57 results about "Dose adjustment" patented technology

The present invention describes a portable medical and cosmetic photon emission adjustment device with the control of dose of photon and a method for using the same. A light source for medical treatment is positioned in a portable device to adjust the dose of photon emission by a dose adjustment device. The dose adjustment device has a microprocessor for processing and transmitting control signals and instruction signals. The dose adjustment device is used to control a plurality of light sources. The light source can be a high power light-emitting diode (LED) or a laser diode, and is combined with a set of lenses to achieve light convergence or light dispersion.

The invention provides a method for determining a dose and schedule and making dose adjustments of PBA prodrugs used to treat nitrogen retention states, or ammonia accumulation disorders, by measuring urinary excretion of phenylacetylglutamine and / or total urinary nitrogen. The invention provides methods to select an appropriate dosage of a PBA prodrug based on the patient's dietary protein intake, or based on previous treatments administered to the patient. The methods are applicable to selecting or modifying a dosing regimen for a subject receiving an orally administered ammonia scavenging drug.

The invention relates to an on-line dose modulation method of an X-ray CT (Computed Tomography) machine, which comprises the following steps: scanning plain film data, extracting Z-direction attenuation information of a human body, and calculating the attenuation area of the human body in each cut film along the Z direction; according to the attenuation area, calculating the average X-ray dose in each cut film to form a dose distribution curve along the Z direction, and supplying to a user as an initial recommended value, so that the user can adjust the dose distribution in the Z direction as required; scanning a patient, and simultaneously carrying out on-line estimation on the attenuation value of the rotation direction of the patient to obtain an attenuation estimated value; combining the dose distribution in the Z direction with the attenuation estimated value of the human body in the rotation direction to calculate a bulb tube mA value; transmitting the mA value to a high-pressure system, and carrying out high-frequency dose adjustment; and finishing the on-line dose modulation process if the scanning is completed. The invention reduces the overexposure and underexposure possibly caused by assuming sine laws. Besides, the invention does not assume that what passes through the central passage is the maximum attenuation, so that the dose modulation is better matched with the shape of the actual object.

The invention provides a method for determining a dose and schedule and making dose adjustments of PBA prodrugs used to treat nitrogen retention states, or ammonia accumulation disorders, by measuring urinary excretion of phenylacetylglutamine and / or total urinary nitrogen. The invention provides methods to select an appropriate dosage of a PBA prodrug based on the patient's dietary protein intake, or based on previous treatments administered to the patient. The methods are applicable to selecting or modifying a dosing regimen for a subject receiving an orally administered ammonia scavenging drug.

The invention provides a method for determining a dose and dosing schedule, and making dose adjustments of patients taking PBA prodrugs as nitrogen scavengers to treat nitrogen retention states, including ammonia accumulation disorders as well as chronic renal failure, by measuring urinary excretion of phenylacetylglutamine and / or total urinary nitrogen. The invention provides methods to select an appropriate dosage of a PBA prodrug based on the patient's dietary protein intake, or based on previous treatments administered to the patient. The methods are applicable to selecting or modifying a dosing regimen for a subject receiving an orally administered waste nitrogen scavenging drug, and to monitoring patients receiving such drugs.

The present invention relates to an injection device for administering doses of liquid drug. The injection device comprises a user operable dose adjustment structure configured to adjust, in a prepared state of the device, a dose of liquid drug of a first size to set a dose of a second size. The present injection device is particularly suitable for self- injection of liquid drugs such as insulin for treating diabetes by the user or patient.

The invention provides a remotely-controlled liquid dosing machine. The remotely-controlled liquid dosing machine comprises multiple storage hoppers, a material passing pipe is arranged at one end of each storage hopper, the other end of each material passing pipe is communicated to a material storage trough, a material inlet pipe is communicated to the other end of each material storage trough, a solenoid valve is arranged in each material inlet pipe, the material inlet pipes are communicated to a converging pipe, the other end of the converging pipe is communicated to a stirring tank, a control signal receiver is arranged on one side of the stirring tank, and a controller is arranged on the other side of the control signal receiver; partition plates are arranged among the material storage trough, a support rod is arranged on one side of the stirring tank, a mounting table is arranged at one end of the support rod, and the control signal receiver and the controller are arranged on one end of the mounting table. According to the remotely-controlled liquid dosing machine, a dosing information control signal of a remote terminal can be received to adjust the solenoid valves, and remote dosing adjustment is achieved; the manpower is saved, the dosing speed is increased, the dosing efficiency is improved, and therefore dosing is more intellectualized.

