39 results about "Radioactive tracer" patented technology

This application relates to the field of medical image processing technology, and provides a method, apparatus, device, and storage medium for reconstructing ECT images. This allows for more thorough capture of subtle changes in the concentration distribution of radioactive tracers at high temporal resolution, helping to reduce image noise levels and improve image quality. This application obtains a first ECT image sequence; the first ECT image sequence is obtained by scanning with an ECT scanning device; the first ECT image sequence is input into a pre-constructed intermediate frame prediction network to obtain an estimated second ECT image sequence; using the estimated second ECT image sequence as a priori image, a target second ECT image sequence is reconstructed; the estimated second ECT image sequence and the target second ECT image sequence belong to the second ECT image sequence; the temporal resolution of the second ECT image sequence is higher than that of the first ECT image sequence.

The invention discloses a medical image coincidence event processing method, system and device, equipment and a medium. The coincidence event processing method for the medical image comprises the steps that an original event is obtained, and the original event is an event composed of single photons and obtained by collecting photons generated by decay of a radioactive tracer through a detector; based on the energy information and the time information of the original events, the original events are discriminated, effective events are obtained, the effective events comprise true coincidence events and random coincidence events, and the true coincidence events are used for medical image reconstruction; determining a time window for the detector to collect photons, and dynamically adjusting the window width of the time window based on the change trend of the event counting rate; the valid events are processed based on the time window to reduce random coincidence events in the valid events.

A method for performing dynamic positron emission tomography (PET) is disclosed. The method includes collecting volumetric radioactive measurement data associated with an administered radioactive tracer present in a target site of a subject over multiple scanning intervals, capturing a magnetic resonance image of the target site, and performing a motion correction process to the volumetric radioactive measurement data to produce motion corrected PET data. The method further includes co-registering the magnetic resonance image and motion corrected data to generate a co-registered dynamic PET volume, and applying a model corrected input function (MCIF) to the co-registered dynamic PET volume to calibrate an uptake amount of the radioactive tracer in the target site.

The present disclosure relates to [18F]-labeled imidazopyridine derivatives or salts thereof as positron emission tomography (PET) radiotracers suitable for imaging the stress-signaling non-receptor tyrosine kinase c-abl, and their use in in vivo diagnosis, preclinical and clinical imaging, patient stratification on the basis of mutational status of c-abl and assessing response to therapeutic treatments. The present disclosure furtherrelates to the use of [18F]-labeled imidazopyridine derivatives as PET radiotracers. Thedisclosure also provides a process for the radiosynthesis of [18F]-labeled imidazopyridinederivatives.

A radiotracer injection system for safe use in industrial plants allows for rapid coupling of the radiotracer element storage bottle. The entire set is fully pneumatically driven and allows radiotracer injection in the form of a rapid pulse or step pulse. The injector system can be used with radiotracers in liquid (aqueous or oil) and gaseous form. The system is a sealed and safe unit to work in systems with internal pressure up to 300 Bar. This prevents the need to handle radioactive material in industrial plants, as the radiotracer used in each injection is already delivered inside its respective bottle. Quick-coupling connections allow quick and safe exchange of a used bottle for one with a new radiotracer, without having to disconnect the injector from the system. The injection machine has cylindrical symmetry, which allows the use of shielding with prismatic lead bricks, forming a protective castle around the unit.

DAZTA 5 -A radioisotope named PPA2 68 Ga and 177 Novel precursors for PET / CT diagnosis and nuclear therapy of SSR-active lesions using Lu improve affinity, specificity, and imaging of small metastases.

The invention belongs to the technical field of nuclear medicine imaging, and discloses a radioactive tracer agent distribution quantification optimization method and related equipment, and the method comprises the steps: obtaining scanning bed deformation information, moving track information and physiological motion dynamic information of a patient, and obtaining a radioactive tracer agent distribution quantification optimization result based on the scanning bed deformation information, the moving track information and the physiological motion dynamic information; the method comprises the steps of constructing a multi-source error integrated influence model, performing radioactive tracer distribution reconstruction on original detection data through an OSEM algorithm based on the multi-source error integrated influence model to obtain real distribution information of a radioactive tracer, and performing calculation according to the real distribution information to obtain a standardized uptake value. By means of the method, the accuracy of the radioactive tracer agent distribution quantification result is improved.

