16 results about "Autonomic nervous system" patented technology

Essentially, the present invention comprises an assembly for transvascular stimulation from within an artery, enabling nerve stimulation to one or more regions of the autonomic nervous system around an artery by a bipolar guidewire having a distal end of a suitable shape, and this stimulation can be performed rapidly or for mapping purposes.

The present invention essentially comprises a catheter that enables both nerve stimulation for mapping purposes in one or more regions of the autonomic nervous system around an artery, and denervation of the mapped one or more regions when those mapped regions are considered targets.

Methods for activating a person's autonomic nervous system may include: electrically coupling a first electrode to a vagus nerve via a transdermal coupling at a location rostral to the human's thoracic spine; electrically coupling a second electrode to a nerve in communication with the same vagus nerve or a different vagus nerve via a transdermal coupling at a site caudal to the human's cervical spine; and applying a therapeutic current waveform to cause current flow between the first and second electrodes and along at least a portion of the vagus nerve or nerves between the first and second electrodes. Apparatuses are disclosed for performing the methods.

Provided is an information presentation method for proposing a fatigue recovery method suitable for the fatigue state of a user from among a plurality of fatigue recovery methods. Specifically provided is a recommendation system which classifies the fatigue state of a user into a third state when the muscle hardness of the user is equal to or greater than a second threshold value, and classifies the fatigue state of the user into a first state when the muscle hardness is equal to or greater than a first threshold value and is smaller than the second threshold value. The recommendation system classifies the fatigue state of the user into a second state when an autonomic nerve index is equal to or smaller than a third threshold value, and classifies the fatigue state of the user into the second state when a cortisol value is equal to or greater than a fourth threshold value. The recommendation system recommends a fatigue recovery method according to the classified fatigue state.

This invention relates to the fields of digital therapy, intelligent medical devices, and applied artificial intelligence technologies, and more specifically to a closed-loop pain management method and system integrating diagnostic assistance and interference-resistant sensing. It includes: a wearable device comprising: a neuromodulation signal generator configured to generate neuromodulation stimulation pulses; a biosensor array physically integrated with the neuromodulation signal generator configured to sense physiological data indicating the user's autonomic nervous system activity; a controller configured to execute a time-division multiplexing protocol; a processor; and a non-transitory computer-readable storage medium associated with the processor for generating a diagnostic support report. This invention enables simultaneous effective neural stimulation and high-fidelity ANS signal acquisition on a single wearable device.

The present invention provides histamine H1 receptor antagonism-based uses for various uses (histamine H1 receptor antagonism uses, uses to improve sleep quality and / or modulate balance of the autonomic nervous system, and uses to improve sleep quality and / or modulate balance of the autonomic nervous system. And a use for preventing the onset of autonomic nervous system dysfunction or a symptom caused thereby or for improving autonomic nervous system dysfunction or a symptom caused thereby). The present invention relates to: a composition comprising, as an active ingredient, at least one substance selected from the group consisting of indole-3-lactic acid, alpha-Asp-Phe, Val-Arg, Asp-Gly-Glu, and salts thereof, or a lactic acid bacteria culture supernatant (not containing lactic acid bacteria cells) of a lactic acid bacteria belonging to any genus selected from the group consisting of the genus Lactobacillus, the genus Lactobacillus, and the genus Lactobacillus; the liquid supernatant contains at least one substance selected from the group consisting of indole-3-lactic acid, alpha-Asp-Phe, Val-Arg, Asp-Gly-Glu, and salts thereof. The liquid supernatant contains at least one substance selected from the group consisting of indole-3-lactic acid, alpha-Asp-Phe, Val-Arg, Asp-Gly-Glu.

