75 results about "Dose adjustment" patented technology

The invention relates to the technical field of medical information, and discloses a dosage regulation and control data storage method and system based on multi-modal diagnosis and treatment data, and the method comprises the steps: obtaining historical diagnosis and treatment data and historical dosage data of a patient; matching the diagnosis result data with health diagnosis result data in the health diagnosis and treatment data, and matching the wearable device data with health wearable device data in the health diagnosis and treatment data; determining whether to adjust the historical dose data to obtain the current dose, and outputting a judgment result needing to be adjusted; and obtaining the adjusted dose data, and storing the diagnosis result data, the diagnosis result similarity, the wearable device data, the wearable data similarity, the historical dose data and the adjusted dose data into a dose adjustment unit in a patient database. According to the invention, multi-modal diagnosis and treatment data can be integrated and applied to dose regulation and control, and a complete medication decision data chain is constructed.

The embodiment of the invention discloses a coprophilous fungus transplantation donor and acceptor dynamic matching method, device and equipment and a medium, and the method comprises the steps: responding to a donor and acceptor matching request, and obtaining the monitoring data of a to-be-matched acceptor after coprophilous fungus transplantation at the current preset sampling time; wherein the monitoring data after coprophilous fungus transplantation is determined on the basis of the coprophilous fungus transplantation operation of a to-be-matched receptor completed by the coprophilous fungus flora of any target donor, and the target donor is determined by performing adaptability matching on the gene feature information, the immune feature information and the clinical feature information of the to-be-matched receptor and a plurality of to-be-selected donors; and inputting monitoring data after coprophilous fungi transplantation into the transplantation strategy control model, outputting at least one of a donor switching strategy and a dose adjustment strategy for adjusting a to-be-matched receptor in a next time period, realizing comprehensive compatibility evaluation through multi-modal data integration, continuously optimizing a treatment scheme by means of a dynamic feedback mechanism, and improving the compatibility of the to-be-matched receptor. And the accuracy and adaptability of coprophilous fungus transplantation treatment are remarkably improved.

The invention discloses a dose adjustment forward and reverse rotation structure of a medicine delivery device, and belongs to the technical field of medical instruments, the dose adjustment forward and reverse rotation structure comprises a knob, a ratchet seat, ratchet teeth, jumping teeth and an injection spring, the ratchet seat is connected with the ratchet teeth through a forward sound generating part, and the ratchet teeth and the jumping teeth are connected through a reverse sound generating part in a clutch mode; a first forward rotation cooperation part and a first reverse rotation cooperation part are arranged on the rotary knob, a second forward rotation cooperation part and a second reverse rotation cooperation part are arranged on the jumping teeth, and the injection spring is used for enabling the ratchet wheel teeth to be connected with the jumping teeth. The device is simple in structure, convenient to install and good in stability, the preset dosage can be adjusted through clockwise rotation, the force stored by the torsion spring can be clamped, the preset dosage can be reduced through anticlockwise rotation until the preset dosage returns to the zero position, forward rotation is converted into radial elastic tooth jumping meshing sound production, and reverse rotation is converted into axial tooth jumping meshing sound production.

The invention discloses a brain tumor disease treatment effect evaluation method, and belongs to the technical field of radiotherapy plan evaluation, and the method specifically comprises the steps: obtaining the brain multi-modal image data of a patient, and extracting a three-dimensional tumor region and a corresponding perfusion parameter; constructing a biological target region hierarchical structure containing a tumor overall region and an anoxic subregion; a relative hypoxia degree parameter is obtained by calculating the cerebral blood flow ratio of the hypoxia subregion to other regions of the tumor; historical treatment case data are deconstructed, and a dose-curative effect associated parameter set is established; training and outputting a dose adjustment strategy model for the hypoxia subregion; and generating a final radiotherapy dose planning scheme according to a dose adjustment value output by the model in combination with a clinical guide basic dose. Through a data-driven dose decision-making mechanism, the limitation of traditional uniform dose irradiation is overcome, so that an objective and reliable evaluation basis is provided for clinical selection and optimization of personalized treatment schemes.

