38 results about "Fetal brain" patented technology

A system for monitoring a brain wave response of a fetus in utero, comprises removably connecting an auditory transducer, including at least one biosensor electrode, producing pulsed auditory sounds to a mother's abdomen to detect brain wave activity in a fetus. The transducer is pulsed with one of rectangular waves and tone pips of a selected frequency to emit pulsed audible sounds at predetermined times. The at least one biosensor electrode, including connected amplifier, detects brain stem auditory responses (BAER) of the fetus. For each pulsed audible sound a series of voltage oscillations corresponding to BAER of the fetus are time-locked to the corresponding audible sound. BAER analog output is converted to BAER digital data. A computer-based QEEG (Quantitative EEG) system improves a signal to noise ratio of the BAER digital data using an adaptive optimum filtering algorithm and analyzes the BAER digital data relative to a reference database.

The invention provides an image processing method for automatically judging fetal hydrocephalus from ultrasonic images, comprising the following steps: firstly extracting skull ellipse of a new fetal brain image on the second plane, lateral ventricle horizontal plane; establishing a space histogram pyramid in the interior zone of the ellipse in the image; respectively calculating the distances among the space histogram pyramids of the given fetal ultrasonic image, the normal fetal brain images in the same gestational week and the image of hydrocephalus in the brain on the lateral ventricle horizontal plane in the same gestational week; and setting a threshold and giving the possibility of fetal hydrocephalus from judgment according to the relationship between the distances among the space histogram pyramids and the threshold.

A portable device utilizes an ultrasound probe, which is placed on the abdomen of a mother and allows ultrasound video and pictures, as well as Doppler heartbeat detection of the fetus. It is also capable of recording fetal brain activity induced by constant-wave or pulsed-wave ultrasound stimuli; and analyzing the fetal EEG measurements. The electrical brain waves are detected by a sensor, amplified, digitized, and analyzed in one portable device, using analog and/or digital filters to improve the signal/noise ratio. The portable computer uses augmented reality imaging and quantitative EEG analysis software to compare the data from the fetus to normative data or to prior states of the fetus' own data. The EEG signals are recorded for an extended period of time and can be analyzed in real time or at a later time for rhythmicity patterns indicative of epilepsy or other developmental brain disorders.

The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human and mouse secreted stem cell growth factor-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries prepared from mouse bone marrow and human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, placental, lymphocyte, lung fibroblast, fetal brain, and testis. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.

Methods and system are described for multi-parametric, non-invasive, and real-time assessment of blood perfusion and oxygenation in the fetal brain during labor and delivery of a fetus through a vaginal birth canal of a maternal pelvis, and include positioning a probe device in the maternal pelvis during active labor, transmitting and receiving a plurality of ultrasound (US) and photoacoustic (PA) signals between the probe device and fetal brain, displaying in real-time on an US machine communicatively coupled to the probe device one or more images of venous and arterial blood flow of respective blood vessels in the fetal brain, measuring oxygen saturation of the respective venous and arterial blood vessels based on data from the one or more images, and estimating the oxygen measurement in the fetal brain during active labor based on the measured oxygen saturation.

The invention relates to a method for positioning three axial positions of a fetal brain through magnetic resonance. The method is used for further rapidly, accurately and normatively positioning an image of the three axial positions of the fetal brain on the basis of the traditional nuclear magnetic resonance scanning and positioning technology and providing a more accurate and normative cross-section image for clinical medicine. Because the position and the direction of a fetus in a parent are possibly changed at any time, the standard three axial positions of only a few fetuses can be directly positioned through the standard three axial positions of the parent; in many cases, the position of the fetus in the parent is changeable; the standard image of the three axial positions cannot be obtained through the traditional technology; when the standard three axial positions of the parent cannot be given or the standard three axial positions of the fetus cannot be better given, a series of images of various positions can be obtained by rotating and positioning in 360 DEG through a haste sequence, namely a heavy T2 weighted line; and the image closest to the standard fetal position is selected from the series of images and served as the standard to position the brain.

