216 results about "Functional analysis" patented technology

A data warehouse design that combines data from multiple source ledgers or modules is constructed and from that an associated, single physical Star or Snow-Flake schema and OLAP hyper-cube analytic structure is generated to enable cross-functional analysis of any those multiple source ledgers or modules. The step of constructing the data warehouse or the step of generating the associated OLAP cube is achieved without significant human intervention using software. The present invention is based on the insight that the technical bias against generating individual data marts and OLAP cubes from multiple source ledgers is not well founded. Previously, the norm has been to generate a single physical OLAP cube for each individual ledger—hence one for the General Ledger, a further one for sales order processing etc. This prior art approach makes cross functional analysis multiple source ledgers and sub-ledgers difficult since it requires the creation of a further level of physical or virtual cubes across multiple physical cubes and complex querying. This is no longer necessary with the present invention.

A cardiac functional analysis system reconstructs a 3D anatomical image volume using image frames acquired at predetermined cardiac phases over multiple cardiac cycles in response to a trigger derived from hemodynamic signals. A medical imaging system generates 3D anatomical imaging volume datasets from acquired 2D anatomical images. The system includes an image acquisition device for acquiring 2D anatomical images of a portion of patient anatomy in selectable angularly variable imaging planes in response to a synchronization signal derived from a patient blood flow related parameter. A synchronization processor provides the synchronization signal derived from the patient blood flow related parameter. An image processor processes 2D images acquired by the image acquisition device of the portion of patient anatomy in multiple different imaging planes having relative angular separation, to provide a 3D image reconstruction of the portion of patient anatomy.

A system and method is presented for determining at what price and when to release so-called ‘flex’ price tickets during an on-sale using hazard functional analyses of sales velocity and sales/inquiry ratios. Exponential, power, and Weibull-gamma models are also used to predict demand, depending on what part of the on-sale is involved. Determining demand of seats from secondary markets is also described with methods to use the demand for either repricing the seats in the primary market or presenting ‘best value’ seats to a prospective purchaser. Demand can be interpolated or extrapolated to individual seats or rows.

The present invention describes a comprehensive system for gene discovery using retrovirus that have been engineered to exhibit increased accessibility to genomic DNA, or to mutate and identify the chromosomal target sequences of DNA binding proteins. The strategy employs the combination of retroviral integrase/DNA binding protein fusion constructs and gene-trapping methodologies. This novel technology provides the ability to establish proviral integration at any location within the genome. In addition, it allows for the generation of a collection of eukaryotic cells in which each cell contains a mutation in a target gene or sequence for a known DNA binding protein which also allow for rapid in vivo functional analysis. Sequence information obtained for genes identified using the described methods identify a collection of eukaryotic genes related by, or directly or indirectly regulated by, a given DNA binding protein.

The present invention relates generally to groups of genes that can be used to diagnose and differentiate between types of specific diseases such as breast cancer. The groups of genes can be further used to develop diagnostic kits for the specific diseases. The diagnostic kits can also differentiate between sub-categories of a disease to help identify the appropriate treatment regimen for a patient.

Gene targeting allows the deletion (knock out), the repair (rescuing) and the modification (gene mutation) of a selected gene and the functional analysis of any gene of interest. Targeting of nuclear genes has been a very inefficient process in most eukaryotes including plants and animals due to the dominance of illegitimate integration of the applied DNA into non-homologous regions of the genome. The present invention provides a method for increasing the ratio of homologous to non-homologous recombination of a polynucleotide into a host cell's DNA by suppressing non-homologous recombination. Surprisingly, the number of non-homologous recombination events can be reduced if the polynucleotide is applied as a purified single-stranded DNA, preferably coated with a single strand binding protein.

