125 results about "Proton therapy" patented technology

The invention relates to the field of medical equipment, and provides a compact multi-chamber proton treatment system based on a shared beam line, and the system comprises a fixed beam transmission line which is used for guiding the movement direction of a proton beam into a vertical direction; the rotating beam transmission line is used for guiding the movement direction of the proton beam into the horizontal direction; one end of the fixed beam transmission line is connected with the proton cyclotron, the other end of the fixed beam transmission line is connected with one end of the rotary beam transmission line, and the other end of the rotary beam transmission line is in butt joint with a plurality of treatment rooms; the rotating beam transmission line rotates around a central axis extending in the vertical direction. According to the invention, the proton beam can be safely, efficiently and accurately transmitted to each treatment room, and a fixed beam transmission system and a rotating rack do not need to be independently arranged for each treatment room, so that the beam control assembly and the system occupied area of the multi-room particle treatment device are minimized, and the number of treated patients can be remarkably increased.

The invention provides an automatic beam debugging method of a proton treatment system. The method comprises the following steps: fixedly mounting external measurement equipment of a beam on a treatment head; a processor of the automatic debugging work station starts to execute a beam automatic beam adjusting program, and beam adjusting target parameters are set; the accelerator loads the automatic loading parameters and the irradiation scheme for irradiation; the ionization chamber and external measurement equipment are used for measuring the performance parameters of the beam current and sending the performance parameters to the automatic debugging work station; and if the angle is within the required threshold range, storing the parameters and debugging the next rack angle, otherwise, adjusting the magnet parameters and sending the adjusted magnet parameters and the irradiation scheme to the accelerator for next iteration. The invention further provides an automatic beam debugging system of the proton treatment system. According to the invention, efficient and automatic debugging of the beam current under different rack rotation angles is realized, the efficiency of the proton treatment system in initial debugging and daily maintenance is remarkably improved, and the method has important significance in guaranteeing the clinical treatment effect.

Systems and methods for guiding radiation therapy including providing particle radiation to a region of interest of a subject and receiving volumetric ionizing radiation acoustic imaging (iRAI) data and ultrasound imaging data from the region of in response the particle radiation. Further, from the iRAI data and the ultrasound imaging, a position of the particle radiation in the region of interest is determined, that position being a treatment position of the particle radiation. Further, the systems and methods determine one or more parameters of the particle radiation for adjusting in response to the determination of the position.

The invention discloses a dual-mode precise regulation and control method and device for a proton treatment system, and relates to the technical field of proton treatment, and the device comprises a superconducting cyclotron, a beam transmission module, a treatment head module which comprises a first ionization chamber, a second ionization chamber, a range regulator, a multi-leaf grating and scanning iron, a treatment chair and a control module, the control module is used for receiving and analyzing a treatment plan and controlling the working states of the superconducting cyclotron, the beam transmission module, the treatment head module and the treatment chair in different working modes according to the treatment plan; the working mode comprises a first working mode and a second working mode, and the radiation dose of a proton beam required by the second working mode is far greater than the radiation dose of the proton beam required by the first working mode. The dual-mode precise regulation and control device can support a conventional working mode and also can support a flash therapy working mode, and different working modes can be switched to realize a treatment plan.

A Flash beam dose control method and a related device. The Flash beam dose control method comprises: obtaining a Flash beam output dose demand; controlling, by means of a Flash tuning mode, the number of pulse periods of output beam charges within a preset time; and / or controlling the pulse width of an ion source voltage by means of a pulse width mapping curve, so as to control a Flash beam output dose rate. By precisely controlling the number of pulse periods of output beam charges and the pulse width of the ion source voltage, the Flash beam output dose rate can be precisely controlled without requiring an additional shielding function for a proton therapy room, so that the dose of Flash can also be tuned in a conventional proton therapy room, thereby facilitating implementation of particle Flash radiotherapy.

Systems and methods for proton therapy treatment planning can include a treatment planning system determining positions of a plurality of energy layers across a dimension of a planning target volume (PTV) along a proton field direction, such that each pair of consecutive energy layers are spaced by a distance that is proportional to a width of a Bragg peak corresponding to at least one energy layer of the pair of energy layers. The treatment planning system can generate a proton therapy plan for irradiating the PTV according to the sequence of energy layers.

