35 results about "Ossification" patented technology

The invention discloses nano-particles with antibacterial and osteogenesis promoting effects as well as a preparation method and application of the nano-particles, and belongs to the technical field of antibacterial nano-materials. On one hand, the invention provides the nano-particles with antibacterial and osteogenesis promoting effects and the preparation method thereof, and on the other hand, the invention provides the application of the nano-particles. The nanoparticles obtained by the method disclosed by the invention have good stability under physiological conditions (PH = 7.4); polyphenol, metal ions and AMP (adenosine monophosphate) can be slowly released in an inflammatory (weakly acidic) environment, and the functions including but not limited to bacterium capturing, bacterium killing, inflammation and oxidation resisting, osteogenesis promoting and the like are realized; the nano-particles can be used for preparing a bone infection treatment drug, and the bone infection treatment drug has a broad-spectrum antibacterial effect and cannot cause antibiotic drug resistance; the treatment medicine can efficiently prevent and treat bone infection and improve bone repair efficiency.

The invention provides an application of a composition in preparation of a bone repair material, the composition is prepared from the following materials in percentage by weight: 70%-90% of coral hydroxyapatite particles, 5%-30% of recombinant human collagen and 0-7% of an excipient, the bone repair material is a cancellous bone imitating material, and the porosity is 85%-99%. The composition provided by the invention has high porosity and a warp-wise gradient structure, can simulate the characteristics of natural bone tissues, has excellent biocompatibility, biodegradability, hydrophilicity, osteogenesis performance and shape memory function, and has excellent clinical use convenience, hemostasis and healing promotion effects and excellent osteogenesis effect; the bone repair material has a wide application prospect in the aspect of preparing the bone repair material for filling and / or repairing bone defects.

The invention discloses a traditional Chinese medicine activity activated bone growth type support implant material and a preparation method thereof, and relates to the technical field of medical materials. The traditional Chinese medicine activity activated bone growth type support implant material is composed of an organic-inorganic composite porous antibacterial scaffold and a pharmacodynamic filler, according to the invention, Co hollow spheres loaded with carbon nanotubes are cross-linked and compounded with sodium alginate, nano-hydroxyapatite and transition metal carbide nanosheets to form an organic-inorganic composite porous antibacterial scaffold, which not only has good mechanical properties and antibacterial properties, but also can stably bear more pharmacodynamic fillers and enable the pharmacodynamic fillers to be slowly released; the stability of the stent structure is further improved through the pharmacodynamic filler, the antibacterial property and the osteogenesis effect of the implant material are remarkably enhanced through the synergistic effect of the pharmacodynamic filler and the stent structure, and the excellent bone repair effect is achieved.

The application relates to the technical fields of medical image processing and artificial intelligence, and provides a bone age evaluation method and system based on an AI model and a bone age instrument. The left wrist X-ray image of a subject detected in the bone age instrument is acquired, and the demographic information of the subject is recorded. The detected left wrist X-ray image is pretreated through gray standardization, noise filtering and a self-supervised learning model. The Vision Transformer is used to extract the distal radius epiphysis and metaphysis width ratio, the third metacarpal metaphysis length and the auxiliary ossification point maturity grading skeletal features, and the multi-modal data fusion is carried out with the demographic information. The multi-layer perception model is used to predict the fused multi-dimensional bone age related data, and a bone age evaluation report is output, so that the error in the bone age prediction of children and adolescents is effectively reduced, and the detection efficiency is improved.

A system for monitoring the ossification of an internally fixated fracture in a bone of a subject includes an implantable fixation device and an external wireless reader operative to transmit relative load data experienced by a bone plate across a fracture to a data server where trends in the change in added bone-support provided by the bone plate may be visualized. The implantable fixation device includes a primary load sensor and a reference load sensor, where a load value from the reference load sensor may be used to normalize the load value from the primary load sensor. The external wireless reader is in wireless communication with the implantable fixation device and is operative to receive a signal indicative of the load from each load sensor and to energize each load sensor via inductive charging.