The invention discloses a method for establishing a fragile X-syndrome non-human primate model on the basis of a CRISPR gene knockout technology. The method comprises the following steps: (1) establishing a FMR1 gene knockout machin model; (2) carrying out identification and related functional analysis on the machin model; (3) carrying out tests on the nerve characteristics and learning and memorizing ability of the machin model. The method utilizes a CRISPR gene knockout technology to establish a fragile X-syndrome non-human primate model. The model fills the blank of non-human primate model, can effectively stimulate the pathological process of human diseases, can be used as an optimum animal model for researching human diseases, can effectively predict the effect of novel vaccine, novel drug or novel diagnostic reagent in clinical applications, and thus greatly reduces the risk of novel drug development.

The present invention relates to articles and methods for determining the function of genes, gene products, and nucleic acid products. The present invention also relates to identifying ligands and binding partners or proteins and nucleic acid products. The present invention also relates to methods and compositions related to reverse-transfection.

A multimodal intravascular analysis uses a structural intravascular analysis modality to compensate for a chemical analysis modality. Examples of structural analysis are IVUS, OCT, including optical coherence domain Reflectometry (OCDR) and optical frequency domain imaging (OFDI), and/or sonar range finding. Examples of chemical or functional analysis are optical, NIR, Raman, fluorescence and spectroscopy, thermography and reflectometry. In one example, the structural analysis is used to characterize the environment structurally, such as catheter head-vessel wall distance. This information is then used to select from two or more algorithms which are depth specific (e.g. shallow vs. deep), to achieve improved accuracy in the chemical or functional analysis.

The present invention is directed to selection systems for the identification of cell proliferation genes based on functional analysis. More specifically, the invention is directed to a process for the identification of a cell proliferation promoting activity, the isolation of genes involved in such cell proliferation promoting activity, and the use of the so identified genes for the diagnosis or treatment of a disease associated with excessive cell proliferation. The invention further is directed to the design and development of antibodies, peptides, nucleic acids, and other compounds which specifically interfere with the function of the identified gene and/or its gene product, and pharmaceutical compositions comprising such compounds, for the treatment of diseases associated with inappropriate or unregulated cell proliferation.

The functional analysis of genes frequently requires the manipulation of large genomic regions. A yeast-bacteria shuttle vector is described, that can be used to clone large regions of DNA by homologous recombination. The important feature of present invention is the presence of the a bacterial replication origin, which allows large DNA insert capacity. The utility of this vector lies in its ability to isolate, manipulate and maintain large fragments in bacteria and yeast, allowing for mutagenesis by yeast genetics and simplified preparation of plasmid DNA in bacteria.

The functional analysis of genes frequently requires the manipulation of large genomic regions. A yeast-bacteria shuttle vector is described that can be used to clone large regions of DNA by homologous recombination. Also described is a method for isolating entire genomes, including chloroplast genomes, or large portions thereof, and manipulating the same. Also described are methods for determining minimal genomes, minimal pathway requirements, and minimal organelle genomes.

The invention discloses a spatial accessibility analysis method based on public facility differences. The method comprises the following seven steps of: 1) obtaining population and service requirement data in a service area; 2) obtaining public facility data; 3) carrying out traffic and distance calculation on the service area; 4) determining the effective service range of a public service facility; 5) carrying out functional analysis on different levels of public facilities; 6) calculating the spatial accessibility value of the public service facility; and 7) carrying out the difference analysis on a spatial accessibility result. A device used for the analysis method comprises an on-site data collection terminal and a remote data processing platform. By use of the method and the device, the hierarchy and the maneuverability of an analysis result are improved. Compared with the traditional method, the method more approaches to a realistic situation, is more favorable for a planning and construction department to evaluate the spatial configuration situation of the existing public facility, provides decision support for the layout regulation and planning of the public facility, and is convenient in carrying out classified guidance on the planning and the construction of the public facility.

A method for functional analysis of neurophysiological data by decomposing neurophysiological data and EEG signal to form a plurality of signal features. The signal features may then optionally be analyzed to determined one or more patterns.

