48 results about "Bone tumours" patented technology

The invention relates to a bone tumor repairing method based on three-dimensional reconstruction and a bionic structure. The method comprises the following steps: acquiring multi-modal medical image data of a bone tumor area of a patient to obtain an initial bone tumor three-dimensional model; generating a three-dimensional dynamic bone defect model for describing a bone tumor area based on the geometric structure of the initial bone tumor three-dimensional model; based on the three-dimensional dynamic bone defect model, generating a bionic implant three-dimensional model meeting bone defects; performing space alignment on the bionic implant three-dimensional model and the three-dimensional dynamic bone defect model to obtain a bone tumor repair model; carrying out restoration stability and osseointegration effect verification on the bone tumor restoration model to obtain a verification result; the verification result is used for indicating dynamic adjustment of the bionic implant three-dimensional model, and a final bone tumor repair three-dimensional model is obtained. By adopting the method, the accuracy, reliability and individuation level of bone tumor treatment can be improved.

The invention discloses a multi-modal bone tumor classification method and system based on blood biochemical text guidance. The method comprises the following steps: acquiring multi-modal data; constructing a blood biochemical text guide factor based on the blood biochemical marker; judging whether a bone tumor image or a pathological section image in the multi-modal data is missing or not, extracting a bone tumor image structure feature or a pathological section image feature when the bone tumor image or the pathological section image is not missing, generating a compensation feature of missing modal data when the bone tumor image or the pathological section image is missing, and compensating an image feature corresponding to the missing modal data; performing cross guide fusion on the bone tumor image structure features and the pathological section image features based on the blood biochemical text guide factors to obtain multi-modal fusion features; and calculating the probability of each bone tumor category according to the multi-modal fusion features through a linear classification layer to obtain a bone tumor classification result. According to the method, effective guidance and supplement of non-image information on image features are realized, and the accuracy and interpretability of a bone tumor classification result are improved.

The invention discloses copper selenide / tricalcium silicate bone cement. The bone cement comprises a liquid phase component and a solid phase component, the liquid phase component is water, and the solid phase component is tricalcium silicate powder and copper selenide nanoparticles. Compared with the existing tricalcium silicate bone cement, the tricalcium silicate bone cement has the advantages that by introducing a trace amount of copper selenide nanoparticles, not only can the hydration and coagulation time of tricalcium silicate be shortened, but also the porosity and degradation rate of the tricalcium silicate after coagulation and solidification can be reduced, the compressive strength can be improved, the stimulation effect on ALP activity of MC3T3-E1 cells can be enhanced, the survival rate of the MC3T3-E1 cells can be improved, and the application prospect is broad. The immunogenic apoptosis of K7M2-wt cells is promoted, and the tumor growth rate is reduced. Besides, the introduction of the copper selenide nanoparticles can also endow the tricalcium silicate bone cement with the performance of temperature rise under near-infrared light, so that in clinical application, the tricalcium silicate bone cement can be further combined with a near-infrared technology to realize ablation of bone tumors, and a new strategy is provided for treatment of the bone tumors.

The present application relates to a kind of self-setting composite bone implants based on gallic acid complex salt and preparation method thereof, belong to bone repair material field.The present application is specifically related to a kind of self-setting composite bone implants, it is characterized in that, component A, component B and component C, the component A is gallic acid and the complex salt of at least two metal elements, wherein the at least two metal elements are the metal element of promoting bone tissue regeneration or the trace metal element required by human body, and the at least two metal elements include calcium, the component B is the complex of calcium / strontium chondroitin sulfate and calcium sulfate, and the component C is magnesium calcium hydrogen phosphate complex.The self-setting composite bone implant of the present application has the characteristics of antibacterial, anti-inflammatory, promoting osteogenesis, instant shaping and all degradation, can meet the clinical needs of bone tumor, bone injury and the like, has wide application prospect in various bone repair, reconstruction and replacement.