This invention relates to the field of remote monitoring technology, and in particular provides a smart elderly care remote monitoring system and intelligent status monitoring method. The system includes a data sequence acquisition subsystem for generating heart rate, blood pressure, and biochemical data sequences; these three data sequences are timestamped within the device to form a synchronized raw physiological and biochemical data stream; a weighted fusion subsystem generates a multidimensional health vector containing cardiovascular load index, metabolic activity, and autonomic nervous system regulation capacity through a weighted fusion algorithm; and an early warning level output subsystem allows edge computing nodes to compare the real-time generated multidimensional health vector with a personalized health baseline for the elderly pre-stored in a local database, calculating the offset between the vector and the baseline; and automatically classifying three early warning levels based on the offset magnitude. This invention strengthens the privacy protection of the elderly's personal health data from a technical architecture perspective.

This invention discloses a plant essential oil spray with anti-anxiety and antidepressant effects and its preparation process, available in daytime and nighttime versions. The plant essential oil mixture is prepared by coupled flash extraction with anhydrous ethanol and 1-octyl-3-methylimidazolium bromide, followed by microfiltration-nanofiltration and vacuum distillation. The excipients and essential oils are then mixed and bottled into spray bottles equipped with an automatic spraying device to obtain the daytime and nighttime plant essential oil sprays. The daytime version stimulates the autonomic nervous system, reduces mental fatigue, improves cognitive mood, and exerts an anti-anxiety effect during the day; the nighttime version regulates neurotransmitter levels, significantly calms and soothes the mind, and adapts to the differences in human mood and nervous state between day and night. This invention features high extraction efficiency, stable essential oil quality, and the product possesses both anti-anxiety and antidepressant effects. It is convenient to use, highly safe, and suitable for daily mood regulation, psychological stress relief, and intervention for anxiety and depression tendencies.

Systems and methods are provided for delivering closed-loop or partially closed-loop baroreflex activation therapy (BAT) to treat conditions associated with autonomic dysfunction. A pulse generator delivers stimulation while physiological data, such as ECG, heart rate variability, bioimpedance, and physical activity levels, is collected from one or more sensors. The data is analyzed to assess autonomic nervous system activity, and stimulation parameters are dynamically adjusted in response. In some embodiments, adjustments are made on a beat-to-beat basis using ECG input. Artificial intelligence algorithms may be used to predict patient-specific responses, optimize therapy, and evaluate effectiveness. The method may further include integrating patient-reported symptoms, wirelessly transmitting data, or adjusting stimulation duty cycle based on time of day. The system may further incorporate patient-reported symptoms, a clinician dashboard for remote monitoring, and a multi-channel lead. Stimulation may be delivered non-invasively or via an implantable device.

This invention proposes a method for detecting autonomic nervous system-mediated events based on the decoupling of surface physiological signals. The method includes the following steps: acquiring surface electrophysiological activity signals from the chest using a surface electrophysiological acquisition device; separating the surface electrophysiological activity signals using a rapid independent component analysis method to obtain a reference electrocardiogram (ECG) signal and a mixed residual signal; using the R-wave sequence of the reference ECG signal as a time reference, excluding the high-energy ECG window centered on the R-wave from the mixed residual signal, and extracting neural-related electrical activity feature vectors from the low cardiac electrical activity intervals between heartbeats; constructing a sequence of cardiac electrical and neural potential activity states, establishing a sequence model, and outputting the continuous time trajectory of the autonomic nervous system-mediated state. This invention uses the R-wave peak value of the reference ECG as a time reference to locate and exclude high-energy ECG windows, and extracts neural-related features from the low cardiac electrical activity intervals between heartbeats, significantly reducing the interference of QRS residues on the assessment of autonomic nervous system-mediated regulation and improving feature stability and repeatability.

To improve the quality of life for the target individuals. [Solution] The information processing device 20 includes a control unit that acquires time-series data including data showing changes in the heart rate of the subject U1, and uses the time-series data to perform a prediction process to predict autonomic nervous system symptoms associated with autonomic nervous system dysfunction.

