79 results about "Multiple dose" patented technology

It is an object of the present invention to provide a liquid composition of semeglutide having phenol at a concentration of from 0.11% w / w to 0.5% w / w, which will enhance the stability of the composition. The invention also provides a method for preparing the composition of semeglutide and a method for treating diabetes and obesity by using the composition.

A method for a system for characterizing a radiation dose distribution in a radiotherapy treatment plan is disclosed. The radiotherapy treatment plan is used to treat an anatomical structure with a radiotherapy device. The system includes a processor and a user interface. The processor is configured to: receive data obtained from a radiation simulation at the anatomical structure under a nominal condition and one or more artificially applied uncertainty conditions; generating a plurality of dose distributions including dose-volume histograms (DVHs) using the received data, each DVH representing a tissue volume of the anatomical structure receiving a respective radiation dose, the DVHs including a nominal DVH corresponding to a nominal condition, and one or more uncertain DVHs corresponding to one or more artificially applied uncertain conditions; and determining a dose distribution characteristic based on statistical characteristics of the generated DVH. The user interface is configured to display the determined dose distribution characteristic to a user.

The invention provides a proton dose distribution determination method and device based on a graphics processor, which can be applied to the technical field of medical radiation dose calculation. The method comprises the following steps: calculating pencil beam tracks of a plurality of pencil beams; obtaining respective dose nuclear parameters of the pencil beam at a plurality of intersection points; according to the radiation field dose truncation radius, voxels of interest are determined from tissue voxels in the tissue voxel grid, and the radiation field dose truncation radius represents the upper limit value of the acting distance of all pencil beams in one radiation field to generate remarkable contribution to dose distribution in the transverse direction; calling a plurality of threads to execute dose calculation tasks of the plurality of voxels of interest in parallel based on the respective dose kernel parameters of the plurality of intersection points to obtain voxel deposition doses of the voxels of interest; and determining a dose distribution result related to the specified tissue according to the voxel deposition doses of the plurality of voxels of interest.

The invention discloses a multi-dose injection pen, and relates to the technical field of medical instruments, the multi-dose injection pen comprises a pen body, a dose adjusting assembly and a driving assembly, the dose adjusting assembly and the driving assembly are installed in an inner cavity of the pen body, a dose indicator is rotated when injection dose is adjusted, dose readings on the outer surface of the dose indicator directly face a reading window, and a sleeve rotates synchronously. Further, the torsion of the torsion spring is increased, and pre-stress is accumulated for injection; during injection, the driving assembly is pressed in the axial direction, the torsion of the torsion spring is released, and the torsion spring recovers to the initial torsion state after a set medicine dosage is injected; the torsion spring comprises the first spiral section and the second spiral section, one end of each spiral section is connected to the shell cover, the other end of each spiral section is connected to the sleeve, compared with a traditional structure, larger torsion can be generated when the torsion spring rotates by the same angle, and the number of rotation turns needed by the torsion spring with the same prestressing force is reduced.

1. The name of the design product: multi-dose pharmaceutical eye drop bottle (bacteria and oxygen double protection type). 2. The use of the design product: for containing eye drops, etc. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The present invention relates to a liquid, multi-dose, ready-to-use pharmaceutical composition comprising: a) warfarin or a pharmaceutically acceptable salt thereof, b) an excipient that is both an antioxidant and pH regulator, and c) a fluid; wherein the composition has a pH of 8.0 – 11.0. The invention further provides a method of manufacturing said pharmaceutical warfarin composition and provides uses of the pharmaceutical warfarin composition.

The invention relates to a firing device for a needleless injector and a needleless injection system. The needleless injector includes an injection chamber housing and a piston assembly. The launch device includes a support housing, a power push rod, and a dose adjustment device. The support housing is configured to be connectable to the injection chamber housing. The power push rod is configured to be connectable to the piston assembly and movable relative to the support housing. The dose adjusting device comprises a dose adjusting disc and a dose adjusting column, the dose adjusting disc is rotatably connected to the supporting shell, a plurality of dose grooves are formed in the dose adjusting disc, the depths of the dose grooves are different from one another, and the dose adjusting column is arranged on the power push rod and can move along with the power push rod. The dose adjusting column can change the movement stroke of the power push rod by being matched with different dose grooves. According to the needleless injection system of the scheme, a user can conveniently achieve injection of a preset dose.