The invention relates to a decision-making auxiliary system for a resection range of a bone tumor degradation region. The decision-making auxiliary system is used for modeling biological characteristics of metabolic activity, blood perfusion and tissue permeability reflected in different image modalities including PET / MRI (Positron Emission Tomography / Magnetic Resonance Imaging); using a space coupling modeling method to generate a functional activity gradient map in the degradation area, and mapping three layers of areas including a central focus, a diffusion boundary and a latent erosion zone; constructing a dynamic interval label mechanism, and forming a variable removal range space; dividing a gradient map generated based on an image into a plurality of different areas, performing joint modeling on each area and corresponding functional positioning parameters and pathological risk parameters, layering tissue structures of cortical bones, cancellous bones, marrow cavities and soft tissue boundaries, and generating a local resection profile cluster according to an anatomical axis; each section cluster is hooked with a single function / risk factor weight, and the whole excision body is re-simulated by adjusting excision target parameters; the excision boundary has the form adaptive capacity in the space, and personalized operation strategy customization and dynamic adjustment are achieved.

This invention discloses a method for preparing and using a long-acting antitumor organic and inorganic bone binder, which is prepared by polymerization, blending, and freeze-drying of porous calcium phosphate and antioxidant-grafted Tremella fuciformis polysaccharide hydrogel. The porous calcium phosphate is prepared by controlling its porous structure and composition to achieve degradation, thereby slowly releasing calcium ions, improving osteogenic properties, and achieving high bonding strength with human bone at the postoperative bone tumor defect site. Simultaneously, leveraging the high bonding strength and long-acting antitumor properties of the Tremella fuciformis polysaccharide hydrogel grafted with one or two antioxidants such as ascorbic acid, tea polyphenols, flavonoids, and tocopherols, the porous calcium phosphate and antioxidant-grafted Tremella fuciformis polysaccharide hydrogel are combined to form a covalently cross-linked network structure, further improving the bonding strength of the bone binder, promoting osteogenic properties with host bone tissue, and providing a long-lasting antitumor cycle.

The application provides a bone tumor classification model training method, a classification method and a system based on multi-view fusion, relates to the technical field of image data processing, and comprises the following steps: a training set containing bone tumor frontal and lateral images is constructed; a three-branch model containing a frontal prediction branch, a lateral prediction branch and a frontal-lateral fusion prediction branch is designed, single-view specific features are extracted through a single-view feature extraction module, and a cross attention mechanism is introduced through a double-view feature extraction module to fuse double-view features; the single-view feature extraction module and the double-view feature extraction module are independently optimized first, then the parameters thereof are fixed, only the classification head is fine-tuned, the classification loss and the consistency loss of the three branches are jointly optimized, and a bone tumor classification model is obtained, so that the benign and malignant classification of bone tumors can be obtained based on the frontal and lateral images of the bone tumors. The application can comprehensively capture the spatial features of bone tumors, deeply fuse the correlation information between multiple views, capture local dependency relationships and improve the classification accuracy.

The invention discloses a radiopharmaceutical for malignant bone tumors and metastatic bone tumors and a preparation method, and belongs to the technical field of radiopharmaceuticals. The preparation method comprises the following steps: firstly preparing a radionuclide stock solution of terbium and lutetium, then preparing a TP-18C6O3N3 stock solution, mixing the radionuclide stock solution with the TP-18C6O3N3 stock solution, and coordinating the radionuclide with the TP-18C6O3N3 to form a complex of terbium and lutetium labeled TP-18C6O3N3, thereby respectively preparing a terbium labeled complex solution and a lutetium labeled complex solution. And filtering, disinfecting and packaging the solution to obtain the radiopharmaceutical. The natural osteotropism of the phosphonic acid group is utilized, radionuclides are carried to reach a bone tumor focus area, and the radionuclides decay to release energy to kill tumor cells. The preparation process is simple, nuclide falling can be effectively reduced through the strong coordination capacity of the TP-18C6O3N3, the targeting property is remarkably improved, and the drug effect durability is remarkably improved.

