highly absorbable, non-allergenic DHA brain-boosting oral liquid specifically designed for students of all ages, belonging to the field of functional nutritional beverage technology for teenagers. This invention uses high-purity Schizochytrium algae oil DHA and perilla seed active molecules as the core brain-boosting matrix, innovatively configuring a grade-specific ingredient system. The formula is customized for the physical condition and brain function needs of students at different grade levels: kindergarten, primary school, junior high school, high school, and university. Through a small-molecule cell-wall breaking extraction process, the nutrients are directly absorbed into the bloodstream and quickly converted into "brain gold" in the brain. This formula strictly avoids eight major food allergens, ensuring safety for all ages. It also specifically addresses sub-health issues related to learning across all grade levels, including early childhood brain development and emotional well-being, exam preparation efficiency and fatigue reduction for students preparing for higher education, and cognitive development and mental sustainability for university students. The product comes in standardized packaging of 50ml / vial and 15 vials / box, with a customized sweet taste tailored to different grade levels, making it highly acceptable to students. It has no side effects and is suitable for long-term healthy consumption by all school students, effectively improving brain efficiency and learning status across all grade levels, with broad market application prospects.

The present application belongs to the technical field of nutrient research, and particularly relates to a nutrient composition for promoting brain development and use thereof. The nutrient composition provided by the present application comprises two necessary components: i) lysophosphatidyl ethanolamine; and ii) docosahexaenoic acid; and the mass ratio of the lysophosphatidyl ethanolamine to the docosahexaenoic acid in the nutrient composition is 1:(10-2100). The combination of lysophosphatidyl ethanolamine and docosahexaenoic acid can effectively promote the overall growth and development of the body, especially the brain development, increase the expression levels of brain-derived neurotrophic factor and glial cell-derived neurotrophic factor in brain tissue, and effectively assist the improvement of cognitive ability.

The utility model relates to the technical field of building block sets, in particular to a preschool brain development building block set made of environment-friendly materials, which comprises a building block loading box, a side plate and a multi-shape building block component, and the multi-shape building block component comprises a sliding rod, a first building block placing plate and a second building block placing plate. Through the multi-shape building block assembly and the multi-shape building block sleeve, one end of the building block loading box is fixedly connected with the guide rail rod, through classification and arrangement of building blocks, the shape, the function, the theme and other characteristics of different building blocks can be known more deeply, the classification awareness of the building blocks is strengthened, and the building blocks can be stored more conveniently by participating in the arrangement and storage process of the building blocks. The children can develop good self-care habits and order feelings, the first building block placing plate and the second building block placing plate can be stretched and contracted easily and conveniently, and the children can expand the storage space and clearly see building block sets in different shapes only by slightly pulling the building block sets with the first building block placing plate and the second building block placing plate.

The invention discloses a fetal brain development assessment method and a computer program product, and belongs to the field of medical image analysis. The method comprises the following steps: firstly, acquiring a brain image of a fetus, and then segmenting the brain image by using a segmentation model trained based on a multi-gestational-age sample and a loss function adjusted along with gestational ages to obtain a brain segmentation result; calculating a brain development index of the fetus based on the segmentation result; estimating the gestational age of the fetus by using a gestational age estimation model, wherein the gestational age estimation model comprises a segmentation model serving as a generator and a discriminator obtained through adversarial training; acquiring a normal brain development index range of the corresponding gestational age from a reference database based on the estimated gestational age; and finally, comparing the calculated brain development index with a normal range to obtain a fetal brain development evaluation result.

The present disclosure provides compositions and methods for providing a health benefit to a growing animal comprising administering a food composition to the animal, wherein the food composition includes a brain development blend. The brain development blend generally comprises DHA, EPA, taurine, choline, thiamine, riboflavin, pantothenic acid, niacin, pyridoxine, vitamin B12, and folic acid.

The present invention provides a fucosylated human milk oligosaccharide (HMO) for use in improving brain development and / or vision development in a subject wherein: a) the fucosylated HMO is lactose-N-fucopentasaccharide-I (LNFP-I) and the subject is an infant of up to 12 months of age; and / or b) the fucosylated HMO is A-tetrasaccharide, wherein the individual is an infant, toddler or child.

The invention relates to the technical field of biology, and particularly discloses a composition, a preparation method of the composition and application of the composition to promotion of brain development and improvement of senescence with cognitive impairment. The composition disclosed by the invention is prepared from the following components: plant lactobacillus HEAL9 and an oat green extract, the mass ratio of the plant lactobacillus HEAL9 to the oat green extract is (1-14): (0.7-20.5). According to the composition disclosed by the invention, a product which can play a role in promoting cognition in two different physiological / pathological states is obtained by combining the plant lactobacillus HEAL9 and the avena sativa green extract in a specific ratio, and the product has the effect of promoting development in the brain development stage and also has the effect of promoting cognition in the brain development stage. And the health-care product has the effect of improving senescence with cognitive impairment in the brain decline stage, and is a novel product beneficial to brain health in the whole life cycle.

