62 results about "Multiple dose" patented technology

The invention provides a proton dose distribution determination method and device based on a graphics processor, which can be applied to the technical field of medical radiation dose calculation. The method comprises the following steps: calculating pencil beam tracks of a plurality of pencil beams; obtaining respective dose nuclear parameters of the pencil beam at a plurality of intersection points; according to the radiation field dose truncation radius, voxels of interest are determined from tissue voxels in the tissue voxel grid, and the radiation field dose truncation radius represents the upper limit value of the acting distance of all pencil beams in one radiation field to generate remarkable contribution to dose distribution in the transverse direction; calling a plurality of threads to execute dose calculation tasks of the plurality of voxels of interest in parallel based on the respective dose kernel parameters of the plurality of intersection points to obtain voxel deposition doses of the voxels of interest; and determining a dose distribution result related to the specified tissue according to the voxel deposition doses of the plurality of voxels of interest.

The invention discloses a multi-dose injection pen, and relates to the technical field of medical instruments, the multi-dose injection pen comprises a pen body, a dose adjusting assembly and a driving assembly, the dose adjusting assembly and the driving assembly are installed in an inner cavity of the pen body, a dose indicator is rotated when injection dose is adjusted, dose readings on the outer surface of the dose indicator directly face a reading window, and a sleeve rotates synchronously. Further, the torsion of the torsion spring is increased, and pre-stress is accumulated for injection; during injection, the driving assembly is pressed in the axial direction, the torsion of the torsion spring is released, and the torsion spring recovers to the initial torsion state after a set medicine dosage is injected; the torsion spring comprises the first spiral section and the second spiral section, one end of each spiral section is connected to the shell cover, the other end of each spiral section is connected to the sleeve, compared with a traditional structure, larger torsion can be generated when the torsion spring rotates by the same angle, and the number of rotation turns needed by the torsion spring with the same prestressing force is reduced.

1. The name of the design product: multi-dose pharmaceutical eye drop bottle (bacteria and oxygen double protection type). 2. The use of the design product: for containing eye drops, etc. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The present invention relates to a liquid, multi-dose, ready-to-use pharmaceutical composition comprising: a) warfarin or a pharmaceutically acceptable salt thereof, b) an excipient that is both an antioxidant and pH regulator, and c) a fluid; wherein the composition has a pH of 8.0 – 11.0. The invention further provides a method of manufacturing said pharmaceutical warfarin composition and provides uses of the pharmaceutical warfarin composition.

The invention relates to a firing device for a needleless injector and a needleless injection system. The needleless injector includes an injection chamber housing and a piston assembly. The launch device includes a support housing, a power push rod, and a dose adjustment device. The support housing is configured to be connectable to the injection chamber housing. The power push rod is configured to be connectable to the piston assembly and movable relative to the support housing. The dose adjusting device comprises a dose adjusting disc and a dose adjusting column, the dose adjusting disc is rotatably connected to the supporting shell, a plurality of dose grooves are formed in the dose adjusting disc, the depths of the dose grooves are different from one another, and the dose adjusting column is arranged on the power push rod and can move along with the power push rod. The dose adjusting column can change the movement stroke of the power push rod by being matched with different dose grooves. According to the needleless injection system of the scheme, a user can conveniently achieve injection of a preset dose.

The present invention relates to formulations of glucagon analogues, or a pharmaceutically acceptable salt thereof and / or a derivative thereof; and their medical use, for example in the treatment of hypoglycaemia. In particular, the present invention relates to stable aqueous liquid formulations of glucagon analogues comprising combinations of excipients that make them suitable for long term storage as liquids, and are capable of use in single-dose (SD) or multi-dose (MD) formulations.

This specification discloses a dose verification method, apparatus, storage medium, and electronic device, relating to the field of radiotherapy technology. It can acquire target distance, equipment distance, detector convolution kernel, CT correction factor, detector dose data, and irradiation distances at multiple dose accumulation points. Based on the dose data at each coordinate point and the detector scattering convolution kernel, the initial deposited dose corresponding to each target point is determined. Then, based on the equipment distance, target distance, and the initial deposited dose at each coordinate point, the output beam intensity of the radiation device is determined. Based on the output beam intensity, initial deposited dose, equipment distance, CT correction factor, and irradiation distances at multiple dose accumulation points, the dose distribution at each dose accumulation point is determined. Finally, the dose distribution is compared and verified with the planned dose distribution. It is evident that the dose verification process considers the influence of various factors such as radiation device performance and detector position, thus improving the accuracy of dose verification.