Radiotherapy is the most widely used and effective anti-tumor therapy, however it can damage healthy tissues surrounding the tumor. One approach to reducing damage to healthy tissue involves irradiation at dose rates far exceeding those currently used in clinical contexts reduces radiation-induced toxicities while maintaining an equivalent tumor response. This is known as the FLASH effect. The mechanism responsible for reduced tissue toxicity following FLASH radiotherapy (FLASH-RT) is still undetermined; multiple hypotheses have been suggested by linking the high dose rate to rapid oxygen depletion, immune response, reduction of peroxyl radical lifetime, preservation of normal tissue stem cells, etc. While effective, proton therapy is underutilized, contributing to fewer than 2% of all external beam radiation treatments. To overcome this shortcoming, provided are methods which utilize the highest energy layer and a universal range shifter (URS) to facilitate rapid spot arc therapy (RAPIDSPARC™).

The invention discloses a flat plate expansion device integrated on a proton treatment head, which is characterized in that the flat plate expansion device is integrated on two sides of a proton treatment head bracket through a motor and a mechanical transmission system, and is arranged between an inverted trapezoidal front panel and an inverted trapezoidal rear panel on two sides of the proton treatment head; when the imaging system is changed from a closed state to a working state, the flat plate telescopic device is unfolded from top to bottom and from inside to outside along the proton treatment head bracket in a splayed track; when the imaging system is changed from a working state to a closed state, the flat plate telescopic device shrinks from bottom to top and from outside to inside along the proton treatment head support in a splayed track, so that integration of the flat plate telescopic device and the proton treatment head support is integration which does not interfere with other devices in a limited space. Due to the fact that the flat plate telescopic device adopts an inward-concave splayed telescopic mode, the problem that the space of the treatment head is not enough is solved, the field angle of the imaging system can be increased, and the resolution ratio is improved.

The invention discloses a multipurpose pen-shaped scanning proton beam detection device and method, and relates to the field of proton therapy detection.In the device, a mounting support is arranged on a machine head of a proton therapy machine and rotates along with a rotating rack of the proton therapy machine; the microstructure gas detector is used for measuring proton information; the detector and motion control part is used for receiving a detection instruction issued by the remote control center; driving the microstructure gas detector and / or the lead point to move to a preset position according to the detection instruction; collecting proton information corresponding to the preset position and transmitting the proton information to the remote control center; the detection instruction is determined according to detection requirements; and the remote control center is used for performing analysis based on the proton information to obtain a detection result. According to the invention, multiple measurements can be completed, one machine has multiple purposes, and the measurement precision can be ensured while the working efficiency is improved.

The present application belongs to the technical field of high-end medical equipment. Disclosed are a multi-room particle therapy room, a radiotherapy system, and a particle accelerator movement method. The multi-room particle therapy room comprises a plurality of treatment rooms. The radiotherapy system comprises the multi-room particle therapy room and a particle accelerator. Each treatment room is provided with a beam window. The particle accelerator can move outside different treatment rooms and is aligned with the beam windows. The particle accelerator directs particle beams into the treatment rooms by means of the beam windows. The particle beams perform radiotherapy by means of therapy heads in the treatment rooms. The radiotherapy system is not provided with a dipole magnet or a quadrupole magnet. The plurality of treatment rooms share one particle accelerator. The particle accelerator is moved to the outside of the treatment room requiring the particle beam, and the particle beam is directed into the treatment room by means of the beam window. When the treatment in the treatment room is completed, the particle accelerator is moved to other treatment rooms requiring the particle beams and performs treatment work, thereby reducing the overall cost of the radiotherapy system and making proton therapy accessible.