The present disclosure provides methods and compositions for testosterone replacement therapy. The methods and compositions employ a fixed dose dosing regimen that does not require titration or dose adjustments and that can provide a therapeutically effective amount of a testosterone ester while avoiding unacceptably high testosterone levels.

The present disclosure provides methods and compositions for testosterone replacement therapy. The methods and compositions employ a fixed dose dosing regimen that does not require titration or dose adjustments and that can provide a therapeutically effective amount of a testosterone ester while avoiding unacceptably high testosterone levels.

The invention relates to a micro-dose flow regulator. The micro-dose flow regulator comprises an upper shell and a lower shell, wherein a liquid inlet conduit joint is arranged in the upper shell; a liquid outlet conduit joint is arranged in the lower shell; the upper shell is connected with the lower shell through a central fastener; a lathy through hole communicated with the liquid inlet conduit joint is radially formed on the bottom end face of the upper shell; the upper end face of the lower shell is contacted with the bottom end face of the upper shell; a reducing transfusion groove from narrow to wide is formed on the upper end face of the lower shell opposite to the lathy through hole on the bottom end face of the upper shell; a liquid outlet round through hole communicated with the liquid outlet conduit joint is formed on the widest part of the reducing transfusion groove; the lathy through hole of the upper shell, the reducing transfusion groove on the upper end face of the lower shell and the liquid outlet round through hole form an interconnected transfusion channel; and the width of the reducing transfusion groove opposite to the lathy through hole is regulated by relatively rotating the upper shell and the lower shell, so that the accurate and micro-dose adjustment of the transfusion flow is realized. The micro-dose flow regulator has the characteristics of reasonable structure, and simple and convenient operation and use.

An automated blood or bodily fluid sampling machine for collecting, measuring and monitoring real time samples from test animals during dosing of the animals, automatically provides real-time adjustment of dosing during testing. Such automated blood or bodily fluid sampling is performed in tandem with implanted physiological monitoring devices to monitor biological and physiological parameters in restrained or freely-moving test animals. The real-time feedback provides for dosing adjustment within testing protocols.

The invention provides an exposure dose adjustment method and system. The method includes obtaining a first image according to a first exposure dose; inputting the first image to a detection model, and determining the region of interest in the first image, the detection model being a machine learning model; determining a gray value of the region of interest in the first image; and adjusting the first exposure dose according to the gray value and a preset gray target value, and obtaining a second exposure dose used for generating a second image. Thus, high-quality images with proper exposure doses can be rapidly obtained, and unnecessary radiation doses received by patients can be effectively reduced.

The invention discloses a fine adjusting injection pen. The injection pen comprises a differential screw drive mechanism, a dose adjustment mechanism, a shell and an injection mechanism, wherein the differential screw drive mechanism comprises a push rod, a push rod nut, a rotary positioning ratchet, an adjusting lever and a ratchet cylinder; the dose adjustment mechanism comprises a knob, a digital tube, an adjusting cylinder, a ratchet connecting ring and an adjusting connecting cylinder, and the adjusting lever is sleeved with the ratchet connecting ring; a differential screw is arranged in the shell in a drive mode, the shell is provided with a window, and the shell is internally provided with a refill holder; the injection mechanism comprises a key connecting piece, a key, a key spring and the like. In the process of adjusting, the contact part of the ratchet connecting ring and the ratchet cylinder makes a 'click' sound under the action of the ratchet, and in the process of retracement, a 'click' sound also be made; through the sounds, a user can be given with a voice warning, and furthermore, combined with a visual warning of the window, the dose adjustment is facilitated. In addition, the fine adjusting injection pen can be used repeatedly, and compared with a traditional direct-push-type injection pen, the injection precision can be effectively improved by transforming spiral motion into linear motion.