A linac-based X-ray system for cargo scanning and imaging applications uses linac design, RF power control, beam current control, and beam current pulse duration control to provide stable sequences of pulses having different energy levels or different dose.

Multi-dose anti-contamination capping device. A capping device for withdrawing a composition from a container using a syringe, comprising: A base portion (10) including: a mounting skirt (11) for attachment to a container neck, an upper wall (12) having an opening (52), an upper portion (20) including a tip (22) for connection to the syringe, a non-return valve (50) configured to open to allow the composition to pass through in case of aspiration of the container contents with the syringe, an antibacterial filter (70), at least one air return path (100) connecting the exterior to the interior of the container through the filter (70), this path opening laterally onto the capping device. Figure for the abbreviation: Fig. 3

Handheld dispensing system devices are disclosed. Aspects of the dispensing devices include a first pathway for directing the liquid from an ampoule to a chamber having an aperture through which the liquid from the ampoule can be dispensed. The device includes an actuator to oscillate a membrane to dispense the liquid through the membrane. The device further includes a second pathway in fluid communication with the interior of the ampoule and the atmosphere to equalize the pressure in the ampoule as liquid is dispensed. The second pathway can be sufficiently designed to prevent liquid from escaping through the second pathway.

The present technology relates to multi-dose injection pens, pharmaceutical compositions of enoxaparin and combinations thereof. The multi-dose injection pens may be configured to contain multiple doses of enoxaparin and to administer a single dose of enoxaparin.

The present invention relates to a liquid pharmaceutical composition of tirzepatide or pharmaceutically acceptable salt or derivative(s) thereof delivered with a multi-dose pen. Further the present invention relates to a reusable or disposable pen comprises one or more cartridge(s) suitable for delivering multiple doses of tirzepatide for the treatment of tirzepatide sensitive diseases. The present invention also relates to a novel liquid pharmaceutical composition comprising tirzepatide in a concentration of 67 mg / mL to 200 mg / mL, wherein such composition is substantially free from sodium chloride, and wherein such composition exhibits long-term stability suitable for storage.

Multi-dose preservative-free ocular fluid delivery devices are provided. The fluid delivery device includes a fluid dispensing system and a fluid package for storing a liquid in the fluid package and supplying the liquid to the dispensing system. The dispensing system includes an elongated chamber including a check valve defining an anterior closure of the chamber. The valve is normally closed and hermetically seals the chamber. The dispenser includes a vibrating motor that causes oscillation of the chamber and the fluid within the chamber. The oscillation of the chamber imparts momentum to the fluid stored in the chamber, which in turn imparts force to cyclically open the valve to dispense a stream or liquid droplets. Fluid is only dispensed when the motor is oscillating, otherwise the valve is hermetically closed.

The present invention relates to a liquid pharmaceutical composition of tirzepatide or pharmaceutically acceptable salt or derivative(s) thereof delivered with a multi-dose pen. Further the present invention relates to a reusable or disposable pen comprises one or more cartridge(s) suitable for delivering multiple doses of tirzepatide for the treatment of tirzepatide sensitive diseases. The present invention also relates to a novel liquid pharmaceutical composition comprising tirzepatide in a concentration of 67 mg / mL to 200 mg / mL, wherein such composition is substantially free from sodium chloride, and wherein such composition exhibits long-term stability suitable for storage.

A multi-dose dispenser comprising an inner housing (16) and an outer housing (12), the inner housing (16) being movable within the outer housing (12) for a defined distance, a plunger rod (20) comprising a shaft (66) mounted within the inner housing (16), the shaft (66) having a plurality of spaced apart teeth (68) formed on the shaft (66), an actuator (22) located at one end of the shaft (66), the inner housing (16) having at least one pawl (70) arranged to engage with the teeth (68), a syringe (74) mounted interiorly of the inner housing (16), the syringe (74) being arranged such that the shaft (66) engages with a plunger within the syringe (74), and a spring member (18), the spring member (18) being biased between the inner housing (16) and the outer housing (12).

