26 results about "Developmental disorder" patented technology

The invention relates to the technical field of children developmental disorder intervention, in particular to a mixed reality assessment intervention system and method for children developmental disorder, and the system comprises an intervention scheme determination module, a data collection module and an intervention control center. The method comprises the steps of determining an adjustment intervention strategy, a short-term target or an intervention stage according to a plurality of second correct rates of execution of an intervention scheme by a child, determining a strategy improvement level or replacement of the intervention strategy based on a strategy level of a current intervention strategy, or determining an adjustment strategy for a current stage based on a first quantity, and under the condition of determining that the current intervention stage is not changed, the short-term target is replaced based on a first quantity proportion, or the short-term target is replaced or the intervention stage is improved based on a second quantity proportion, and the development trend of the qualified rate of a plurality of execution cycles is obtained to adjust the judgment criterion of the intervention level. According to the method, the timeliness of intervention decision adjustment and the individual suitability are improved.

The invention discloses a method for constructing a neurodevelopmental disorder animal model based on central nervous system myelin sheath function change and application, and belongs to the technical field of biological engineering. An Msl2 gene conditional knockout mouse model is constructed by adopting a gene engineering technology, the space-time specific knockout of a second exon of the Msl2 gene in a specific cell type is realized through a Cre-LoxP recombinase system, and the exon encodes a key enzyme activity region for catalyzing ubiquitination. Model construction is based on central nervous system oligodendrocyte / myelin sheath dysfunction, the behavior phenotype of the model is similar to the behavior of a typical neurodevelopment disorder animal, a brand new perspective is provided for exploring an etiology mechanism, model mice can be prepared on a large scale by performing directional mating on the gene modified mice, and the development of the model is promoted. And consistency of different experiment batches and reliable reproduction of experiment data are ensured.

The presently disclosed subject matter relates to a play environment for children and infants for detecting motor delays or impairments, evaluating neurological development, and for diagnosing developmental disorders, and methods and systems of using the same.

The presently disclosed subject matter relates to a play environment for children and infants for detecting motor delays or impairments, evaluating neurological development, and for diagnosing developmental disorders, and methods and systems of using the same.

An apparatus and method for diagnosing developmental disorder using an artificial neural network are disclosed. An apparatus for diagnosing developmental disorders according to one exemplary embodiment includes a communication unit that performs communication with one or more user terminals and a control unit connected to the communication unit, in which the control unit receives at least one of image data and voice data for an analysis target from the user terminal and performs a first developmental disorder diagnosis through one or more artificial neural networks learned to perform a developmental disorder diagnosis, receives questionnaire response data from the user terminal and performs a second developmental disorder diagnosis according to predetermined standard, and generates developmental disorder diagnosis data for the analysis target based on the first developmental disorder diagnosis and the second developmental disorder diagnosis.

Embodiments described herein include a portable device having a user detection device, such as an eye tracker device or other sensor, and data including such a portable device or data collected from such a device, such as eye tracking data and / or other multi-modal data, some examples of the system may provide useful assessments for developmental disorders and may generate normative treatment plans that have separate lengths of time for different treatment-specific skill fields over a period of time.

A data processing apparatus includes a processor configured to: acquire subject information indicating a daily state of a subject; input a first prompt to a generation model that generates information according to input data, the first prompt being a prompt for outputting a characteristic of a developmental disorder and a degree of disorder of the subject indicated by the acquired subject information; and output the characteristic of the developmental disorder and the degree of the disorder of the subject, which are output results of the generation model, to a predetermined output target.

The methods and apparatus disclosed herein can diagnose or identify a subject as at risk of having one or more developmental disorders with fewer questions, decreased amounts of time, and determine a plurality of developmental disorders, and provide clinically acceptable sensitivity and specificity in a clinical environment. The methods and apparatus disclosed herein can be configured to diagnose or determine the subject as at risk of a developmental disorder among a plurality of developmental disorders, and decreasing the number of questions presented can be particularly helpful where a subject presents with a plurality of possible developmental disorders. A processor can be configured with instructions to identify a most predictive next question, such that a person can be diagnosed or identified as at risk with fewer questions.

