45 results about "Developmental disorder" patented technology

The methods and apparatus disclosed herein can diagnose or identify a subject as at risk of having one or more developmental disorders with fewer questions, decreased amounts of time, and determine a plurality of developmental disorders, and provide clinically acceptable sensitivity and specificity in a clinical environment. The methods and apparatus disclosed herein can be configured to diagnose or determine the subject as at risk of a developmental disorder among a plurality of developmental disorders, and decreasing the number of questions presented can be particularly helpful where a subject presents with a plurality of possible developmental disorders. A processor can be configured with instructions to identify a most predictive next question, such that a person can be diagnosed or identified as at risk with fewer questions.

The invention provides a neural developmental disorder prediction model construction method, system and device and a medium, and the method comprises the steps: obtaining the clinical information of a child patient, the clinical information comprises severity of developmental retardation / dyspepsia, complexity of syndromic neurodevelopmental disorder, autism spectrum disorder, epilepsy, attention deficit hyperactivity disorder, head circumference deformity, brain development deformity, hearing / visual function impairment and related ear-eye development deformity; applying logistic regression analysis to screen out predictive factors significantly related to the positive diagnosis rate of third-generation whole exon genome sequencing in the clinical information; constructing a neural developmental disorder prediction model based on binary logistic regression according to the prediction factor; and verifying the neurodevelopmental disorder prediction model by applying data of the internal verification group and the external verification group so as to evaluate the prediction efficiency of the neurodevelopmental disorder prediction model, so that the probability of obtaining positive diagnosis after the child patient receives trio-WES detection can be accurately evaluated, and the prediction efficiency is remarkably improved.

A method comprises collecting questionnaires completed by guardians or test records filled out by experts for one or more developmental test items, selecting developmental test items that require imaging among developmental test items, providing an imaging guide for the selected developmental test items, capturing images of an infant or a toddler according to the imaging guide, pre-processing captured images and converting the pre-processed images into data suitable for AI analysis, a first diagnosis of analyzing converted data through AI to determine any presence of a developmental disorder and a developmental delay for selected developmental test items, a second diagnosis of determining any presence of a developmental disorder and a developmental delay for unselected developmental test items of the questionnaire or the test record, a comprehensive diagnosis of determining a comprehensive developmental disorder and developmental delay of an infant or a toddler, and providing a development report.

Embodiments described herein include portable devices having user-detection equipment, such as eye-tracker devices or other sensors, and computer systems including such portable devices or the data collected from such devices (such as eye-tracking data and / or other multi-modal data such as facial expressions, verbal expression, and / or physical movements). Some examples of the systems include can provide useful assessments for developmental disorders and can generate prescriptive treatment plans having individual time lengths for different treatment-specific skill areas during a period of time.

An apparatus and method for diagnosing developmental disorder using an artificial neural network are disclosed. An apparatus for diagnosing developmental disorders according to one exemplary embodiment includes a communication unit that performs communication with one or more user terminals and a control unit connected to the communication unit, in which the control unit receives at least one of image data and voice data for an analysis target from the user terminal and performs a first developmental disorder diagnosis through one or more artificial neural networks learned to perform a developmental disorder diagnosis, receives questionnaire response data from the user terminal and performs a second developmental disorder diagnosis according to predetermined standard, and generates developmental disorder diagnosis data for the analysis target based on the first developmental disorder diagnosis and the second developmental disorder diagnosis.

To provide a system for providing expert knowledge and appropriate assistance to children having developmental disorder and their families.SOLUTION: Provided is a system for providing children having developmental disorder and their families with a learning environment and learning method, whole-day action management, communication skill training, and introduction to reliable experts. The system includes: means for providing a learning environment that can be customized to suit the characteristics of children; means for managing the actions of children and proposing appropriate schedules and routines; means for providing training programs for assisting to improve communication skills; and information provision means for promoting linkage for collaboration with experts or service providers.SELECTED DRAWING: Figure 1

Systems, devices, devices, methods, and computer-readable storage media for development assessment using eye tracking are provided. In one aspect, a system for developmental assessment via eye tracking includes a patient-side computing device having a screen for presenting visual stimuli to a patient; an eye tracking device integrated with the patient-side computing device and configured to collect eye tracking data of the patient while presenting the visual stimuli to the patient on a screen of the patient-side computing device; and an operator-side computing device configured to present a user interface to an operator to communicate with the patient-side computing device.