Disclosed is a disposable multi-dose high-precision insulin injection apparatus, comprising a housing, and a dose adjustment unit and an injection transmission unit that are arranged in the housing. The dose adjustment unit is arranged in the upper part in the housing, and the injection transmission unit is arranged in the lower part in the housing. A dose setting unit is in transmission connection with the injection transmission unit. The dose adjustment unit is used for presetting an injection dose, and the injection transmission unit is used for transmitting injection power and discharging the preset injection dose to complete an injection. The disposable multi-dose high-precision insulin injection apparatus described in the present invention uses the dose setting unit to set a dose of insulin to be injected and uses the injection transmission unit to complete the injection of the corresponding dose. The dose setting unit can accurately set a dose to be injected. The apparatus is simple and convenient to operate and cost-effective.

Ablation catheters and systems include flexible catheter tips with at least one positioning element and ports for delivery of an ablative agent to a target tissue. The positioning element is used to define a treatment zone and position the catheter proximate the target tissue for ablation. Ablative fluid is delivered to the target tissue at subtherapeutic, therapeutic, or supratherapeutic doses over different time periods, with rest periods between each dose, to cause effective ablation of the target tissue.

The utility model relates to a storage type multi-dose dry powder inhaler, and belongs to the field of powder inhalation administration. Comprising a main body, an airflow indicating assembly and a counting assembly. Wherein a medicine bin is arranged in the main body, the medicine bin is used for uniformly containing multiple doses of medicine powder, a set air inlet flow channel is formed in the position, located on the peripheral face of the medicine bin, of the main body, and a vertical indication channel is arranged in the air inlet flow channel. The indicating channel can allow the indicating ball to freely move up and down along a linear path, the position of the indicating ball in the indicating channel is driven to change through the inspiration action in the using process of a patient, the patient can obtain real-time feedback about whether the inspiration action reaches the standard or not, and therefore the subsequent inspiration force is adjusted, and the inspiration effect is improved. And the optimal administration effect is ensured.

To provide improved methods, devices, and systems to provide multi-dose injection regimens without risking contamination of a therapeutic agent disposed within a reusable injector.SOLUTION: Systems and devices include multi-dose injection systems for delivering drugs, hormones, biologics, and other therapeutic agents. The systems include multiple single-injection needle connectors 102 attachable to a reusable injector. The needle connectors include a needle 104 having a distal end 106 for administering a therapeutic agent to a patient and a proximal end 108 to pierce a septum of the reusable injector. Proximal ends of the needles across the multiple needle connectors can be varied such that a piercing location on the septum varies.SELECTED DRAWING: Figure 1

The invention discloses a handheld dispensing system device. Some aspects of the dispensing device include a first passage for directing liquid from an ampoule to a chamber provided with an orifice through which liquid from the ampoule can be dispensed. The device includes an actuator to oscillate the membrane to dispense the liquid through the membrane. The device also includes a second passage in fluid communication with the interior of the ampoule and the atmosphere to balance pressure in the ampoule when dispensing the liquid. The second passage may be sufficiently configured to prevent liquid from escaping through the second passage.

Dose counter for a dispensing device, associated dispensing device and dispensing assembly This dose counter (100) for a dispensing device (20) for several doses of a product, comprises a first graduated rotary element (110), a second graduated rotary element (120), and a transmission mechanism (130) between the first and second rotary elements. The first rotary element comprises first reliefs (119A) and second reliefs (119B), which cooperate alternately with the transmission mechanism (130) so as to rotate the second rotary element by one graduation each time the first rotary element makes a complete revolution. The graduation of the second rotary element comprises at least two identical adjacent numbers.The dose counter (100) comprises a priming cover (150), which is arranged so as to mask a window (302) for viewing the graduations until the second rotating element (120) has been rotated at least once. Figure for abstract: Figure 4.

The present application provides a method, apparatus, terminal, and medium for generating a dose distribution map in a radiotherapy plan based on deep learning. In the present invention, a fitted beam segmentation mask is added on the basis of cascading, and predicting a dose distribution map is disassembled into predicting multiple dose distribution maps along the beam direction, and then the dose distribution maps in multiple directions are fused into a dose distribution map through a multi-beam voting mechanism. This method enables the network to effectively learn and predict the dose distribution in the beam direction. A novel loss function is further developed, and the dose evaluation indexes in the target area and the critical organ area in clinical practice are used as the loss function, which can make the dose in the target area and the critical organ area of the predicted dose distribution map more in line with the clinical treatment standard.