The present invention discloses a photothermal bone tumor scaffold with controlled drug release, as well as its preparation method and application. The scaffold has two sets of curved, independently connected channels, with the outer channel being open and connected, and the inner channel being closed and connected. The scaffold is made of a Ca2MgSi2O7 / ZTA composite ceramic material. The preparation process involves adding ceramic slurry to a photocuring printing device, performing photocuring printing based on a photothermal bone tumor scaffold model to produce a ceramic blank, performing secondary curing on the blank to produce a ceramic green body, and sintering the green body to obtain the photothermal bone tumor scaffold. The scaffold provided by the present invention has high porosity and strength, possesses an independent dual-channel structure, and integrates multiple functions: osteogenesis, controlled release of chemotherapy drugs, and photothermal killing of bone tumor cells.

The invention relates to the field of bone repair, and discloses a 3D printing bone-imitating biological scaffold and a preparation method thereof.The preparation method comprises the steps that firstly, ammonium bromide is added into a mixture of deionized water and absolute ethyl alcohol, and an ammonium bromide solution is obtained; sequentially adding an ammonia solution, tetraethoxysilane, triethyl phosphate, calcium nitrate and sodium vanadate, continuously stirring, centrifuging, and collecting a precipitate; washing, aging, heating, cooling, grinding, crushing, and screening to obtain V-MBG powder; preparing a TA solution and a V-MBG solution, mixing and putting the TA solution and the V-MBG solution, and freeze-drying to obtain TA-coated V-MBG powder; preparing a trichloromethane solution of PLGA (poly (lactic-co-glycolic acid)), adding the V-MBG powder, fully stirring, and pumping out the trichloromethane solution to obtain solid slurry; printing an inner-layer stent and a hollow-tube outer-layer stent to obtain a bone-imitating biological stent, and soaking the bone-imitating biological stent in a TA solution to obtain a PLGA / TA-V-MBG composite stent; the problems that in the prior art, the bone repairing effect is poor, the bone-like cell proliferation and differentiation effect is poor, and bone defect repairing caused by bone tumor treatment cannot be achieved are solved.

The application discloses a kind of multi-modal bone tumor classification method and system based on blood biochemical text guide, the method includes the following steps: obtaining multi-modal data;Blood biochemical markers are used to construct blood biochemical text guide factor;Determine whether the bone tumor image or pathological section image in multi-modal data is missing, when not missing, the bone tumor image structure feature or pathological section image feature is extracted, when missing, the compensation feature of missing modal data is generated, and the image feature corresponding to the compensation of missing modal data is extracted;Blood biochemical text guide factor is used to cross guide fusion on bone tumor image structure feature and pathological section image feature, and multi-modal fusion feature is obtained;The probability of each bone tumor category is calculated by linear classification layer to multi-modal fusion feature, and bone tumor classification result is obtained.The application realizes the effective guidance and supplement of non-image information to image feature, and improves the accuracy and explainability of bone tumor classification result.

The invention discloses an integrated bone marrow microenvironment-bone tumor organoid micro-fluidic chip, and relates to the technical field of bone tumor in-vitro research models, the key points of the technical scheme are as follows: the chip is of a double-layer structure, is separated by a porous membrane in the middle, and is matched with a micro-fluidic structure formed by combining a plurality of cavities; the multiple chambers comprise a tumor organ chamber, a blood vessel communication chamber and a marrow chamber; the bone marrow upper-layer chamber and the bone marrow lower-layer chamber are separated by a porous membrane, the bone marrow upper-layer chamber is a nutrition supply layer, the bone marrow lower-layer chamber is a cell culture layer, and the porous membrane allows gradient diffusion of micromolecule nutrition / cell factors, so that nutrition supply of the bone marrow upper-layer chamber to the bone marrow lower-layer chamber is realized. The chip can reproduce a complex three-dimensional structure of the BMME, realizes dynamic microenvironment control and real-time visual monitoring, and provides a more accurate in-vitro model for research of bone tumor organs.

