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217 results about "Functional analysis" patented technology

Functional analysis is a branch of mathematical analysis, the core of which is formed by the study of vector spaces endowed with some kind of limit-related structure (e.g. inner product, norm, topology, etc.) and the linear functions defined on these spaces and respecting these structures in a suitable sense. The historical roots of functional analysis lie in the study of spaces of functions and the formulation of properties of transformations of functions such as the Fourier transform as transformations defining continuous, unitary etc. operators between function spaces. This point of view turned out to be particularly useful for the study of differential and integral equations.

Method and apparatus for automatically creating a data warehouse and OLAP cube

A data warehouse design that combines data from multiple source ledgers or modules is constructed and from that an associated, single physical Star or Snow-Flake schema and OLAP hyper-cube analytic structure is generated to enable cross-functional analysis of any those multiple source ledgers or modules. The step of constructing the data warehouse or the step of generating the associated OLAP cube is achieved without significant human intervention using software. The present invention is based on the insight that the technical bias against generating individual data marts and OLAP cubes from multiple source ledgers is not well founded. Previously, the norm has been to generate a single physical OLAP cube for each individual ledger—hence one for the General Ledger, a further one for sales order processing etc. This prior art approach makes cross functional analysis multiple source ledgers and sub-ledgers difficult since it requires the creation of a further level of physical or virtual cubes across multiple physical cubes and complex querying. This is no longer necessary with the present invention.
Owner:ANALYSOFT DEV

System for multi-dimensional anatomical functional imaging

A cardiac functional analysis system reconstructs a 3D anatomical image volume using image frames acquired at predetermined cardiac phases over multiple cardiac cycles in response to a trigger derived from hemodynamic signals. A medical imaging system generates 3D anatomical imaging volume datasets from acquired 2D anatomical images. The system includes an image acquisition device for acquiring 2D anatomical images of a portion of patient anatomy in selectable angularly variable imaging planes in response to a synchronization signal derived from a patient blood flow related parameter. A synchronization processor provides the synchronization signal derived from the patient blood flow related parameter. An image processor processes 2D images acquired by the image acquisition device of the portion of patient anatomy in multiple different imaging planes having relative angular separation, to provide a 3D image reconstruction of the portion of patient anatomy.
Owner:SIEMENS HEALTHCARE GMBH

Cardiovascular imaging and functional analysis system

A cardiovascular imaging and functional analysis system and method is disclosed, wherein a dedicated fast, sensitive, compact and economical imaging gamma camera system that is especially suited for heart imaging and functional analysis is employed. The cardiovascular imaging and functional analysis system of the present invention can be used as a dedicated nuclear cardiology small field of view imaging camera. The disclosed cardiovascular imaging system and method has the advantages of being able to image physiology, while offering an inexpensive and portable hardware, unlike MRI, CT, and echocardiography systems.The cardiovascular imaging system of the invention employs a basic modular design suitable for cardiac imaging with one of several radionucleide tracers. The detector can be positioned in close proximity to the chest and heart from several different projections, making it possible rapidly to accumulate data for first-pass analysis, positron imaging, quantitative stress perfusion, and multi-gated equilibrium pooled blood (MUGA) tests..In a preferred embodiment, the Cardiovascular Non-Invasive Screening Probe system can perform a novel diagnostic screening test for potential victims of coronary artery disease. The system provides a rapid, inexpensive preliminary indication of coronary occlusive disease by measuring the activity of emitted particles from an injected bolus of radioactive tracer. Ratios of this activity with the time progression of the injected bolus of radioactive tracer are used to perform diagnosis of the coronary patency (artery disease).
Owner:NORTH COAST IND INC

Sports and concert event ticket pricing and visualization system

A system and method is presented for determining at what price and when to release so-called ‘flex’ price tickets during an on-sale using hazard functional analyses of sales velocity and sales / inquiry ratios. Exponential, power, and Weibull-gamma models are also used to predict demand, depending on what part of the on-sale is involved. Determining demand of seats from secondary markets is also described with methods to use the demand for either repricing the seats in the primary market or presenting ‘best value’ seats to a prospective purchaser. Demand can be interpolated or extrapolated to individual seats or rows.
Owner:TIXTRACK