A method for evaluating induced fractures in a wellbore includes obtaining a first set of data in a wellbore using a downhole tool. The method also includes pumping a first proppant into the wellbore after the first set of data is obtained. The first proppant includes a first tracer that is not radioactive. The method also includes pumping a second proppant into the wellbore. The second proppant includes a second tracer that is not radioactive. The second tracer is different than the first tracer. The first proppant and the second proppant flow into fractures in the wellbore. The method also includes obtaining a second set of data in the wellbore using the downhole tool after the first and second proppants are pumped into the wellbore. The method also includes comparing the first and second sets of data.

The application discloses a radioactive separation laboratory environment radiation field dynamic modeling method and system, and belongs to the field of chemical process modeling. Step 1, the concentration distribution of a non-radioactive process tracer physically associated with a target radionuclide in a process fluid is obtained; step 2, based on the concentration distribution and the macroscopic residence time distribution of the material, the pre-judgment source term of the radionuclide is obtained through time translation and decay scaling; step 3, the radiation field observation waveform collected by a heterogeneous radiation sensitive field sensor network and independent of the pre-judgment source term is obtained; step 4, the theoretical radiation field change waveform calculated based on the pre-judgment source term is obtained; the application can obtain the concentration distribution of the non-radioactive tracer physically associated with the target radionuclide, eliminate the inherent bias of the source term from the source, and accurately depict the time-varying characteristics of the source term caused by the continuous migration of the material without making steady-state or quasi-static simplification assumptions on fluid turbulence, two-phase interface dynamic change and other processes.

The invention belongs to the technical field of pharmaceutical chemicals, and provides a dopamine D3 receptor radioactive tracer and a preparation method and application thereof. According to the dopamine D3 receptor radiotracer (11C-YQA14) disclosed by the invention, a structure as shown in a formula 1 is used as a precursor compound, and gaseous 11C-CH3I is introduced under a closed condition to obtain the 11C-YQA14. The dopamine D3 receptor radioactive tracer has ideal affinity to a dopamine D3 receptor and has low affinity to a dopamine D2 receptor, so that the dopamine D3 receptor radioactive tracer can selectively recognize the dopamine D3 receptor and has low recognizability to the dopamine D2 receptor.

Systems, methods, and devices provide data correction for positron emission tomography (PET) examinations using an external, supplemental radioactive source. The supplemental radioactive source is formed of a uniformly distributed radionuclide. The uniformly distributed radionuclide is positioned in a support structure which is positioned into an inner bore of a PET scanner and secured in place by a friction fit, or directly integrated into the PET system. A transmission source control system moves the one or more 2024 / 059537 transmission sources into the support structure for performing the PET examination (e.g., using a hydraulic system). The transmission source control system also retracts the one or more transmission sources back into a source storage device upon completing the PET examination. Various data correction algorithms use the first PET signal data, originating from a radiotracer injected in the patient, and second PET signal data, originating from the uniformly distributed radionuclide.

This invention discloses a method for preparing non-radioactive tracer ceramsite with a stable signal-to-noise ratio, and designs a gamma capture value ζ per unit volume of tracer ceramsite green body. o The acquisition method establishes a ζ o This method, based on real-time online control of tracer element content in tracer ceramsite, eliminates the phenomenon of excessively low or high tracer element content caused by uneven mixing or other factors during tracer ceramsite production, precisely controlling the tracer element content within a set threshold. Based on downhole measured data... 测 Feedback is provided to adjust the set threshold ζ of the tracer ceramsite in real time. 阈 The wellbore and downhole linkage can achieve a stable signal-to-noise ratio when monitoring fracturing information using tracer ceramsite neutron-activated transient gamma ray method in complex fracturing environments. It can avoid the fluctuations in the captured gamma signal during fracturing fracture logging due to different logging tool parameters, wellbore environment and oil and gas reservoir, thereby improving the logging success rate.

