170 results about "Ossification" patented technology

A cage for facilitating fusion of bones, such as vertebrae, or fusion of adjacent bone surfaces is disclosed. In one form, the cage includes a plurality of spaced apart walls comprising a biodegradable polymeric material (e.g., polycaprolactone); an osteoconductive mineral coating (e.g., a calcium compound) on at least a portion of the walls; and a bioactive agent (e.g., a bone morphogenetic protein) associated with the polymeric material and / or the coating. The bioactive agent is present in amount that induces ossification between the bones or adjacent bone surfaces. The cage may also include a fixation plate connected to at least one of the walls.

The invention discloses a core making method by gas-blowing hardening, which is characterized in that the mass percentage of mixing materials of the making core sand is as follows: 0.9-7.0 percent of soluble glass, 0.1-1.0 percent of moisture absorption resistant agent and raw sand for the rest; the used moisture absorption resistant agent can be triacetyl glycerine, diacetin, glycerol mono acetate bulk, diethylene glycol acetic ester, propylene glycol acetic ester, other polylol organic acid ester or the mixture thereof; the volume percentage of the blowing gas for hardening is as follows: 25-100 percent of C2-C4 organic ester and 0-75 percent of C1-C2 alcohols. The method of the invention has no toxicity and odor in production process, and the produced cores have better stripping strength.

A method and an apparatus for estimating bone age by at least one acoustic signal in an ossification-actuated skeletal structure. The apparatus includes an acoustic transmitter and an acoustic receiver positioned facing each other so that the structure is positioned between them. The structure has at least two bones. The transmitter is adapted for transmitting a signal to cross the structure transversely. An electronic moveable gantry is provided for adjusting the position of the acoustic transmitter and the acoustic receiver in relation to the structure. A computer system is enabled to perform one or more functions to position the moveable gantry; transmit the signal by the transmitter; control the signal transmitted by the transmitter; receive the transmitted signal by the receiver; and estimate bone age responsive to the received signal by at least one bone age calculation formula.

A cage for facilitating fusion of bones, such as vertebrae, or fusion of adjacent bone surfaces is disclosed. In one form, the cage includes a plurality of spaced apart walls comprising a biodegradable polymeric material (e.g., polycaprolactone); an osteoconductive mineral coating (e.g., a calcium compound) on at least a portion of the walls; and a bioactive agent (e.g., a bone morphogenetic protein) associated with the polymeric material and / or the coating. The bioactive agent is present in amount that induces ossification between the bones or adjacent bone surfaces. The cage may also include a fixation plate connected to at least one of the walls.

The invention provides a multifunctional mesoporous glass bracket with biological activity, and the glass bracket with biological activity has a amorphous form glass structure, and 90%-99.999% of macropores are communicated; the glass bracket with biological activity also contains 1-15 mol% of copper, which is based on calculation of total substance amount of the glass bracket with biological activity CuO-CaO-P2O5-SiO2. The invention also provides a preparation method of multifunctional mesoporous glass bracket with biological activity, which employs a sol-gel method to prepare mesoporous glass bracket with biological activity containing different copper contents; the copper-containing mesoporous glass bracket with biological activity has the advantages of blood vessel forming potential, ossification property, medicament deliver and antibacterial property.

The invention relates to a metal bone graft material with a porous structure, and preparation and application thereof. The metal bone graft material is used as a filling material for transplantation after orthopaedic and oral damage and defects. The metal bone graft material contains the following trace elements in the human body by weight: 70.0 to 98.0 of Mg, 0.1 to 10.0% of Si, 0.1 to 10% of Sr and 0.1 to 10.0% of Ca, wherein the trace elements are uniformly distributed in a substrate and a coating. According to the invention, good ossification capability and matching in-vivo absorption capability are obtained by adjusting the contents of components in an alloy, controlling the shape, quantity and distribution of mesophase in metal, changing processing technology and surface coating protection of the alloy and preparing the porous structure; and the metal bone graft material has good biocompatibility and bone conduction capability, is a medical absorbent metal bone graft material with excellent mechanical properties, and is applicable to bone defects caused by wounds, malformation, bone tumors, osteomyelitis and joint displacement in clinical practice to promote bone restoration and applicable as a drug sustained release system.

