57 results about "Radioactive tracer" patented technology

The invention is suitable for the technical field of biological medicine and nuclear medicine, and provides a PD-L1 targeting compound, a radioactive tracer agent and a preparation method and application of the PD-L1 targeting compound and the radioactive tracer agent. The radioactive tracer provided by the invention has strong binding force with PD-L1, can accurately locate PD-L1 in vivo, has excellent in-vivo targeting performance, and can achieve the purpose of tumor molecular imaging through nuclear medicine imaging; meanwhile, noninvasive visualization of PD-L1 expression is achieved, non-invasive tumor diagnosis can be effectively completed through small animal PET / CT verification, and the clinical application prospect is wide; in addition, the PD-L1 targeting compound and the radioactive tracer derived from the PD-L1 targeting compound further have the advantages of being simple in preparation process, low in cost, high in specificity, good in in-vivo and in-vitro stability, long in imaging period, easy to clinically convert and the like, and the comprehensive performance is outstanding.

This application relates to the field of medical image processing technology, and provides a method, apparatus, device, and storage medium for reconstructing ECT images. This allows for more thorough capture of subtle changes in the concentration distribution of radioactive tracers at high temporal resolution, helping to reduce image noise levels and improve image quality. This application obtains a first ECT image sequence; the first ECT image sequence is obtained by scanning with an ECT scanning device; the first ECT image sequence is input into a pre-constructed intermediate frame prediction network to obtain an estimated second ECT image sequence; using the estimated second ECT image sequence as a priori image, a target second ECT image sequence is reconstructed; the estimated second ECT image sequence and the target second ECT image sequence belong to the second ECT image sequence; the temporal resolution of the second ECT image sequence is higher than that of the first ECT image sequence.

The invention belongs to the technical field of agricultural drip irrigation, and provides a method for monitoring water, fertilizer and growth vigor of crops by using C14 drip irrigation, which comprises the following steps of: after injecting a C14-containing radioactive tracer into a drip irrigation system, monitoring spatial distribution and migration of C14 in a drip irrigation zone, soil and crop tissues in real time, and performing gamma-ray imaging and soil profile detection by using an unmanned aerial vehicle to obtain the growth vigor of the crops. Obtaining multi-source data; fusing the data to construct a water and fertilizer migration-absorption model, analyzing the water and fertilizer utilization rate of a root zone, obtaining crop growth parameters in combination with a multispectral image, and dynamically generating a water and fertilizer optimization scheme; according to the scheme, the flow, the concentration and the irrigation time of the drip irrigation system are automatically adjusted, and the adjustment period is 12-24 hours; the C14 tracing mode is combined with the unmanned aerial vehicle imaging technology, water and fertilizer migration and utilization are comprehensively monitored in real time, the conduction path and usage amount of water and fertilizer in the root zone are accurately analyzed, dynamic optimization and closed-loop control of water and fertilizer management are achieved, and therefore the water and fertilizer utilization efficiency is improved, and crop yield improvement is promoted.

The invention discloses a medical image coincidence event processing method, system and device, equipment and a medium. The coincidence event processing method for the medical image comprises the steps that an original event is obtained, and the original event is an event composed of single photons and obtained by collecting photons generated by decay of a radioactive tracer through a detector; based on the energy information and the time information of the original events, the original events are discriminated, effective events are obtained, the effective events comprise true coincidence events and random coincidence events, and the true coincidence events are used for medical image reconstruction; determining a time window for the detector to collect photons, and dynamically adjusting the window width of the time window based on the change trend of the event counting rate; the valid events are processed based on the time window to reduce random coincidence events in the valid events.

A method for performing dynamic positron emission tomography (PET) is disclosed. The method includes collecting volumetric radioactive measurement data associated with an administered radioactive tracer present in a target site of a subject over multiple scanning intervals, capturing a magnetic resonance image of the target site, and performing a motion correction process to the volumetric radioactive measurement data to produce motion corrected PET data. The method further includes co-registering the magnetic resonance image and motion corrected data to generate a co-registered dynamic PET volume, and applying a model corrected input function (MCIF) to the co-registered dynamic PET volume to calibrate an uptake amount of the radioactive tracer in the target site.