An object of a system according to an embodiment is to eliminate anxiety of a parent about development of a child and to provide appropriate information.SOLUTION: A system includes an interpretation unit, a generation unit, an information providing unit, and a determination unit. The interpretation unit interprets the user's question. The generation unit generates a reassuring word based on the question interpreted by the interpretation unit. The information providing unit returns appropriate information based on the question interpreted by the interpretation unit. The determination unit determines a possible developmental disorder based on the information provided by the information providing unit.SELECTED DRAWING: Figure 1

To provide a system, a program and a storage medium for analyzing characteristics of a developmental disorder, which allow how children with a developmental disorder use their eyes to be grasped one by one.SOLUTION: A characteristic analysis system for a developmental disorder analyzes characteristics of a developmental disorder of a subject by: displaying the analysis image data selected from the analysis image data for analyzing how the eyes are used; storing the displayed target data and the line-of-sight data on the subject acquired by line-of-sight detection means at each of predetermined time intervals; performing coordinate-conversion of the stored target data and line-of-sight data into XY-axis coordinates; and analyzing how the eyes are used based on the time-series movement of the XY-axis coordinates of the line-of-sight data with respect to the XY-axis coordinates of the target data and / or the change in the time-series deviation amount between the XY-axis coordinates of the target data and the XY-axis coordinates of the line-of-sight data.SELECTED DRAWING: Figure 3

The application discloses a growth file dynamic recording and tracking system for children with development disorders, relates to the technical field of children development disorder assessment and rehabilitation, and comprises a data acquisition module, a feature extraction module, a feature fusion module, a semantic projection module and a semantic output module; the system collects behavior text records, audio and video streams, course types, noise spectra, interactive objects and other environmental context data, extracts behavior feature vectors and environmental feature vectors, and generates environmental-behavior fusion vectors by using a cross attention mechanism; the fusion vectors are projected to a semantic space to calculate semantic similarity, and the result confidence is judged according to the difference value between the highest and the second highest similarity; if the result confidence is insufficient, environmental features are re-extracted based on an extended time window and are weighted and fused to generate environmental feature reinforcement vectors, and then fusion, semantic projection and semantic category output are performed again; the application can ensure that the growth file maintains context consistency and development coherence in long-term tracking.

This invention provides a method for estimating neuropsychological activity that can accurately predict developmental disorders, mental illnesses, and other conditions. [Solution] Time-series data of the subject's pupil diameter and time-series data of the subject's eye movements are obtained. The time-averaged value of the pupil diameter is calculated from the time-series data of the pupil diameter, and the complexity of eye movements for each time scale is quantified from the time-series data of eye movements. Based on the time-averaged value of the pupil diameter and the complexity of eye movements, the subject's neuropsychiatric activity is estimated.

The system according to this embodiment aims to support general pediatricians in the diagnosis and treatment of developmental disorders. [Solution] The system according to this embodiment comprises a reception unit, a developmental analysis unit, a feature detection unit, a disease probability calculation unit, a medical interview support unit, and an advice provision unit. The reception unit receives input of photos and videos of children from parents. The developmental analysis unit analyzes the data received by the reception unit. The feature detection unit detects features specific to developmental disorders based on the data analyzed by the developmental analysis unit. The disease probability calculation unit calculates the probability of disease onset based on the features detected by the feature detection unit. The medical interview support unit presents observation points during the medical interview based on the probability calculated by the disease probability calculation unit. The advice provision unit provides advice on treatment plans, how to interact with the child at home, and family care based on the information presented by the medical interview support unit.