This invention discloses a multimodal perception fusion-based emergency training virtual reality closed-loop control system and method, belonging to the field of virtual reality technology. It includes: a multi-source data synchronous acquisition module, which synchronously acquires trainees' eye-tracking data, visual three-dimensional skeletal posture key point data, and wrist-worn physiological sensor data; a virtual-real space dynamic registration and multimodal feature extraction engine, which calculates mapping relationships and extracts feature vectors representing visual attention allocation patterns, kinematic features of movements, and autonomic nervous system stress response parameters; a real-time state quantification assessment module, which outputs a real-time state assessment vector containing a comprehensive risk avoidance index and a state stability coefficient; a virtual environment dynamic control module, which matches teaching intervention strategies and generates scene control instructions; and an immersive situational cognition guidance and feedback module, which, when the state stability coefficient is determined to be lower than a preset stress safety threshold, prohibits the triggering of new preset environmental disaster events and activates a parameterized flexible situational guidance mechanism.

The application discloses a monitoring system and method for silent delirium in an intensive care unit, and relates to the technical field of medical monitoring. The method comprises the following steps: acquiring an original video sequence of a patient's pupil under standardized light stimulation through a high-frequency infrared imaging device; performing image processing on the original video sequence to generate a pupil diameter time sequence; extracting a pupil light reflection feature parameter vector based on the pupil diameter time sequence; inputting the feature parameter vector into a pupil dynamics fingerprint generation model to calculate a pupil dynamics fingerprint vector, wherein the pupil dynamics fingerprint vector contains an approximate entropy index reflecting the complexity of autonomic nervous system regulation function; inputting the pupil dynamics fingerprint vector into a delirium risk assessment model to generate a delirium risk index; and triggering an alarm signal when the delirium risk index exceeds a preset threshold. The application can realize early continuous objective monitoring of silent delirium.

A wrist or finger mounted wearable device and method for determining a state or activity level of the autonomic nervous system, such as the respiratory rate or activity of the vagus nerve. The wearable device having at least a pair of electrocardiograms (ECG) measurement electrode pads configured to perform hand-to-hand ECG measurements. The device or method including monitoring of the pair of ECG measurement pads at a first time period to arrive at a first reading of hand-to-hand ECG, and at a second time period to arrive at a second reading of hand-to-hand ECG. The device or method analyzing the first and second readings of ECG to arrive at various indications of the state of a user.

This invention relates to the field of sleep aid technology, specifically to a multimodal physiological rhythm traction sleep intervention method and system. It dynamically determines a target guiding heart rate based on heart rate data, generating a physiological guidance cycle that includes inhalation and exhalation phases with durations adaptively adjusted according to heart rate changes, ensuring the guiding rhythm remains synchronized with the user's actual heart rate changes. Synchronous control signals are generated, acting on the visual, auditory, and tactile channels respectively. Through forced synchronous changes of the three sensory channels under the same rhythmic clock, a cross-sensory rhythm traction field is formed, actively inducing the user's heart rate to approach the target resting level. The physiological guidance cycle is continuously adjusted based on real-time updated heart rate data, forming a closed-loop control chain of monitoring, intervention, evaluation, and re-intervention until the user's autonomic nervous system switches to a sleep preparation state, thereby achieving active physiological rhythm traction under multimodal synergy.

This invention discloses a transcutaneous autonomic nervous system modulated electrical stimulation device, belonging to the field of transcutaneous autonomic nervous system modulated electrical stimulation technology. It includes an ear loop with an internal insertion groove. A connector is inserted into the groove, and a connector is fixedly connected to the outside of the connector. Multiple wires are fixedly connected inside the connector, with a patch fixedly connected to one end of each wire. A micro-puncture head is fixedly connected to one side of the patch. Two corresponding main unit shells are snapped onto the outside of the ear loop. The beneficial effects of this invention are: minimally invasive puncture of the skin is performed using the micro-puncture head, and the patch is firmly adhered to the outer side of the skin using medical adhesive; the percutaneous microelectrode structure directly acts on the vagus nerve, effectively bypassing the skin impedance layer, significantly reducing contact impedance, improving the utilization rate of stimulation energy, reducing adverse reactions such as skin stinging and redness, resulting in a more stable stimulation signal and significantly improved treatment effect.