The invention discloses a proton therapy evaluation method and system, a storage medium and a computer program product, and relates to the field of data processing. The evaluation method comprises the following steps: forming a data set by data pairs of a historical proton beam delivery dose distribution image and a historical positron nuclide distribution image; constructing a first model, and training the first model by using the data set to obtain a second model; inputting the positron nuclide distribution image in the actual proton therapy into the second model to obtain a proton beam delivery dose distribution image in the actual proton therapy; and extracting the falling edge of the far end of the Bragg peak of the proton beam delivery dose distribution image in the actual proton therapy to obtain the range information of the proton beam in the actual proton therapy. According to the method, the delivery condition of the planned dose can be directly reflected, Monte Carlo simulation does not need to be carried out on different patients to obtain reference positron nuclide distribution images, time and computing resources are saved, and each treatment process can be verified.

The invention belongs to the technical field of high-end medical equipment, and discloses a multi-chamber particle treatment room, a radiotherapy system and a particle accelerator moving method, the multi-chamber particle treatment room comprises a plurality of treatment rooms, and the radiotherapy system comprises the multi-chamber particle treatment room and a particle accelerator. Each treatment room is provided with a beam window, the particle accelerator can move out of different treatment rooms and is aligned with the beam window, the particle accelerator injects particle beams into the treatment rooms through the beam windows, the particle beams are subjected to radiotherapy through treatment heads in the treatment rooms, and the radiotherapy system is not provided with a dipole magnet or a quadrupole magnet. A plurality of treatment rooms share one particle accelerator, the particle accelerator is moved to the outside of the treatment room needing the particle beam, the particle beam is emitted into the treatment room through the beam window, and when the treatment room completes treatment, the particle accelerator is moved to other treatment rooms needing the particle beam and carries out treatment work, so that the overall cost of the radiotherapy system is reduced, and the treatment efficiency is improved. And the proton treatment is accessible.

The invention discloses a rotary particle treatment head curtain sealing structure, and belongs to the technical field of proton therapy, the rotary particle treatment head curtain sealing structure comprises a hollow rack and a telescopic particle treatment head, the inner side of the rack is provided with a C-shaped mounting port, the particle treatment head is rotatably arranged in the mounting port, the rack is internally provided with a C-shaped first track, and the first track is provided with a second track. And a C-shaped second rail is fixedly arranged between the two ends of the first rail. According to the rotary particle treatment head curtain sealing structure, the sliding frame on the first track is matched with the curtain to seal the particle treatment head and the rack, the second track is matched with the first track to enable the sliding frame to move along with rotation of the particle treatment head, and dust on the curtain is cleaned through the dust collection assembly at the second track. Compared with an existing device, the problem that dust falls into and is accumulated in a gap between the particle treatment head and the rack is solved, the stability of the device is improved, and the service life of the device is prolonged.

The present disclosure provides a cone beam computed tomography system for proton therapy comprising an x-ray source configured to generate x-rays and positioned to rotate around a patient at a treatment isocenter, a detector assembly positioned opposite the x-ray source and configured to receive x-rays that have passed through the patient, a rotation mechanism configured to rotate the x-ray source and the detector assembly around the patient while maintaining their relative positions, a translation mechanism configured to translate at least one of the x-ray source, the detector assembly, or a patient couch during rotation to implement a wobbled scan orbit, and a scatter rejection grid attached to the detector assembly and focused on the x-ray source to reduce scattered x-rays. The translation mechanism distributes missing projection data across multiple radii and angles, enabling improved reconstruction quality through iterative reconstruction methods.

The invention discloses special anesthesia and proton treatment integrated equipment for children and a control method, relates to the field of intelligent medical treatment, and integrates five functional modules, namely anesthesia depth monitoring, respiratory gating synchronization, proton treatment positioning, intelligent feedback control and central control. The system collects multi-mode physiological signals such as electroencephalogram and myoelectricity in real time, and anesthesia state indexes and body movement early warning information are generated; a future displacement track is predicted in combination with the breathing phase, and accurate synchronization is achieved; a beam releasing and interrupting mechanism is linked through the feedback control module; the proton positioning module dynamically adjusts an irradiation path; the central module is scheduled in a unified mode, closed-loop control and safety protection are achieved, and the precision and safety of child proton treatment are remarkably improved.