The invention discloses an application of a JAM3 modified engineered vesicle in preparation of a medicine for treating bone injury, the JAM3 modified engineered vesicle is prepared, and the osteogenesis promoting effect of the JAM3 modified engineered vesicle on bone marrow mesenchymal stem cells (BMSCs) is proved through ALP staining, RT-qPCR, WB and other experiments at the cellular level, so that the osteogenesis promoting effect of the JAM3 modified engineered vesicle on the bone marrow mesenchymal stem cells (BMSCs) is improved, and the osteogenesis promoting effect of the JAM3 modified engineered vesicle on the bone marrow mesenchymal stem cells (BMSCs) is improved. Meanwhile, the effect of JAM3 modified engineered vesicles on promoting osteogenesis of bone defect mice is defined through in-vivo experiments. According to the invention, osteogenesis direction differentiation and bone formation capability of BMSC can be promoted, and bone formation capability of bone defect mice can be promoted in vivo; the compound can be used for treating related diseases such as bone injury.

The invention relates to the technical field of bone repair materials, in particular to a horse antler powder support material preparation device and system, and the device comprises an ossification degree pretreatment unit, a crushing unit, a mixing unit, a printing unit and a regulation and control unit; the ossification degree pretreatment unit comprises a transmission table and a controller, a positioning conveying assembly is arranged on the surface of a transmission part of the transmission table, and a detection assembly and a cutting assembly are arranged on a support part of the transmission table; the preparation system comprises an ossification degree pretreatment module, an air pressure crushing module, a proportioning and mixing module, a 3D printing module and a degradation rate regulation and control module. According to the method, ossification degree grading pretreatment is carried out on the raw material antler, precise recognition and directional cutting are carried out on a cancellous bone region, a compact bone mass core is removed, and the problems of active ingredient fluctuation and non-uniform pore structure caused by individual difference of ossification degrees are solved.

The invention belongs to the technical field of medicines, and particularly relates to application of lycium barbarum glycopeptide in preparation of a medicine for preventing or treating senile ossification. The experimental results show that the wolfberry glycopeptide can improve the posterior limb movement ability and the bone trabecula condition of old mice by increasing the femoral hardness, relieving the bone tissue calcium loss condition, improving the bone formation rate, promoting osteoblasts and inhibiting osteoclasts, so that the effect of treating bone aging is achieved. As a traditional Chinese medicinal material extraction product, the lycium barbarum glycopeptide can be effectively used for preventing and treating senile ossification, has the prospect of being developed into the medicine for preventing and treating senile ossification, provides more treatment choices for clinically preventing or treating senile ossification, and has important social benefits and economic values.

The application discloses a traditional Chinese medicine active activated bone growth type support implant material and a preparation method thereof, and relates to the technical field of medical materials.The traditional Chinese medicine active activated bone growth type support implant material is composed of an organic-inorganic composite porous antibacterial support and a medicinal efficacy filler.Co hollow spheres loaded with carbon nanotubes, sodium alginate, nano-hydroxyapatite and transition metal carbide nanosheets are cross-linked and compounded to form the organic-inorganic composite porous antibacterial support, which not only has good mechanical properties and antibacterial properties, but also can stably bear more medicinal efficacy fillers and slowly release the medicinal efficacy fillers, and the medicinal efficacy fillers further improve the stability of the support structure.The synergistic effect of the two can significantly enhance the antibacterial property and osteogenesis of the implant material, and excellent bone repair effect is achieved.

The application discloses an oral implant with a surface provided with an osteogenesis-promoting and antibacterial coating and a preparation method of the oral implant, wherein the coating comprises chitosan and an antibacterial osteogenesis-promoting fusion polypeptide, and the amino acid sequence of the chitosan and the antibacterial osteogenesis-promoting fusion polypeptide is shown as SEQ ID NO. 1 or SEQ ID NO. 2. The application further provides a method for preparing the oral implant by using the coating of the implant. The oral implant has obvious bacteriostatic and osteogenesis-promoting effects, has good biocompatibility, and has a wide application prospect in the field of oral implantation.