The invention provides microencapsulated peony seed oil, compound composition and a preparation method of the microencapsulated peony seed oil. The microencapsulated peony seed oil is prepared from a peony seed oil core material and a Maillard product wall material and has good antioxidant effect. The microencapsulated peony seed oil is taken as a raw material and compounded with folic acid and xylooligosaccharide for further preparation of a product which has better antioxidant property, is high in storage stability and meets special physiological needs of pregnant women in the gestation period. The compound product has the better antioxidant property, is high in storage stability, meets physiological characteristics of the pregnant women in the gestation period and needs of growth and development of fetuses, can promote fetal brain development, guarantee normal development of fetal organs, relieve constipation of the pregnant women in the gestation period, improve organism immunity of the pregnant women and reduce blood pressure, blood fat and blood sugar, and reduces incidence rate of diseases such as hypertension, diabetes mellitus and the like in the gestation period.

The invention discloses a construction method of a brain corpus callosum segmentation prediction image for corpus callosum state evaluation, which comprises the following steps: drawing a corpus callosum initial contour line from an acquired fetal brain ultrasonic image, and calculating a key point offset of the corpus callosum initial contour line; and cutting a brain corpus callosum segmentation prediction image from the fetal brain ultrasound image according to the initial contour line of the corpus callosum and the key point offset. According to the deep neural network model for fetal ultrasound image state analysis, the blank of brain ultrasound image brain corpus callosum state analysis is filled, and a method for evaluating the brain corpus callosum state through a brain ultrasound image is created for the first time.

The invention discloses the technical field of edible oil and specifically relates to compound edible oil for pregnant women and a preparation method thereof. Raw materials of the compound edible oilcomprise: camellia seed oil, refined sesame oil, walnut oil, purple perilla seed oil and a DHA emulsion. The camellia seed oil and purple perilla seed oil have a good regulating effect on the heart and cerebral vessels, digestion, reproduction, neuroendocrine and immune system of pregnant women, and effectively reduce the occurrence of hypertensive symptoms during pregnancy. Refined sesame oil isrich in vitamin E, and has a flavor-enhancing effect. Vomiting and loss of appetite are prone to occur for pregnant women in the early stage of pregnancy. Refined sesame oil makes the compound edibleoil for pregnant women taste delicious so as to effectively improve the appetite of pregnant women. Walnut oil and the DHA emulsion promote the development of fetal brain. The DHA emulsion is preparedfrom DHA algae oil as a raw material. With the addition of the emulsifier, stability of DHA algae oil is increased so as to increase stability of the compound edible oil for pregnant women and make the compound edible oil to be easily stored.

The invention discloses a method for imaging fetal brain channeling three-dimensional image in an ultrasonic image, which aims to quickly and visually evaluate the development condition of fetal brainchanneling by adopting an artificial intelligence method through three-dimensional volume data of fetal brain. The method comprises the following steps: obtaining a large amount of three-dimensionalultrasonic volume data of fetal brain; inputting volume data to an intelligent imaging processing system, and manually marking brain channeling so as to obtain fetal craniocerebral three-dimensional brain channeling volume image data; inputting the fetal craniocerebral three-dimensional brain channeling volume image data into a trained 3D FCN network to obtain voxels of a fetal craniocerebral three-dimensional brain channeling volume image; automatically reconstructing a fetal craniocerebral channeling three-dimensional image by using voxels of the fetal craniocerebral three-dimensional channeling volume image, and outputting the fetal craniocerebral channeling three-dimensional image. The method can solve the technical problems that an existing clinician cannot reconstruct a fetal brain channeling three-dimensional image, the reconstruction steps are complex, the reconstruction individual difference is large, an objective analysis basis is lacked, and the result repeatability is poor.

The invention discloses whey yak milk protein powder for postpartum women in confinement and a preparation method thereof and belongs to the technical field of nutritious and health-care food. The whey yak milk protein powder can be used for women in pregnancy and postpartum confinement. A formula of the whey yak milk protein powder involves a large number of nutrient substances including proteins, vitamins, minerals and the like which are required by women in pregnancy and childbirth; lactoferrin can resist bacteria and viruses and regulate the absorption of iron by the gastrointestinal tract; folic acid can help the normal development of fetal brains and nervous systems and promote the formation of red blood cells; docosahexaenoic acid (DHA) can help children develop intelligence. The whey yak milk protein powder is a new product prepared from various high-quality nutrient components, has the advantages of being high in purity and absorption and utilization rate, free of toxic or side effects, convenient to take and remarkable in effect, and is particularly suitable for pregnant and lying-in women.

