235 results about "Gamma camera" patented technology

The invention provides methods and apparatus for detecting radiation including x-ray photon (including gamma ray photon) and particle radiation for radiographic imaging (including conventional CT and radiation therapy portal and CT), nuclear medicine, material composition analysis, container inspection, mine detection, remediation, high energy physics, and astronomy. This invention provides novel face-on, edge-on, edge-on sub-aperture resolution (SAR), and face-on SAR scintillator detectors, designs and systems for enhanced slit and slot scan radiographic imaging suitable for medical, industrial, Homeland Security, and scientific applications. Some of these detector designs are readily extended for use as area detectors, including cross-coupled arrays, gas detectors, and Compton gamma cameras. Energy integration, photon counting, and limited energy resolution readout capabilities are described. Continuous slit and slot designs as well as sub-slit and sub-slot geometries are described, permitting the use of modular detectors.

The invention consists in structuring scintillation radiation detectors as Photonic Bandgap Crystals or 3D layers of thin filaments, thus enabling extremely high spatial resolutions and achieving virtual voxellation of the radiation detector without physical separating walls. The ability to precisely measure the recoil electron track in a Compton camera enables to assess the directions of the gamma rays hitting the detector and consequently dispensing with collimators that strongly reduce the intensity of radiation detected by gamma cameras. The invention enables great enhancements of the capabilities of gamma cameras, SPECT, PET, CT and DR machines as well as their use in Homeland Security applications. Methods of fabrication of such radiation detectors are decribed.

The invention relates to a portable mini gamma camera for intrasurgical use. The inventive camera is based on scintillation crystals and comprises a stand-alone device, i.e. all of the necessary systems have been integrated next to the sensor head and no other system is required. The camera can be hot-swapped to any computer using different types of interface, such as to meet medical grade specifications. The camera can be self-powered, can save energy and enables software and firmware to be updated from the Internet and images to be formed in real time. Any gamma ray detector based on continuous scintillation crystals can be provided with a system for focusing the scintillation light emitted by the gamma ray in order to improve spatial resolution. The invention also relates to novel methods for locating radiation-emitting objects and for measuring physical variables, based on radioactive and laser emission pointers.

A medical tracking system includes a localization system operative to spatially localize medical instruments; a computer operative to assign absolute and / or relative positions of said instruments in a coordinate system; and at least one localizable gamma camera operative to detect gamma radiation emitted from a tracer material.

A gamma camera having a scintillation detector formed of multiple bar detector modules. The bar detector modules in turn are formed of multiple scintillation crystal bars, each being designed to have physical characteristics, such as light yield, to achieve a sufficient spatial resolution for nuclear medical imaging applications. According to another aspect of the invention, the bar detector modules are arranged in a three-dimensional array, where each module is made up of a two-dimensional array of bar detectors with at least one photosensor optically coupled to each end of the module. Such a camera can be used for both PET (coincidence) and single photon imaging applications. According to another aspect of the invention, a bar detector gamma camera is provided, which utilizes an improved positioning algorithm that greatly enhances spatial resolution in the z-axis direction (i.e., the direction along the length of the scintillation crystal bar).

A cardiovascular imaging and functional analysis system and method is disclosed, wherein a dedicated fast, sensitive, compact and economical imaging gamma camera system that is especially suited for heart imaging and functional analysis is employed. The cardiovascular imaging and functional analysis system of the present invention can be used as a dedicated nuclear cardiology small field of view imaging camera. The disclosed cardiovascular imaging system and method has the advantages of being able to image physiology, while offering an inexpensive and portable hardware, unlike MRI, CT, and echocardiography systems.The cardiovascular imaging system of the invention employs a basic modular design suitable for cardiac imaging with one of several radionucleide tracers. The detector can be positioned in close proximity to the chest and heart from several different projections, making it possible rapidly to accumulate data for first-pass analysis, positron imaging, quantitative stress perfusion, and multi-gated equilibrium pooled blood (MUGA) tests..In a preferred embodiment, the Cardiovascular Non-Invasive Screening Probe system can perform a novel diagnostic screening test for potential victims of coronary artery disease. The system provides a rapid, inexpensive preliminary indication of coronary occlusive disease by measuring the activity of emitted particles from an injected bolus of radioactive tracer. Ratios of this activity with the time progression of the injected bolus of radioactive tracer are used to perform diagnosis of the coronary patency (artery disease).