Cardiovascular imaging and functional analysis system

A Cardiovascular imaging and functional analysis system and method employing a dedicated fast, sensitive, compact and economical imaging gamma camera system that is especially suited for heart imaging and functional analysis. The system uses a dedicated nuclear cardiology small field of view imaging camera, allowing image physiology, while offering inexpensive and portable hardware. In some variations, a basic modular design suitable for cardiac imaging with one of several radionucleide tracers is used. The detector is positioned in close proximity to the chest and heart from several different projections, allowing rapid accumulation of data for first-pass analysis, positron imaging, quantitative stress perfusion, and multi-gated equilibrium pooled blood tests. In one variation, a Cardiovascular Non-Invasive Screening Probe system provides rapid, inexpensive preliminary indication of coronary occlusive disease by measuring the activity of emitted particles from an injected bolus of radioactive tracer.
Owner:NORTH COAST IND INC

Targeted gene discovery

InactiveUS6139833AEnhancing general accessibilityRaise the possibilityBiocideBacteriaGenomic DNAIn vivo
The present invention describes a comprehensive system for gene discovery using retrovirus that have been engineered to exhibit increased accessibility to genomic DNA, or to mutate and identify the chromosomal target sequences of DNA binding proteins. The strategy employs the combination of retroviral integrase / DNA binding protein fusion constructs and gene-trapping methodologies. This novel technology provides the ability to establish proviral integration at any location within the genome. In addition, it allows for the generation of a collection of eukaryotic cells in which each cell contains a mutation in a target gene or sequence for a known DNA binding protein which also allow for rapid in vivo functional analysis. Sequence information obtained for genes identified using the described methods identify a collection of eukaryotic genes related by, or directly or indirectly regulated by, a given DNA binding protein.
Owner:LEXICON PHARM INC

Novel methods for functional analysis of high-throughput experimental data and gene groups identified therefrom

The present invention relates generally to groups of genes that can be used to diagnose and differentiate between types of specific diseases such as breast cancer. The groups of genes can be further used to develop diagnostic kits for the specific diseases. The diagnostic kits can also differentiate between sub-categories of a disease to help identify the appropriate treatment regimen for a patient.
Owner:CAMELOT UK BIDCO LTD

Method for Increasing the Ratio of Homologous to Non-Homologous Recombination

Gene targeting allows the deletion (knock out), the repair (rescuing) and the modification (gene mutation) of a selected gene and the functional analysis of any gene of interest. Targeting of nuclear genes has been a very inefficient process in most eukaryotes including plants and animals due to the dominance of illegitimate integration of the applied DNA into non-homologous regions of the genome. The present invention provides a method for increasing the ratio of homologous to non-homologous recombination of a polynucleotide into a host cell's DNA by suppressing non-homologous recombination. Surprisingly, the number of non-homologous recombination events can be reduced if the polynucleotide is applied as a purified single-stranded DNA, preferably coated with a single strand binding protein.
Owner:HEGEMANN PETER +1

Method for establishing fragile X-syndrome non-human primate model on basis of CRISPR gene knockout technology

InactiveCN103642836APredictive effectReduce the risk of research and developmentVector-based foreign material introductionAnimal husbandryDiseaseFragile X chromosome
The invention discloses a method for establishing a fragile X-syndrome non-human primate model on the basis of a CRISPR gene knockout technology. The method comprises the following steps: (1) establishing a FMR1 gene knockout machin model; (2) carrying out identification and related functional analysis on the machin model; (3) carrying out tests on the nerve characteristics and learning and memorizing ability of the machin model. The method utilizes a CRISPR gene knockout technology to establish a fragile X-syndrome non-human primate model. The model fills the blank of non-human primate model, can effectively stimulate the pathological process of human diseases, can be used as an optimum animal model for researching human diseases, can effectively predict the effect of novel vaccine, novel drug or novel diagnostic reagent in clinical applications, and thus greatly reduces the risk of novel drug development.
Owner:SUZHOU TONGSHAN BIO TECH

Cytomegalovirus gene function and methods for developing antivirals, anti-CMV vaccines, and CMV-based vectors

ActiveUS20050064394A1Enhance their long-term survivabilitySugar derivativesMicrobiological testing/measurementSurvivabilityORFS
A global functional analysis of HCMV genes is performed by constructing virus gene-deletion mutants and examining their growth phenotypes in different natural HCMV host cells. This systematic analysis of the HCMV genome identified 45 viral ORFs essential for viral replication and characterizes of 115 growth-dispensable viral genes. Of particular interest is the finding that HCMV encodes genes (temperance factors) that repress its own replication on a cell type-specific basis. In addition to HCMV, pathogen temperance may be a strategy employed by other infectious agents to enhance their long-term survivability within their respective host population.
Owner:RGT UNIV OF CALIFORNIA