The present disclosure relates to [18F]-labeled imidazopyridine derivatives or salts thereof as positron emission tomography (PET) radiotracers suitable for imaging the stress-signaling non-receptor tyrosine kinase c-abl, and their use in in vivo diagnosis, preclinical and clinical imaging, patient stratification on the basis of mutational status of c-abl and assessing response to therapeutic treatments. The present disclosure furtherrelates to the use of [18F]-labeled imidazopyridine derivatives as PET radiotracers. Thedisclosure also provides a process for the radiosynthesis of [18F]-labeled imidazopyridinederivatives.

A radiotracer injection system for safe use in industrial plants allows for rapid coupling of the radiotracer element storage bottle. The entire set is fully pneumatically driven and allows radiotracer injection in the form of a rapid pulse or step pulse. The injector system can be used with radiotracers in liquid (aqueous or oil) and gaseous form. The system is a sealed and safe unit to work in systems with internal pressure up to 300 Bar. This prevents the need to handle radioactive material in industrial plants, as the radiotracer used in each injection is already delivered inside its respective bottle. Quick-coupling connections allow quick and safe exchange of a used bottle for one with a new radiotracer, without having to disconnect the injector from the system. The injection machine has cylindrical symmetry, which allows the use of shielding with prismatic lead bricks, forming a protective castle around the unit.

DAZTA 5 -A radioisotope named PPA2 68 Ga and 177 Novel precursors for PET / CT diagnosis and nuclear therapy of SSR-active lesions using Lu improve affinity, specificity, and imaging of small metastases.

The invention belongs to the technical field of nuclear medicine imaging, and discloses a radioactive tracer agent distribution quantification optimization method and related equipment, and the method comprises the steps: obtaining scanning bed deformation information, moving track information and physiological motion dynamic information of a patient, and obtaining a radioactive tracer agent distribution quantification optimization result based on the scanning bed deformation information, the moving track information and the physiological motion dynamic information; the method comprises the steps of constructing a multi-source error integrated influence model, performing radioactive tracer distribution reconstruction on original detection data through an OSEM algorithm based on the multi-source error integrated influence model to obtain real distribution information of a radioactive tracer, and performing calculation according to the real distribution information to obtain a standardized uptake value. By means of the method, the accuracy of the radioactive tracer agent distribution quantification result is improved.

The present invention relates to the fields of medicinal chemistry, radiopharmaceutical chemistry, and clinical nuclear medicine, and in particular to a compound targeting CDK4 / 6 and a radioactive tracer derived therefrom. The CDK4 / 6-targeting compound has the structures shown in the following formulas (I) and (II). The radioactive tracer provided by the present invention has strong binding affinity with CDK4 / 6, can accurately locate CDK4 / 6 in vivo, exhibits excellent in vivo targeting performance, and achieves tumor molecular imaging through nuclear medicine imaging. Formula (I); Formula (II).

A method for evaluating induced fractures in a wellbore includes obtaining a first set of data in a wellbore using a downhole tool. The method also includes pumping a first proppant into the wellbore after the first set of data is obtained. The first proppant includes a first tracer that is not radioactive. The method also includes pumping a second proppant into the wellbore. The second proppant includes a second tracer that is not radioactive. The second tracer is different than the first tracer. The first proppant and the second proppant flow into fractures in the wellbore. The method also includes obtaining a second set of data in the wellbore using the downhole tool after the first and second proppants are pumped into the wellbore. The method also includes comparing the first and second sets of data.

The present disclosure relates to compounds of Formula (1a), (1b), (1c) or (1d) and pharmaceutically acceptable salts thereof, wherein X, Z, L, CM and R1 are defined herein, and their use as cancer diagnostic or imaging agents.