Embodiments of the present disclosure provide compositions comprising compounds useful to make radiotracers for positron emission tomography imaging, as well as methods for making and using these compositions.

The invention discloses a radioactive separation laboratory environment radiation field dynamic modeling method and system, and belongs to the field of chemical process modeling, and the method comprises the steps: 1, obtaining the concentration distribution of a non-radioactive process tracer agent which is in a physical associated relationship with a target radionuclide in a process fluid; step 2, based on the concentration distribution and the macroscopic retention time distribution of the material, obtaining a prejudgment source item of the radionuclide through time translation and scaling according to decay; step 3, acquiring a radiation field observation waveform which is acquired by the heterogeneous radiation sensitive field sensor network and is independent of the pre-judgment source item; 4, changing the waveform of the theoretical radiation field calculated based on the pre-judgment source item; according to the method, the non-radioactive tracer physically associated with the target radionuclide can be adopted to obtain the concentration distribution, steady-state or quasi-static simplified assumption does not need to be made in the processes of fluid turbulence, two-phase interface dynamic change and the like, the inherent deviation of the source item is eliminated from the source, and the time-varying characteristic of the source item caused by continuous migration of the material is accurately described.

The present invention relates to the technical field of biomedicine, and in particular to a preparation method for 18F-DOPA and an F-18-labeled precursor thereof. The structural formula of an F-18-labeled phenolic precursor compound is as shown in formula I, wherein R1 and R2 are hydroxyl protecting groups; R3 is a leaving group; R4 and R5 are each independently hydrogen or an amino protecting group; and R6 is a carboxyl protecting group. The present invention provides a simple and efficient preparation method for 18F-DOPA, specifically by constructing a key phenolic precursor compound and by means of a simple and efficient photocatalytic aromatic hydrocarbon deoxyfluorination reaction to implement the preparation of 18F-DOPA. The method has fewer steps, high yield, simple and convenient operation, good reproducibility, and good automated production potential. The radiotracer 18F-DOPA synthesized by means of the method has high specific activity and high chemical purity and radiochemical purity, and has significant value for the clinical promotion of 18F-DOPA.

The present disclosure relates to radiotracers that selectively bind to voltage-gated sodium channels (e.g., NaV1.7 or NaVl.8) and which are useful for detecting, imaging, and / or quantifying the NaVs, e.g., using positron-emission tomography (PET). The disclosure is also directed to processes for preparing the radiotracers, and to the use of the radiotracers for imaging a tissue or a subject, e.g., in vivo. The disclosure is further related to methods of pain management and improved identification and diagnosis allowing for rapidly identifying the location of or source of pain. The disclosure also relates to growth mediums, cell cultures, and kits.

This invention discloses a radiotracer targeting pan-KRAS mutant proteins, its preparation method, and its applications. The tracer uses small molecule ligands that specifically recognize multiple KRAS mutant proteins as targeting modules, and is coupled to diagnostic radionuclides through an optimized linkage system. This tracer is independent of specific mutation sites and can broadly and specifically bind to multiple high-frequency KRAS mutant subtypes, including G12C, G12D, and G12V. Based on PET / SPECT imaging, this tracer enables rapid, non-invasive, systemic, visualized, and quantitative assessment of KRAS mutant protein expression load in living tumors, overcoming the invasiveness, spatiotemporal limitations, and tumor heterogeneity challenges of traditional biopsies. It provides a novel molecular imaging tool for accurate companion diagnosis of KRAS-mutant tumors, screening of patients benefiting from pan-KRAS inhibitors, and monitoring efficacy, possessing significant clinical translational value.

Positron emission tomography (PET) radiotracers for imaging macrophage colony-stimulating factor-1 receptors in subjects suffering from or suspected of suffering from a neuroinflammatory or neurodegenerative disease or disorder are disclosed.