This invention relates to an embedded system fingerprint identifying and matching method belonging to image processing and mode identifying technology realm, comprising the following steps: first, basing on area line character calculating direction graph, then making neighborhood differences statistic to realize fingerprint line enhancement; second, thinning fingerprint by adopting ossification method; third, extracting fingerprint character points by structure character; last, matching the character points. The invention can process image of fingerprint with multiple breakpoints, enhance restoring ability to breakpoint and scar, improve identifying ability to character point with similar structure.

The invention relates to the field of medical food and discloses an aquatic collagen peptide food used for adjuvant therapy of osteoporosis and arthritis. Every 100g of the food contains multiple nutritional ingredients as follows: 9-11g of cod skin collagen protein peptide powder, 4-6g of squid skin collagen protein peptide powder, 2-3g of whey protein powder, 2-3g of soybean protein powder, 9-11g of MCT fat, 2-3g of soybean oil, 58-62g of carbohydrate and other vitamins and microelements. The aquatic collagen peptide food takes cod skin collagen protein peptide powder, squid skin collagen protein peptide powder and whey protein powder as main raw materials and has relatively high digestive absorptivity, and collagen protein peptide can promote bone formation and reinforce a bone collagen structure at low calcium level, so that bone strength is improved; bone metabolism can be improved, and ossification can be enhanced; and bone diseases such as the osteoporosis, hyperostosis and swelling and pain of bone joints can be prevented.

The invention discloses a flexible rehabilitation training glove for stroke patients, which comprises a flexible retractable finger traction component and a driving component, and there are five flexible retractable finger traction components arranged in a hand shape. All flexible retractable finger traction components are connected with the driving component, and are stretched under the drive of the driving component; all flexible retractable finger traction components are provided with finger band and / or finger stall. According to the flexible rehabilitation training glove, stroke patients can carry out rehabilitation training for hands, stimulate the reestablishment of neural pathways, prevent the adhesion of soft tissue, prevent muscle atrophy, and avoid the ossification of hand tissue due to calcification, so as to promote the rehabilitation of stroke.

The invention relates to a bone matrix material containing various proteins secreted by umbilical cord mesenchymal stem cells and a preparation method thereof. The material is an animal bone matrix material with the umbilical cord mesenchymal stem cells inoculated on the surface of a decalcified bone matrix and used for secreting osteogenic induction function proteins to promote osteogenesis. The bone matrix material has natural structures and characteristics of bone tissues and a good osteogenic induction effect, has a better osteogenesis promoting effect in a bone defect repair process, and is helpful for large-scale preparation and clinical application of tissue-engineered bones.

The invention relates to a bone cement, and a preparation method and application thereof, belonging to the technical field of biomaterials. The bone cement is prepared from the following components expressed in weight percentage: 50 to 80% of solid phase borate bioglass powder and 20 to 50% of modified liquid phase chitosan sol liquid. Compared with conventional bone cement, the bone cement provided by the invention has the advantages of biodegradability, excellent bone conduction, bone induction, osseointegration performance and ossification performance during degradation and capacity of forming bone tissue at last. The preparation method for the bone cement has the advantages of a simple process, simple equipment, easy operation and low cost; the bone cement is injectable and can realize minimally invasive, even noninvasive, treatment; the method can be used for preparing a bone filler and a carrier material for orthopaedic drugs; and the bone cement is applied in bone formation and regeneration in bone tissue engineering or in treatment of orthopaedic diseases.

A dental implant is disclosed comprising an anchoring part for anchoring within a bone and comprising a mounting part for receiving a prosthetic build-up construction, wherein the anchoring part and the mounting part are configured integrally of a material comprising zirconia, wherein at least the anchoring part is treated at its outer surface at least partially by a subtractive, removing process, such as by sand blasting or is provided with a coating which facilitates an ossification.

An implantable bone-containing composition and a method for making same are disclosed. The compositions includes sterilized bone, which has been exposed to a dose of radiation in excess of about 45 kGy in the absence of radio-protective agents. The sterilized bone has higher osteogenic capacity than bone sterilized at the conventional dose of between 15 kGy and 35 kGy, approaching or surpassing the osteogenic capacity of the bone prior to irradiation.