Use of short oligonucleotides for reagent redundancy experiments in RNA functional analysis

The present invention relates to functional analysis of miRNAs or other short non-coding RNAs involving the use of two or more sequence distinct miRNAs antagonising oligomeric compounds, which enables the reagent redundancy experiments to reduce the risk of reporting false positive effects of miRNA / ncRNA antagonists.
Owner:EXIQON AS

Reverse transfection of cell arrays for structural and functional analyses of proteins

The present invention relates to articles and methods for determining the function of genes, gene products, and nucleic acid products. The present invention also relates to identifying ligands and binding partners or proteins and nucleic acid products. The present invention also relates to methods and compositions related to reverse-transfection.
Owner:INTEGRAL MOLECULAR

System and Method for Intravascular Structural Analysis Compensation of Chemical Analysis Modality

A multimodal intravascular analysis uses a structural intravascular analysis modality to compensate for a chemical analysis modality. Examples of structural analysis are IVUS, OCT, including optical coherence domain Reflectometry (OCDR) and optical frequency domain imaging (OFDI), and / or sonar range finding. Examples of chemical or functional analysis are optical, NIR, Raman, fluorescence and spectroscopy, thermography and reflectometry. In one example, the structural analysis is used to characterize the environment structurally, such as catheter head-vessel wall distance. This information is then used to select from two or more algorithms which are depth specific (e.g. shallow vs. deep), to achieve improved accuracy in the chemical or functional analysis.
Owner:INFRAREDX INC

Process for identification of genes encoding proteins having cell proliferation-promoting activity

The present invention is directed to selection systems for the identification of cell proliferation genes based on functional analysis. More specifically, the invention is directed to a process for the identification of a cell proliferation promoting activity, the isolation of genes involved in such cell proliferation promoting activity, and the use of the so identified genes for the diagnosis or treatment of a disease associated with excessive cell proliferation. The invention further is directed to the design and development of antibodies, peptides, nucleic acids, and other compounds which specifically interfere with the function of the identified gene and / or its gene product, and pharmaceutical compositions comprising such compounds, for the treatment of diseases associated with inappropriate or unregulated cell proliferation.
Owner:DELTAGEN PROTEOMICS

Functional analysis of neurophysiological data

A method for functional analysis of neurophysiological data by decomposing neurophysiological data and EEG signal to form a plurality of signal features. The signal features may then optionally be analyzed to determined one or more patterns.
Owner:ELMINDA LTD

New yeast-bacteria shuttle vector

The functional analysis of genes frequently requires the manipulation of large genomic regions. A yeast-bacteria shuttle vector is described, that can be used to clone large regions of DNA by homologous recombination. The important feature of present invention is the presence of the a bacterial replication origin, which allows large DNA insert capacity. The utility of this vector lies in its ability to isolate, manipulate and maintain large fragments in bacteria and yeast, allowing for mutagenesis by yeast genetics and simplified preparation of plasmid DNA in bacteria.
Owner:BRADSHAW M SUZANNE +2

System for capturing and modifying large pieces of genomic DNA and constructing organisms with synthetic chloroplasts

The functional analysis of genes frequently requires the manipulation of large genomic regions. A yeast-bacteria shuttle vector is described that can be used to clone large regions of DNA by homologous recombination. Also described is a method for isolating entire genomes, including chloroplast genomes, or large portions thereof, and manipulating the same. Also described are methods for determining minimal genomes, minimal pathway requirements, and minimal organelle genomes.
Owner:RENEW BIOPHARMA INC

Spatial accessibility analysis method and device based on public facility differences

