53 results about "Proton therapy" patented technology

Radiotherapy is the most widely used and effective anti-tumor therapy, however it can damage healthy tissues surrounding the tumor. One approach to reducing damage to healthy tissue involves irradiation at dose rates far exceeding those currently used in clinical contexts reduces radiation-induced toxicities while maintaining an equivalent tumor response. This is known as the FLASH effect. The mechanism responsible for reduced tissue toxicity following FLASH radiotherapy (FLASH-RT) is still undetermined; multiple hypotheses have been suggested by linking the high dose rate to rapid oxygen depletion, immune response, reduction of peroxyl radical lifetime, preservation of normal tissue stem cells, etc. While effective, proton therapy is underutilized, contributing to fewer than 2% of all external beam radiation treatments. To overcome this shortcoming, provided are methods which utilize the highest energy layer and a universal range shifter (URS) to facilitate rapid spot arc therapy (RAPIDSPARC™).

The present application belongs to the technical field of high-end medical equipment. Disclosed are a multi-room particle therapy room, a radiotherapy system, and a particle accelerator movement method. The multi-room particle therapy room comprises a plurality of treatment rooms. The radiotherapy system comprises the multi-room particle therapy room and a particle accelerator. Each treatment room is provided with a beam window. The particle accelerator can move outside different treatment rooms and is aligned with the beam windows. The particle accelerator directs particle beams into the treatment rooms by means of the beam windows. The particle beams perform radiotherapy by means of therapy heads in the treatment rooms. The radiotherapy system is not provided with a dipole magnet or a quadrupole magnet. The plurality of treatment rooms share one particle accelerator. The particle accelerator is moved to the outside of the treatment room requiring the particle beam, and the particle beam is directed into the treatment room by means of the beam window. When the treatment in the treatment room is completed, the particle accelerator is moved to other treatment rooms requiring the particle beams and performs treatment work, thereby reducing the overall cost of the radiotherapy system and making proton therapy accessible.

The present disclosure provides a cone beam computed tomography system for proton therapy comprising an x-ray source configured to generate x-rays and positioned to rotate around a patient at a treatment isocenter, a detector assembly positioned opposite the x-ray source and configured to receive x-rays that have passed through the patient, a rotation mechanism configured to rotate the x-ray source and the detector assembly around the patient while maintaining their relative positions, a translation mechanism configured to translate at least one of the x-ray source, the detector assembly, or a patient couch during rotation to implement a wobbled scan orbit, and a scatter rejection grid attached to the detector assembly and focused on the x-ray source to reduce scattered x-rays. The translation mechanism distributes missing projection data across multiple radii and angles, enabling improved reconstruction quality through iterative reconstruction methods.

The invention discloses a proton adaptive radiotherapy triggering decision method and system based on multi-modal data quantitative evaluation. The method comprises the following steps: acquiring image data, dose data and clinical data, respectively calculating a dosimetry scoring function, an anatomical structure scoring function and a proton specificity scoring function based on the image data and the dose data, obtaining an enhanced core quantitative score through weighted geometric average fusion, and obtaining the enhanced core quantitative score; determining parts, stages and prognosis adjustment parameters based on clinical data, and fusing a BMI dynamic evaluation factor, a treatment response prediction factor and a multi-factor interaction factor to obtain an enhanced clinical background adjustment coefficient; and calculating a final decision score in combination with the time modulation factor and the risk prediction index based on the LSTM, and outputting a grading decision result. According to the method, objective quantitative evaluation of deep fusion of multi-modal data is realized, specific risks of proton therapy are accurately captured, personalized intelligent decision is supported, and the method has good clinical operability.

The invention discloses a proton treatment plan verification and optimization device and method and related equipment, and relates to the technical field of radiotherapy. The device comprises an image acquisition module which is used for acquiring a PET image of a patient after completing at least one proton treatment irradiation; the dose prediction module is used for mapping the treated PET image into actual deposited dose distribution in the body of the patient based on the trained generative model so as to predict actual distribution dose distribution; and the adjustment and optimization module is used for generating an adjusted fractional treatment plan when the deviation between the predicted actual distribution dose distribution and the initial planned dose distribution is greater than a deviation threshold value. Based on in-vivo measurement information, the actual deposition dose is accurately verified and dynamically optimized, and accurate and safe proton therapy is achieved.