The invention provides all-purpose nutrient biscuits suitable for early-pregnancy consumption. The all-purpose nutrient biscuits suitable for early-pregnancy consumption are prepared from the following raw materials in parts by mass: 100 parts of milk powder for pregnant women, 20 parts of sweet milk powder, 50 parts of wheat flour, 50 parts of eggs, and water. The formulated milk powder for the pregnant women is rich in proteins, vitamins, minerals, DHA and other essential fatty acids, as well as appropriate in calcium-phosphorus ratio, so that calcium absorption is facilitated; the DHA is anessential fatty acid which is capable of promoting development of fetal brain and nervous system; and the sweet milk powder is capable of adjusting taste of the biscuits so as to increase appetite. Thus, the prepared all-purpose nutrient biscuits suitable for early-pregnancy consumption are rich in nutrients, higher in content of proteins, vitamin A, vitamin B and minerals compared with common biscuits, and enriched with essential fatty acids such as the DHA. The biscuits provide nutrients and energy to pregnant women, and are simple in production processes and common in raw material source;finished products of the biscuits are convenient to carry, crispy in taste and unique in milk aroma, so that the biscuits can be accepted by the pregnant women during early pregnancy. Moreover, the biscuits are beneficial for relieving vomiting during pregnancy, as well as capable of improving nutritional status of the pregnant women and fetuses; and thus, the biscuits are suitable as an extra-meal food for the pregnant women.

The invention discloses a quick fetal MR image brain extraction method based on a multi-scale neural network, and belongs to the technical field of medical images. The method comprises the following steps: carrying out the multi-scale learning of fetal MR image features; fusing the fetal MR image multi-scale features by using a channel attention model; performing brain extraction on the fetal MR image based on the multi-scale features; according to the method, the MR image containing the fetal brain is quickly extracted by using the full convolutional network, and the extracted multi-scale features are fused by using a channel attention mode, so that an accurate fetal brain extraction result is obtained.

Disclosed is a method for reducing or preventing fetal opioid dependence in a drug dependent or opioid tolerant pregnant subject. The method involves administering to the pregnant subject a composition comprising an opioid antagonist in an amount effective to reduce or prevent fetal opioid dependence, wherein the opioid antagonist a) is orally available or delivered systemically and reaches the circulation of the pregnant subject, b) is substantially excluded from the subject's brain by the blood brain barrier, and c) penetrates the placenta and enters the fetal brain. The method also includesadministering the opioid antagonist to the neonate in increasing amounts to facilitate weaning the neonate from continued opioid maintenance.

A novel neuroprotectant was identified by microarray analysis that is differentially expressed between the ventricular zone and the cortex of human adult and fetal brain. The secreted protein antagonizes Wnt action in Xenopus embryos. Methods are described for modulating free radical neurotoxicity by contacting cells with the protein, treating neuronal diseases associated with free radical-mediated cell death by administering the protein, determining neuroprotective genomic targets associated with select free radical toxicity pathways by screening with the protein and using the protein to identify other compounds that modulate the biological activity of the secreted protein and the cell machinery that reacts to the secreted protein.

The invention relates to a method for building an hiPSCs source autism-like model. The method mainly comprises the steps of (1) preparing a micro-column array chip; (2) inducing a brain organoid on the chip; and (3) performing VPA treatment on a 3D brain organoid in the early period of the induction stage. According to the method, stem cells and tissue engineering are mainly combined to generate 3D brain organoid tissues; and VPA (sodium valproate) conforming to the physiological concentration is applied to simulate the influence on fetal brain development after VPA is taken by a pregnant woman with bidirectional affective disorder or epilepsy, so that a pathological mechanism of occurrence of autism is explored. The model is a novel autism in vitro model; the morphological changes of theVPA on the fetal brain development can be observed; and meanwhile, the pathogenic mechanism of the VPA increasing the fetal autism risk is explored by various measures of molecular biology and the like. Therefore, the species difference caused by animal experiments, the simplicity of cell experiments and the defects of 2D conditions can be eliminated, and a novel model and thought are provided forexploring the occurrence of autism.