The invention provides a mammary gland X-ray imaging exposure dose adjustment method. The method includes the following steps: training a plurality of mammary gland type classifiers based on a training image set, wherein the training image set includes a plurality of mammary gland pre-exposure images, each of the mammary gland pre-exposure images includes at least mark information, image information, and physical information, dividing the training image set into a plurality of mammary gland type training image sets based on the marker information, calculating the target image feature values ofeach mammary gland type training image set, collecting a pre-exposure image of the mammary gland, extracting image information of the acquired pre-exposure image, acquiring physical information of the mammary gland, inputting the extracted image information and the acquired physical information into a plurality of breast type classifiers to determine the type of breast to which the pre-exposure image is acquired, calculating a pre-exposure image feature value of the acquired pre-exposure image, according to the pre-exposed image feature value of the acquired pre-exposure image and the targetimage feature value of the training image set corresponding to the mammary gland type as a reference, adjusting the formal exposure dose. The present invention also provides a computer-readable storage medium for performing the above method.

The invention relates to a micro-dose flow regulator. The micro-dose flow regulator comprises an upper shell and a lower shell, wherein a liquid inlet conduit joint is arranged in the upper shell; a liquid outlet conduit joint is arranged in the lower shell; the upper shell is connected with the lower shell through a central fastener; a lathy through hole communicated with the liquid inlet conduit joint is radially formed on the bottom end face of the upper shell; the upper end face of the lower shell is contacted with the bottom end face of the upper shell; a reducing transfusion groove fromnarrow to wide is formed on the upper end face of the lower shell opposite to the lathy through hole on the bottom end face of the upper shell; a liquid outlet round through hole communicated with the liquid outlet conduit joint is formed on the widest part of the reducing transfusion groove; the lathy through hole of the upper shell, the reducing transfusion groove on the upper end face of the lower shell and the liquid outlet round through hole form an interconnected transfusion channel; and the width of the reducing transfusion groove opposite to the lathy through hole is regulated by relatively rotating the upper shell and the lower shell, so that the accurate and micro-dose adjustment of the transfusion flow is realized. The micro-dose flow regulator has the characteristics of reasonable structure, and simple and convenient operation and use.

The invention discloses a multi-dose adjustable prefillable injection pen. The multi-dose adjustable prefillable injection pen comprises a pen body, an injection push rod, a push rod sleeve, a clutch hub, an end limiting piece and a dose hub. The injection push rod is in threaded connection with the pen body. The push rod sleeve is in sliding fit with the injection push rod along the injection direction and can transmit a torque along the screwing-in direction of the injection push rod. The push rod sleeve is connected with the pen body through a first group of ratchet and pawl mechanism. The clutch hub is in sliding fit with the push rod sleeve along the injection direction. The dose hub is rotationally connected with the pen body through threads. Rotation between the clutch hub and the dose hub is limited through a clamping structure capable of being disengaged along the injection direction. The end limiting piece and the dose hub are supported through a supporting foot capable of elastic-deformation along the injection direction. The clamping structure can be pushed to be disengaged from connection by rotating the dose hub prior to elastic-deformation of supporting foot. The multi-dose adjustable prefillable injection pen can effectively solve problems of inconvenient operation and poor effect of dose adjustment in existing injection pens.

The invention relates to the technical field of agricultural machinery, in particular to a system and method for conveying and distributing soil pesticides. The soil application delivery distribution system includes a controller, a syringe pump, a dispenser, and a dose adjustment pump; the dispenser includes a dispenser housing, an electromagnetic pipeline clutch and a distribution pipeline interface; on the distributor housing There is a medicine feeding tank and a delivery tank; the electromagnetic pipeline clutch is movably arranged on the distributor housing, and is used to control the opening and closing and the flow rate between the medicine feeding tank and the delivery tank; the The controller is respectively connected to the electromagnetic pipeline clutch and the injection pump, the injection pump is connected to the drug feeding tank, the multiple distribution pipeline interfaces are connected to the delivery tank, and each distribution pipeline interface is respectively connected to the drug volume adjustment Pump connection. The soil application conveying and distributing system can make the liquid medicine distribution more uniform and stable, and is beneficial to realize the purpose of scientific soil application.

