Application of lactobacillus reuteri in preparation of products for preventing or treating developmental disorder diseases

A Lactobacillus reuteri, developmental disorder technology, applied in the field of microorganisms, can solve problems such as low actual IQ

Active Publication Date: 2021-07-30
ZHONGKE WISBIOM(BEIJING)BIOTECHNOLOGY CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Prader-Willi Syndrome (Prader-Willi Syndrome, PWS), also known as low muscle tone-low intelligence-hypogonadal development-obesity syndrome, commonly known as chubby-Willi syndrome, has no racial and gender differences in the incidence, and the incidence is about 1 / 12000~1 / 15000, the cause is caused by the gene defect of chromosome 15, the patient has normal language ability, but the actual IQ is lower than ordinary people

Method used

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  • Application of lactobacillus reuteri in preparation of products for preventing or treating developmental disorder diseases
  • Application of lactobacillus reuteri in preparation of products for preventing or treating developmental disorder diseases
  • Application of lactobacillus reuteri in preparation of products for preventing or treating developmental disorder diseases

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preparation example Construction

[0042] The above-mentioned Lactobacillus reuteri preparation method adopts high-density fermentation to prepare the above-mentioned Lactobacillus reuteri, and the yield is high.

[0043] Based on the above-mentioned functions of the above-mentioned Lactobacillus reuteri, one embodiment of the present invention provides an application of the above-mentioned Lactobacillus reuteri in the preparation of a product for preventing or treating Prader-Willi syndrome.

[0044] Specifically, the product for preventing or treating Prader-Willi syndrome (hereinafter referred to as "the product") includes the above-mentioned Lactobacillus reuteri and / or the fermentation product of the above-mentioned Lactobacillus reuteri. Optionally, the fermentation product of the above-mentioned Lactobacillus reuteri refers to the culture product of the above-mentioned Lactobacillus reuteri, including at least one of metabolites located inside the bacteria and metabolites secreted outside the bacteria. W...

Embodiment 1

[0076] A strain was isolated from the milk of healthy women by anaerobic culture method, and was identified by 16S rRNA full-length sequencing and mass spectrometry. The strain was a new strain, belonging to Lactobacillus reuteri, named Reuteri Lactobacillus LR99 (or "LR99"). The strain has been deposited in the General Microbiology Center of China Committee for Culture Collection of Microorganisms (CGMCC for short, Address: No. 3, Yard 1, Beichen West Road, Chaoyang District, Beijing, Institute of Microbiology, Chinese Academy of Sciences, Zip code 100101) on December 31, 2020. , the classification name is Lactobacillus reuteri (Lactobacillus reuteri), and the preservation number is CGMCC No.21577.

[0077] 1. Taxonomic characteristics of Lactobacillus reuteri LR99:

[0078] (1) Observing Lactobacillus reuteri LR99 under a microscope, the results are as follows figure 1 shown.

[0079] (2) The physical and chemical test results are shown in Tables 1 and 2.

[0080] Table ...

Embodiment 2

[0101] This example is used to illustrate the high-density fermentation of Lactobacillus reuteri LR99 and the preparation process of freeze-dried bacterial powder.

[0102] (1) Lactobacillus reuteri LR99 is anaerobically cultured in a modified MRS medium to obtain fermentation strains.

[0103] (2) Carry out three activation cultures to Lactobacillus reuteri LR99 to improve the viability of the strain. The temperature of the three activation cultures is 37°C and the time is 16h. After the activation of the strain is completed, the growth curve of the Lactobacillus reuteri LR99 strain is carried out. The results are shown in Table 4.

[0104] Table 4

[0105] time pH OD 5h 4.48 4.5 6h 4.31 4.71 7h 4.17 6.05 8h 4.06 6.97 9h 3.73 7.26 10h 3.67 7.78

[0106] From the detection results of the growth curve of Lactobacillus reuteri LR99, it can be seen that the time point when Lactobacillus reuteri LR99 reaches the end of logarith...

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Abstract

The invention relates to application of lactobacillus reuteri in preparation of products for preventing or treating developmental disorder diseases. The preservation number of the lactobacillus reuteri is CGMCC (China General Microbiological Culture Collection Center) No. 21577. The lactobacillus reuteri can improve the composition of intestinal flora of patients with developmental disorder diseases such as the Prallard-Willard syndrome and the autism, and improve the disorder of the intestinal flora. The bacteria can prevent obesity or promote weight loss caused by diet, can improve brain development of patients with developmental disorder diseases such as the Prallard-Willie syndrome and autism, can improve social contact disorders and communication disorders of the patients, and can improve fine exercise ability of the patients.

Description

technical field [0001] The invention relates to the technical field of microorganisms, in particular to the application of Lactobacillus reuteri in the preparation of products for preventing or treating developmental disorders. Background technique [0002] Prader-Willi Syndrome (Prader-Willi Syndrome, PWS), also known as low muscle tone-low intelligence-hypogonadal development-obesity syndrome, commonly known as chubby-Willi syndrome, has no racial and gender differences in the incidence, and the incidence is about It is 1 / 12000~1 / 15000, and the cause is caused by a gene defect on chromosome 15. The patient has normal language ability, but the actual IQ is lower than that of ordinary people. [0003] Prader-Willi syndrome manifests differently during different growth periods. Newborns and infants manifest as: poor muscle tone, difficulty feeding, difficulty gaining weight, poor mobility of limbs, and weak crying. Facial features include almond-shaped dark eyes, long strai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23C9/13A23C19/032A23C19/06A23C19/09A23G3/36A23G3/42A23K10/12A23K20/163A23L2/38A23L2/84A23L11/50A23L33/135A23L33/14A23L33/21A61K35/747A61P1/00A61P3/04A61P25/00
CPCA23C9/1307A23C19/0321A23C19/0323A23C19/0325A23C19/061A23C19/09A23G3/42A23G3/366A23L2/382A23L2/84A23L33/135A23L33/14A23L33/21A23K10/12A23K20/163A61K35/747A61P3/04A61P1/00A61P25/00A23V2002/00A23V2400/21A23V2400/11A23V2400/31A23V2400/41A23V2400/61A23V2400/51A23V2200/3202A23V2200/3204A23V2250/76
Inventor 段云峰张烨梁桦崔雷刘智
Owner ZHONGKE WISBIOM(BEIJING)BIOTECHNOLOGY CO LTD
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