The invention relates to the technical field of medical instruments, and discloses a bone tumor pathological tissue sampling device integrated with a cutting function, which comprises a left side shell and a right side shell which are connected through a screw, and also comprises a cutting assembly and a tumor sampling assembly, the front ends of the left side shell and the right side shell are connected with end covers through screws, the end faces of the end covers are fixedly connected with sleeves, and the outer walls of the sleeves are fixedly connected with lug blocks and side blocks. Sampling and cutting functions are ingeniously combined, after cutting is completed, a buckle plate is pulled to drive a string, a micro winch and other parts, so that a biting block rotates around a vertical shaft to be close to a cutting blade, the biting block and the cutting blade are matched to bite tumor pathological tissue, and sawteeth on the side edge of the biting block facilitate easy sampling; by means of the integrated design, the sampling process of bone tumor pathological tissue is effectively simplified, the tedious step of switching multiple tools in traditional operation is avoided, and the sampling efficiency is greatly improved.

The application discloses a 3D printing long bone osteotomy guide plate, and belongs to the technical field of orthopedic medical instruments. The 3D printing long bone osteotomy guide plate comprises a guide plate main body, the guide plate main body comprises a tumor fixing part, an osteotomy guiding part and an intermediate connecting part, the tumor fixing part and the osteotomy guiding part are fixedly connected through the intermediate connecting part, the tumor fixing part is in a spherical shape, the inner side of the tumor fixing part is in close contact with the outer surface of a long bone tumor, the osteotomy guiding part is clamped at the connecting position of the long bone and the long bone tumor, and the long bone tumor is cut off from the side of the osteotomy guiding part away from the tumor fixing part. The tumor fixing part is in close contact with the irregular shape of the tumor surface, the edge of the osteotomy guiding part is designed according to the direction of the osteotomy line, the guide plate is stably and closely combined with the bone and the tumor surface, sliding or misplacement is avoided, more accurate surgical positioning is provided for clinical doctors, the structure is simple, the operation is convenient, and the guide plate is suitable for large-scale popularization and application.

The present application relates to a kind of distal anchoring bone cement type prosthesis stem, including stem body, several anchoring blades and piston.The bottom end of the stem body is fixed on prosthesis, top end is inserted into medullary cavity, bone cement channel is provided in the stem body along the axial direction, injection hole is formed on the side wall of the stem body, and the injection hole is communicated with the bone cement channel;The anchoring blade is arranged at the top of the stem body, the bottom of the anchoring blade is rotatably connected with the top end of the stem body, the piston is sleeved in the bone cement channel, and under the driving of bone cement, it slides upward, when the piston slides to the top of the stem body, several anchoring blades are opened, and the anchoring blade is converted from the first state to the second state.The distal anchoring bone cement type prosthesis stem can improve the long-term stability of tumor type prosthesis, reduce the aseptic loosening of prosthesis, and improve the long-term function of limb of patients with malignant bone tumor.

The invention belongs to the field of nuclear medicine imaging agents, and relates to an LAT1 targeted phosphoramidated tyrosine PET molecular probe as well as a preparation method and application thereof. The probe has a structure as shown in a formula I. The LAT1-targeted phosphoramidated tyrosine PET molecular probe provided by the invention can be used for high-specificity uptake of bones, and has excellent in-vivo metabolism performance and bone uptake retention capacity. The targeted PET molecular probe provided by the invention has a clear tumor ratio, can be rapidly metabolized out of a body through a kidney, and has important application value for early and accurate diagnosis of bone tumors and bone metastatic tumors.

The invention relates to the technical field of medical equipment, in particular to a rib bone fracture plate, a limiting and fixing assembly and a lock catch assembling method of the limiting and fixing assembly, and is suitable for internal fixation after rib fracture or rib bone tumor excision. The rib bone fracture plate is assembled in a combined mode and can be assembled and used according to the requirements of different patients, the left encircling claw and the right encircling claw reinforce fixation, and the adjustable moving claw is installed according to different positions of the affected bone so that the requirement for fixing the ribs of the patients with comminuted fractures can be met. The movable claw is mainly used for fixing broken bone blocks in rib fracture fixation, the lower plane of the cross beam makes contact with the broken bone blocks and provides a fixing face, and the movable claw fixes the broken bone blocks left and right to achieve the mechanical fixing effect of the broken bone blocks.