The invention discloses a three-dimensional-structured silk fibroin / hydroxyapatite composite stent and a preparation method thereof. The preparation method of the three-dimensional-structured silk fibroin / hydroxyapatite composite stent comprises preparing silk fibroin / hydroxyapatite composite powder uniform in size through biomimetic mineralization; then through the three-dimensional printing technology, precisely controlling the appearance of the composite stent and the shape, size and connectivity of internal holes to obtain the special three-dimensional-structured silk fibroin / hydroxyapatite composite stent applicable to bone tissue engineering for facilitating cell growth and ossification. The three-dimensional-structured silk fibroin / hydroxyapatite composite stent has the advantage of achieving one stent in one structure and is a bone repair composite material stent high in porosity and pore connectivity and controllable in mechanical property, thereby being beneficial to osteogenic induction and differentiation and cell adhesion, migration and proliferation and capable of creating microenvironment meeting growth demands of osteoblasts. The three-dimensional-structured silk fibroin / hydroxyapatite composite stent is simple and practicable in preparation, low in process and equipment requirements, easy to control of experiment parameters and capable of promoting popularization and application of the three-dimensional printing technology in the biological field.

The invention relates to a pilose antler deep processing method. The method takes traditional health-care tonic deer as a raw material, a preparation method of a pilose antler composition, which takes a desclerotized pilose antler extract product liposome and a pilose antler ossification object as main components, is established. Compared with the traditional pilose antler, the prepared pilose antler composition keeps original efficacy of pilose antler and provides novel function for pilose antler, the problem that the pilose antler can be degraded as possible by digesting enzyme during an administration process can be solved, and the method has wide application prospect.

The invention discloses a composite stent, which comprises a three-dimensional porous stent and a composite coating, wherein the three-dimensional porous stent is of a three-dimensional communicated porous reticular structure; the composite coating main body structure is of a gel layer formed by hyaluronic acid-dopamine; the composite coating also comprises functional nanometer particles; the functional nanometer particles are uniformly distributed in the gel layer; the composite coating is adhered onto the surface of the three-dimensional porous stent. The invention also provides a preparation method of the composite stent. The composite stent can be applied to the preparation of a bone defect restoration material; the requirement of the bone restoration material on the mechanical strength is met; better biocompatibility and hydrophilicity are realized; the material after the coating is favorable for the cell adhesion; the inside functional nanometer particles are favorable for the deviation in directions of ossification, vascularization and the like; the tissue restoration is promoted.

The invention discloses a fingerprint locating method and server. A plurality of sets of fingerprint databases in different environments are previously established. In an actual locating process, the optimal fingerprint database is obtained according to current fingerprint information of real-time reference points, and the current position of a terminal is finally estimated according to the optimal fingerprint database. Thus, the problem that due to the fact that power is prone to being affected by the dynamic change of environments, a traditional method cannot effectively locate in actual application is solved, the locating errors caused by the ossification and the singleness of fingerprint databases in the traditional method are reduced, the accuracy of indoor fingerprint location is improved, and the environmental adaptability of the fingerprint databases is improved.

The invention relates to a bioactive degradable magnesium alloy guided bone regeneration membrane and a processing method of dense holes of the bioactive degradable magnesium alloy guided bone regeneration membrane. The bioactive degradable magnesium alloy guided bone regeneration membrane comprises a barrier membrane, the shape of the barrier membrane is attached to bone tissue around a defect area, the barrier membrane is divided into an upper part and a lower part, a skeleton structure area and through hole areas arranged regularly are designed on the barrier membrane, and the arrangement rule of the through holes is that the through holes are distributed alternately in a sparse and dense mode; and the framework structure is not provided with through holes, the through hole area comprises a plurality of circular areas of 0.5-5 mm, a plurality of dense holes smaller than or equal to 0.2 mm are evenly distributed in the circular areas, and the distance between the dense holes is adjusted according to the corrosion rate of actually used materials and the required corrosion effect. The barrier membrane further comprises blind holes with the depth ranging from 0.05 mm to 0.25 mm, and medicine is loaded at the blind holes. According to the invention, the through holes can achieve the effects of discharging degraded gas, penetrating body fluid, nutrient substances and red blood cells and hindering soft tissue cells from penetrating through the holes; dense holes in the through hole area mainly play a role in preventing early-stage soft tissue from growing in, and can be degraded and release magnesium ions to play a role in osteogenesis while being implanted; and a skeleton structure is designed on the barrier membrane, no through hole is arranged in the skeleton structure, surface modification and slow degradation can be achieved, the mechanical supporting effect of the barrier membrane in the bone repairing process is maintained, and the technical problems that materials between through holes of an existing barrier membrane are rapidly degraded, the whole barrier membrane loses mechanical supporting too early after the through holes are connected, and bone defect area repairing is not facilitated can be solved.