The invention relates to the technical field of children developmental disorder intervention, in particular to a mixed reality assessment intervention system and method for children developmental disorder, and the system comprises an intervention scheme determination module, a data collection module and an intervention control center. The method comprises the steps of determining an adjustment intervention strategy, a short-term target or an intervention stage according to a plurality of second correct rates of execution of an intervention scheme by a child, determining a strategy improvement level or replacement of the intervention strategy based on a strategy level of a current intervention strategy, or determining an adjustment strategy for a current stage based on a first quantity, and under the condition of determining that the current intervention stage is not changed, the short-term target is replaced based on a first quantity proportion, or the short-term target is replaced or the intervention stage is improved based on a second quantity proportion, and the development trend of the qualified rate of a plurality of execution cycles is obtained to adjust the judgment criterion of the intervention level. According to the method, the timeliness of intervention decision adjustment and the individual suitability are improved.

The invention discloses a method for constructing a neurodevelopmental disorder animal model based on central nervous system myelin sheath function change and application, and belongs to the technical field of biological engineering. An Msl2 gene conditional knockout mouse model is constructed by adopting a gene engineering technology, the space-time specific knockout of a second exon of the Msl2 gene in a specific cell type is realized through a Cre-LoxP recombinase system, and the exon encodes a key enzyme activity region for catalyzing ubiquitination. Model construction is based on central nervous system oligodendrocyte / myelin sheath dysfunction, the behavior phenotype of the model is similar to the behavior of a typical neurodevelopment disorder animal, a brand new perspective is provided for exploring an etiology mechanism, model mice can be prepared on a large scale by performing directional mating on the gene modified mice, and the development of the model is promoted. And consistency of different experiment batches and reliable reproduction of experiment data are ensured.

The presently disclosed subject matter relates to a play environment for children and infants for detecting motor delays or impairments, evaluating neurological development, and for diagnosing developmental disorders, and methods and systems of using the same.

This disclosure provides compounds, compositions and methods of treatment of diseases and / or disorders associated with TAF1 loss-of-function (LOF). Non-limiting examples of these diseases and / or disorders include X-linked Dystonia Parkinsonism (XDP) X-linked syndromic intellectual developmental disorder-33. Non-limiting examples of compounds useful in the treatment of diseases and / or disorders associated with TAF1 LOF include, and are not limited to, SAK3, pridopidine, and / or lamotrigine.

The presently disclosed subject matter relates to a play environment for children and infants for detecting motor delays or impairments, evaluating neurological development, and for diagnosing developmental disorders, and methods and systems of using the same.

Embodiments described herein include portable devices having user-detection equipment, such as eye-tracker devices or other sensors, and computer systems including such portable devices or the data collected from such devices (such as eye-tracking data and / or other multi-modal data such as facial expressions, verbal expression, and / or physical movements). Some examples of the systems include can provide useful assessments for developmental disorders and can generate prescriptive treatment plans having individual time lengths for different treatment-specific skill areas during a period of time.

An apparatus and method for diagnosing developmental disorder using an artificial neural network are disclosed. An apparatus for diagnosing developmental disorders according to one exemplary embodiment includes a communication unit that performs communication with one or more user terminals and a control unit connected to the communication unit, in which the control unit receives at least one of image data and voice data for an analysis target from the user terminal and performs a first developmental disorder diagnosis through one or more artificial neural networks learned to perform a developmental disorder diagnosis, receives questionnaire response data from the user terminal and performs a second developmental disorder diagnosis according to predetermined standard, and generates developmental disorder diagnosis data for the analysis target based on the first developmental disorder diagnosis and the second developmental disorder diagnosis.