The invention relates to the technical field of gastrointestinal tumor chemotherapy risk assessment, and particularly discloses a gastrointestinal tumor chemotherapy risk scoring model and a construction method thereof, and the method comprises the steps: obtaining the individualized feature data and basic physiological data of a historical patient, and constructing an individualized difference library with a unique ID, and a core influence library; the method comprises the following steps: standardizing and coding double-library data, synchronizing clinical data containing treatment effect codes, forming a data dictionary, acquiring and coding current gastrointestinal tumor patient data, and matching the data dictionary to judge individual difference abnormity; when the first data set is abnormal, constructing a first data set, screening core independent variables through Logistic regression, and constructing a scoring model by using an LSTM (Long Short Term Memory) model; when no abnormity exists, redundant codes are removed to obtain a second data set, and modeling is conducted through the same method. Through double-library linkage and scene-divided modeling, the three-level toxicity risk prediction precision is improved, data support is provided for clinical chemotherapy dose adjustment and toxicity prevention, and the risk of excessive treatment or insufficient treatment is reduced.

This invention belongs to the field of acute lymphoblastic leukemia (ALL) technology and discloses an ALL scoring system. The system divides the entire treatment cycle into three major phases: induction remission, consolidation therapy, and maintenance therapy. Each phase is further subdivided into sub-phases, forming a two-tiered data acquisition architecture. During data collection, baseline data such as age and fusion genes are included, along with dynamic data such as the rate of MRD decline and drug exposure concentration. Simultaneously, anchor triggering mechanisms are set at different sub-phases, making the risk score more closely aligned with the patient's real-time condition and providing a more accurate reference for clinical treatment strategy selection. The feature adaptation module matches subtype-specific biomarkers and analyzes the interaction between rare subtypes and comorbidities. The matching module calls upon a three-dimensional protocol library to select standardized protocols for common subtypes, targeted protocols for rare subtypes, and dose adjustment or drug substitution protocols for patients with comorbidities, matching more suitable protocols for different patients.

The invention provides an individualized ovulation promoting scheme and gonadotropin initial dose prediction method based on multi-cycle time sequence modeling and related equipment, and is applied to the technical field of data processing. The method comprises the following steps: firstly, receiving multi-cycle clinical data and basic information of a target user for IVF / ICSI pregnancy-assisted patients, and eliminating unqualified samples to generate an initial data set; after SHAP screening features, training / test set division and SMOTE sample equalization are carried out, an initial model is constructed through a sliding window time sequence module and a multi-algorithm engine; a target model is generated through training and evaluation, and a COS scheme prediction signal and multi-period Gn dose adjustment information are generated in combination with hierarchical classification and weighted integration; calibration information is generated through clinical data verification, after target user information is subjected to standardization processing, an individualized COS scheme and a Gn initial dose are output through a target model, and multi-cycle dynamic accurate recommendation is achieved.

Most therapeutic treatments require dose adjustment after initial administration. Dosage adjustment is crucial to ensuring optimal safety and efficacy characteristics of the treatment. Gene therapy is inherently limited by the inability to adjust the dose after initial administration. This invention describes a genetic element capable of dose adjustment after the initial administration of gene therapy. The realization of dose adjustment allows for the replacement of multiple subcutaneous protein injection regimens with single-injection gene therapy, thereby improving pharmacokinetics, safety / efficacy characteristics, medication adherence, and reducing healthcare costs.

The invention discloses a medication management system with dose adjustment and a medication management method, and the method comprises the steps: enabling a doctor to give a medication scheme according to the illness state of a patient, update an individualized medication scheme according to a medication compliance report of the patient, and upload the medication scheme to a cloud server through the arrangement of a doctor terminal; and the cloud server sends a generated patient medication compliance report to a doctor end. The patient end confirms the medication scheme and generates a medication plan scheme according to the medication scheme; the intelligent medicine box controls the target medicine bin to discharge medicine according to the medicine taking scheme and the medicine taking plan scheme. Through cooperative work among the doctor end, the patient end and the intelligent medicine box, an individualized medicine taking scheme based on the doctor end is realized, and a patient can automatically execute a new medicine taking plan scheme and record medicine taking behaviors, so that dynamic dose control is realized in the medicine taking process of the patient, data interaction and medicine taking compliance feedback between the doctor and the patient are completed, and the patient can take medicine conveniently. The safety and the standardization of long-term medication of patients with chronic diseases are improved.