The implantable scaffold matrix composition for osteogenic regeneration has a biodegradable polymer material selected from the group consisting of one or more of polylactic acid, polyglycolic acid, or polycaprolactone, or any combination thereof to provide a time release delivery of an osteogenic effect and further has a pharmaceutical composition selected from the group consisting of one or more of ibuprofen, non-steroidal anti-inflammatory drugs (NSAIDS), acetaminophen, or naproxen sodium or any combination thereof and wherein the implantable composition has a primary and a secondary time release. The primary time release being one of the polymer compositions; each time release extending occurring between 0 days and 19 days, both not being at 0 days. In a preferred composition, the scaffold has an organic material for inhibiting osteoclast selected from a group consisting of one or more of Galardin, Decorin, Actinonin, Marimastat, Batimastat, and phosphodiesterase type 4 or any combination of osteoclast inhibitors.

The instant application provides kits and methods for identifying agents which induce or inhibit the osteogenic effect of LMP or BMP proteins. The kits are directed to methods which measure either an amount of a complex between a Smurf protein or a fragment thereof and an LMP protein or a fragment thereof. Alternatively, the kits are directed to methods of measuring an amount of the ubiquitinated Smad protein or a fragment thereof.

The invention discloses a method for constructing a small and medium-sized reservoir dam safety evaluation index system based on the important contribution degree, which includes the following steps: analyzing and researching the main influencing factors of the small and medium-sized reservoir dam safety through data analysis, field investigation, expert consultation and other methods , cause and degree of influence, using the Delphi method to conduct expert questionnaire surveys, calculating the importance of indicators, and initially selecting evaluation indicators; using the gray correlation analysis method to quantitatively calculate the contribution rate of the evaluation indicators to the evaluation results; assigning the importance and contribution rate combination In order to evaluate the important contribution of indicators; determine the index screening criteria and threshold; according to the screening criteria, retain the top k indicators with a large cumulative important contribution, and eliminate the smallest important contribution indicators, and construct a small and medium-sized reservoir dam safety evaluation index system. It avoids the subjectivity of artificial index selection and the rigidity of data analysis, making the dam safety evaluation index system more scientific, refined, and pertinent.

A cage for facilitating fusion of bones, such as vertebrae, or fusion of adjacent bone surfaces is disclosed. In one form, the cage includes a plurality of spaced apart walls comprising a biodegradable polymeric material (e.g., polycaprolactone); an osteoconductive mineral coating (e.g., a calcium compound) on at least a portion of the walls; and a bioactive agent (e.g., a bone morphogenetic protein) associated with the polymeric material and / or the coating. The bioactive agent is present in amount that induces ossification between the bones or adjacent bone surfaces. The cage may also include a fixation plate connected to at least one of the walls.

The invention discloses a seedling culture matrix and a preparation method thereof and relates to the field of plant seedling culture. The seedling culture matrix is prepared from, by mass, sandy soil, magnesium sulfate, thoroughly decomposed cow dung, a water absorption water-retaining agent, carbonized rice husks, palm bark fibers, calcium magnesium phosphate fertilizer, nitrogen-phosphorus-potassium mixed fertilizer, ammonium sulfate, monoammonium phosphate, boric acid, polyaspartic acid, glucosamine oligosaccharides, a plant disease protective agent and shock-resistant bacteria. By the adoption of the technical scheme, the matrix has the functions that fertilizer efficiency is sufficient, nutrients are slowly released, disease resistance and stress tolerance are achieved, the nutrients are comprehensive, and pertinence is high, and all indexes reach industrial standards. Through volume production and use in multiple seedling culture factories, the seed germination rate and emergence rate can be increased, seedlings emerge in order and grow vigorously, the seedlings are strong and are free of excessive growth, root macerating, dwarfing and ossification, flower bud differentiation of the seedlings is normal, and the properties, yield and quality of crop varieties are guaranteed.