The utility model discloses a perioperative nursing turning-over auxiliary device for orthopedic bone tumor patients, and aims to solve the problems that an existing triangular pillow needs to be operated by multiple persons in a matched mode, and the state that the bone tumor patients are almost completely disabled in clinical nursing is difficult to deal with. The device comprises an elastic cushion body, and the elastic cushion body comprises an insertion bucket part used for being inserted into the back of a patient, a pressure-bearing supporting part connected with the insertion bucket part, an abutting part connected with the pressure-bearing supporting part and a plane arranged at the end of the abutting part. According to the utility model, the insertion bucket part is inserted into the back of a patient until the insertion bucket part is exposed, and then the patient is lightly and slowly turned over, due to the existence of the pressure-bearing supporting part, the body of the patient is always supported in the turning-over process, and the abutting part abuts against the body until the patient finishes the turning-over action, so that the patient can turn over more stably. And the whole operation can be completed by one medical worker, so that the working efficiency of the medical worker is greatly improved.

The invention relates to the technical field of nano materials, and discloses a composite nano material as well as a preparation method and application thereof. The composite nano material is of a core-shell structure and comprises BiVO4 nano particles as a core; the MnO2 layer is coated on the surfaces of the BiVO4 nano particles; and the alendronate is used for modifying the outer part of the MnO2 layer. The composite nanomaterial can obviously inhibit the growth of bone tumors, has a good analgesic effect on mechanical pain and cold and heat pain, and has no obvious side effect after treatment. The pharmaceutical preparation provided by the invention has the advantages that the raw materials are easy to obtain, and the pharmaceutical preparation has a good application prospect in preparation of drugs with dual effects of resisting tumors and relieving pain.

The invention belongs to biomedical materials and application thereof, and particularly relates to a bionic bone scaffold with the surface modified with MXene as well as a preparation method and application of the bionic bone scaffold. The bionic bone scaffold is a porous Si3N4 scaffold, and MXene is loaded on the surface of the porous Si3N4 scaffold through an impregnation method. The preparation method comprises the following specific preparation steps: uniformly mixing hydrochloric acid, lithium fluoride and niobium aluminum carbide, carrying out a reaction, carrying out centrifugal washing, and then carrying out ultrasonic stripping and differential centrifugation to obtain a d-Nb2CTx nanosheet suspension; preparing the Si3N4 slurry into a green body bracket by utilizing 3D printing, and discharging glue, sintering, cleaning and drying to obtain a Si3N4 bracket; after ascorbic acid is added into the nanosheet suspension liquid, the Si3N4 support is put into the suspension liquid to be soaked and dried, and the bionic bone support with the surface modified with MXene is obtained. The bionic bone scaffold prepared by the invention can inhibit residual tumor cells while meeting the requirement of tissue reconstruction at a bone tumor defect, and has a good application prospect.

The invention relates to the technical field of medical instruments, and discloses a combined minimally invasive instrument auxiliary bone tumor precise biopsy device and a focus sampling method.The combined minimally invasive instrument auxiliary bone tumor precise biopsy device comprises a tool apron, the top of the tool apron is rotationally connected with a protective shell, the interior of the tool apron is slidably connected with six cutters, and a dust collecting mechanism is arranged between every two cutters; a connecting cylinder is fixedly connected to the interior of the tool apron, a sampling needle is slidably connected to the interior of the connecting cylinder, an unfolding mechanism is arranged on the outer side of the connecting cylinder, a driving mechanism is arranged at the top of the connecting cylinder, the unfolding mechanism comprises a fixed ring and a sliding ring, and the inner side of the fixed ring is fixedly connected to the outer side of the connecting cylinder; the sliding ring is slidably connected to the outer side of the connecting cylinder through an inner side protruding block, and the inner side protruding block of the sliding ring abuts against the outer side of the sampling needle. According to the invention, through a linkage structure unfolded by the tool bit, accurate fixation of a cutting part is realized, a stable channel is opened up for the sampling needle, the sampling needle is ensured to directly reach a focus, and the sampling accuracy and stability are effectively improved.