The invention discloses a spatial accessibility analysis method based on public facility differences. The method comprises the following seven steps of: 1) obtaining population and service requirement data in a service area; 2) obtaining public facility data; 3) carrying out traffic and distance calculation on the service area; 4) determining the effective service range of a public service facility; 5) carrying out functional analysis on different levels of public facilities; 6) calculating the spatial accessibility value of the public service facility; and 7) carrying out the difference analysis on a spatial accessibility result. A device used for the analysis method comprises an on-site data collection terminal and a remote data processing platform. By use of the method and the device, the hierarchy and the maneuverability of an analysis result are improved. Compared with the traditional method, the method more approaches to a realistic situation, is more favorable for a planning and construction department to evaluate the spatial configuration situation of the existing public facility, provides decision support for the layout regulation and planning of the public facility, and is convenient in carrying out classified guidance on the planning and the construction of the public facility.
Owner:HENAN POLYTECHNIC UNIV

Clinical applications of neuropsychological pattern analysis and modeling

A method for functional analysis of neurophysiological data by decomposing neurophysiological data and EEG signal to form a plurality of signal features. The signal features may then optionally be analyzed to determined one or more patterns.
Owner:ELMINDA LTD

Modeling method for intelligent substation secondary equipment interval information model

The present invention provide a modeling method for intelligent substation secondary equipment interval information model. The method particularly comprises the following steps of: establishing an association relationship between a primary equipment model and a secondary equipment model, dividing a secondary equipment interval model, and automatically collecting secondary equipment elements to the secondary equipment interval model. According to the method, the association relationship between the primary equipment model and the secondary equipment model is established, and advanced applications of intelligent analysis of mutual interference of reorganization and expansion, intelligent alarming, five-prevention interlocking, data identification and the like are powerfully supported, thereby reducing labor and time consumption, improving the security and stability of a substation and a power grid, and enhancing the support of the substation to a primary station; According to the method provided by the present invention, the association relationship between the primary equipment model and the secondary equipment model in an SCD (substation configuration description) model of the intelligent substation can be accurately analyzed, so that isolated states of information models can be avoided and correct functional analysis application of intelligent alarming, five-prevention interlocking, data identification and source-end maintenance in the intelligent substation can be facilitated.
Owner:CHINA ELECTRIC POWER RES INST +2

Automatic right ventricle segmentation method based on deep learnin

InactiveCN110120051AFully automatic segmentation is accurateReduce the impact of segmentation resultsImage enhancementImage analysisDiseaseData set
The invention provides an automatic right ventricle segmentation method based on deep learning, and the method is characterized in that the method comprises the following steps: carrying out the preprocessing of all collected heart magnetic resonance film short-axis images; extracting the ROI of the region of interest; expanding the data set; constructing a U-shaped network model in a keras library of deep learning, and training the U-shaped network model; and performing result prediction by using the trained U-shaped network model. The invention provides a full-automatic right ventricle segmentation method based on deep learning. Firstly, the influence of surrounding tissues on a segmentation result is reduced by automatically identifying a ventricle region, and an original U-shaped network is improved, so that accurate and full-automatic segmentation of a right ventricle is realized, and a basis is provided for further functional analysis and disease diagnosis of the heart.
Owner:UNIV OF SHANGHAI FOR SCI & TECH

Plants flower pesticide specificity promoter and uses thereof

The invention discloses a plant anther-specific promoter and application thereof. The promoter is 179 to 1174 bp in length at least containing the 996-1174th nucleotide sequence at the 5' end of sequence 1 in the sequence listing at the 3' end and extending to the 5' end according to the nucleotide arrangement of sequence 1 deoxynucleotide fragments. The anther-specific promoter of the present invention has great application prospects in the functional analysis and identification of plant anther growth and development genes, the establishment of artificial male sterile lines, the prevention of plant transgene drift or escape, and the extension of shelf life of flowers.
Owner:CHINA AGRI UNIV

High fidelity PCR cloning

The present invention describes a methodology for generating high fidelity PCR products, and also cloning of such high fidelity PCR products in a suitable vector. Generation of polymerase-induced mutant fraction of target sequences during PCR amplification is linearly proportional to the number of doublings of the target sequences. Thus the high fidelity PCR products are generated by minimizing the number of doublings of the target nucleic acid sequences during PCR amplification. Minimization of number of doublings of the target sequences is achieved by reducing the number of cycles of PCR amplification of the target sequences. The high fidelity PCR products thus obtained are then cloned into a suitable vector. As an example, a 960 bp target sequence from E. coli DNA was PCR-amplified only for 3 cycles, and it was then directly cloned into a positive selection cloning vector pRGR2Ap. The functional analysis of the inserts in all clones showed that the clones carried functionally wild-type DNA fragments, and hence the inserts most probably carry no mutation. Cloning of PCR products obtained from 3 cycles of amplification, instead of 30 cycles of amplification, theoretically achieves 10-fold reduction of mutations in the cloned fragments. The invention also contemplates cloning of a target cDNA obtained by primer extension.
Owner:SYNTHEGEN SYST

