8 results about "Ossification" patented technology

The application relates to the technical fields of medical image processing and artificial intelligence, and provides a bone age evaluation method and system based on an AI model and a bone age instrument. The left wrist X-ray image of a subject detected in the bone age instrument is acquired, and the demographic information of the subject is recorded. The detected left wrist X-ray image is pretreated through gray standardization, noise filtering and a self-supervised learning model. The Vision Transformer is used to extract the distal radius epiphysis and metaphysis width ratio, the third metacarpal metaphysis length and the auxiliary ossification point maturity grading skeletal features, and the multi-modal data fusion is carried out with the demographic information. The multi-layer perception model is used to predict the fused multi-dimensional bone age related data, and a bone age evaluation report is output, so that the error in the bone age prediction of children and adolescents is effectively reduced, and the detection efficiency is improved.

The application discloses a traditional Chinese medicine active activated bone growth type support implant material and a preparation method thereof, and relates to the technical field of medical materials.The traditional Chinese medicine active activated bone growth type support implant material is composed of an organic-inorganic composite porous antibacterial support and a medicinal efficacy filler.Co hollow spheres loaded with carbon nanotubes, sodium alginate, nano-hydroxyapatite and transition metal carbide nanosheets are cross-linked and compounded to form the organic-inorganic composite porous antibacterial support, which not only has good mechanical properties and antibacterial properties, but also can stably bear more medicinal efficacy fillers and slowly release the medicinal efficacy fillers, and the medicinal efficacy fillers further improve the stability of the support structure.The synergistic effect of the two can significantly enhance the antibacterial property and osteogenesis of the implant material, and excellent bone repair effect is achieved.

The invention belongs to the field of tissue regeneration materials, and relates to a 3D printing triboelectric material and application thereof in bone and cartilage defect repair. The material can be used as 3D printing ink for manufacturing a triboelectric bracket. The scaffold is prepared by taking biodegradable PGS as a matrix, PEDOT: PSS as a conductive component and sodium chloride as a pore-forming agent through combination of 3D printing and a salt particle pore-forming method, and has a multi-stage porous structure and excellent triboelectric properties. The wire diameter, interlayer spacing and micropore distribution of the stent are accurately regulated and controlled through the 3D printing technology, so that in-situ self-energized electrical stimulation of the stent is realized in an in-vivo dynamic mechanical environment; the scaffold can promote the BMSCs to differentiate into cartilage cells, construct tissue engineering cartilage and accelerate the process of ossification in cartilage, finally realizes efficient repair of bone and cartilage defects, is excellent in biocompatibility and biodegradable, does not need an external power supply device, and has a wide clinical transformation prospect in the field of bone and cartilage defect repair.

To provide methods for treating disease and disorders associated with pathological calcification or pathological ossification.SOLUTION: The method comprises administering a composition comprising at least one agent selected from the group consisting of Ecto-Nucleotide pyrophosphate / Phosphodiesterase-1 (NPP1) polypeptide and a fragment, derivative, mutant or mutant fragment thereof, and an activator of NPP1 polypeptide and a fragment, mutant or mutant fragment thereof. Preferably, the NPP1 polypeptide or a fragment, mutant or mutant fragment thereof is a soluble recombinant NPP1 polypeptide or a fragment, mutant or mutant fragment thereof.SELECTED DRAWING: Figure 1

The invention discloses a customized tibia prosthesis, and relates to the technical field of skeleton prostheses, the customized tibia prosthesis comprises a tibia prosthesis main body, the two opposite ends of the tibia prosthesis main body are both provided with positioning bosses, the section of each positioning boss is the same as the shape of a marrow cavity of a tibia backbone, and the positioning bosses are used for being embedded into the marrow cavity of the tibia backbone; the tibia artificial bone body further comprises a pore support and a solid support, the pore support is of a porous structure, and the solid support is fixedly connected with the pore support. And the dense pore structures of the positioning boss and the pore bracket are beneficial to promoting the formation of new bone tissues, so that the bone tissues can grow in each pore, and the tibia prosthesis has enough mechanical stability and long-term ossification support. The bone prosthesis has the technical effect of improving the adaptive positioning performance and stability of the bone prosthesis and the original bone.

The present invention relates to a novel lappaconitine derivative and a pharmaceutically acceptable salt thereof, a preparation method therefor, and a medical use thereof using osteogenesis-promoting activity. The lappaconitine derivative induces the differentiation of stem cells into preosteoblasts, and increases bone density when administered to an osteoporosis animal model, and induces osteogenesis, and thus can be effectively used for preventing, alleviating, or treating bone-related diseases such as osteoporosis.

This invention discloses a guidewire-connected negative electrode spinal fusion device system, comprising a fusion device body for mounting between the upper and lower vertebrae, supporting the upper and lower vertebrae and providing bone graft space; a screw-rod fixation mechanism for connecting to and fixing the upper and lower vertebrae on their sides; a positive electrode component for generating positive charge and located outside the bone graft space within the screw-rod fixation mechanism; a guidewire, with its two ends electrically connected to the fusion device body and the positive electrode component respectively; and a guidewire sleeve fitted over the guidewire. The system of this invention places the positive electrode component on the top wire and connects it to the fusion device body via the guidewire. The positive electrode component carries a negative charge on its surface, allowing it to directly contact the upper and lower vertebrae, effectively attracting calcium and phosphate ion deposition, activating osteoblast proliferation and differentiation, accelerating bone ingrowth and fusion, and promoting osteogenic growth. By placing the positive electrode component outside the bone graft space and not contacting the bone graft area, the problem of positive charge inhibiting osteogenic growth near the bone graft area is solved.

The application discloses a method for screening sika deer bone peptide segments and application of the peptide segments, and belongs to the technical field of peptide screening and application. According to the screening method, sika deer cancellous bone samples in five different development periods, i.e., an initial stage of tray shedding, a two-culm early stage, a two-culm stage, a four-culm stage and a complete ossification stage, are collected respectively; the sika deer cancellous bone samples in the five different development periods are mechanically broken respectively, protein extraction is carried out by using a lysis buffer, the extracted protein samples in the five different development periods are subjected to enzyme cutting treatment respectively, five peptide segment samples in the five different development periods are obtained, liquid chromatography-mass spectrometry is used for peptide segment separation and identification, six common difference peptide segments in comparative development periods are obtained, and specific difference peptide segments conforming to the periodic osteoporosis phenomenon of sika deer are screened out. According to the screening method, sika deer bone active peptides for treating osteoporosis can be obtained, and bone formation can be promoted and bone resorption can be inhibited.