The invention related to a monitoring unit (30) for a multi-dose medicament delivery device (2) having a distal activation button (13) and comprising a positioning mechanism configured to move back the activation button (13) distally after an injection and before a next injection, wherein the5 medicament delivery device extends axially between a proximal end and a distal end, the distal end being the one pointing away from a dose delivery site during use of the medicament delivery device, the monitoring unit (30) comprising: - A sheath (301) removably attachable around a distal portion of the10 medicament delivery device (2); - A knob (30a) axially moveable relative to the sheath (301) between an unpressed position and a pressed position, wherein in the unpressed position, the knob (30a) protrudes from a distal end of the sheath (301) by a longer extent than in the pressed position, wherein the knob15 (30a) comprises a support surface (303c) extending radially and configured to bias or be biased by a distal surface of the activation button (13); - An assembly (30b) axially fixed relative to the sheath (301) and distal relative to the support surface (303c), comprising a mechanical switch20 (306) configured to transition between an open state and a closed state as a result from axial movements of the activation button (13).

A method of providing and / or injecting octreotide acetate to a subject in need thereof includes storing the octreotide acetate in a cartridge of a multi-use multi-dose injector provided with a variable dose setter and actuator. The injector includes a needle configured for subcutaneous administration of the octreotide acetate, the octreotide acetate having a concentration of 2,500 μg / mL. The method further includes permitting setting of a dose of the octreotide acetate by rotation of the variable dose setter. The injector is configured to provide at least one audible feedback during the rotation. The method further includes operating the actuator to deliver the octreotide acetate from the cartridge through the needle to treat the subject. The injector is provided with multiple surface portions.

The invention related to a medicament delivery device (2) for accommodating a medicament container (3) containing a medicament and for expelling multiple pre-defined doses of the medicament from the medicament container (3), the medicament delivery device (2) defining a device axis (A) and comprising: - a device body (5); - a plunger rod assembly arranged to move axially in a proximal direction relative to the device body (5) for interacting with the medicament container (3) for expelling the medicament therefrom; and - a biasing member (9) configured to bias the plunger rod assembly in a proximal direction; wherein the plunger rod assembly comprises a plunger nut (8) and a plunger rod device (6, 7), wherein the plunger rod device (6, 7) is configured to act, by moving in proximal direction, on a plunger (31) of the medicament container (3) for expelling the medicament therefrom; wherein the medicament delivery device further comprises a loading mechanism configured for a user to cause a distal helical movement of the plunger nut (8), relative to the device body (5) and to the plunger rod device (6, 7), from an unloaded position into a loaded position, and to thereby bias the biasing member (9); wherein the device body (5) comprises a status window (51), and the plunger nut (8) comprises a first symbol (260) positioned such that at the end of the distal helical movement of the plunger nut (8), the first symbol (260) is visible through the status window (51).

A manual multi-dose auto-injector structured to manually dispense multiple discrete doses of a drug is provided with a hollow housing having at least a first housing end and a second housing end. An at least partially compressible vial is disposed in the housing and contains multiple doses of the drug. The vial is in mechanical communication with both housing ends. Each housing end has a needle spring-biasedly disposed in an unactivated configuration and disposed at least partially protruding from the housing end in an activated configuration. Each needle is manually selectively in fluid communication with the vial. Pressing a housing end against a user's body causes its respective needle to move from the unactivated configuration to the activated configuration and compresses the vial to dispense a dose of the drug. Each end / needle operates independent of the other. Post-injection, each needle is locked within the housing.

The invention relates to a multi-dose form program release alprimilast double-layer tablet and a preparation method and application thereof.The multi-dose form program release alprimilast double-layer tablet comprises a quick-release tablet layer containing enteric particles and a bioadhesive sustained-release tablet layer containing sustained-release enteric particles, and the enteric particles in the quick-release tablet layer comprise sugar balls, a drug polymer matrix and an enteric coating; the drug polymer comprises aprecilast and hydroxypropyl methyl cellulose, and the enteric coating comprises any one of phthalic acid hydroxypropyl methyl cellulose and a methacrylic acid copolymer. The alpramilast double-layer tablet has the effect of improving the high efficiency of the alpramilast double-layer tablet.

The present disclosure provides a method of treating a human patient comprising the steps of: systematically administering multiple doses of a parenteral formulation of a replication capable oncolytic adenovirus of subgroup B in a single treatment cycle, wherein the total dose given in each dose is in the range of 1×1010 to 1×1014 viral particles, and wherein each dose of virus is administered over a period of 1 to 90 minutes, for example at a rate of viral particle delivery in the range of 2×1010 particles per minute to 2×1012 particles per minute. The disclosure further extends to formulations of the oncolytic adenoviruses and combination therapies of the viruses and formulations with other therapeutic agents.