The present invention relates to formulations of glucagon analogues, or a pharmaceutically acceptable salt thereof and / or a derivative thereof; and their medical use, for example in the treatment of hypoglycaemia. In particular, the present invention relates to stable aqueous liquid formulations of glucagon analogues comprising combinations of excipients that make them suitable for long term storage as liquids, and are capable of use in single-dose (SD) or multi-dose (MD) formulations.

This specification discloses a dose verification method, apparatus, storage medium, and electronic device, relating to the field of radiotherapy technology. It can acquire target distance, equipment distance, detector convolution kernel, CT correction factor, detector dose data, and irradiation distances at multiple dose accumulation points. Based on the dose data at each coordinate point and the detector scattering convolution kernel, the initial deposited dose corresponding to each target point is determined. Then, based on the equipment distance, target distance, and the initial deposited dose at each coordinate point, the output beam intensity of the radiation device is determined. Based on the output beam intensity, initial deposited dose, equipment distance, CT correction factor, and irradiation distances at multiple dose accumulation points, the dose distribution at each dose accumulation point is determined. Finally, the dose distribution is compared and verified with the planned dose distribution. It is evident that the dose verification process considers the influence of various factors such as radiation device performance and detector position, thus improving the accuracy of dose verification.

A linac-based X-ray system for cargo scanning and imaging applications uses linac design, RF power control, beam current control, and beam current pulse duration control to provide stable sequences of pulses having different energy levels or different dose.

The utility model provides a kind of with the butt joint of multi-dose medicine bottle liquid medicine transfer device, including medicine bottle attachment and puncture ware;Puncture ware includes the pedestal being set on medicine bottle attachment, and the pedestal is equipped with puncture needle and syringe connector;Puncture needle has first flow passage and second flow passage inside;The pedestal has pedestal air passage and pedestal liquid channel inside;Pedestal air passage is communicated first flow passage and pedestal outside, and air filter membrane is installed in pedestal air passage;Pedestal liquid channel is communicated syringe connector and second flow passage, and self-sealing valve is equipped in syringe connector;When needleless syringe is installed on syringe connector, self-sealing valve is forced to switch from closed state to open state;In this way, when liquid medicine transfer device is installed on multi-dose medicine bottle, and injection connector on it is not connected needleless syringe, self-sealing valve is automatically in closed state, to prevent external pollutants along syringe connector into multi-dose medicine bottle and pollute liquid medicine, improve the effective time of liquid medicine in multi-dose medicine bottle after opening.

Multi-dose anti-contamination capping device. A capping device for withdrawing a composition from a container using a syringe, comprising: A base portion (10) including: a mounting skirt (11) for attachment to a container neck, an upper wall (12) having an opening (52), an upper portion (20) including a tip (22) for connection to the syringe, a non-return valve (50) configured to open to allow the composition to pass through in case of aspiration of the container contents with the syringe, an antibacterial filter (70), at least one air return path (100) connecting the exterior to the interior of the container through the filter (70), this path opening laterally onto the capping device. Figure for the abbreviation: Fig. 3

Handheld dispensing system devices are disclosed. Aspects of the dispensing devices include a first pathway for directing the liquid from an ampoule to a chamber having an aperture through which the liquid from the ampoule can be dispensed. The device includes an actuator to oscillate a membrane to dispense the liquid through the membrane. The device further includes a second pathway in fluid communication with the interior of the ampoule and the atmosphere to equalize the pressure in the ampoule as liquid is dispensed. The second pathway can be sufficiently designed to prevent liquid from escaping through the second pathway.

The present technology relates to multi-dose injection pens, pharmaceutical compositions of enoxaparin and combinations thereof. The multi-dose injection pens may be configured to contain multiple doses of enoxaparin and to administer a single dose of enoxaparin.