This application discloses a three-dimensional dose reconstruction method and related equipment based on in-beam positron emission tomography (PET) data. The method includes: acquiring list-pattern data during proton therapy beam exit; performing conformation processing on the list-pattern data and reconstructing a three-dimensional activity distribution map; performing multi-nucleus dynamic deconvolution processing on the activity time series corresponding to the three-dimensional activity distribution map according to the physical half-life of the target nuclide and preset biological elution parameters to obtain the initial activity distribution corresponding to the target nuclide; mapping the initial activity distribution to a three-dimensional relative dose distribution using a preset dose mapping algorithm; converting the three-dimensional relative dose distribution into a three-dimensional absolute dose distribution according to a pre-established water phantom calibration curve; and generating a cumulative dose distribution report based on the three-dimensional absolute dose distribution. The embodiments of this application can reconstruct the three-dimensional absolute dose distribution with high accuracy and support inter-session dose accumulation analysis. This application can be widely applied in the field of dose reconstruction technology.

The application discloses a rotating motion mechanism of a proton treatment patient positioning system, which comprises a supporting assembly, a rotating assembly and an auxiliary function assembly, wherein the supporting assembly comprises a base and a slewing bearing, the inner ring of the slewing bearing is fixed to the base, the rotating assembly is arranged on the top of the supporting assembly and comprises a rotating body, a fixed flange, a gear assembly and a driving part, the bottom of one end of the rotating body is provided with the fixed flange, the fixed flange is connected between the rotating body and the outer ring of the slewing bearing, the driving part is arranged in the rotating body and connected with the gear assembly, the gear assembly is arranged eccentrically in the inner ring and engaged with the inner ring, and the auxiliary function assembly is arranged between the supporting assembly and the rotating assembly. The rotating motion mechanism has the advantages of simple and compact structure, high load capacity, and the ability to realize the rotating motion of the rotating assembly in the proton treatment patient positioning system. Meanwhile, the auxiliary function assembly can determine and / or limit the motion position of the rotating body, thereby improving the motion accuracy and safety performance.

The application discloses a matching method for realizing beam dosimetry equivalence between multiple treatment room units and related equipment, and belongs to the technical field of proton heavy ion radiotherapy. The method comprises the following steps: obtaining beam physical characteristic parameters of each treatment room unit under multiple mono-energetic beam conditions covering a clinical treatment energy region; defining a reference benchmark, taking the beam physical characteristic parameters of the reference benchmark as a target, and determining a matching parameter set for a to-be-matched treatment unit, so that the beam characteristics of the to-be-matched treatment unit are equivalent to the reference benchmark as a whole in a multi-dimensional characteristic space after adjustment; and the matching parameter set comprises physical additional module parameters and dose correction parameters. Through the hierarchical method of one-by-one matching of mono-energetic beams, multi-energy comprehensive iterative optimization, and unified matching parameter output, the method realizes dosimetry equivalent treatment between multiple treatment room units without the need of formulating a treatment plan again, improves the cross-device universality, treatment efficiency and safety of a multi-source multi-room proton radiotherapy system, and makes proton treatment available everywhere.

This invention relates to the field of radiation early warning technology, specifically to an early warning system for the radiation impact on the environment surrounding a proton therapy system. The system includes a radiation monitoring data acquisition module, a radiation spatial distribution generation module, a radiation risk level determination module, a radiation leakage analysis module, a dynamic risk information notification module, and a treatment optimization suggestion module. In this invention, by real-time monitoring and data integration of the radiation monitoring environment, the response speed and accuracy of radiation safety early warning are improved. By utilizing spatial data and radiation intensity information, a detailed radiation distribution map can be constructed, making risk assessment more intuitive and easier to understand. Accurate assessment of radiation risk allows for specific and targeted protective measures, and potential leakage points are classified according to radiation level deviations. Dynamic notification of risk information ensures that treatment personnel receive critical safety alerts in a timely manner, optimizing the treatment process and reducing the radiation risk to patients.