Embodiments described herein include a portable device having a user detection device, such as an eye tracker device or other sensor, and data including such a portable device or data collected from such a device, such as eye tracking data and / or other multi-modal data, some examples of the system may provide useful assessments for developmental disorders and may generate normative treatment plans that have separate lengths of time for different treatment-specific skill fields over a period of time.

A data processing apparatus includes a processor configured to: acquire subject information indicating a daily state of a subject; input a first prompt to a generation model that generates information according to input data, the first prompt being a prompt for outputting a characteristic of a developmental disorder and a degree of disorder of the subject indicated by the acquired subject information; and output the characteristic of the developmental disorder and the degree of the disorder of the subject, which are output results of the generation model, to a predetermined output target.

This disclosure relates to uses of inhibitors of YTH family proteins in the management of fragile X syndrome, fragile X-associated disorders, cognitive disorders, developmental disorders, or central nervous system (CNS) disorders. In certain embodiments, this disclosure relates to treating fragile X syndrome, fragile X-associated disorders, cognitive disorders, developmental disorders, or central nervous system (CNS) disorders by administering an effective amount of an inhibitor of YTHDF1 to a subject in need thereof. In certain embodiments, the YTHDF1 inhibitor is a small molecule inhibitor such as salvianolic acid C, derivatives, prodrugs, esters, or salts thereof.

The present invention relates to a composition for preventing, ameliorating, or treating fragile X syndrome, a developmental disorder associated with fragile X syndrome, an autism spectrum disorder, or schizophrenia, comprising Rilmenidine, a Rilmenidine metabolite, or a pharmaceutically acceptable salt thereof. The present invention relates to a composition for preventing, ameliorating, or treating fragile X syndrome, a developmental disorder associated with fragile X syndrome, or a composition for preventing, ameliorating, or treating schizophrenia.

The methods and apparatus disclosed herein can diagnose or identify a subject as at risk of having one or more developmental disorders with fewer questions, decreased amounts of time, and determine a plurality of developmental disorders, and provide clinically acceptable sensitivity and specificity in a clinical environment. The methods and apparatus disclosed herein can be configured to diagnose or determine the subject as at risk of a developmental disorder among a plurality of developmental disorders, and decreasing the number of questions presented can be particularly helpful where a subject presents with a plurality of possible developmental disorders. A processor can be configured with instructions to identify a most predictive next question, such that a person can be diagnosed or identified as at risk with fewer questions.

An object of a system according to an embodiment is to eliminate anxiety of a parent about development of a child and to provide appropriate information.SOLUTION: A system includes an interpretation unit, a generation unit, an information providing unit, and a determination unit. The interpretation unit interprets the user's question. The generation unit generates a reassuring word based on the question interpreted by the interpretation unit. The information providing unit returns appropriate information based on the question interpreted by the interpretation unit. The determination unit determines a possible developmental disorder based on the information provided by the information providing unit.SELECTED DRAWING: Figure 1

To provide a system, a program and a storage medium for analyzing characteristics of a developmental disorder, which allow how children with a developmental disorder use their eyes to be grasped one by one.SOLUTION: A characteristic analysis system for a developmental disorder analyzes characteristics of a developmental disorder of a subject by: displaying the analysis image data selected from the analysis image data for analyzing how the eyes are used; storing the displayed target data and the line-of-sight data on the subject acquired by line-of-sight detection means at each of predetermined time intervals; performing coordinate-conversion of the stored target data and line-of-sight data into XY-axis coordinates; and analyzing how the eyes are used based on the time-series movement of the XY-axis coordinates of the line-of-sight data with respect to the XY-axis coordinates of the target data and / or the change in the time-series deviation amount between the XY-axis coordinates of the target data and the XY-axis coordinates of the line-of-sight data.SELECTED DRAWING: Figure 3

The application discloses a growth file dynamic recording and tracking system for children with development disorders, relates to the technical field of children development disorder assessment and rehabilitation, and comprises a data acquisition module, a feature extraction module, a feature fusion module, a semantic projection module and a semantic output module; the system collects behavior text records, audio and video streams, course types, noise spectra, interactive objects and other environmental context data, extracts behavior feature vectors and environmental feature vectors, and generates environmental-behavior fusion vectors by using a cross attention mechanism; the fusion vectors are projected to a semantic space to calculate semantic similarity, and the result confidence is judged according to the difference value between the highest and the second highest similarity; if the result confidence is insufficient, environmental features are re-extracted based on an extended time window and are weighted and fused to generate environmental feature reinforcement vectors, and then fusion, semantic projection and semantic category output are performed again; the application can ensure that the growth file maintains context consistency and development coherence in long-term tracking.