The invention discloses application of Trolox in preparation of a medicine for treating neurodevelopment disorder related diseases, and belongs to the technical field of biological medicine. The invention firstly discovers that Trolox has new application of drugs for preventing and / or treating neurodevelopment disorder related diseases; furthermore, the Trolox restores the neural connectivity by repairing the densities of the damaged neuron dendritic spines of the brain hippocampus and / or striatum; abnormal dopaminergic signal channels are corrected, so that expression of key receptors and downstream molecules thereof is recovered to be normal, and therefore, diseases related to neurodevelopment disorders are prevented and / or treated; the neuroprotective effect of Trolox depends on the activation of dopamine D1 and D2 receptor pathways; in addition, the invention discloses the potential of Trolox in the aspect of targeted repair of the core pathology link of the neurodevelopmental disorder for the first time, and a clear candidate compound and an action target are provided for developing a novel medicine for treating the diseases.

Provided herein are methods for treating autism; and systems and devices for administering transcutaneous auricular vagal nerve stimulation (taVNS).

The invention relates to the technical field of neural developmental disorder eTNS dynamic intervention systems, in particular to a neural developmental disorder-oriented adaptive eTNS dynamic intervention system, which comprises an acquisition unit, a signal processing unit, a state judgment unit, an eTNS treatment unit, a stimulation parameter library unit and a closed-loop control algorithm unit, the acquisition unit is used for acquiring a physiological signal, an electroneurographic signal and a behavior state of the neurodevelopment disorder of a patient in real time; the signal processing unit is used for carrying out filtering and artifact removal preprocessing on the data acquired in the acquisition unit, and then extracting a theta / beta proportion, a heart rate variability index and an activity level characteristic value from the processed data; the state judgment unit analyzes characteristic values of the signal processing unit by utilizing a machine learning model and a rule algorithm; by continuously monitoring and updating physiological signal data acquired by the acquisition unit, a closed loop of acquisition, analysis, stimulation and re-acquisition is formed, and the treatment effect is improved.

The invention discloses a growth file dynamic recording and tracking system for children with development disorder, which relates to the technical field of children development disorder evaluation and rehabilitation and comprises a data acquisition module, a feature extraction module, a feature fusion module, a semantic projection module and a semantic output module. The system extracts a behavior feature vector and an environment feature vector by collecting behavior text records, audio and video streams, course types, noise spectrums, interaction objects and other environment context data, and generates an environment-behavior fusion vector by using a cross attention mechanism; the fusion vector is projected to a semantic space to calculate semantic similarity, and the result confidence is judged according to the difference between the highest similarity and the second highest similarity; if not, re-extracting the environment features based on an extended time window, carrying out weighted fusion to generate an environment feature enhancement vector, carrying out fusion and semantic projection again, and outputting a semantic category; the method can ensure that the growth archive keeps context consistency and development coherence in long-term tracking.

The invention relates to an application of TLR < 4 > siRNA (TLR < 4 > siRNA (at) LNP-CSA-BP) coated with TLR < 4 > siRNA (TLR < 4 > siRNA) connected with placental Chondroitin sulfate A binding peptide (Placental Chondroitin sulfate A binding peptide, CSA-BP) injected in a maternal pregnancy period, in improvement of pregnancy complications and prevention of progeny neurodevelopment disorder diseases, in particular to an application of TLR < 4 > siRNA coated with LNP-CSA-BP coated with TLR < 4 > siRNA coated with LNP-CSA-BP. According to the invention, TLR4siRNA (at) LNP-CSA-BP is used for carrying out caudal vein injection on a pregnant mouse, so that a placenta and fetal brain inflammation microenvironment (induced by toxoplasma gondii STAg) maternal immune activation can be inhibited. Behavior experiments further prove that under a maternal immune activation model, TLR4siRNA (at) LNP-CSA-BP caudal vein injection pregnant mice can significantly improve phenotypes of neurodevelopmental disorder diseases of filial generation mice, such as core symptoms (social ability and repeated engraving behaviors) of autism behaviors, and the promising transformation prospect is proved.

The present invention relates to a composition for preventing, alleviating, or treating autism spectrum disorders or related developmental disorders, the composition comprising Tebipenem pivoxil or a pharmaceutically acceptable salt thereof.