The application discloses a method for precisely controlling a proton treatment process, comprising the following steps: selecting a feeding voltage fluctuation amplitude greater than or equal to U0 as a late fault prediction standard; collecting data of a leakage current, a cavity vacuum degree and a feeding voltage value, and establishing a time sequence sample database; constructing and training an LSTM-based time sequence prediction model; collecting electrostatic deflection plate leakage current and vacuum degree data at a current t time point in real time; using the data collected at the current t time point as input of the prediction model, and predicting a feeding voltage fluctuation amplitude at a t+1 time point through the prediction model; after predicting that a fault is about to occur, issuing an instruction through a PLC to control a central area vertical deflection plate to shut off a beam current; and after predicting that the fault is eliminated, issuing a reset signal; through the combination of the two predictions, the application excludes factors causing instability of the beam current in the treatment process, and immediately resumes the treatment after the factors causing instability of the beam current are excluded, so that the proton treatment process is precisely controlled.

The invention discloses a proton adaptive radiotherapy triggering decision method and system based on multi-modal data quantitative evaluation. The method comprises the following steps: acquiring image data, dose data and clinical data, respectively calculating a dosimetry scoring function, an anatomical structure scoring function and a proton specificity scoring function based on the image data and the dose data, obtaining an enhanced core quantitative score through weighted geometric average fusion, and obtaining the enhanced core quantitative score; determining parts, stages and prognosis adjustment parameters based on clinical data, and fusing a BMI dynamic evaluation factor, a treatment response prediction factor and a multi-factor interaction factor to obtain an enhanced clinical background adjustment coefficient; and calculating a final decision score in combination with the time modulation factor and the risk prediction index based on the LSTM, and outputting a grading decision result. According to the method, objective quantitative evaluation of deep fusion of multi-modal data is realized, specific risks of proton therapy are accurately captured, personalized intelligent decision is supported, and the method has good clinical operability.

The invention discloses a proton treatment plan verification and optimization device and method and related equipment, and relates to the technical field of radiotherapy. The device comprises an image acquisition module which is used for acquiring a PET image of a patient after completing at least one proton treatment irradiation; the dose prediction module is used for mapping the treated PET image into actual deposited dose distribution in the body of the patient based on the trained generative model so as to predict actual distribution dose distribution; and the adjustment and optimization module is used for generating an adjusted fractional treatment plan when the deviation between the predicted actual distribution dose distribution and the initial planned dose distribution is greater than a deviation threshold value. Based on in-vivo measurement information, the actual deposition dose is accurately verified and dynamically optimized, and accurate and safe proton therapy is achieved.

An example system for magnetic resonance imaging (MRI) guided proton therapy includes a source configured to generate and emit a heavy ion or proton beam; and an MRI assembly including at least one segmented coil magnet comprising a plurality of windings, where the plurality of windings of the at least one segmented coil magnet include a medium or high-temperature superconductor such that the at least one segmented coil magnet does not require a cryogenic liquid for cooling. An example magnet for MRI proton therapy includes field coils and shield coils arranged in Helmholtz coil pairs, where the field coils and the shield coils include a medium or high-temperature superconductor so the magnet does not require cryogenic liquid cooling, and where the field coils and the shield coils form a central opening through which a heavy ion or proton beam is directed during proton therapy.

This application discloses a three-dimensional dose reconstruction method and related equipment based on in-beam positron emission tomography (PET) data. The method includes: acquiring list-pattern data during proton therapy beam exit; performing conformation processing on the list-pattern data and reconstructing a three-dimensional activity distribution map; performing multi-nucleus dynamic deconvolution processing on the activity time series corresponding to the three-dimensional activity distribution map according to the physical half-life of the target nuclide and preset biological elution parameters to obtain the initial activity distribution corresponding to the target nuclide; mapping the initial activity distribution to a three-dimensional relative dose distribution using a preset dose mapping algorithm; converting the three-dimensional relative dose distribution into a three-dimensional absolute dose distribution according to a pre-established water phantom calibration curve; and generating a cumulative dose distribution report based on the three-dimensional absolute dose distribution. The embodiments of this application can reconstruct the three-dimensional absolute dose distribution with high accuracy and support inter-session dose accumulation analysis. This application can be widely applied in the field of dose reconstruction technology.