The present disclosure is directed to methods for evaluating a gravel pack, a frac-pack, or cement in a wellbore. In at least one embodiment, a method for evaluating a gravel pack, frac-pack or cement in a wellbore, includes pumping a first material into the wellbore, wherein the first material comprises a first tracer that is not radioactive. The method includes pumping a second material into the wellbore, wherein the second material comprises a second tracer that is not radioactive. The method includes obtaining a set of data using the downhole tool in the wellbore after the first and second materials are pumped into the wellbore. The method includes obtaining a baseline using the downhole tool in the wellbore in a depth interval without the first or second material. The method includes comparing the set of data with the baseline.

The application discloses a kind of cyclic peptide radioactive tracer targeting tumor HER2, labeled precursor and application, it is related to the field of biological medicine.The labeled precursor is A-B-C structure, A is chelating agent, B is connecting arm, C is cyclic peptide compound, the amino acid sequence of cyclic peptide compound is as shown in SEQ ID NO:1, and its 1st cysteine and 10th cysteine form cyclization structure by disulfide bond;Cyclic peptide radioactive tracer includes nuclide and labeled precursor;The application also provides the application of labeled precursor or cyclic peptide radioactive tracer in preparing labeled diagnostic or therapeutic nuclide or HER2 high expression tumor diagnosis and treatment product.The radioactive tracer prepared in the application has good in-vivo stability, has high binding specificity with tumor HER2, has longer tumor retention time, and is simple to synthesize, and has important significance for promoting the clinical application of HER2 targeted polypeptide in nuclear medicine tumor diagnosis and treatment integration.

The present invention relates to a ligand-SIFA-chelator conjugate, comprising, within in a single molecule three separate moieties: (a) one or more ligands which are capable of binding to a disease-relevant target molecule, (b) a silicon-fluoride acceptor (SIFA) moiety which comprises a covalent bond between a silicon atom and a fluorine atom, and (c) one or more chelating groups, optionally containing a chelated nonradioactive or radioactive cation.

The present invention relates to a method for stabilizing the production yield of [18F]-labelled radiotracers by adding a radical scavenger in the reaction medium of the nucleophilic [18F]-fluorination step.

The application discloses a kind of based on fluorescent tracer substation fire-fighting pipe network flaw detection method, comprising the following steps: S1: the outer wall of fire-fighting pipe network is cleaned, rusted and dry treated;S2: coating fluorescent response flaw detection coating and curing;S3: fluorescent tracer is mixed with fire-fighting water;S4: start fire-fighting pump, and detection medium is filled into fire-fighting pipe network and maintains design pressure maintaining value;S5: after pressure maintaining, the outer wall of pipe network is checked;S6: if found abnormality is marked, enter S7, if no abnormality is found, fire-fighting pipe network is temporarily defect-free, enter S9;S7: repair the leakage point position marked in S6;S8: return S4 and recheck;S9: complete flaw detection work;The flaw detection method is replaced by radioactive tracer medium by safe fluorescent tracer medium, and using fluorescent response flaw detection coating and optical identification means, realize the rapid positioning and intuitive discrimination of fire-fighting pipe network leakage point position, greatly improve detection efficiency and accuracy.

The invention provides a multi-field coupling simulation test system, and relates to the technical field of test simulation equipment, the multi-field coupling simulation test system comprises a three-axis heat exchange simulation module and a PET-CT imaging module, the three-axis heat exchange simulation module comprises a three-axis heat exchange simulation test cabin and a control and data synchronous analysis platform, the triaxial heat exchange simulation test cabin is used for applying confining pressure and temperature to a test sample and synchronously monitoring a temperature field and a stress field; the control and data synchronous analysis platform is used for realizing dynamic quantitative measurement; and the PET-CT imaging module is used for injecting the heat exchange working medium containing the radioactive tracer into the test sample and monitoring and reconstructing a fluid space distribution three-dimensional diagram in the test sample in real time. According to the invention, centralized control and data integration can be carried out on the triaxial heat exchange simulation module and the PET-CT imaging module, consistency monitoring and dynamic analysis of thermal, fluid and solid physical fields on time and space scales are realized, and a brand new test means is provided for revealing a multi-field interaction mechanism in a hot dry rock geothermal development process.

The current invention relates to a method of nuclear imaging, wherein said method uses an isotope-labeled radiotracer, wherein said isotope has a half-life of at least (750) minutes, said method comprises acquiring a first image by means of a nuclear imaging method of a target area, and obtaining a second image from said first image, wherein said second image is obtained by improving said first image quality by means of a deep learning model.