The invention relates to a firing device for a needleless injector and a needleless injection system. The needleless injector includes an injection chamber housing and a piston assembly. The launch device includes a support housing, a power push rod, and a dose adjustment device. The support housing is configured to be connectable to the injection chamber housing. The power push rod is configured to be connectable to the piston assembly and movable relative to the support housing. The dose adjusting device comprises a dose adjusting disc and a dose adjusting column, the dose adjusting disc is rotatably connected to the supporting shell, a plurality of dose grooves are formed in the dose adjusting disc, the depths of the dose grooves are different from one another, and the dose adjusting column is arranged on the power push rod and can move along with the power push rod. The dose adjusting column can change the movement stroke of the power push rod by being matched with different dose grooves. According to the needleless injection system of the scheme, a user can conveniently achieve injection of a preset dose.

This application discloses a feedback-optimized injection pen, relating to the field of medical device technology. The feedback-optimized injection pen includes a pen body, an adjustment mechanism, and an injection mechanism. The pen body includes a pen body with an outer cylinder and an inner cylinder, with a feedback rib on the outer side of the inner cylinder. The adjustment mechanism includes a dose hub, the outer side of which is threaded into the outer cylinder. The dose hub has a spring arm, which contacts the feedback rib to generate feedback when the dose hub rotates. The injection mechanism and adjustment mechanism have both coupled and decoupled states. When the injection mechanism is coupled to the adjustment mechanism, the injection mechanism pushes the liquid medication from the vial container under the action of the adjustment mechanism. This feedback-optimized injection pen, through its double-cylinder design, strengthens the assembly relationship with the dose hub and generates precise adjustment feedback during dose adjustment through the contact between the spring arm and the feedback rib, thereby improving the accuracy of dose setting and the reliability of the injection pen.

An assembly and method for housing and securing exposed dose adjustment control mechanisms of medical devices used to administer various medical therapies, is provided. In an exemplary embodiment, the inventive assembly and method serve to house and secure exposed dose adjustment control mechanisms of oxygen concentrators used to provide oxygen therapy. The inventive assembly, which securely encloses a dose adjustment control mechanism, permitting access only to select individuals, is made up of a cup-shaped hollow member having a through-hole in a distal wall, and a lid. The cup-shaped hollow member and the lid are held together by a hinge or fastening means, and fastening / locking means.

This invention relates to the field of clinical medical and nursing device technology, specifically to an auxiliary turntable for blood glucose management and insulin dose adjustment in critically ill patients. It includes a base and a recommendation component. A support column is fixedly connected to the top of the base. The recommendation component includes a recommendation disc fitted outside the support column. A judgment component, including a judgment disc fitted outside the support column, is fitted outside the support column and is located on top of the recommendation cover. An identification component, including an identification disc fitted outside the support column, is fitted outside the support column. A base component, including a base disc fitted outside the support column, is located on top of the identification cover. Through the base, support column, and four sets of adjustment components, standardized and visual matching of multiple blood glucose indicators and insulin adjustment recommendations is achieved. Combined with three-color risk label strips, it quickly identifies abnormal blood glucose levels and fluctuation risks, enabling early detection and intervention, and reducing dose adjustment errors due to experience.

The invention relates to the field of medical health and intelligent optimization, and discloses a dialysis anticoagulation risk intelligent early warning method and system fused with multi-modal physiological signals, and the method comprises the steps: S1, synchronously collecting the multi-modal data of a patient in the dialysis process, and standardizing the multi-modal data into a unified time sequence matrix; s2, inputting the unified time sequence matrix into an anticoagulation risk prediction model, performing first-class feature extraction on continuous monitoring signals, performing second-class feature extraction on discrete detection signals, and extracting embedding features of patient individualization and treatment scene data; performing cross-modal fusion on the three types of extracted features to generate a fusion feature vector, and outputting a thrombus risk probability and a bleeding risk probability in a future preset time period; s3, when the risk probability exceeds the corresponding early warning threshold value, performing search optimization on the administration parameter of the current anticoagulant, and generating a dose adjustment instruction; and S4, executing the adjustment instruction, predicting the anti-coagulation risk again, and evaluating the regulation and control effect. Therefore, the safety and effectiveness of the hemodialysis process are remarkably improved.