A preparation method for a mesoporous-silicon medicine-carrying system modified by bone-morphogenetic-protein active polypeptide comprises: dispersing mesporous silicon into an organic solvent, adding a silane coupling agent 3- aminopropyltriethoxysilane, mixing and reacting to obtain aminated mesoporous silicon; utilizing a cross-linking agent to perform covalent grafting on bone-morphogenetic-protein active polypeptide and aminated mesoporous silicon; utilizing a cross-linking agent to react polyethylene glycol monocarboxylic acid with residual amino on mesoporous silicon; and loading with medicine molecules capable of realizing induction ossification. The method is easy to operate, simple in equipment and mild in reaction conditions, and price is low. The prepared mesoporous silicon medicine-carrying particles are good in dispersibility, good in stability and good in biological compatibility. The medicine-carry system comprises bone-morphogenetic-protein active polypeptide and the medicine molecules both containing bone induction activity, and is applicable to bone defect restoration.

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, which specifically bind to BMP2, BMP4, BMPRlA, BMPRlB, ACTRl, and / or BMPR2 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Also provided are immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention and, optionally, one or more additional therapeutic. The invention also provides methods for treating diseases associated with abnormal bone formation and ossification mediated by BMP2, -BMP4, BMPRlA, BMPRlB, ACTRl5 and / or BMPR2.

The invention provides a titanium dioxide nanotube with a good osteogenesis promoting function and a preparation method thereof, and belongs to the field of biomedical materials. The method comprises the following steps that A, a titanium dioxide nanotube array is prepared on the surface of a titanium material; B, self-polymerization of dopamine on the surface of the nanotube array is conducted, and polydopamine is formed; C, osteogenic growth peptide is fixed to the surface of the nanotube array through the polydopamine, and the titanium dioxide nanotube with the good osteogenesis promoting function is obtained. On the one hand, the titanium dioxide nanotube array provides a proper topological structure for cell growth; and on the other hand, the osteoblast activity can be stimulated by the osteogenic growth peptide, through the synergistic effect of the nanometer topological structure and the osteogenic growth peptide, the osteoblast differentiation function is promoted, and thus the early osseointegration performance of the titanium material is improved.

The invention provides a method for preparing polyelectrolyte composite coating. Disulfide bonds formed between sulfydryl of RGD specifically crosslink the polyelectrolyte composite coating, as a result, crosslinking of the polyelectrolyte composite coating is realized while RGD is introduced; and in addition, as the disulfide bonds are introduced, the biodegradable property of the final polyelectrolyte composite coating can be provided with in vivo responsiveness. The coating is suitable for surface treatment of titanium radical implants embedded in vivo, can promote adherence proliferation differentiation of bone precursors, can promote early development of ossification around the implants, can realize fast osseointegration between hard tissues and permanent implanted materials and facilitates long-term stability of implanted materials. Polyelectrolytes used in the invention all have fine biodegradability and biocompatibility, the degradation products of the polyelectrolytes can be absorbed by human bodies; and in addition, animal experiments indicate that the polyelectrolyte composite coating can promote osteogenesis of injured parts and can be constructed on the surface of medical pure titanium or titanium alloy implants.

The invention provides a stem cell-loaded injectable bone repair adhesive for highly bionic active bone tissues. The stem cell-loaded injectable bone repair adhesive is composed of hydrogel with a multiple hybrid cross-linked network structure and stem cells distributed in the hydrogel with the multiple hybrid cross-linked network structure. The bone repair adhesive has an interpenetrating networkstructure after freeze drying. A high polymer material with carboxyl and catechol functional groups is subjected to oxidation self-crosslinking, the high polymer material with carboxyl and catechol functional groups and a high polymer material with amino and carboxyl are subjected to Michael addition reaction, phenolic hydroxyl groups on the high polymer material with carboxyl and catechol functional groups and calcium ions dissociated from micron-sized spherical hydroxyapatite are chelated to form the multiple hybrid cross-linked network structure, and the micron-sized spherical hydroxyapatite is uniformly distributed in the multiple hybrid cross-linked network structure. The bone repair adhesive can promote adhesion and proliferation of stem cells while improving the tissue adhesion, and enhance angiogenesis and osteogenesis of stem cells.

The invention discloses application of a maca amide compound and pharmaceutically acceptable salt thereof to preparation of bone mineral density improving products. A maca amide compound monomer is obtained by extracting and separating from Lepidiummeyenii Walp., and is found through in-vitro cell experiments and animal experiments to have an excellent ossification promoting effect and a bone mineral density improving effect; the natural maca amide compound is safe without toxic or side effects.