This invention relates to the field of food and medicine homology products and their processing technology, and particularly to a fermented beverage made from food and medicine homology that promotes brain development and its preparation method. This invention uses hawthorn, malt, poria cocos, yam, longan pulp, ophiopogon japonicus, and alpinia oxyphylla as fermentation raw materials. The fermentation process yields a fermentation stock solution, which is then blended with concentrated apple juice, concentrated lemon juice, maltodextrin, walnut protein peptides, N-acetylneuraminic acid, γ-aminobutyric acid, and water. This invention combines food and medicine homology with fermentation, employing low-temperature enzymatic hydrolysis and ultrasound-assisted extraction of the food and medicine homology raw materials combined with low-temperature fermentation using probiotics. It also incorporates new brain-nourishing nutritional resources, combining sialic acid, GABA, walnut peptides, and spleen-strengthening and intelligence-boosting herbal fermentation to create a synergistic effect. This results in a beverage that promotes brain development in children, especially suitable for children aged 3-14 years, improving brain development, spleen and stomach function, memory, and concentration. Furthermore, the formula is mild and safe, tailored to children's physiological characteristics, and has a good taste and is easily absorbed.

The invention belongs to the technical field of microorganisms, and particularly relates to a synbiotics preparation of lactobacillus helveticus as well as a preparation method and application of the synbiotics preparation. The synbiotics preparation of the lactobacillus helveticus, provided by the invention, is a microcapsule preparation prepared by taking the lactobacillus helveticus as probiotics and sialylated breast milk oligosaccharide as prebiotics and sequentially embedding by adopting sodium alginate and chitosan; wherein the lactobacillus helveticus is lactobacillus helveticus HL88. The lactobacillus helveticus HL88 adopted by the invention has better cracking activity on the sialylated breast milk oligosaccharide, and can effectively improve the utilization efficiency of the sialylated breast milk oligosaccharide. Furthermore, the lactobacillus helveticus and the sialylated breast milk oligosaccharide are subjected to composite embedding, so that the synergistic metabolism effect can be achieved, and the brain development process is effectively promoted. Therefore, the invention can provide a treatment thought for improving the brain development retardation, and can also provide a technical basis for developing probiotic medicines for promoting brain development.

This invention relates to nutritional compositions and their uses. Specifically, this invention relates to a nutritional composition comprising: (1) component A consisting of docosahexaenoic acid and arachidonic acid; (2) component B consisting of medium- and long-chain fatty acid triglycerides and 1,3-dioleoyl-2-palmitoyl triglycerides; and (3) component C consisting of choline and taurine. This invention also relates to the use of this nutritional composition for non-therapeutic purposes, including: promoting neurotransmitter expression; improving neuronal structure and function; and improving anxiety. This invention further relates to the use of this nutritional composition in the preparation of products for non-therapeutic purposes, including improving brain development and / or memory and / or improving anxiety. The nutritional composition of this invention can significantly improve brain development and / or memory and / or improve anxiety, which is beneficial for meeting current market demands.

The application relates to the technical field of brain network construction, and particularly discloses a brain structure and metabolic image synchronously acquired brain network construction method and device, which comprises the following steps: acquiring a structure image and a metabolic image to be processed; registering the structure image to be processed to a standard brain template; registering the metabolic image to the standard brain template by taking the structure image as an intermediate; fusing brain structure information and metabolic information of the nuclear medicine image to obtain a metabolic image; performing brain partition processing on the metabolic image to form a multi-partition brain model; obtaining a co-correlation matrix by analyzing the correlation between multiple brain regions; and obtaining a metabolic brain network by optimizing the co-correlation matrix of the brain model. The brain structure and metabolic image synchronously acquired brain network construction method and device can more effectively find metabolic differences between brain disease patients and normal people in network attribute indexes, and provide valuable information for brain development, maturity and aging.

Disclosed is an ActiOmega® composition (unsaturated fatty acids and phospholipids) comprising Bacopa monnieri extracts. The composition in the present invention can improve concentration, enhance cognition, improve learning and memory abilities, increase the release and transmission rate of neurotransmitters, enhance hippocampal activity, promote the absorption and utilization of DHA in the human body and the brain development. The DHA in the present invention achieves efficient purification and impurity removal through ultra-high vacuum molecular distillation technology (without the need for solvents), and ensures almost no fishy odourthrough the high vacuum steam deodorization process, with higher DHA content and purity, natural green colour, easy access to the brain, and high bioavailability.

The invention relates to the technical field of biology, and particularly discloses a composition as well as a preparation method and application thereof in improvement of brain health. Research finds that after the oat green extract and sialic acid are combined according to a specific proportion, the oat green extract and the sialic acid can have the effects of promoting brain development and improving senescence and cognitive impairment at the same time, and then the composition is provided and comprises the oat green extract and the sialic acid; the mass ratio of the oat green extract to the sialic acid is (0.7-41.5): (1-14). The composition can promote brain development and improve senescence with cognitive impairment at the same time, and an effective new scheme which can take effect across the whole life cycle is provided for improving brain health.