Engineering method and tools for capability-based families of systems planning

A method of enhancing capabilities is provided. A family of systems capability and operational analysis is conducted to generate a set of operationally decomposed capability needs. Further, a family of systems functional analysis and allocation is conducted on the set of operationally decomposed capability needs to determine a set of deficiencies. In addition, a family of systems design synthesis is conducted on the set of operationally decomposed capability needs, a set of existing solutions, and a set of emerging solutions to identify and describe an optimal integrated solution set of existing solutions and emerging solutions to satisfy the set of operationally decomposed capability needs. Further, the optimal integrated solution set of existing solutions and emerging solutions is generated from the family of systems design synthesis.
Owner:BAE SYST INFORMATION & ELECTRONICS SYST INTERGRATION INC

Method and system for modularization development of products

The invention discloses a method and a system for modularization development of products. The method comprises the following steps: dividing the project into a plurality of subprojects by analyzing the project requirement of a project corresponding to the products in advance, wherein business with the same or relevant functions is put in the same subproject; analyzing the product requirement of a customer, selecting corresponding subprojects according to the product requirement of the customer, and packaging to generate corresponding products. Based on the functional analysis of the products, a plurality of functionally corresponding subprojects are divided, different customized products are generated according to the combination of the subprojects, so that repeated use of the subprojects is realized, reusing of a source code is reached, and writing of multiple suits of codes is prevented; moreover, when problems occur, the subprojects can be amended in a pertinence mode, and the current amending is prevented from influencing other projects, so that the development efficiency is greatly improved, and batch development can be realized.
Owner:BEIJING CLOUD SPOWER EDUCATION & TECH

Gene functional analysis and discovery using randomized or target-specific ribozyme gene vector libraries

The present invention provides a hairpin ribozyme library having a randomized recognition sequence, packaged in a vector and operably linked to a promoter suitable for high level expression in a wide variety of cells. The invention comprises using the library in a variety of selection protocols for identifying, isolating and characterizing known or unknown target RNAs, to reveal the phenotypic effects of such cleavage, and to identify the gene products that produce those phenotypic effects.
Owner:IMMUSOL

Fuel cell hydrogen test system and test method

The invention discloses a fuel cell hydrogen test system and test method. The test system comprises a heat exchanger having a first hydrogen flow channel and a first water flow channel, a stack simulator, a water supply module comprising a heating water tank, a booster pump and a radiator, a hydrogen supply module and a hydrogen circulating pump, wherein the booster pump is connected between an outlet of the heating water tank and an inlet of the first water flow channel, the hydrogen supply module is connected with an inlet of the first hydrogen flow channel through a pipeline, an outlet of the first hydrogen flow channel is connected with an inlet of a galvanic pile simulator through a pipeline, a proportional valve is arranged between an outlet of the first hydrogen flow channel and theinlet of the galvanic pile simulator, the hydrogen circulating pump is connected between an outlet of the galvanic pile simulator and the outlet of the first hydrogen flow channel, temperature sensors and pressure sensors are arranged on a circulation path of hydrogen and a circulation path of the water, and a hydrogen flow meter is arranged between the hydrogen supply module and the inlet of thefirst hydrogen flow channel. The test system is advantaged in that efficiency and reliability of functional analysis of a fuel cell hydrogen subsystem are improved.
Owner:SHANGHAI ELECTRICGROUP CORP

Method of designing a system comprising hardware and software components

The invention relates to a method of designing a system. The system includes an application having software components and an architecture having hardware components on which the application is run. The system has to satisfy at least one functional and one non-functional requirement. The functional analysis step (11) obtains a breakdown of the functional need relating to the application. A step defines the architecture (12). A step for designs hardware components (13) according to the architecture. A step design software components (14) based on the breakdown of the functional need. A step for integrates the software components in the hardware components (15). A step validates the functional requirements of the system (16). A step validates the non-functional requirement of the system (17). An upstream step (21) validates the non-functional requirement of the system, preceding the steps for designing hardware components (13) and software components (14).
Owner:THALES SA
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