Radiotherapy is the most widely used and effective anti-tumor therapy, however it can damage healthy tissues surrounding the tumor. One approach to reducing damage to healthy tissue invoves irradiation at dose rates far exceeding those currently used in clinical contexts reduces radiation-induced toxicities while maintaining an equivalent tumor response. This is known as the FLASH effect. The mechanism responsible for reduced tissue toxicity following FLASH radiotherapy (FLASH-RT) is still undetermined; multiple hypotheses have been suggested by linking the high dose rate to rapid oxygen depletion, immune response, reduction of peroxyl radical lifetime, preservation of normal tissue stem cells, etc. While effective, proton therapy is underutilized, contributing to fewer than 2% of all external beam radiation treatments. To overcome this shortcoming, compact radiotherapy systems are provided that incorporate multi-function components, reducing bot equipment size and expense.

The application provides a kind of proton therapy system and its use method, the proton therapy system includes: treatment planning module, for generating irradiation data according to input treatment planning data;Beam control module, for generating the control parameter of accelerator module according to irradiation data and preset compensation data;Accelerator module, for generating proton beam current in response to control parameter;Measurement module, for measuring the actual current parameter of proton beam current;Treatment head, set in the path of proton beam current to target treatment location, to control the on-off of proton beam current path;Wherein, beam control module is also used to compare actual current parameter with target current parameter in irradiation data, and update compensation data based on comparison result, until the actual current parameter of proton beam current and target current parameter are the same according to updated compensation data.The application can enhance the treatment effect by determining the accuracy of dosimetric parameters through pre-checking process.

System and techniques may be adapted for use in composite field sequencing for proton therapy. A technique may include generating a proton therapy plan in a treatment planning system, the proton therapy plan including a plurality of static fields. The technique may include creating a single data file of a single dynamic field representing the plurality of static fields. The single data file may be sent to a proton therapy system for delivery of the single dynamic field. The technique may include receiving a response information related to a dose delivered to a patient by the single dynamic field.

To provide an accelerator and a proton beam treatment device capable of reducing an occupied area space of related components of a conductor and a water pipe of the accelerator.SOLUTION: An accelerator 1 includes a yoke 4, a conductor 21 connected to the yoke 4, and a water pipe 29 connected to the yoke 4, and the conductor 21 and the water pipe 29 are housed together in a cable carrier 25 arranged outside the yoke 4.SELECTED DRAWING: Figure 4

This invention discloses a matching method and related equipment for achieving beam dosimetric equivalence between multiple treatment chamber units, belonging to the field of proton and heavy ion radiotherapy technology. The method includes: acquiring beam physical characteristic parameters of each treatment chamber unit under multiple single-energy beam conditions covering the clinical treatment energy range; defining a reference benchmark; and determining a matching parameter set for the treatment unit to be matched, using the beam physical characteristic parameters of the reference benchmark as the target, so that its beam characteristics are adjusted to be overall equivalent to the reference benchmark in the multi-dimensional characteristic space; the matching parameter set includes physical additional module parameters and dose correction parameters. Through a hierarchical method of matching single-energy beams one by one, multi-energy comprehensive iterative optimization, and unified matching parameter output, dosimetrically equivalent treatment can be performed between multiple treatment chamber units without re-planning the treatment. This improves the cross-device versatility, treatment efficiency, and safety of multi-source multi-chamber proton radiotherapy systems, making proton therapy readily accessible.

The invention discloses a calibration device and a calibration method for proton treatment equipment, and the calibration device comprises a fixing assembly which is provided with an accommodation space; the curved surface adjusting assembly comprises a first matching part and a second matching part, the first matching part and the second matching part are matched with each other and can relatively rotate around a central point, and the central point is a rotation reference center of the calibration device; the isocenter assembly is partially arranged in the fixing assembly and limited by the fixing assembly, the isocenter assembly is provided with an extension part extending outwards in the axial direction of the fixing assembly, the extension part is provided with a calibration piece, and the axis of the calibration piece always points to or passes through the center point when the curved surface adjusting assembly acts; and the fine adjustment driving assembly is arranged in the isocenter assembly and used for driving the isocenter assembly to carry out position fine adjustment on at least two degrees of freedom relative to the fixing assembly, a unified, stable and high-precision space reference is established for the subsystems, and the calibration efficiency and the overall precision of the equipment are guaranteed.