The application discloses a rotating motion mechanism of a proton treatment patient positioning system, which comprises a supporting assembly, a rotating assembly and an auxiliary function assembly, wherein the supporting assembly comprises a base and a slewing bearing, the inner ring of the slewing bearing is fixed to the base, the rotating assembly is arranged on the top of the supporting assembly and comprises a rotating body, a fixed flange, a gear assembly and a driving part, the bottom of one end of the rotating body is provided with the fixed flange, the fixed flange is connected between the rotating body and the outer ring of the slewing bearing, the driving part is arranged in the rotating body and connected with the gear assembly, the gear assembly is arranged eccentrically in the inner ring and engaged with the inner ring, and the auxiliary function assembly is arranged between the supporting assembly and the rotating assembly. The rotating motion mechanism has the advantages of simple and compact structure, high load capacity, and the ability to realize the rotating motion of the rotating assembly in the proton treatment patient positioning system. Meanwhile, the auxiliary function assembly can determine and / or limit the motion position of the rotating body, thereby improving the motion accuracy and safety performance.

The application discloses a kind of fast energy regulation system and proton radiotherapy device for proton radiotherapy, belong to medical equipment technical field, including first quaternary iron, energy switching device and momentum cooling device sequentially arranged on energy beam transmission line, energy switching device includes sequentially connected first impact magnet, second quaternary iron, second impact magnet, energy switching energy reducer, third impact magnet and fourth impact magnet, first impact magnet is connected with first quaternary iron, fourth impact magnet is connected with momentum cooling device, energy switching energy reducer is one-piece wedge structure, it includes low-energy beam energy reduction zone, ideal beam energy reduction zone and high-energy beam energy reduction zone.It is simple in structure, energy switching time is short, transmission efficiency is high, and it can safely and efficiently transmit energy divergence less than 15%, energy is 70-230MeV proton, and transmission efficiency can reach 5%.

The application relates to a guide support assembly of a rotary floor, which comprises a fixed bin and a suspended bin arranged in parallel along an axial direction, a first floor guide rail is arranged on the fixed bin in a circumferential direction, a second floor guide rail is arranged on the suspended bin in a circumferential direction, the first floor guide rail and the second floor guide rail are respectively arranged in sliding connection with two ends of a floor assembly, and the suspended bin is fixedly connected with the fixed bin. The guide support assembly of the rotary floor of the application is connected with the fixed bin and keeps the bottom horizontal, thereby providing support and guidance for the floor assembly and enabling the floor assembly to rotate by 360 degrees.

The application relates to the technical field of equipment motion control, and discloses a proton treatment rotating gantry motion control method, system, equipment and medium, the method comprises the following steps: in response to a gantry motion intention, performing pre-checking on a field programmable logic controller before motion, collecting a plurality of discrete input quantities and absolute angle feedback, and generating a safety snapshot; if the safety snapshot meets a motion prohibition condition, the motion is rejected and the reason is output; if the prohibition condition is not triggered, a target gantry angle and a speed given value are written to the PLC, and an ascending edge pulse is applied to a position starting coil to trigger the motion. It is determined whether the gantry is in place, after the gantry is in place, a standardized gantry public interlocking signal set is output to a treatment control layer, and the gantry is controlled to enter a stable standby state, and the treatment control layer calculates a proton beam emission permission based on the interlocking signal set. Through the safety snapshot pre-checking, mixed angle determination and standardized interlocking output, the motion control safety and positioning accuracy of the gantry are improved.