The present invention relates to a liquid pharmaceutical composition of tirzepatide or pharmaceutically acceptable salt or derivative(s) thereof delivered with a multi-dose pen. Further the present invention relates to a reusable or disposable pen comprises one or more cartridge(s) suitable for delivering multiple doses of tirzepatide for the treatment of tirzepatide sensitive diseases. The present invention also relates to a novel liquid pharmaceutical composition comprising tirzepatide in a concentration of 67 mg / mL to 200 mg / mL, wherein such composition is substantially free from sodium chloride, and wherein such composition exhibits long-term stability suitable for storage.

Multi-dose preservative-free ocular fluid delivery devices are provided. The fluid delivery device includes a fluid dispensing system and a fluid package for storing a liquid in the fluid package and supplying the liquid to the dispensing system. The dispensing system includes an elongated chamber including a check valve defining an anterior closure of the chamber. The valve is normally closed and hermetically seals the chamber. The dispenser includes a vibrating motor that causes oscillation of the chamber and the fluid within the chamber. The oscillation of the chamber imparts momentum to the fluid stored in the chamber, which in turn imparts force to cyclically open the valve to dispense a stream or liquid droplets. Fluid is only dispensed when the motor is oscillating, otherwise the valve is hermetically closed.

The present invention relates to the field of pharmaceutical technology and relates to emulsion compositions comprising the active pharmaceutical ingredient Cyclosporin and the method of preparing this composition.

The present invention relates to a liquid pharmaceutical composition of tirzepatide or pharmaceutically acceptable salt or derivative(s) thereof delivered with a multi-dose pen. Further the present invention relates to a reusable or disposable pen comprises one or more cartridge(s) suitable for delivering multiple doses of tirzepatide for the treatment of tirzepatide sensitive diseases. The present invention also relates to a novel liquid pharmaceutical composition comprising tirzepatide in a concentration of 67 mg / mL to 200 mg / mL, wherein such composition is substantially free from sodium chloride, and wherein such composition exhibits long-term stability suitable for storage.

A multi-dose dispenser comprising an inner housing (16) and an outer housing (12), the inner housing (16) being movable within the outer housing (12) for a defined distance, a plunger rod (20) comprising a shaft (66) mounted within the inner housing (16), the shaft (66) having a plurality of spaced apart teeth (68) formed on the shaft (66), an actuator (22) located at one end of the shaft (66), the inner housing (16) having at least one pawl (70) arranged to engage with the teeth (68), a syringe (74) mounted interiorly of the inner housing (16), the syringe (74) being arranged such that the shaft (66) engages with a plunger within the syringe (74), and a spring member (18), the spring member (18) being biased between the inner housing (16) and the outer housing (12).

An apparatus for delivering a precise amount of a pharmaceutical fluid to an eye is provided. The apparatus includes an ampoule for storing a liquid and an orifice through which the liquid is expelled. The apparatus also includes a diaphragm that includes a needle that protrudes from the diaphragm and extends to the orifice to form a needle valve. The needle valve provides an air-tight closure of the orifice to allow the pharmaceutical fluid to be stored in the apparatus without a preservative. The system also includes an electromagnetic transducer to move the diaphragm back and forth to expel the liquid through the nozzle. Finally, the system also includes a vent to allow air to enter the ampoule as the fluid is expelled from the ampoule. Preferably, the vent includes a filter to prevent microorganisms or other contaminants from entering the ampoule.

Disclosed is a disposable multi-dose high-precision insulin injection apparatus, comprising a housing, and a dose adjustment unit and an injection transmission unit that are arranged in the housing. The dose adjustment unit is arranged in the upper part in the housing, and the injection transmission unit is arranged in the lower part in the housing. A dose setting unit is in transmission connection with the injection transmission unit. The dose adjustment unit is used for presetting an injection dose, and the injection transmission unit is used for transmitting injection power and discharging the preset injection dose to complete an injection. The disposable multi-dose high-precision insulin injection apparatus described in the present invention uses the dose setting unit to set a dose of insulin to be injected and uses the injection transmission unit to complete the injection of the corresponding dose. The dose setting unit can accurately set a dose to be injected. The apparatus is simple and convenient to operate and cost-effective.