The invention provides methods and apparatus for detecting radiation including x-ray, gamma ray, and particle radiation for nuclear medicine, radiopaphic imaging, material composition analysis, high energy physics, container inspection, mine detection and astronomy. The invention provides detection systems employing one or more detector modules (102) comprising edge-on scintillator detectors (101) with sub-aperture resolution (SAR) capability employed, e.g., in nuclear medicine, such as radiation therapy portal imaging, nuclear remediation, mine detection, container inspection, and high energy physics and astronomy. The invention also provides edge-on imaging probe detectors for use in nuclear medicine, such as radiation therapy portal imaging, or for use in nuclear remediation, mine detection, container inspection, and high energy physics and astronomy.

A Cardiovascular imaging and functional analysis system and method employing a dedicated fast, sensitive, compact and economical imaging gamma camera system that is especially suited for heart imaging and functional analysis. The system uses a dedicated nuclear cardiology small field of view imaging camera, allowing image physiology, while offering inexpensive and portable hardware. In some variations, a basic modular design suitable for cardiac imaging with one of several radionucleide tracers is used. The detector is positioned in close proximity to the chest and heart from several different projections, allowing rapid accumulation of data for first-pass analysis, positron imaging, quantitative stress perfusion, and multi-gated equilibrium pooled blood tests. In one variation, a Cardiovascular Non-Invasive Screening Probe system provides rapid, inexpensive preliminary indication of coronary occlusive disease by measuring the activity of emitted particles from an injected bolus of radioactive tracer.

A method and apparatus of obtaining and reconstructing an image of a portion of a body, administered by a radiopharmaceutical substance, by using Single-photon emission computerized tomography (SPECT) for determination of functional information thereon. The method comprises (a) acquiring gamma ray photons emitted from said portion by means of a detector capable of converting the photons into electric signals, the detector having at least one crystal and allowing said gamma rays having incident angles essentially exceeding 5 degrees and, preferably, exceeding 10 degrees to be detected; (b) processing said electric signals by a position logic circuitry and thereby transforming them into data indicative of positions on said photon detector crystal, where the photons have impinged the detector; and (c) reconstructing an image of a spatial distribution of the pharmaceutical substance within the portion of the body by processing said data and taking into consideration weight values which are functions of angles and, possibly, distances between different elements of the portion of the body and corresponding elements of this position's projection on the detector.

A method of producing a nuclear medicine image of a subject comprising the steps of acquiring nuclear image data suitable to produce a nuclear tomographic image, the data being acquired by at least one gamma camera head (12, 14) rotating about the subject at an average first rate, acquiring x-ray imaging data suitable to produce an x-ray tomographic image for attenuation correction of the gamma camera image, the data being acquired by an array of detectors (20) irradiated by an x-ray source (18) rotating around the subject at an average second rate which is within a factor of 10 of the first rate, and reconstructing an attenuation corrected nuclear medicine image utilizing the nuclear imaging data and x-ray imaging data.

A method and apparatus of obtaining and reconstructing an image of a portion of a body, administered by a radiopharmaceutical substance, by using Single-photon emission computerized tomography (SPECT) for determination of functional information thereon. The method comprises (a) acquiring gamma ray photons emitted from said portion by means of a detector capable of converting the photons into electric signals, the detector having at least one crystal and allowing said gamma rays having incident angles essentially exceeding 5 degrees and, preferably, exceeding 10 degrees to be detected; (b) processing said electric signals by a position logic circuitry and thereby transforming them into data indicative of positions on said photon detector crystal, where the photons have impinged the detector; and (c) reconstructing an image of a spatial distribution of the pharmaceutical substance within the portion of the body by processing said data and taking into consideration weight values which are functions of angles and, possibly, distances between different elements of the portion of the body and corresponding elements of this position's projection on the detector.

The present invention pertains to a remote center of motion robot for medical image scanning and image-guided targeting, hereinafter referred to as the “Euler” robot. The Euler robot allows for ultrasound scanning for 3-Dimensional (3-D) image reconstruction and enables a variety of robot-assisted image-guided procedures, such as needle biopsy, percutaneous therapy delivery, image-guided navigation, and facilitates image-fusion with other imaging modalities. The Euler robot can also be used with other handheld medical imaging probes, such as gamma cameras for nuclear imaging, or for targeted delivery of therapy such as high-intensity focused ultrasound (HIFU). 3-D ultrasound probes may also be used with the Euler robot to provide automated image-based targeting for biopsy or therapy delivery. In addition, the Euler robot enables the application of special motion-based imaging modalities, such as ultrasound elastography.