The application discloses a matching method for realizing beam dosimetry equivalence between multiple treatment room units and related equipment, and belongs to the technical field of proton heavy ion radiotherapy. The method comprises the following steps: obtaining beam physical characteristic parameters of each treatment room unit under multiple mono-energetic beam conditions covering a clinical treatment energy region; defining a reference benchmark, taking the beam physical characteristic parameters of the reference benchmark as a target, and determining a matching parameter set for a to-be-matched treatment unit, so that the beam characteristics of the to-be-matched treatment unit are equivalent to the reference benchmark as a whole in a multi-dimensional characteristic space after adjustment; and the matching parameter set comprises physical additional module parameters and dose correction parameters. Through the hierarchical method of one-by-one matching of mono-energetic beams, multi-energy comprehensive iterative optimization, and unified matching parameter output, the method realizes dosimetry equivalent treatment between multiple treatment room units without the need of formulating a treatment plan again, improves the cross-device universality, treatment efficiency and safety of a multi-source multi-room proton radiotherapy system, and makes proton treatment available everywhere.

The application relates to a synchrotron for a proton-helium ion therapy device, which comprises eight dipole deflection magnets connected in sequence through eight straight-line sections to form a ring structure, the deflection angle of the eight dipole deflection magnets is 45 degrees, and the maximum magnetic field strength is 2.4T; the eight straight-line sections comprise four long straight-line sections and four short straight-line sections, which are used for accelerating the helium ion beam from an injection energy of 8-10 MeV / u to 200-235 MeV / u and leading out for helium ion therapy, or accelerating the proton beam from an injection energy of 8-10 MeV to 200-750 MeV and leading out for proton therapy. According to the synchrotron for the proton-helium ion therapy device, the structure is very compact, unnecessary gaps and magnet elements are reduced, the circumference of the whole accelerator is reduced, the space of the synchrotron is effectively utilized, and the construction cost of the device and the building is reduced to the maximum extent, and the treatment cost is reduced.

This invention relates to the field of radiation early warning technology, specifically to an early warning system for the radiation impact on the environment surrounding a proton therapy system. The system includes a radiation monitoring data acquisition module, a radiation spatial distribution generation module, a radiation risk level determination module, a radiation leakage analysis module, a dynamic risk information notification module, and a treatment optimization suggestion module. In this invention, by real-time monitoring and data integration of the radiation monitoring environment, the response speed and accuracy of radiation safety early warning are improved. By utilizing spatial data and radiation intensity information, a detailed radiation distribution map can be constructed, making risk assessment more intuitive and easier to understand. Accurate assessment of radiation risk allows for specific and targeted protective measures, and potential leakage points are classified according to radiation level deviations. Dynamic notification of risk information ensures that treatment personnel receive critical safety alerts in a timely manner, optimizing the treatment process and reducing the radiation risk to patients.

The present invention discloses a proton Flash therapy device based on a linear induction accelerator, which includes a proton injector, a linear induction acceleration mechanism, a beam current regulation mechanism, a radiation dose rate measurement system, a pulse power source system, and a pulse transmission system; the linear induction acceleration mechanism is configured to be connected to the proton injector; the beam current regulation mechanism is configured to be connected to the linear induction acceleration mechanism; the radiation dose rate measurement system is used to measure and monitor the dose rate of the proton beam passing through the beam current regulation mechanism in real time; the pulse power source system is used to provide pulse power for the proton injector and the linear induction acceleration mechanism; the pulse transmission system is used to effectively transmit the pulse power generated in the pulse power source system to the proton injector and the linear induction acceleration mechanism; the proton Flash therapy device based on the linear induction accelerator has a simple structure and is suitable for popularization and use in major hospitals.

Radiotherapy is the most widely used and effective anti-tumor therapy, however it can damage healthy tissues surrounding the tumor. One approach to reducing damage to healthy tissue invoves irradiation at dose rates far exceeding those currently used in clinical contexts reduces radiation-induced toxicities while maintaining an equivalent tumor response. This is known as the FLASH effect. The mechanism responsible for reduced tissue toxicity following FLASH radiotherapy (FLASH-RT) is still undetermined; multiple hypotheses have been suggested by linking the high dose rate to rapid oxygen depletion, immune response, reduction of peroxyl radical lifetime, preservation of normal tissue stem cells, etc. While effective, proton therapy is underutilized, contributing to fewer than 2% of all external beam radiation treatments. To overcome this shortcoming, compact radiotherapy systems are provided that incorporate multi-function components, reducing bot equipment size and expense.