This invention provides a method for estimating neuropsychological activity that can accurately predict developmental disorders, mental illnesses, and other conditions. [Solution] Time-series data of the subject's pupil diameter and time-series data of the subject's eye movements are obtained. The time-averaged value of the pupil diameter is calculated from the time-series data of the pupil diameter, and the complexity of eye movements for each time scale is quantified from the time-series data of eye movements. Based on the time-averaged value of the pupil diameter and the complexity of eye movements, the subject's neuropsychiatric activity is estimated.

The system according to this embodiment aims to support general pediatricians in the diagnosis and treatment of developmental disorders. [Solution] The system according to this embodiment comprises a reception unit, a developmental analysis unit, a feature detection unit, a disease probability calculation unit, a medical interview support unit, and an advice provision unit. The reception unit receives input of photos and videos of children from parents. The developmental analysis unit analyzes the data received by the reception unit. The feature detection unit detects features specific to developmental disorders based on the data analyzed by the developmental analysis unit. The disease probability calculation unit calculates the probability of disease onset based on the features detected by the feature detection unit. The medical interview support unit presents observation points during the medical interview based on the probability calculated by the disease probability calculation unit. The advice provision unit provides advice on treatment plans, how to interact with the child at home, and family care based on the information presented by the medical interview support unit.

The present invention relates to a composition for preventing, improving, or treating fragile X syndrome, fragile X syndrome-related developmental disorders, autism spectrum disorder or schizophrenia, comprising rilmenidine, a rilmenidine metabolite, or a pharmaceutically acceptable salt thereof.

The invention discloses application of Trolox in preparation of a medicine for treating neurodevelopment disorder related diseases, and belongs to the technical field of biological medicine. The invention firstly discovers that Trolox has new application of drugs for preventing and / or treating neurodevelopment disorder related diseases; furthermore, the Trolox restores the neural connectivity by repairing the densities of the damaged neuron dendritic spines of the brain hippocampus and / or striatum; abnormal dopaminergic signal channels are corrected, so that expression of key receptors and downstream molecules thereof is recovered to be normal, and therefore, diseases related to neurodevelopment disorders are prevented and / or treated; the neuroprotective effect of Trolox depends on the activation of dopamine D1 and D2 receptor pathways; in addition, the invention discloses the potential of Trolox in the aspect of targeted repair of the core pathology link of the neurodevelopmental disorder for the first time, and a clear candidate compound and an action target are provided for developing a novel medicine for treating the diseases.

Provided herein are methods for treating autism; and systems and devices for administering transcutaneous auricular vagal nerve stimulation (taVNS).

The invention relates to the technical field of neural developmental disorder eTNS dynamic intervention systems, in particular to a neural developmental disorder-oriented adaptive eTNS dynamic intervention system, which comprises an acquisition unit, a signal processing unit, a state judgment unit, an eTNS treatment unit, a stimulation parameter library unit and a closed-loop control algorithm unit, the acquisition unit is used for acquiring a physiological signal, an electroneurographic signal and a behavior state of the neurodevelopment disorder of a patient in real time; the signal processing unit is used for carrying out filtering and artifact removal preprocessing on the data acquired in the acquisition unit, and then extracting a theta / beta proportion, a heart rate variability index and an activity level characteristic value from the processed data; the state judgment unit analyzes characteristic values of the signal processing unit by utilizing a machine learning model and a rule algorithm; by continuously monitoring and updating physiological signal data acquired by the acquisition unit, a closed loop of acquisition, analysis, stimulation and re-acquisition is formed, and the treatment effect is improved.