This disclosure relates to compounds and compositions for forming bone and methods related thereto. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting a bone graft composition comprising a growth factor such as BMP in a subject at a site of desired bone growth or enhancement in combination with a JAB1 blocker.

The application discloses a piezoelectric porous scaffold with high efficient osteogenesis and a preparation method thereof. The piezoelectric porous scaffold is obtained by mixing a biological component and a piezoelectric component through an adhesive, sintering and then performing polarization treatment. The piezoelectric porous scaffold can efficiently load and adsorb bioactive protein factors, realizes effective release of the protein, and has piezoelectric performance and osteogenesis activity. Under the multiple effects of the piezoelectric effect, the porous structure and the bioactivity of the protein of the scaffold, the piezoelectric porous scaffold can quickly start early response of bone marrow stromal cells in a synergistic manner, and then promote cell adhesion, proliferation and osteogenic differentiation. The piezoelectric porous scaffold has important significance for efficient and rapid repair of large bone defects, bone nonunion and other bone defects.

The application discloses an ultrasonic probe structure and a method for detecting vascularization and osteogenesis of bone powder, and comprises a probe main body and a shell cover. The probe main body is detachably connected to the inside of the shell cover, the detection surface of the probe main body is exposed to the outside of the shell cover, and a baffle is detachably connected to the side wall of the shell cover and located on both sides of the detection surface of the probe main body. The probe main body shell cover combination device with added coupling agent is placed on the position of the patient's alveolar bone defect, the bilateral baffles are tightly attached to the inner and outer sides of the gums, the coupling agent is injected above the alveolar bone defect and is relatively fixed between the two baffles, the detection surface of the probe main body and the surrounding teeth, so that the loss of the coupling agent is avoided, air is prevented from entering between the detection surface and the bone defect, and the image quality is affected. In addition, the method for detecting the vascularization and osteogenesis of the bone powder after the bone powder is used for repairing the bone defect is provided, and the method has the advantages of non-invasion and non-radiation compared with the traditional imaging method.

The application discloses a preparation method and application of an injectable high-strength bone tissue adhesive, and belongs to the technical field of biomaterials. The hydrogel tissue adhesive comprises micron or nanometer organic particles carrying amino groups, water-soluble polymer which can be chemically crosslinked with the amino groups, and micron or nanometer inorganic particles which can promote osteogenesis; under the action of water, the hydrogel tissue adhesive can form a continuous and porous particle network, and the chemical reaction between the particles and the polymer can provide good adhesive performance, and the adhesive strength can reach 5Mpa. In addition, the non-covalent interaction between the particles can make the material better stay in the defect site, and realize the filling of the bone defect. The inorganic component in the material component of the application can release ions which can promote osteogenesis, and promote the repair of the bone defect. In addition, the hydrogel tissue adhesive can also be used as a bone wound hemostatic material and a cell scaffold material, and has a wide application prospect in the field of bone repair.

A system for monitoring the ossification of an internally fixated fracture in a bone of a subject includes an implantable fixation device and an external wireless reader operative to transmit relative load data experienced by a bone plate across a fracture to a data server where trends in the change in added bone-support provided by the bone plate may be visualized. The implantable fixation device includes a primary load sensor and a reference load sensor, where a load value from the reference load sensor may be used to normalize the load value from the primary load sensor. The external wireless reader is in wireless communication with the implantable fixation device and is operative to receive a signal indicative of the load from each load sensor and to energize each load sensor via inductive charging.