The present invention relates to an injection device for administering doses of liquid drug. The injection device comprises a user operable dose adjustment structure configured to adjust, in a prepared state of the device, a dose of liquid drug of a first size to set a dose of a second size. The present injection device is particularly suitable for self-injection of liquid drugs such as insulin for treating diabetes by the user or patient.

The invention discloses a method and a system for automatically controlling the ion implantation dose, which belong to the technical field of semiconductor manufacture. The method includes the following steps: acquiring the influence parameters of ion implantation dose in the manufacture process of a specific layer before the current layer, and getting the target implantation dose of the current layer through processing according to all the influence parameters and the standard implantation dose of an implantation process corresponding to the manufacture process of the current layer; comparing the target implantation dose of the current layer with a preset target dose range to determine a target dose range matching the target implantation dose; and selecting an ion implantation program corresponding to the determined target dose range, and determining the ion implantation dose in the manufacture process of the current layer according to the selected ion implantation program. The system is implemented according to the method. The technical scheme has the beneficial effect that the complexity of ion implantation dose automatic control is reduced, and the stability and safety of implantation dose adjustment are ensured.

A drive and metering apparatus for an injection apparatus for releasing a liquid product, the drive and metering apparatus comprising: a) a housing, b) a dose adjustment member, which is rotatable relative to the housing for adjusting the product dose to be released, c) an actuation member which is displaceable from a non-actuated position, which it assumes while adjusting the product dose to be released, into an actuated position, which it assumes while it releases the product, wherein the displacement of the actuation member into the actuated position triggers a product release and the actuation member comprises an actuation section, which is accessible to a user of the drive and metering apparatus and by means of which the user can displace the actuation member from the non-actuated position into the actuated position, d) wherein the actuation section is arranged distally in relation to the dose adjustment member.

An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition preferably comprises a extended release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules. The composition is designed to release hydrocodone in a way such that the increase in hydrocodone exposure in hepatically impaired patients is not clinically significant. The oral dosage units are supplied as part of a kit, which also includes a primary package and a package insert all sold as a commercially marketed product. The primary package and package insert are contained in an optional secondary package and the package insert does not contain a warning, a dosing instruction, or a dosing table specifically directed to patients suffering from mild, moderate or severe hepatic impairment, and preferably explicitly states that dosing adjustment is not required for mild or moderate hepatic impairment

Delivery of glial cell line-derived neurotrophic factor (GDNF) has provided benefits to Parkinsonian patients and is currently being tested in a Phase 1 / 2a clinical trial for ALS patients. However, chronic trophic factor delivery prohibits dose adjustment or shut off in the event of side effects. To address this, the Inventors engineered a stably integrating, third-generation doxycycline-regulated vector, allowing inducible and reversible expression of a therapeutic molecule Human iPSC-derived neural progenitors were stably transfected with the vector, expanded and transplanted into the adult mouse brain. The Inventors observed that the addition and withdrawal of doxycycline led to GDNF expression that could be induced and reversed multiple times, demonstrating that doxycycline can penetrate the graft and regulate transgene expression in vivo. The Inventors' findings provide a proof of concept for combining gene and stem cell therapy for effective modulation of ectopic protein expression in transplanted cells.

The invention discloses enema liquid and a preparation method thereof. The enema liquid comprises, by mass, 5.0-20.0g of montelukast, 10.0-100.0g of tween 80, 5-10g of hydroxypropyl methylcellulose, 0.3-0.5g of ethylparaben, 6.0-8.0g of hydroxypropyl-beta-cyclodextrin and the balance of purified water, wherein the total mass of the enema liquid is 1000g. The enema liquid has the advantages that precise dose adjustment is achieved through dose fractionation so as to prepare miniature montelukast enema gel, the problems that the dose of current montelukast tablets and granules cannot be accurate fractionated, inaccurate medicine taking dose caused by the swallowing difficulty of infants during oral medicine taking, and accordingly an uncertain curative effect and unpredictable adverse effects are caused can be avoided, medicine bioavailability is increased, and liver damage caused by medicine is reduced.