The utility model discloses a rotary particle treatment head curtain sealing structure, which belongs to the technical field of proton therapy, and comprises a hollow rack and a telescopic particle treatment head, a C-shaped mounting port is arranged on the inner side of the rack, the particle treatment head is rotatably arranged in the mounting port, a C-shaped first track is arranged in the rack, and a second track is arranged in the rack. And a C-shaped second rail is fixedly arranged between the two ends of the first rail. According to the rotary particle treatment head curtain sealing structure, the sliding frame on the first track is matched with the curtain to seal the particle treatment head and the rack, the second track is matched with the first track to enable the sliding frame to move along with rotation of the particle treatment head, and dust on the curtain is cleaned through the dust collection assembly at the second track. Compared with an existing device, the problem that dust falls into and is accumulated in a gap between the particle treatment head and the rack is solved, the stability of the device is improved, and the service life of the device is prolonged.

1. The name of the design product: treatment room skin (02). 2. The use of the design product: for proton therapy system treatment room, etc. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

Proton therapy system (1) for treating a patient (2) by means of proton radiation (3), comprising a particle accelerator (4) for generating a proton beam, a movable patient table (5) for holding and positioning a patient (2), a beam guidance device comprising several electromagnets (6) for focusing and / or defocusing and / or deflecting the proton beam (3), and a gantry (7) rotatable about a horizontal axis of rotation (R) for directing the proton beam (3) onto a target volume within a patient (2) held on the patient table (5), wherein the proton beam (3) has a maximum energy of less than 180 MeV, and the beam guidance device comprising a first scanner magnet (8A) and a second scanner magnet (8B) arranged in the direction of the proton beam behind the first scanner magnet (8A) for deflecting the proton beam (3), as well as a Proton beam direction between the scanner magnets (8A,8B) has a deflection magnet (9) arranged, wherein the deflection magnet (9) is configured to focus the proton beam (3) at the magnet input (9.1) in the plane of the beam deflection by the first scanner magnet (8A).

1. Name of the product in this design: Treatment head (02). 2. Intended use of this design: for use in proton therapy system treatment rooms, etc. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

The application discloses a flat plate telescopic device integrated on a proton treatment head, characterized in that the flat plate telescopic device is integrated on both sides of a proton treatment head support through a motor and a mechanical transmission system and is arranged between an inverted trapezoidal front panel and an inverted trapezoidal rear panel on both sides of the proton treatment head; when an imaging system changes from a closed state to a working state, the flat plate telescopic device is unfolded along the proton treatment head support in an eight-shaped track from top to bottom and from inside to outside; when the imaging system changes from the working state to the closed state, the flat plate telescopic device is folded along the proton treatment head support in the eight-shaped track from bottom to top and from outside to inside, so that the integration of the flat plate telescopic device and the proton treatment head support is the integration in a limited space without interference with other devices. Since the flat plate telescopic device adopts the concave eight-shaped telescopic mode, the problem of insufficient space of the treatment head is solved, and the field angle of the imaging system can be increased and the resolution can be improved.

The utility model relates to the technical field of medical treatment, in particular to a breast cancer proton treatment body position fixing device which is detachably installed on a treatment bed and comprises a body bracket used for supporting the body of a patient and arranged on the treatment bed, and a headrest is installed on the body bracket; the angle adjusting mechanism is mounted on the treatment bed, connected with the body bracket and used for adjusting the placement angle of the body bracket relative to the treatment bed; the two arm brackets are symmetrically arranged on the two sides of the body bracket, the arm brackets are connected with multi-direction adjusting mechanisms installed at the side ends of the body bracket, and the multi-direction adjusting mechanisms are used for adjusting the vertical position and the horizontal position of the arm brackets. The arranged multi-direction adjusting mechanism can adjust the position of the arm bracket in the vertical direction and the horizontal direction, the distance between the arm of a patient and a mammary gland treatment area is adaptively increased, the path of a proton beam penetrating through the arm is remarkably reduced, and therefore the radiation dose received by the arm is reduced to the maximum extent.