The invention belongs to the field of tissue regeneration materials, and relates to a 3D printing triboelectric material and application thereof in bone and cartilage defect repair. The material can be used as 3D printing ink for manufacturing a triboelectric bracket. The scaffold is prepared by taking biodegradable PGS as a matrix, PEDOT: PSS as a conductive component and sodium chloride as a pore-forming agent through combination of 3D printing and a salt particle pore-forming method, and has a multi-stage porous structure and excellent triboelectric properties. The wire diameter, interlayer spacing and micropore distribution of the stent are accurately regulated and controlled through the 3D printing technology, so that in-situ self-energized electrical stimulation of the stent is realized in an in-vivo dynamic mechanical environment; the scaffold can promote the BMSCs to differentiate into cartilage cells, construct tissue engineering cartilage and accelerate the process of ossification in cartilage, finally realizes efficient repair of bone and cartilage defects, is excellent in biocompatibility and biodegradable, does not need an external power supply device, and has a wide clinical transformation prospect in the field of bone and cartilage defect repair.

To provide methods for treating disease and disorders associated with pathological calcification or pathological ossification.SOLUTION: The method comprises administering a composition comprising at least one agent selected from the group consisting of Ecto-Nucleotide pyrophosphate / Phosphodiesterase-1 (NPP1) polypeptide and a fragment, derivative, mutant or mutant fragment thereof, and an activator of NPP1 polypeptide and a fragment, mutant or mutant fragment thereof. Preferably, the NPP1 polypeptide or a fragment, mutant or mutant fragment thereof is a soluble recombinant NPP1 polypeptide or a fragment, mutant or mutant fragment thereof.SELECTED DRAWING: Figure 1

The invention discloses a preparation method for constructing a piezoelectric bone scaffold for bone tumor repair through 3D printing, and belongs to the field of biomedical materials. The method constructs a piezoelectric bone scaffold material for bone tumor treatment and repair through 3D printing, and specifically comprises the following steps: uniformly mixing barium titanate (BTO) and hydroxyapatite (HA) in a fixed volume ratio, printing a green body with a specific pore structure through light-cured resin, and then performing degreasing, sintering, polarization and post-treatment to prepare the BTO / HA piezoelectric composite bone scaffold. The piezoelectric composite bone scaffold prepared by the invention has an accurate shape highly matched with a bone defect part, can catalyze and generate reactive oxygen free radicals through a piezoelectric effect, realizes efficient in-situ inactivation of residual bone tumor cells, integrates two major functions of bone tumor treatment (piezoelectric anti-tumor) and bone defect repair (HA ossification promotion), and has a good application prospect. The treatment and repair effects are improved and the life quality of patients is improved.

The invention discloses a customized tibia prosthesis, and relates to the technical field of skeleton prostheses, the customized tibia prosthesis comprises a tibia prosthesis main body, the two opposite ends of the tibia prosthesis main body are both provided with positioning bosses, the section of each positioning boss is the same as the shape of a marrow cavity of a tibia backbone, and the positioning bosses are used for being embedded into the marrow cavity of the tibia backbone; the tibia artificial bone body further comprises a pore support and a solid support, the pore support is of a porous structure, and the solid support is fixedly connected with the pore support. And the dense pore structures of the positioning boss and the pore bracket are beneficial to promoting the formation of new bone tissues, so that the bone tissues can grow in each pore, and the tibia prosthesis has enough mechanical stability and long-term ossification support. The bone prosthesis has the technical effect of improving the adaptive positioning performance and stability of the bone prosthesis and the original bone.

The invention relates to a demonstration device and a demonstration method for cervical vertebra posterior longitudinal ligament ossification. The demonstration device comprises a box body and a demonstration model arranged in the box body, the demonstration model comprises a cervical vertebra, a power supply, a power mechanism, a storage chamber and more than two ossification cavities, a first ossification cavity is arranged in a first spinal canal and extends along a first direction, and a second ossification cavity is arranged in a second spinal canal and extends along a second direction; a first power unit is connected with the first ossification cavity through a first pipeline and used for injecting the ossification medium in the storage chamber into the first ossification cavity, and a second power unit is connected with the second ossification cavity through a second pipeline and used for injecting the ossification medium in the storage chamber into the second ossification cavity. And the second power unit is used for injecting the ossification medium in the storage chamber into the second ossification cavity. Different from the prior art, the system can truly reflect the lesion process of the cervical vertebra posterior longitudinal ligament ossification.

