The invention discloses a radiotherapy planning system, a determining device and a storage medium. The system includes one or more processors, and a storage device for storing one or more programs; the one or more programs are executed by one or more processors, and the one or more processors perform the following steps: acquiring image sequences distributed with time, wherein the image sequencesincluding sample points corresponding to the same location of an interest region; establishing an optimization model based on the sampling points and the weight of each image in the image sequences; and solving the optimization model to determine the radiation therapy plan. The above technical scheme solves the problem that in the prior art, a tumor target area generates periodic movements due tobreathing, heartbeat, and the like, so that the actual exposure dose of the target area and surrounding endangered organs is different from the target dose, the system provides a more precise radiotherapy plan for the movement target area, facilitates more precise treatment, effectively protects the surrounding endangered organs of the target area, and is suitable for use with most existing radiotherapy equipment that implements radiotherapy plans.