The application discloses a radioactive separation laboratory environment radiation field dynamic modeling method and system, and belongs to the field of chemical process modeling. Step 1, the concentration distribution of a non-radioactive process tracer physically associated with a target radionuclide in a process fluid is obtained; step 2, based on the concentration distribution and the macroscopic residence time distribution of the material, the pre-judgment source term of the radionuclide is obtained through time translation and decay scaling; step 3, the radiation field observation waveform collected by a heterogeneous radiation sensitive field sensor network and independent of the pre-judgment source term is obtained; step 4, the theoretical radiation field change waveform calculated based on the pre-judgment source term is obtained; the application can obtain the concentration distribution of the non-radioactive tracer physically associated with the target radionuclide, eliminate the inherent bias of the source term from the source, and accurately depict the time-varying characteristics of the source term caused by the continuous migration of the material without making steady-state or quasi-static simplification assumptions on fluid turbulence, two-phase interface dynamic change and other processes.

The invention belongs to the technical field of pharmaceutical chemicals, and provides a dopamine D3 receptor radioactive tracer and a preparation method and application thereof. According to the dopamine D3 receptor radiotracer (11C-YQA14) disclosed by the invention, a structure as shown in a formula 1 is used as a precursor compound, and gaseous 11C-CH3I is introduced under a closed condition to obtain the 11C-YQA14. The dopamine D3 receptor radioactive tracer has ideal affinity to a dopamine D3 receptor and has low affinity to a dopamine D2 receptor, so that the dopamine D3 receptor radioactive tracer can selectively recognize the dopamine D3 receptor and has low recognizability to the dopamine D2 receptor.

A fluorine-18-labeled positron emission tomography (PET) radiotracer for diagnosing neuroinflammation, stroke or cerebral infarction and a method for using the radiotracer are provided.

The invention provides a low-dose PET image denoising method and system based on prompt learning and line integral projection constraint. The method comprises the following steps: constructing a PET image denoising model fused with a magnetic resonance multi-mode prompt learning mechanism; constructing a multi-domain loss function with physical consistency constraints; constructing a pairing training data set of a low-dose PET image, a standard-dose PET image and an MR image spatially corresponding to the PET image, and performing end-to-end training on the PET image denoising model by using the multi-domain loss function; and taking the acquired low-dose PET image and the MR image corresponding to the low-dose PET image as input, and carrying out denoising recovery on the low-dose PET image by utilizing the trained PET image denoising model to obtain a denoised PET image. According to the invention, on the premise of reducing the dosage of the radioactive tracer agent, the structural accuracy and the physical interpretability of the PET image are effectively improved, and a solution with high efficiency, low risk and high reliability is provided for clinical low-dosage PET examination.

Systems, methods, and devices provide data correction for positron emission tomography (PET) examinations using an external, supplemental radioactive source. The supplemental radioactive source is formed of a uniformly distributed radionuclide. The uniformly distributed radionuclide is positioned in a support structure which is positioned into an inner bore of a PET scanner and secured in place by a friction fit, or directly integrated into the PET system. A transmission source control system moves the one or more 2024 / 059537 transmission sources into the support structure for performing the PET examination (e.g., using a hydraulic system). The transmission source control system also retracts the one or more transmission sources back into a source storage device upon completing the PET examination. Various data correction algorithms use the first PET signal data, originating from a radiotracer injected in the patient, and second PET signal data, originating from the uniformly distributed radionuclide.

This invention discloses a method for preparing non-radioactive tracer ceramsite with a stable signal-to-noise ratio, and designs a gamma capture value ζ per unit volume of tracer ceramsite green body. o The acquisition method establishes a ζ o This method, based on real-time online control of tracer element content in tracer ceramsite, eliminates the phenomenon of excessively low or high tracer element content caused by uneven mixing or other factors during tracer ceramsite production, precisely controlling the tracer element content within a set threshold. Based on downhole measured data... 测 Feedback is provided to adjust the set threshold ζ of the tracer ceramsite in real time. 阈 The wellbore and downhole linkage can achieve a stable signal-to-noise ratio when monitoring fracturing information using tracer ceramsite neutron-activated transient gamma ray method in complex fracturing environments. It can avoid the fluctuations in the captured gamma signal during fracturing fracture logging due to different logging tool parameters, wellbore environment and oil and gas reservoir, thereby improving the logging success rate.