The invention discloses application of a phenolic acid derivative or a salt thereof in treatment of osteoarticular degenerative diseases, and particularly relates to a compound shown in the following formula A, the invention also relates to application of the pharmaceutically acceptable salt, the optical isomer, the crystal form, the hydrate, the solvate or the prodrug thereof in preparation of a pharmaceutical composition for treating or preventing degeneration of bone and / or arthritis. The compound provided by the invention can increase the generation of bone tissue collagen I, enhance the osteogenesis of bone tissues, increase the generation of articular cartilage collagen II and delay subchondral bone remodeling, so that the effect of protecting articular cartilage is achieved, and therefore, the compound can be used for preparing medicines for treating and / or preventing bone and joint degenerative diseases. # imgabs0 #

The invention relates to the technical field of medical biological materials, in particular to bone cement with an osteogenesis promoting effect and a preparation method of the bone cement. The invention provides application of enoxaparin sodium in preparation of a product with an osteogenesis effect. According to the invention, a natural polymer material chitosan (Chitosan, CS) is used as a drug sustained release carrier, enoxaparin sodium-chitosan drug-loaded microspheres are prepared by an emulsification cross-linking method, and the enoxaparin sodium-chitosan drug-loaded microspheres are compounded in a PMMA (polymethyl methacrylate) matrix to construct the novel enoxaparin sodium-chitosan-polymethyl methacrylate bone cement (ES-CS-PMMA). The bone cement prepared by the method can improve the bone volume fraction and the expression level of osteogenesis-related proteins BMP-2 and RUNX2, and has important biological significance and clinical application value for bone tissue regeneration and repair.

Aspects of the disclosure relate to compositions and methods for modulating bone growth, for example by increasing osteogenesis and / or decreasing osteoclastogenesis. The disclosure is based, in part, on recombinant adeno-associated virus (rAAV) vectors encoding microRNAs or miRNA inhibitors that inhibit endogenous miR-214-3p and / or mediate overexpression of miR-34a-5p in osteoblasts and osteoclasts. In some embodiments, compositions described by the disclosure are useful for treating certain bone diseases or disorders, such as osteoporosis.

The invention discloses a preparation method of a double-drug-loading antibacterial bone repair scaffold capable of inducing bone and blood vessel generation, and aims to provide a preparation method of a novel 3D printing multifunctional sodium alginate scaffold. The preparation method is characterized in that copper peptide molecules are grafted on the surfaces of the dopamine surface modified cellulose acetate microspheres through an EDC cross-linking effect, so that effective loading of copper peptide drugs is realized. The obtained cellulose acetate drug-loaded microspheres are dispersed in a sodium alginate solution for low-temperature 3D printing, and the printed stent is subjected to in-situ grafting with an alendronate sodium drug under the action of coordinate bonds in the Zn < 2 + > crosslinking process to obtain the double-drug-loaded stent. The preparation method has the characteristics that the prepared 3D printing double-drug-loading sodium alginate stent embedded with the cellulose acetate drug-loading microspheres can slowly release copper peptide, alendronate sodium drugs and Zn < 2 + > in a lasting manner, and is a multifunctional bone repair stent which has enhanced biological activity, mechanical properties and osteogenesis and excellent angiogenesis promoting and anti-infection capabilities at the same time.