The application is suitable for the field of artificial intelligence and medical health technology, and provides a medicine mutual exclusion identification and dose adjustment method and device and a storage medium, which comprises the following steps: obtaining a first prescription and a second prescription corresponding to a target disease; wherein the first prescription and the second prescription are obtained based on different medical systems; the first prescription comprises at least one first medicine and a first dose corresponding to the first medicine; the second prescription comprises at least one second medicine and a second dose corresponding to the second medicine; identifying medicine mutual exclusion according to the first prescription and the second prescription to obtain a first identification result; and adjusting the first dose according to the first identification result to obtain an adjusted first prescription. The above method provides a safer and more suitable medication scheme for cross-medical system joint diagnosis and treatment.

The invention discloses a cardiovascular drug dose regulation and control system based on reinforcement learning, and relates to the technical field of medical artificial intelligence, and the system comprises a data acquisition module which collects physiological data, metabolic parameters, a drug interaction matrix and a current drug combination of a patient in real time; the adjustment factor calculation module calculates a drug metabolism rate adjustment factor through a pharmacokinetic model; the interaction modulation module adjusts the interaction intensity according to the adjustment factor; the risk score calculation module calculates the adverse reaction risk of the patient based on the adjusted interaction matrix, the drug combination and the physiological data; the first processing module judges whether the risk score exceeds the standard or not, and if yes, the risk is reduced through medicine replacement or dosage reduction; if the risk score is lower than a second threshold value, the second processing module maintains the current dose, otherwise, a dose adjustment strategy is optimized based on reinforcement learning; according to the method, the medicine dosage adjustment can be more fit with the actual metabolic characteristics of the patient, and the accuracy and individualization degree of treatment are improved.

The present invention relates to an injection mechanism and syringe with an injection dose adjustment function. The injection mechanism (1) has a housing (10) which contains a plunger (80) and an injection dose adjustment means (1a) and a retraction control means (1b) connected to the plunger (80). The injection dose adjustment means (1a) drives the plunger (80) by rotating a tubular member (20) with a dose adjustment knob (30) to drive a drive ring (50), thereby generating elastic potential energy in an elastic means (40).

The invention discloses a pen type insulin syringe with digital display and data transmission functions. The pen type insulin syringe comprises a shell assembly, a refill sleeve, a shell lock, a dose adjusting knob, a hollow penetrating contact type rotary encoder, an injection driving mechanism, a dose memory display module, an injection dose indication window and an NFC data transmission system. When the device works, the dose adjusting knob is pulled out in the axial direction of the shell assembly, locking of the clamping structure on the dose adjusting knob is relieved, the dose adjusting knob is made to rotate freely, then the hollow penetrating contact type rotary encoder is driven by the dose adjusting knob to conduct dose adjustment, and after dose parameter setting is completed, the injection button is pressed in the axial direction, so that the dose parameter setting is completed. The injection driving mechanism is triggered to move along a preset track so as to push the medicament to complete the injection process. High-precision digital control and intelligent data management in the insulin infusion process are achieved, the accuracy of dose adjustment and injection is remarkably improved, and the convenience of user operation experience and medication compliance management is also optimized.

Disclosed is a disposable multi-dose high-precision insulin injection apparatus, comprising a housing, and a dose adjustment unit and an injection transmission unit that are arranged in the housing. The dose adjustment unit is arranged in the upper part in the housing, and the injection transmission unit is arranged in the lower part in the housing. A dose setting unit is in transmission connection with the injection transmission unit. The dose adjustment unit is used for presetting an injection dose, and the injection transmission unit is used for transmitting injection power and discharging the preset injection dose to complete an injection. The disposable multi-dose high-precision insulin injection apparatus described in the present invention uses the dose setting unit to set a dose of insulin to be injected and uses the injection transmission unit to complete the injection of the corresponding dose. The dose setting unit can accurately set a dose to be injected. The apparatus is simple and convenient to operate and cost-effective.