Embodiments of the present disclosure provide compositions comprising compounds useful to make radiotracers for positron emission tomography imaging, as well as methods for making and using these compositions.

The invention discloses a radioactive separation laboratory environment radiation field dynamic modeling method and system, and belongs to the field of chemical process modeling, and the method comprises the steps: 1, obtaining the concentration distribution of a non-radioactive process tracer agent which is in a physical associated relationship with a target radionuclide in a process fluid; step 2, based on the concentration distribution and the macroscopic retention time distribution of the material, obtaining a prejudgment source item of the radionuclide through time translation and scaling according to decay; step 3, acquiring a radiation field observation waveform which is acquired by the heterogeneous radiation sensitive field sensor network and is independent of the pre-judgment source item; 4, changing the waveform of the theoretical radiation field calculated based on the pre-judgment source item; according to the method, the non-radioactive tracer physically associated with the target radionuclide can be adopted to obtain the concentration distribution, steady-state or quasi-static simplified assumption does not need to be made in the processes of fluid turbulence, two-phase interface dynamic change and the like, the inherent deviation of the source item is eliminated from the source, and the time-varying characteristic of the source item caused by continuous migration of the material is accurately described.

A system and methods are provided for constructing positron lifetime images based on the lifetimes of positronium (and / or positrons) emitted from a scanning subject into which a suitable radioactive tracer has been introduced. The system includes a positron emission tomography (PET) scanner having time of flight (TOE) capability that captures single events that may reflect any or all of a prompt gamma, a 511 keV annihilation photon, and a time delay between emission (or detection) of a prompt gamma and emission (or detection) of corresponding annihilation photons. Correlated singles are combined to form coincidence events indexed by the lines of response (LOR) in which they were detected. The disclosed methods use the coincidence events to generate images that reflect the lifetimes of the positronium (or positrons) within the subject, which may be used to identify a hypoxic region.

Radiolabeled compounds and methods of use thereof of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: R1 is a C1-C6 alkyl; R2 is H, a C1-C6 alkyl, or a C1-C6 haloalkyl; or R1 and R2 together form a 5- or 6-membered cycloalkyl ring, a substituted or unsubstituted thiophenyl, or a substituted or unsubstituted phenyl; R3 is H, a C1-C6 alkyl, a C1-C6 haloalkyl, a C1-C6 hydroxyl alkyl, a C3-C6 cycloalkyl, a C1-C6 alkylnitrile, or an C1-C6 alkylcycloalkyl; R4 is alkyl or haloalkyl; R5 is H or halide; and L is a 2 to 10 carbon linking group; provided that: when R1 is Me, R2 is Me, R3 is H, R4 is —OCH2CF3, and L is —CH2—CH2—CH2—, R5 is not H; and when R1 is Me, R2 is H, R3 is H, R4 is —OCH2CF3, and L is —CH2—CH2—CH2—, R5 is not H.

The present invention relates to the technical field of biomedicine, and in particular to a preparation method for 18F-DOPA and an F-18-labeled precursor thereof. The structural formula of an F-18-labeled phenolic precursor compound is as shown in formula I, wherein R1 and R2 are hydroxyl protecting groups; R3 is a leaving group; R4 and R5 are each independently hydrogen or an amino protecting group; and R6 is a carboxyl protecting group. The present invention provides a simple and efficient preparation method for 18F-DOPA, specifically by constructing a key phenolic precursor compound and by means of a simple and efficient photocatalytic aromatic hydrocarbon deoxyfluorination reaction to implement the preparation of 18F-DOPA. The method has fewer steps, high yield, simple and convenient operation, good reproducibility, and good automated production potential. The radiotracer 18F-DOPA synthesized by means of the method has high specific activity and high chemical purity and radiochemical purity, and has significant value for the clinical promotion of 18F-DOPA.