The present invention is entitled "Inducing osteogenesis by delivering BMP encoding RNA". The present invention relates to a pharmaceutical composition comprising a polyribonucleotide (RNA) having a sequence encoding bone morphogenetic protein (BMP), the purpose of which is to (i) treat or prevent bone disease, bone disorder or bone injury in a patient; and / or (ii) induce or enhance osteogenic differentiation, osteogenesis, ossification, bone regeneration and / or bone morphogenesis. The present invention also relates to respective BMP encoding RNA (BMP RNA), in particular chemically modified forms thereof. The present invention also relates to complexes comprising BMP RNA or complexed with BMP RNA, in particular respective transfection complexes, such as lipofection, magnetofection and magnetic lipofection complexes. The present invention further relates to carriers and carrier bodies that have been loaded with RNA or complexes, and to pharmaceutical compositions comprising the carriers or carrier bodies. The present invention further relates to a matrix or scaffold for sustained mRNA delivery, and its use in in vivo, ex vivo and in vitro bone regeneration.

The present invention provides a system for monitoring ossification of an internally fixed bone fracture in a subject, comprising an implantable fixation device and an external wireless reader operable to transmit data regarding the relative load experienced by a bone plate across the fracture to a data server, where a trend in the increased bone support provided by the bone plate can be visualized. The implantable fixation device comprises a primary load sensor and a reference load sensor, wherein the load value from the reference load sensor can be used to normalize the load value from the primary load sensor. The external wireless reader is in wireless communication with the implantable fixation device and operable to receive a signal indicative of the load from each load sensor and to energize each load sensor via inductive charging.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a composition with an osteogenesis effect, which is prepared from the following raw materials in parts by weight: 15-45 parts of magnetic nanoparticles and 2-10 parts of aspartatide. According to the invention, the magnetic nanoparticles and the aspartatide are combined, and the nanoparticles magnetized in a magnetic field are coupled with the aspartatide, so that thickening of local alveolar bone can be promoted, and an excellent alveolar bone osteogenesis effect is achieved. The magnetic nanoparticles and the aspartatide are coupled and then act on the alveolar bone through hydrogel wrapping, the slow release effect can be achieved, the concentration of active ingredients in a treatment window is maintained, the curative effect is improved, the unstable curative effect caused by medicine concentration fluctuation is reduced, meanwhile, the administration frequency is reduced, the medication compliance of a patient is improved, and the treatment effect of the alveolar bone is improved. The practical popularization and application value is realized.

The present invention relates to a novel lappaconitine derivative and a pharmaceutically acceptable salt thereof, a preparation method therefor, and a medical use thereof using osteogenesis-promoting activity. The lappaconitine derivative induces the differentiation of stem cells into preosteoblasts, and increases bone density when administered to an osteoporosis animal model, and induces osteogenesis, and thus can be effectively used for preventing, alleviating, or treating bone-related diseases such as osteoporosis.

The invention provides a preparation method and application of a nano composite material compounded with a metal material and amino acid on the basis of polydopamine nano particles. According to the material, three elements are combined, the antibacterial, anti-inflammatory and osteogenesis promoting effects are achieved through the synergistic effect so as to treat periodontitis, the ROS removing function in the periodontitis environment is achieved, the obvious anti-oxidation / anti-inflammatory effect is achieved, meanwhile, growth of periodontitis bacteria can be more efficiently inhibited after NO gas is released, and the periodontitis treatment effect is achieved. And the metal ions contained in the nano composite material can realize the repair of bone tissues, so that the nano composite material has remarkable advantages compared with single nano particles formed by elements.

Aspects of the disclosure relate to compositions and methods for modulating bone growth, for example by increasing osteogenesis and / or decreasing osteoclastogenesis. The disclosure is based, in part, on recombinant adeno-associated virus (rAAV) vectors encoding microRNAs or miRNA inhibitors that inhibit expression or activity of gene products in the WNT pathway, for example Schnurri-3 (SHN3), sclerostin (SOST), and / or dickkopf-1 (DKK-1). In some embodiments, compositions described by the disclosure are useful for treating certain bone diseases, disorders, or injuries, such as alveolar bone loss and bone fractures.