Embodiments of the present disclosure relate to dose adjustment for maximum field delivery time in radiation therapy treatment planning. A proton therapy system may include at least one processor and a memory storing computer executable instructions. The at least one processor is configured to execute the computer executable instructions to cause the proton therapy system to selectively adjust a treatment plan for a proton therapy treatment of a target volume based on a treatment delivery time of the treatment plan and a threshold maximum treatment delivery time, the treatment plan specifies at least proton therapy field characteristics for treating the target volume.

The invention relates to the technical field of medical injection pens, in particular to an intelligent electronic dosage adjusting injection pen. According to the technical scheme, the injector comprises a supporting cylinder and further comprises a manual injector movably installed at one end of the supporting cylinder, and the manual injector is provided with an adjusting knob gear sleeve, a display mark and an injection button. Through cooperation of the supporting cylinder, the transmission mechanism, the reading mechanism, the pushing mechanism and other structures, when the intelligent electronic dose adjusting injection pen is used, the manual injector is fixed through the clamping sleeve and the locking mechanism, and the reading mechanism reads and displays identification information for voice prompt. When a motor button is pressed down, the motor drives the inner gear sleeve to rotate through belt transmission and is meshed with the adjusting knob gear sleeve to realize automatic dose adjustment without manual rotation. After dose adjustment, the first cylinder pushes the pressing block to trigger the injection button. Manual operation is reduced, rotation deviation and misreading of scales are avoided, and the using burden and the error risk of chronic disease patients and people with inflexible fingers and poor eyesight are reduced.

The present invention relates to pharmaceutical compositions comprising a controlled-release PTH compound or a pharmaceutically acceptable salt, hydrate, or solvate thereof, for use in a method of treating, controlling, delaying or preventing a condition which can be treated, controlled, delayed or prevented with PTH, wherein the pharmaceutical composition comprising the controlled-release PTH compound is administered in accordance with a dosage regimen in which dose adjustment in response to hypocalcemia or hypercalcemia is performed in increments of no more than 25%.

A proton therapy system may include at least one processor and a memory storing computer executable instructions. The at least one processor is configured to execute the computer executable instructions to cause the proton therapy system to selectively adjust a treatment plan for proton therapy treatment of a target volume based on a treatment delivery time for the treatment plan and a threshold maximum treatment delivery time, the treatment plan at least prescribing proton therapy field characteristics for treatment of the target volume.

The application discloses a kind of pneumatic needleless injectors.It includes needle cylinder assembly, gas source assembly, dose adjustment assembly, injection piston assembly, shell assembly, the rear end of injector housing is fixed with the magnet that can be magnetically attracted impact piece, rear end is equipped with the airflow passage that is connected with cylinder inner cavity, the dose of inhaled liquid is adjusted by dose adjustment mechanism, compressed gas is filled into needleless injector energy storage cavity by gas source assembly, when the air pressure in energy storage cavity reaches a certain value, injection piston assembly overcomes the attraction between magnets and impacts forward and completes injection process.The needleless injector of the application has simple structure, low manufacturing process requirement, easy operation, low cost, dose adjustment, wide application range, high injection efficiency and high reliability.

The application relates to the field of medical data, and discloses a real-time monitoring method for drug efficacy of Chinese and Mongolian and Western medicine based on a biosensing technology, which is used for realizing real-time monitoring of drug efficacy and individualized drug use guidance. The method comprises the following steps: obtaining original sensing signals from real-time multi-modal biosignals collected from the body surface or minimally invasive body fluid samples of a drug user, and obtaining sensor array outputs; extracting real-time pharmacokinetic characteristic signals based on a preset pharmacokinetic model, and mapping the real-time pharmacokinetic characteristic signals into efficacy evaluation parameters according to the types of the drugs; comparing the efficacy evaluation parameters with a preset safe and effective concentration range, and generating real-time drug use state indications and dose adjustment prompt information. The application designs a quantitative evaluation mode for different types of drugs, can compare and generate efficacy state codes and dose adjustment suggestions in real time, comprehensively generates a drug use guidance report, and transmits the drug use guidance report to a drug user end or a clinical monitoring end in real time, so that instant adjustment of a drug use scheme is realized, and the safety and effectiveness of drug use are ensured.