A hand, gamma camera system for generating an image of a gamma radiation source, said camera comprising a housing designed to be hand held, a gamma radiation image detector mounted on or in said housing that generates detection data responsive to radiation data from a gamma source incident on said radiation detector, a controller connected to said radiation detector that receives said detection data and generates image data and a display mounted on or in said housing that receives said image data from said controller and generates an image.

The invention provides reagents and methods for their use in in vivo diagnosis of atherosclerosis. In particular, the invention provides monoclonal antibodies which bind oxidation specific epitopes in atherosclerotic plaque lesions, such as those which occur in oxidized LDL, in vivo with high binding specificity; i.e., at about 10 to 20 times the rate of binding of the antibodies to adjacent normal arterial tissue. When detectably labeled and administered according to the invention, the antibodies are clearly imaged when bound to atherosclerotic plaque using known imaging techniques and devices, such as a gamma camera. In addition, the invention provides a method for substantially reducing interference from background signal in the blood pool into which such agents are introduced for detection and quantification of atherosclerotic plaque burden in the cardiovascular tissue of a host.

The invention belongs to the field of special equipment for nuclear industries, and in particular relates to an emergency treatment and rescue robot which can be used for a nuclear radiation environment. The robot consists of a walking base plate, a mechanical arm, a robot body motion control system, a robot redundancy navigation control system, a gamma camera, a holder, a gamma ray imaging system, a battery and a controller, wherein the walking base plate has a crawler-type structure; a motor is arranged in the middle of the base plate and is used for driving a crawler belt to operate through a chain; the mechanical arm is arranged at the front end of the base plate and has four degree of freedom; the gamma camera and the imaging system are positioned on the rear part of the robot and are arranged above the battery; and the gamma camera can be used for detecting the intensity and the direction of radiation and the robot can perform emergency treatment through the mechanical arm of the robot.

A gamma camera comprising:a plurality of pixelated detectors wherein each pixelated detector provides a detector signal responsive to photons that are incident on it;a plurality of processing circuits that receive said detector signals and provide processed signals responsive to said detector signals; andat least one printed circuit board on which said processing circuits are mounted and having conductors thereon that carry said detector signals to said processing circuits;wherein said processing circuits are mounted on said printed circuit board at locations remote from said detectors; andwherein said plurality of pixelated detectors form a two-dimensional planar array.

The invention provides a radioactive substance detection method, a radioactive substance detection device and a radioactive substance detection system based on a gamma camera. The detection method comprises the following steps of: receiving gamma photons incident from all directions of a target angle plane (alpha, beta) defined by radioactive substances by using the gamma camera; generating gamma photon energy spectrums and projection data of the radioactive substances; and reconstructing the projection data by using a 'maximum likelihood estimation' statistical iterative algorithm to obtain a gamma radiation image with quantitative information. By the method, the spatial resolution and the signal to noise ratio of the gamma radiation image are increased, spaces of the radioactive substances are positioned, the radiation dose is measured, nuclide types of the radioactive substances are identified, and the radioactive activity is measured.

The invention relates generally to biopsy needle guidance which employs an x-ray / gamma image spatial co-registration methodology. A gamma camera is configured to mount on a biopsy needle gun platform to obtain a gamma image. More particular, the spatially co-registered x-ray and physiological images may be employed for needle guidance during biopsy. Moreover, functional images may be obtained from a gamma camera at various angles relative to a target site. Further, the invention also generally relates to a breast lesion localization method using opposed gamma camera images or dual opposed images. This dual head methodology may be used to compare the lesion signal in two opposed detector images and to calculate the Z coordinate (distance from one or both of the detectors) of the lesion.

A hand gamma camera system for generating an image of a gamma radiation source, said camera comprising a housing designed to be hand held, a gamma radiation image detector mounted on or in said housing that generates detection data responsive to radiation data from a gamma source incident on said radiation detector, a controller connected to said radiation detector that receives said detection data and generates image data and a display mounted on or in said housing that receives said image data from said controller and generates an image.

A nuclear medical diagnostic equipment wherein radiation which is emitted by a nuclide administered into the body of a patient is detected as projection data by a gamma camera, and an image which indicates the distribution of the nuclide within the body of the patient is obtained on the basis of the projection data. The equipment comprises a rotation unit which rotates the radiation detector round the patient, a respiration identification unit which identifies breathing of the patient and non-breathing thereof based on breath holding, a data storage unit in which the radiation detection data acquired by the radiation detector are stored in an identifiable manner on the basis of a result of the identification by the respiration identification unit, and an image generation unit which generates the image from the radiation detection data stored in the data storage unit on the basis of the result of the identification by the respiration identification unit.