The present invention provide a modeling method for intelligent substation secondary equipment interval information model. The method particularly comprises the following steps of: establishing an association relationship between a primary equipment model and a secondary equipment model, dividing a secondary equipment interval model, and automatically collecting secondary equipment elements to the secondary equipment interval model. According to the method, the association relationship between the primary equipment model and the secondary equipment model is established, and advanced applications of intelligent analysis of mutual interference of reorganization and expansion, intelligent alarming, five-prevention interlocking, data identification and the like are powerfully supported, thereby reducing labor and time consumption, improving the security and stability of a substation and a power grid, and enhancing the support of the substation to a primary station; According to the method provided by the present invention, the association relationship between the primary equipment model and the secondary equipment model in an SCD (substation configuration description) model of the intelligent substation can be accurately analyzed, so that isolated states of information models can be avoided and correct functional analysis application of intelligent alarming, five-prevention interlocking, data identification and source-end maintenance in the intelligent substation can be facilitated.

The invention discloses a plant anther-specific promoter and application thereof. The promoter is 179 to 1174 bp in length at least containing the 996-1174th nucleotide sequence at the 5' end of sequence 1 in the sequence listing at the 3' end and extending to the 5' end according to the nucleotide arrangement of sequence 1 deoxynucleotide fragments. The anther-specific promoter of the present invention has great application prospects in the functional analysis and identification of plant anther growth and development genes, the establishment of artificial male sterile lines, the prevention of plant transgene drift or escape, and the extension of shelf life of flowers.

The invention discloses a method and a system for modularization development of products. The method comprises the following steps: dividing the project into a plurality of subprojects by analyzing the project requirement of a project corresponding to the products in advance, wherein business with the same or relevant functions is put in the same subproject; analyzing the product requirement of a customer, selecting corresponding subprojects according to the product requirement of the customer, and packaging to generate corresponding products. Based on the functional analysis of the products, a plurality of functionally corresponding subprojects are divided, different customized products are generated according to the combination of the subprojects, so that repeated use of the subprojects is realized, reusing of a source code is reached, and writing of multiple suits of codes is prevented; moreover, when problems occur, the subprojects can be amended in a pertinence mode, and the current amending is prevented from influencing other projects, so that the development efficiency is greatly improved, and batch development can be realized.

The invention discloses a fuel cell hydrogen test system and test method. The test system comprises a heat exchanger having a first hydrogen flow channel and a first water flow channel, a stack simulator, a water supply module comprising a heating water tank, a booster pump and a radiator, a hydrogen supply module and a hydrogen circulating pump, wherein the booster pump is connected between an outlet of the heating water tank and an inlet of the first water flow channel, the hydrogen supply module is connected with an inlet of the first hydrogen flow channel through a pipeline, an outlet of the first hydrogen flow channel is connected with an inlet of a galvanic pile simulator through a pipeline, a proportional valve is arranged between an outlet of the first hydrogen flow channel and theinlet of the galvanic pile simulator, the hydrogen circulating pump is connected between an outlet of the galvanic pile simulator and the outlet of the first hydrogen flow channel, temperature sensors and pressure sensors are arranged on a circulation path of hydrogen and a circulation path of the water, and a hydrogen flow meter is arranged between the hydrogen supply module and the inlet of thefirst hydrogen flow channel. The test system is advantaged in that efficiency and reliability of functional analysis of a fuel cell hydrogen subsystem are improved.

The invention relates to a method of designing a system. The system includes an application having software components and an architecture having hardware components on which the application is run. The system has to satisfy at least one functional and one non-functional requirement. The functional analysis step (11) obtains a breakdown of the functional need relating to the application. A step defines the architecture (12). A step for designs hardware components (13) according to the architecture. A step design software components (14) based on the breakdown of the functional need. A step for integrates the software components in the hardware components (15). A step validates the functional requirements of the system (16). A step validates the non-functional requirement of the system (17). An upstream step (21) validates the non-functional requirement of the system, preceding the steps for designing hardware components (13) and software components (14).