Metal bone graft material with porous structure, and preparation and application thereof

A porous structure and bone grafting technology, applied in coatings, medical science, prostheses, etc., can solve the problems of complications in the bone harvesting area, limited amount of bone harvesting, lack of bone formation and osteoinductivity, lack of absorption speed, etc. , to achieve the effect of promoting crawling growth, excellent tensile strength, and promoting growth

Active Publication Date: 2015-08-05
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Autologous bone grafting is considered to be an ideal bone graft, but it inevitably has its limitations: complications in the bone harvesting area and limited amount of bone harvesting
[0005] For the existing bone filling materials, they do not have bone formation and osteoinductivity, and the osteoinductivity can only be improved by adding growth factors and bone morphogenetic proteins
At the same time, studies have found that some so-called resorbable bone fillers still exist after several years of implantation in the body. On the other hand, excessive resorption and lack of bone formation can also cause harmful consequences.

Method used

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  • Metal bone graft material with porous structure, and preparation and application thereof
  • Metal bone graft material with porous structure, and preparation and application thereof
  • Metal bone graft material with porous structure, and preparation and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0068] In this embodiment, the composition and weight percentage of the matrix alloy material are: Sr 1.5%, and the rest is magnesium. The alloy contains a small amount of impurity elements such as iron, nickel, aluminum and copper, each of which is not more than 0.1% by weight percentage, and the total amount is not more than 0.4%. The purity of the raw material Mg is not lower than 99.99wt%, and the purity of Sr is not lower than 99.99wt%. After 99~99.5% CO by volume 2 and 0.5~1.0%SF 6 (sulfur hexafluoride) high cleanliness melting and casting in protective atmosphere. In this embodiment, a porous structure with a pore arrangement angle of 60°, a pore diameter of 0.5 mm, and a porosity of 33.6% was prepared by machining the matrix alloy obtained according to the above preparation method. Then carry out micro-arc oxidation treatment, the voltage is 360V, the frequency is 1000Hz, the duty cycle is 30%, the time is 5 minutes, and the electrolyte composition is 0.8g / L stronti...

Embodiment 2

[0071] In this embodiment, the composition and weight percentage of the base alloy material are: 2% Si, and the rest is magnesium. The alloy contains a small amount of impurity elements such as iron, nickel, aluminum and copper, each of which is not more than 0.1% by weight percentage, and the total amount is not more than 0.4%. The purity of the raw material Mg is not lower than 99.99wt%, and the purity of Si is not lower than 99.99wt%. After 99~99.5% CO by volume 2 and 0.5~1.0%SF 6 (sulfur hexafluoride) high cleanliness melting and casting in protective atmosphere. In this example, a porous structure with a pore arrangement angle of 45°, a pore diameter of 0.5 mm, and a porosity of 36% was prepared by machining the matrix alloy obtained according to the above preparation method. Then carry out micro-arc oxidation treatment, the voltage is 400V, the frequency is 1000Hz, the duty cycle is 30%, the time is 5 minutes, and the electrolyte composition is 0.8g / L strontium hydrox...

Embodiment 3

[0074] In this embodiment, the composition and weight percentage of the base alloy material are: Sr 0.5%, Ca 1.0%, and the rest is magnesium. The alloy contains a small amount of impurity elements such as iron, nickel, aluminum and copper, each of which is not more than 0.1% by weight percentage, and the total amount is not more than 0.4%. The purity of the raw material Mg is not lower than 99.99wt%, the purity of Sr is not lower than 99.99wt%, and the purity of Ca is not lower than 99.75wt%. After 99~99.5% CO by volume 2 and 0.5~1.0%SF 6 (sulfur hexafluoride) high cleanliness melting and casting in protective atmosphere. In this example, a porous structure with a pore arrangement angle of 90°, a pore diameter of 0.5 mm, and a porosity of 40% was prepared by machining the matrix alloy obtained according to the above-mentioned preparation method ( Figure 5). Then carry out micro-arc oxidation treatment, the voltage is 400V, the frequency is 1000Hz, the duty cycle is 30%, t...

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Abstract

The invention relates to a metal bone graft material with a porous structure, and preparation and application thereof. The metal bone graft material is used as a filling material for transplantation after orthopaedic and oral damage and defects. The metal bone graft material contains the following trace elements in the human body by weight: 70.0 to 98.0 of Mg, 0.1 to 10.0% of Si, 0.1 to 10% of Sr and 0.1 to 10.0% of Ca, wherein the trace elements are uniformly distributed in a substrate and a coating. According to the invention, good ossification capability and matching in-vivo absorption capability are obtained by adjusting the contents of components in an alloy, controlling the shape, quantity and distribution of mesophase in metal, changing processing technology and surface coating protection of the alloy and preparing the porous structure; and the metal bone graft material has good biocompatibility and bone conduction capability, is a medical absorbent metal bone graft material with excellent mechanical properties, and is applicable to bone defects caused by wounds, malformation, bone tumors, osteomyelitis and joint displacement in clinical practice to promote bone restoration and applicable as a drug sustained release system.

Description

technical field [0001] The invention relates to the field of bone filling and repairing, in particular to a metal bone grafting material with a porous structure and its preparation and application, which is suitable as a filling material for orthopedics and oral injury and defect transplantation. Background technique [0002] Bone injury is the most common clinical trauma in medicine. Common bone injuries include: ordinary fractures, comminuted fractures, hip fractures, joint fractures, bone tumors, hand injuries, and skull injuries. According to reports, 18-20% of the total number of orthopedic surgeries performed worldwide each year require bone grafting, and bone grafting is also the most common tissue transplantation in clinical practice after blood transfusion. The repair of bone defects due to various reasons is a clinically challenging problem. Autologous bone grafting is considered to be an ideal bone graft, but it inevitably has its limitations: complications in th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C23/00C22C1/08A61L27/04A61L27/30A61L27/32A61L27/56A61L27/50
Inventor 万鹏韩军杰谭丽丽杨柯
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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