The invention discloses milk powder rich in sialylated oligosaccharide and capable of regulating brain development and a preparation method of the milk powder. The sialylated oligosaccharide disclosed by the invention is a mixture of 3 '-sialylated lactose and 6'-sialylated lactose. The invention also discloses a formula of the milk powder rich in sialylated oligosaccharide and capable of regulating brain development. The milk powder comprises the following components in parts by weight: 620-720 parts of raw milk, 200-300 parts of whey protein powder, 15-25 parts of soybean phospholipid, 150-250 parts of OPO structure fat, 15-30 parts of linseed oil, 45-66 parts of coconut oil and 120-180 parts of sunflower seed oil. And 10 to 20 parts of sialylated oligosaccharide. The invention further discloses a preparation method of the milk powder rich in sialylated oligosaccharide and capable of regulating brain development. The milk powder developed by the invention has the effects of promoting brain growth and promoting cognitive development.

The invention discloses a culture medium and a method for obtaining an induced cortical-like neuron precursor cell cluster from iPSCs (induced pluripotent stem cells), and belongs to the technical field of biology. The culture medium comprises a neural stem cell induction liquid I and a neural stem cell induction liquid II, a single-layer adherent induction method is adopted, and iPSCs are efficiently differentiated into an induced cortical neuron precursor cell cluster through optimized inoculation density, matrix treatment and a staged induction process. The neural stem cells comprise neural stem cells, transition-state nerve cells and differentiated mature nerve cells (the cell type composition is highly similar to that of tissue-derived neural stem cells). The method overcomes the problems of complex induction process and high cell heterogeneity in a traditional embryoid body method, the induction efficiency can reach 100%, single cell sequencing analysis shows that all cells are nerve cells, the purity is 100%, and non-target cells are not detected. A uniform, stable and efficient cell tool is provided for brain development research, nervous system disease modeling and cell therapy.

The invention relates to the technical field of attention detection, in particular to an fNIRS-based student classroom attention assessment system, which comprises a multi-channel fNIRS signal acquisition headband, a signal preprocessing module, a feature extraction module, an attention state assessment model, a data storage and management module and a visualization and feedback module, the attention state evaluation model is a sub-age evaluation model library formed by a plurality of sub-models of different age groups; through adaptive adjustment of filter parameters, a motion artifact correction strategy and an evaluation model, brain development characteristics, physiological noise characteristics and behavior mode differences of different age groups are fully considered, the accuracy and applicability of attention evaluation of various student groups are remarkably improved, and real personalized education monitoring is realized.

The utility model discloses a child super-soft pasting quilt, which comprises a quilt main body, the other side of three stitches of the quilt main body is provided with a seamless smooth area, the surface of the quilt main body is sewed with a decorative paster, and the decorative paster is positioned at the seamless smooth area. The pillow has the advantage of being good in comfort, and solves the problems that the comfort is poor in the using process of an existing child, the child is in the key period of rapid growth and development, sufficient high-quality sleep is crucial to the body and brain development of the child, and the child cannot feel comfortable. An uncomfortable quilt may cause frequent waking up at night, increased turning over or difficulty in falling asleep of children, so that the deep sleep time is shortened, and normal growth hormone secretion is affected.

1. Name of the designed product: Labyrinth toy (for preschool education). 2. Use of the designed product: for entertainment and leisure, brain development, and intelligence. 3. Design points of the designed product: in shape. 4. Picture or photo that best indicates the design points: front view.

The application discloses a brain cortex surface morphology high-order feature extraction method, which comprises the following steps: firstly, acquiring brain magnetic resonance T1 structural image data; for individual brain magnetic resonance T1 weighted structural image data, using an open source magnetic resonance data processing toolkit to reconstruct a brain cortex surface; secondly, acquiring brain cortex surface vertex original morphology features, constructing brain cortex surface morphology vertex node strength, and obtaining high-order features; then, constructing a brain region level complex network based on the cortex vertex morphology high-order features, and obtaining complex network features; finally, based on the high-order features and the complex network features, using feature selection combined with machine learning to realize a cognitive ability evaluation model, and completing effectiveness evaluation. The application helps to expand traditional brain cortex surface morphology research to the field of brain connection and brain network research, improves the validity of brain network research, reveals the brain cortex morphology connection mechanism of brain cognition and brain development, and promotes the progress of brain science research.

The invention discloses a method and system for predicting infant brain function connection based on morphological characteristics and a diffusion model, a storage medium and electronic equipment. The method in the formula comprises the following steps: extracting cortex morphological characteristics in an infant structure magnetic resonance image (sMRI), constructing a morphological similarity network (MSN), and realizing infant brain function full-connection layer prediction by utilizing a diffusion model in combination with classifier irrelevant guidance and a cross-modal attention mechanism. According to the method, individual development features are stably captured by using a longitudinal information extraction module, accurate mapping from morphological features to function connection is realized in combination with a classifier irrelevant guidance diffusion model and a morphological guidance attention mechanism, the prediction precision and stability are remarkably improved, and the prediction efficiency is improved. The problem that infant functional magnetic resonance imaging (fMRI) data is scarce or low in quality can be effectively solved, functional networks in different development stages are accurately reconstructed, and the accuracy of infant early brain development monitoring is improved.