3 results about "Ossification" patented technology

To provide methods for treating disease and disorders associated with pathological calcification or pathological ossification.SOLUTION: The method comprises administering a composition comprising at least one agent selected from the group consisting of Ecto-Nucleotide pyrophosphate / Phosphodiesterase-1 (NPP1) polypeptide and a fragment, derivative, mutant or mutant fragment thereof, and an activator of NPP1 polypeptide and a fragment, mutant or mutant fragment thereof. Preferably, the NPP1 polypeptide or a fragment, mutant or mutant fragment thereof is a soluble recombinant NPP1 polypeptide or a fragment, mutant or mutant fragment thereof.SELECTED DRAWING: Figure 1

The present invention relates to a novel lappaconitine derivative and a pharmaceutically acceptable salt thereof, a preparation method therefor, and a medical use thereof using osteogenesis-promoting activity. The lappaconitine derivative induces the differentiation of stem cells into preosteoblasts, and increases bone density when administered to an osteoporosis animal model, and induces osteogenesis, and thus can be effectively used for preventing, alleviating, or treating bone-related diseases such as osteoporosis.

This invention discloses a guidewire-connected negative electrode spinal fusion device system, comprising a fusion device body for mounting between the upper and lower vertebrae, supporting the upper and lower vertebrae and providing bone graft space; a screw-rod fixation mechanism for connecting to and fixing the upper and lower vertebrae on their sides; a positive electrode component for generating positive charge and located outside the bone graft space within the screw-rod fixation mechanism; a guidewire, with its two ends electrically connected to the fusion device body and the positive electrode component respectively; and a guidewire sleeve fitted over the guidewire. The system of this invention places the positive electrode component on the top wire and connects it to the fusion device body via the guidewire. The positive electrode component carries a negative charge on its surface, allowing it to directly contact the upper and lower vertebrae, effectively attracting calcium and phosphate ion deposition, activating osteoblast proliferation and differentiation, accelerating bone ingrowth and fusion, and promoting osteogenic growth. By placing the positive electrode component outside the bone graft space and not contacting the bone graft area, the problem of positive charge inhibiting osteogenic growth near the bone graft area is solved.