The invention relates to the technical field of fluid power, and particularly discloses a flow field detection method and device, electronic equipment, a storage medium and a program product, and the method comprises the steps: controlling a radiation detection device to detect a fluid containing a radioactive tracer agent, so as to obtain a radiation detection signal; performing image reconstruction based on the radiation detection signal to generate an image reconstruction result; and constructing a velocity vector field based on an image reconstruction result. According to the method, a radioactive tracer is introduced into fluid, so that the motion characteristic of the radioactive tracer in the fluid can represent the motion characteristic of the fluid, meanwhile, the fluid is detected in cooperation with a radiation detection device, then image reconstruction and velocity vector field construction are sequentially carried out, and the process adopts a radioactive imaging technology. Compared with a particle image velocity measurement technology, the method is not limited by light penetration, and can be used in the research of fluid with low optical transmissivity.

The application is suitable for the fields of biological medicine and nuclear medicine technology, and provides a compound targeting PD-L1, a radioactive tracer and a preparation method and application thereof. The radioactive tracer provided by the application has strong binding force with PD-L1, can accurately position PD-L1 in the body, has excellent in-vivo targeting performance, and can realize the tumor molecular imaging purpose through nuclear medical imaging. Meanwhile, the radioactive tracer realizes non-invasive visualization of PD-L1 expression, can effectively complete non-invasive diagnosis of tumors through small animal PET / CT verification, and has wide clinical application prospect. In addition, the compound targeting PD-L1 and the radioactive tracer derived therefrom also have advantages of simple preparation process, low cost, high specificity, good in-vivo and in-vitro stability, long imaging cycle and easy clinical transformation, and have outstanding comprehensive performance.

The invention discloses a sub-packaging injection consumable for injecting a radioactive tracer, and belongs to the field of nuclear medicine equipment consumables. The consumable comprises a split charging transfer catheter, a tracer injector, a normal saline injector, an injection tube, a pump body connecting tube, a first air filter, a normal saline connecting tube, a stock solution extraction tube, a diluent extraction tube and a breather tube. The subpackage transfer catheter comprises six serially connected three-way valves, one end of the breather pipe is communicated with the breather needle, the other end is connected with a first port of the first three-way valve, and the first air filter is connected with a third port of the first three-way valve; one end of the stock solution extraction tube is connected with the stock solution extraction needle, and the other end is connected with the dilution bottle ventilation needle; one end of the diluent extraction tube is connected with the dilution bottle extraction needle, and the other end is connected with a second port of the sixth three-way valve; and ports of the other three-way valves are respectively connected with a pump body connecting pipe, an injection pipe, a tracer injector, a normal saline injector and a normal saline connecting pipe. The consumable parts are complete, connection is simple, centralized packaging is achieved, and replacement operation is convenient and rapid.

According to the radioisotope tritium labeled selamectin and the preparation method thereof, doramectin is taken as a starting raw material, sodium boron tritide is taken as a tritium source, accurate tritium atom labeling is realized at a specific site of a 16-membered macrolide carbon skeleton through a'directional oxidation-tritiated reduction 'strategy, the defects of an existing labeling technology can be overcome, and the radioisotope tritium labeled selamectin is prepared. And enough high-purity and high-stability radioactive tracer can be provided for related isotope tracing research in time.

Various embodiments of a device for in-vivo measurements radiopharmaceuticals used for diagnosis and monitoring of radiotherapy are presented. In some embodiments, the present disclosure relates to a device having a cannula that may include a measurement chamber, a radiation detector and a delivery lumen, wherein the device may be used to both deliver material to the patient (e.g., radiotracers used in radiopharmaceuticals) and measure levels and concentrations of radioactive material in, for example, the patient's blood both during and after administration of the radioactive material. In some embodiments, a plunger may be utilized to draw blood through a first opening into the measurement chamber and then return it to the bloodstream. In some embodiments, particle absorbing materials may be used to limit measurements to materials within the measurement chamber or other area of interest.