This invention discloses a variable-dose spray assembly and spray device, including a nozzle, a spray pump, and a dose adjustment component. One end of the nozzle has a connecting portion, and the connecting portion has a guide portion. The spray pump is coaxially arranged with the nozzle and compresses its internal space as the nozzle is axially pressed to pump the medication into the nozzle. The dose adjustment component is sleeved with the connecting portion and has a first dose guiding channel and a second dose guiding channel extending along the axial direction of the spray pump. The guide portion can be switched to connect with and move along either the first or second dose guiding channel. The travel distance of the guide portion along the first dose guiding channel is greater than that along the second dose guiding channel. By switching the guide portion with different dose guiding channels, the compressible internal space of the spray pump varies, thereby enabling flexible switching between two doses in a single device, meeting differentiated dosage requirements, and improving the accuracy and convenience of medication administration.

The invention provides an intestinal flora metabolite monitoring-based depression drug dose dynamic adjustment method and device, and is applied to the field of medical data processing. The method comprises the following steps: acquiring intestinal flora metabolite data including short-chain fatty acid concentration and drug in-vitro parameters including metabolic rate; processing the data to capture action rules of metabolites and drugs, and generating initial dose regulation reference data and metabolic risk prompts; simulating interaction under different doses, and combining a safety threshold and an active target to obtain a target adjustment parameter and a curative effect prediction report; through drug half-life period and environmental stability correction, a scheme considering both curative effect and safety is formed. Further generating a comprehensive strategy fused with a metabolism rule; and finally integrating the information to generate dose regulation effect evaluation information containing in-vitro effective rate and metabolic safety coefficient.

The application discloses a dose adjusting mechanism and an injection pen, relates to the technical field of medical devices, and comprises a torsional spring support, a bidirectional stop, a knob and a power sleeve. The torsional spring support is provided with a bidirectional ratchet meshing groove, and the bidirectional stop is provided with bidirectional ratchet meshing teeth and a first driving groove. The knob is rotatable and is provided with a second driving groove, a ratchet window, a first spade tooth and a second spade tooth. The bidirectional ratchet meshing teeth are arranged to pass through the ratchet window and mesh with the bidirectional ratchet meshing groove. The power sleeve is provided with a first driving protrusion which is in transmission with the first driving groove and a second driving protrusion which is in transmission with the second driving groove. When the dose is corrected, the second spade tooth of the knob exerts a force on the bidirectional stop, and the force can be decomposed into two components along the tangential direction and the axial direction of the knob. The component along the axial direction can lift the bidirectional stop, and the meshing between the bidirectional stop and the torsional spring support can be smoothly disengaged, so that the torsion of the knob is reduced, and the smoothness of operation is improved.

An injection dose adjustment assembly is connected with an injection assembly to form an injection mechanism, and is further coupled with a vial mounting tube to form an injection syringe. The injection dose adjustment assembly has a mounting sleeve mounted in an outer tube. Two resilient ratchet arms of the mounting sleeve abut against two different one-way ratchet teeth of an inner ratchet portion of the outer tube respectively. An elastic transmission element and a pressing element are mounted on the mounting sleeve. A dose adjusting knob is mounted on the outer tube and is rotatable in a first direction and a second direction. By rotating the mounting sleeve through the elastic transmission element, an injection dose can be adjusted and a moving distance of an injection push rod of the injection assembly can be controlled.

A dose adjustment mechanism includes a power rod, a cylinder, a ball, a sleeve and a torsion spring; the cylinder is outer-mounted on the power rod, a spiral channel extending along the axial direction of the power rod is formed between the inner wall of the cylinder and the outer wall of the power rod, and the ball is rollable in the spiral channel; the cylinder and the upper pen holder of the injector pen are relatively fixed in the circumferential direction; the upper end of the torsion spring is relatively fixed to the upper pen holder, and the lower end is connected to the sleeve; the power rod rotates relative to the cylinder under the action of an external force; the sleeve is limitedly connected to the power rod in a circumferential direction, and the sleeve is configured for transmission cooperation with the transmission mechanism of the injector pen.