The present disclosure relates to radiotracers that selectively bind to voltage-gated sodium channels (e.g., NaV1.7 or NaVl.8) and which are useful for detecting, imaging, and / or quantifying the NaVs, e.g., using positron-emission tomography (PET). The disclosure is also directed to processes for preparing the radiotracers, and to the use of the radiotracers for imaging a tissue or a subject, e.g., in vivo. The disclosure is further related to methods of pain management and improved identification and diagnosis allowing for rapidly identifying the location of or source of pain. The disclosure also relates to growth mediums, cell cultures, and kits.

This invention discloses a radiotracer targeting pan-KRAS mutant proteins, its preparation method, and its applications. The tracer uses small molecule ligands that specifically recognize multiple KRAS mutant proteins as targeting modules, and is coupled to diagnostic radionuclides through an optimized linkage system. This tracer is independent of specific mutation sites and can broadly and specifically bind to multiple high-frequency KRAS mutant subtypes, including G12C, G12D, and G12V. Based on PET / SPECT imaging, this tracer enables rapid, non-invasive, systemic, visualized, and quantitative assessment of KRAS mutant protein expression load in living tumors, overcoming the invasiveness, spatiotemporal limitations, and tumor heterogeneity challenges of traditional biopsies. It provides a novel molecular imaging tool for accurate companion diagnosis of KRAS-mutant tumors, screening of patients benefiting from pan-KRAS inhibitors, and monitoring efficacy, possessing significant clinical translational value.

The present disclosure describes the use of c-abl as a positron emission tomography (PET) tracer suitable for imaging the stress-signaling non-receptor tyrosine kinase c-abl. 18 The present disclosure further relates to [F]-labeled imidazopyridine derivatives or salts thereof and their use in in vivo diagnostics, preclinical and clinical imaging, stratification of patients based on c-abl mutation status, and assessing response to therapeutic treatment. 18 The present disclosure also relates to the use of [F]-labeled imidazopyridine derivatives. 18 [0013] A process for the radiosynthesis of [F]-labeled imidazopyridine derivatives is provided.

A precursor designated as DAZTA5-PPA2 for PET / CT diagnosis and nuclear therapy|of SSR active lesions with radioisotopes 68Ga and 177Lu provides improved|affinity, specificity and imaging of small metastases.

The invention relates to a medical PET / MRI imaging technology, in particular to a method and a system for generating a PET image based on an MRI image, which are used for solving the problems of blurring, artifacts, detail missing, functional information missing and the like existing in generation from the MRI image to the PET image. According to the scheme, an anatomical structure feature image is obtained based on an MRI image of a patient; and generating a PET image of the patient based on the anatomical structure feature image and the coding control random noise image. According to the scheme, the MRI image is adopted as a structure guiding condition, and the functional PET image highly consistent with the original MRI in anatomical structure is effectively guided to be generated, so that a non-invasive, low-cost and high-reliability functional imaging substitution scheme is realized on the premise of no radioactive tracer agent.

Positron emission tomography (PET) radiotracers for imaging macrophage colony-stimulating factor-1 receptors in subjects suffering from or suspected of suffering from a neuroinflammatory or neurodegenerative disease or disorder are disclosed.

The present disclosure is directed to methods for evaluating a gravel pack, a frac-pack, or cement in a wellbore. In at least one embodiment, a method for evaluating a gravel pack, frac-pack or cement in a wellbore, includes pumping a first material into the wellbore, wherein the first material comprises a first tracer that is not radioactive. The method includes pumping a second material into the wellbore, wherein the second material comprises a second tracer that is not radioactive. The method includes obtaining a set of data using the downhole tool in the wellbore after the first and second materials are pumped into the wellbore. The method includes obtaining a baseline using the downhole tool in the wellbore in a depth interval without the first or second material. The method includes comparing the set of data with the baseline.