This invention discloses a method and device for coordinated temporal modulation of central and peripheral ultrasound for children with motor neuron developmental disorders, comprising: acquiring multidimensional medical information and target physiological parameter information of the target child; prioritizing central and peripheral targets and determining the synergistic relationship between central and peripheral targets based on neural circuit conduction mechanisms; generating initialization timing parameters based on priority ranking and synergistic relationship, combined with a preset timing parameter database; controlling the ultrasound transducer to perform coordinated ultrasound stimulation on central and peripheral targets according to the initialization timing parameters, and monitoring the physiological response signal of the target child in real time; dynamically adjusting at least one of the initialization timing parameters, and continuing to perform coordinated ultrasound stimulation according to the adjusted timing parameters, thereby achieving synergistic enhancement by adjusting the timing to match the physiological neural conduction delay of the child, rather than basic synchronous energy superposition stimulation.

The invention discloses application of Granzyme B as a target spot in development of a medicine for preventing and treating progeny neurodevelopmental disorder diseases caused by pregnancy inflammation. The invention provides an application of a Granzyme B inhibitor in preparation of a medicine or a kit for preventing and / or treating neurodevelopment disorder diseases. The maternal NK cell Granzyme B is knocked out or a Granzyme B selective inhibitor is used for treating a pregnant mouse, so that the embryonic brain dysplasia induced by polyIC can be remarkably improved, and meanwhile, the autism-like behavior of a filial generation is also remarkably relieved. The results show that the Granzyme B can be used as a drug target for preventing offspring neurodevelopment disorder diseases caused by gestational infection, and has important significance for developing drugs for preventing / treating the diseases in the future.

To provide a developmental disorder diagnosis support device capable of supporting diagnosis of a child having a developmental disorder.SOLUTION: The processor 22 analyzes the parent-child activity video data 41 to acquire time-series data indicating the characteristics of the child's movements, and calculates a movement index that evaluates the child's movements related to the presence or absence of developmental disorders based on the time-series data. The processor 22 then estimates the likelihood that the child has a developmental disorder on the basis of the motion index.SELECTED DRAWING: Figure 1

Disclosed are a child developmental disorder diagnosis assistance device and a child developmental disorder diagnosis assistance method based on virtual reality (VR) evaluation data collection pipeline technology. The child developmental disorder diagnosis assistance device according to an embodiment of the present invention is a child developmental disorder diagnosis assistance device for assisting diagnosis of child developmental disorders and comprises: a virtual reality (VR) evaluation data collection unit configured to collect VR evaluation data including a VR image provided to a user by a VR device and user data generated from the user's voice, gaze, face, and hands; and a child developmental disorder assessment unit configured to, on the basis of the VR evaluation data, evaluate the user's cognitive ability, social ability, and language ability to assess child developmental disorders.

The invention relates to the technical field of medical instruments, and discloses a multi-target percutaneous electrical stimulator and a neurodevelopmental disorder diagnosis and treatment method.The multi-target percutaneous electrical stimulator comprises a stimulator body, a wire is installed on the lower surface of the stimulator body, the other end of the wire is fixedly connected with a connector, and the exterior of the wire is fixedly connected with a connecting base; a clamping frame is attached to the outer portion of the lower side of the connecting base, a clamping pad is fixedly connected to the outer portion of the clamping frame, a target point position is fixedly connected to the outer portion of the clamping pad, a shell is arranged on the lower surface of the clamping pad, a motor is fixedly connected to the outer portion of the shell, and a rotating disc is connected to the output end of the motor. A first adjusting assembly is arranged in one side of the rotating disc. The motor drives the rotating disc to rotate, the rotating disc drives the first sliding column to slide, the first sliding column drives the first sliding plate to move when sliding, the first sliding plate pushes the clamping pad to drive the target point to move, and therefore the target point can be tightly attached to a target stimulation area of the body surface of a patient, and the stability of stimulation treatment is improved.