1. Name of the design product: treatment room skin. 2. Use of the design product: for proton therapy system treatment room, etc. 3. Design points of the design product: in shape. 4. Picture or photo best indicating the design points: perspective view.

This invention discloses a medical radiation-proof wall structure and construction method. The structure includes a first square tube connected to the roof structure and a second square tube connected to the floor structure. The first and second square tubes are connected by a third square tube to form a keel body. Multiple layers of lead plates are also provided on one side of the keel body. The keel body forms a closed structure to create a radiation-proof space. An adjustable gap exists between the first square tube and the roof structure. The bottom surface of the roof structure is connected to the side wall of the first square tube by a first angle steel to allow the decorative surface layer to fill the gap. This invention not only facilitates the construction of the decorative surface layer of a proton therapy center building structure but also effectively protects against radiation from highly penetrating proton therapy equipment.

Proton therapy treatment system to be deployed in an existing radiotherapy treatment vault such that radiation exposure is limited and meets radiation safety requirements. Patient support platform disposed in vault is configured for supporting patient, such as in a seated position. Imager is configured for imaging patient on patient support platform. A proton beam generator comprising a synchrotron is disposed in a region of vault. A proton beam delivery device is configured to deliver proton irradiation dose to isocenter of target tissue during treatment session, where delivery device may be gantry-less pencil beam scanning device operating without a collimator. Synchrotron may be disposed adjacent to entrance wall of vault and proton irradiation dose directed toward rear wall of vault. Synchrotron may extend through apertures of rear intermediate wall of vault and proton irradiation dose directed toward entrance intermediate wall of vault.

The application provides a proton building-based water supply and drainage system and a construction method thereof, wherein the proton treatment area is provided with a sewage collection area for collecting sewage of the proton treatment area; a vacuum sewage discharge device is arranged adjacent to the sewage collection area of the proton treatment area; a waste water well and a decay tank are arranged outside the proton building; a first drainage sleeve is embedded in a wall; the first drainage sleeve is connected with the proton treatment area inside the proton building and the outside of the proton building; a medical sewage drainage pipeline comprises a first medical sewage collection pipe section, a second medical sewage collection pipe section and a third medical sewage collection pipe section; the first medical sewage collection pipe section passes through the first drainage sleeve; the sewage collection area of the proton treatment area, the first medical sewage collection pipe section, the vacuum sewage discharge device, the second medical sewage collection pipe section, the decay tank, the third medical sewage collection pipe section and the waste water well are sequentially connected. The application is used for solving the water supply and drainage problem of the proton building.

A control circuit presents, via a user interface, linear energy transfer information that corresponds to optimizing an energy therapy treatment plan (such as a proton therapy treatment plan). Upon detecting certain user input, the control circuit can respond by accessing a precomputed influence matrix to provide corresponding accessed information and then present modified linear energy transfer information via the user interface as a function, at least in part, of that accessed information.

1. The name of the design product: intelligent hand control box (02). 2. The use of the design product: for the control of the movement of the rotating floor, treatment head, etc. in the treatment room of the proton therapy system. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

Radiotherapy is the most widely used and effective anti-tumor therapy, however it can damage healthy tissues surrounding the tumor. One approach to reducing damage to healthy tissue involves irradiation at dose rates far exceeding those currently used in clinical contexts reduces radiation-induced toxicities while maintaining an equivalent tumor response. This is known as the FLASH effect. The mechanism responsible for reduced tissue toxicity following FLASH radiotherapy (FLASH-RT) is still undetermined; multiple hypotheses have been suggested by linking the high dose rate to rapid oxygen depletion, immune response, reduction of peroxyl radical lifetime, preservation of normal tissue stem cells, etc. While effective, proton therapy is underutilized, contributing to fewer than 2% of all external beam radiation treatments. To overcome this shortcoming, provided are methods which utilize the highest energy layer and a universal range shifter (URS) to facilitate rapid spot arc therapy (RAPIDSPARC™).