Ablation catheters and systems include flexible catheter tips with at least one positioning element and ports for delivery of an ablative agent to a target tissue. The positioning element is used to define a treatment zone and position the catheter proximate the target tissue for ablation. Ablative fluid is delivered to the target tissue at subtherapeutic, therapeutic, or supratherapeutic doses over different time periods, with rest periods between each dose, to cause effective ablation of the target tissue.

The invention relates to the technical field of performance testing of medical instruments, and mainly discloses an aerosol challenge instrument and a method for testing packaging and sealing integrity of a multi-dose eye drop bottle and bacterial resistance of a physical bacterial resistance system when the aerosol challenge instrument is used. The test conditions of vacuumizing and pressurizing can be set, and the possible pressure change of the packaging system in the actual storage and transportation process can be simulated; according to the multi-dose eye drop bottle package sealing integrity test method, the integrity of the package of the eye drop bottle is subjected to a microbiological test on the whole, the sensitivity of the test method is improved, and the reliability of a test result is improved; the invention relates to a method for testing the bacterium resistance of a physical bacterium blocking system when a multi-dose eye drop bottle is used, which actually simulates whether liquid microorganisms pollute internal eye drops when eyes are infected, and carries out an aerosol gas return valve challenge test on a gas return valve of the physical bacterium blocking system. Whether microorganisms in air pollute internal eye drops or not during air return of a physical bacteria blocking system is actually simulated.

The utility model relates to a storage type multi-dose dry powder inhaler, and belongs to the field of powder inhalation administration. Comprising a main body, an airflow indicating assembly and a counting assembly. Wherein a medicine bin is arranged in the main body, the medicine bin is used for uniformly containing multiple doses of medicine powder, a set air inlet flow channel is formed in the position, located on the peripheral face of the medicine bin, of the main body, and a vertical indication channel is arranged in the air inlet flow channel. The indicating channel can allow the indicating ball to freely move up and down along a linear path, the position of the indicating ball in the indicating channel is driven to change through the inspiration action in the using process of a patient, the patient can obtain real-time feedback about whether the inspiration action reaches the standard or not, and therefore the subsequent inspiration force is adjusted, and the inspiration effect is improved. And the optimal administration effect is ensured.

To provide improved methods, devices, and systems to provide multi-dose injection regimens without risking contamination of a therapeutic agent disposed within a reusable injector.SOLUTION: Systems and devices include multi-dose injection systems for delivering drugs, hormones, biologics, and other therapeutic agents. The systems include multiple single-injection needle connectors 102 attachable to a reusable injector. The needle connectors include a needle 104 having a distal end 106 for administering a therapeutic agent to a patient and a proximal end 108 to pierce a septum of the reusable injector. Proximal ends of the needles across the multiple needle connectors can be varied such that a piercing location on the septum varies.SELECTED DRAWING: Figure 1

A linac-based X-ray system for cargo scanning and imaging applications uses linac design, RF power control, beam current control, and beam current pulse duration control to provide stable sequences of pulses having different energy levels or different dose.

The invention discloses a handheld dispensing system device. Some aspects of the dispensing device include a first passage for directing liquid from an ampoule to a chamber provided with an orifice through which liquid from the ampoule can be dispensed. The device includes an actuator to oscillate the membrane to dispense the liquid through the membrane. The device also includes a second passage in fluid communication with the interior of the ampoule and the atmosphere to balance pressure in the ampoule when dispensing the liquid. The second passage may be sufficiently configured to prevent liquid from escaping through the second passage.

Dose counter for a dispensing device, associated dispensing device and dispensing assembly This dose counter (100) for a dispensing device (20) for several doses of a product, comprises a first graduated rotary element (110), a second graduated rotary element (120), and a transmission mechanism (130) between the first and second rotary elements. The first rotary element comprises first reliefs (119A) and second reliefs (119B), which cooperate alternately with the transmission mechanism (130) so as to rotate the second rotary element by one graduation each time the first rotary element makes a complete revolution. The graduation of the second rotary element comprises at least two identical adjacent numbers.The dose counter (100) comprises a priming cover (150), which is arranged so as to mask a window (302) for viewing the graduations until the second rotating element (120) has been rotated at least once. Figure for abstract: Figure 4.