The invention relates to the technical field of medical instruments, in particular to a dose-adjustable liquid medicine feeding device, which comprises a pen container, wherein a containing cavity is formed in the pen container in the axial direction, a pen cap is arranged at the front end of the pen container, the front end of the pen container is an injection needle end; the dosage-adjustable liquid medicine feeding device further comprises an injection device and an adjusting assembly, wherein the injection device comprises an injection part which is movably arranged in the containing cavity, and the adjusting assembly comprises a fixedly-arranged limiting piece and a movably-arranged dose adjusting piece; a plurality of dose adjusting grooves are formed in the inner side wall of the pen container in the axial direction, the lengths of the dose adjusting grooves being different; the dose adjusting part is provided with a sliding part in sliding fit with the dose adjusting groove,wherein the limiting part limits the injection part to move only close to the injection needle end, and the dose adjustment member is limited to only move away from the injection needle end relative to the injection member. According to the dosage-adjustable liquid medicine feeding device, the injection dosage can be adjusted according to the conditions of different patients, and the injection dosage is not prone to being affected by external force in the injection process.

The present disclosure provides methods and compositions for testosterone replacement therapy. The methods and compositions employ a fixed dose dosing regimen that does not require titration or dose adjustments and that can provide a therapeutically effective amount of a testosterone ester while avoiding unacceptably high testosterone levels.

The embodiment of the invention discloses a maximum dose point optimization method and device, electronic equipment and a storage medium. The method comprises the steps: acquiring an initial maximum dose area; determining a first area where the at least one protection area is overlapped with the initial maximum dose area, determining a second area except the first area in the initial maximum dosearea, and determining a target area according to the initial maximum dose region, the first region and the second region, thereby achieving the automatic determining of the target area; acquiring a first maximum dose value of the target area and a second maximum dose value of a non-target area; performing dose adjustment on a voxel point corresponding to the second maximum dose value greater thanthe first maximum dose value based on a preset dose adjustment rule, thereby solving the problem that doctors need to have more experiences to optimize the maximum dose point in the prior art, achieving the purposes of automatically determining the target area and automatically optimizing the maximum dose point, and achieving the effect of improving the optimization efficiency and accuracy of themaximum dose point.

The invention discloses a scanning method and a scanning device. The scanning method comprises the steps that a scanning state of CT equipment is monitored; when a high milliampere radioactive ray scanning state of the CT equipment is switched into a low milliampere radioactive ray scanning state, the scanning duration of the CT equipment under the low milliampere radioactive ray scanning state istimed to obtain the first duration; when the first duration reaches the preset maximum duration, the scanning state of the CT equipment is triggered to be switched from the low milliampere radioactive ray scanning state into the high milliampere radioactive ray scanning state, wherein the preset maximum duration is the longest time which can be sustained by low milliampere radioactive ray scanning on the premise of ensuring that a CT image can be reconstructed. By controlling the continuous scanning time in the low milliampere radioactive ray scanning state, the switching of the scanning state of the CT equipment is controlled, namely the low milliampere radioactive ray scanning state is switched into the high milliampere radioactive ray scanning state to ensure that the CT image can be reconstructed, and the effectiveness of dose adjustment of CT scanning of the CT equipment is improved.

A packaging container for a drug having a recording medium and / or an identification mark for recording and updating one or more arbitrary information(s) selected from the group consisting of the information: an active ingredient of a drug, usage of a drug, drug dose, date of manufacture of a drug, expiration date of a drug, drug shipping date of a drug, traceability of drug delivery route from manufacturing to usage of a drug, and storage conditions (e.g., temperature, light (dark / light), humidity, etc.) including storage temperature and changes thereof, information including the administration date of a drug and a breakdown of the administration, amount of drug presented in drug-enclosing portion.