The invention provides methods and apparatus for detecting radiation including x-ray, gamma ray, and particle radiation for nuclear medicine, radiographic imaging, material composition analysis, high energy physics, container inspection, mine detection and astronomy. The invention provides detection systems employing one or more detector modules (102) comprising edge-on scintillator detectors (101) with sub-aperture resolution (SAR) capability employed, e.g., in nuclear medicine, such as radiation therapy portal imaging, nuclear remediation, mine detection, container inspection, and high energy physics and astronomy. The invention also provides edge-on imaging probe detectors for use in nuclear medicine, such as radiation therapy portal imaging, or for use in nuclear remediation, mine detection, container inspection, and high energy physics and astronomy.

A radiation detector, in particular a gamma camera, is constructed and operated in such a fashion that only a predetermined number of light sensors (such as PMT's) adjoining each other in a cluster are used to generate a signal with amplitude and event position information. The camera may also use an array of individual scintillation elements (crystals) in place of a single crystal, with certain advantages obtained thereby. According to another aspect of the invention, there is a reflector sheet that defines an array of apertures through which scintillation light can pass from the scintillation crystal to a plurality of light sensors optically coupled to an optical window in an array corresponding to the array of apertures in the reflector.

A multimodal source for imaging with at least one of a gamma camera, a positron emission tomography (PET) scanner and a single-photon-emission computed tomography (SPECT) scanner, and at least one of a computed tomography (CT) scanner, magnetic resonance imaging (MRI) scanner and optical scanner. The multimodal source has radioactive material permanently incorporated into a matrix of material, at least one of a material that is a target for CT, MRI and optical scanning, and a container which holds the radioactive material and the CT, MRI and / or optical target material. The source can be formed into a variety of different shapes such as points, cylinders, rings, squares, sheets and anthropomorphic shapes. The material that is a target for gamma cameras, PET scanners and SPECT scanners and / or CT, MRI and / or optical scanners can be formed into shapes that mimic biological structures.

The invention relates generally to biopsy needle guidance which employs an x-ray / gamma image spatial co-registration methodology. A gamma camera is configured to mount on a biopsy needle gun platform to obtain a gamma image. More particular, the spatially co-registered x-ray and physiological images may be employed for needle guidance during biopsy. Moreover, functional images may be obtained from a gamma camera at various angles relative to a target site. Further, the invention also generally relates to a breast lesion localization method using opposed gamma camera images or dual opposed images. This dual head methodology may be used to compare the lesion signal in two opposed detector images and to calculate the Z coordinate (distance from one or both of the detectors) of the lesion.

According to the present invention, there is provided a gamma camera system for brain SPECT imaging including slanted detectors with slanted hole collimators and a special hood-shaped head support device. The present invention eliminates the need for radial detector motion and therefore for collision sensing devices and safety related circuitry as required in prior art gamma cameras. Furthermore, the design and shape of the present invention reduces the necessary camera setup procedure, thereby improving camera workflow and output. The present invention's hood-shaped head support encapsulates the patient's head, preventing long hair from being entangled with the detectors while providing increased patient safety and comfort. Furthermore, the hood gently restrains the patients head, leading to less patient movement and improved image quality. In addition the hood enables very close detector proximity to the patient's head leading to further improvements in image quality.

An dual head molecular based imaging system includes at least one gamma camera having slanted collimators The use of one or more slant collimators can greatly improve viewing coverage of a dual-head gamma camera breast imaging system, providing improved three-dimensional localization and biopsy capability as well as improved coverage of axilla and chest wall tissue. The dual-head gamma camera breast imaging capability may be provided in a dedicated system, or alternatively as part of a fused x-ray, molecular based imaging system.

A gamma camera plate incorporates scintillation crystal which is sufficiently thick to effectively capture high energy radiation. The crystal is provided on its light output side with an array of light path-modifying partitions which extend partly through its thickness. These partitions define individual light collimating cells which reduce the light spreading which would otherwise prevent effective use of the plate for low energy radiation.

A system and method for performing quantitative lesion analysis in molecular breast imaging (MBI) using the opposing images of a slightly compressed breast that are obtained from the dual-head gamma camera. The method uses the shape of the pixel intensity profiles through each tumor to determine tumor diameter. Also, the method uses a thickness of the compressed breast and the attenuation of gamma rays in soft tissue to determine the depth of the tumor from the collimator face of the detector head. Further still, the method uses the measured tumor diameter and measurements of counts in the tumor and background breast region to determine relative radiotracer uptake or tumor-to-background ratio (T / B ratio).