The invention provides an ROS (reactive oxygen species) response paclitaxel lipid prodrug, a carboxyl liposome and a carboxyl solid lipid preparation. The ROS-responsive paclitaxel lipid prodrug disclosed by the invention has good tumor inflammation environmental response capability, keeps a prodrug structure in a normal physiological environment, releases a parent drug paclitaxel at a high active oxygen site in tumors or inflammations, improves the biological activity of the drug, and reduces systemic side effects at the same time. The carboxyl lipidosome can be used for preparing a lipid nanoparticle preparation with carboxyl on the surface, the carboxyl has a certain bone targeting property due to the calcium ion chelating ability, and meanwhile, the pKa of the carboxyl is smaller than that of a physiological environment, so that the surface of the carboxyl has electronegativity and is not easily adsorbed with in-vivo protein; due to the characteristics, the nano-material has excellent targeting property and stability in vivo. The preparation method of the carboxyl solid lipid preparation is mild in condition, simple and easy to implement, the carboxyl solid lipid preparation can be efficiently enriched at the bone tumor part, paclitaxel is continuously released at the bone tumor part, and tumors are efficiently inhibited.

The application discloses a perspective image analysis method for bionic repair of bone tumors, comprising the following steps: acquiring perspective image data of a bone tumor area; performing cross-modal feature alignment on the data, constructing a three-dimensional bone tumor image model in a three-dimensional voxel space coordinate system, and eliminating image artifacts; performing segmentation processing on the bone tumor through a deep learning segmentation network, identifying a bone tumor infiltration boundary, and acquiring three-dimensional morphological parameters and bone tumor characteristic parameters of the bone tumor area; reconstructing a bionic scaffold structure of a bone defect area through biomechanical modeling, and implanting the bionic scaffold into the bone tumor area; and acquiring bone-scaffold interface fusion rate, stress distribution uniformity and new bone growth depth indexes based on postoperative image data. The application has the advantages that: through the combination of accurate segmentation at the voxel level and a convolutional neural network, the bone tumor area and morphology can be accurately identified and divided, thereby providing reliable support for subsequent tumor infiltration evaluation and bionic scaffold design.

This invention discloses a 3D-printed biodegradable drug-loaded artificial bone repair scaffold, belonging to the field of orthopedic implant technology. The scaffold adopts a gradient porous structure and biodegradable composite material, with internal through-holes and tapered interfaces on the surface, which can load drugs for sustained release. It also has functions of bone induction, anti-infection, mechanical support and prosthesis adaptation, and is suitable for individualized repair of large bone defects after bone tumor resection.

This invention discloses a multi-level semantically guided bone tumor image segmentation method, belonging to the field of medical image processing technology. The method first completes the spatial alignment and coordinate unification of CT and MR images through affine registration and spatial resampling based on mutual information, and simultaneously performs image preprocessing by enhancing the CT and MR image data. A 3D SwinUNETR encoder is used to extract multi-scale spatial features from the registered and aligned bone tumor CT and MR images, and a 3D bidirectional cross-attention fusion mechanism is used to achieve complementary fusion of multimodal features within the same lesion region. Simultaneously, a multi-level semantic guidance path is constructed, embedding class-level and case-level textual semantics into a dynamic controller, which, together with the multimodal image fusion features, is input into a multilayer perceptron to predict and generate dynamic convolutional kernel parameters with strong semantic directionality. This enables adaptive weighting and region focusing of the decoded feature map of the CT image, and finally outputs a semantically guided corrected bone tumor prediction mask. Experimental results show that this invention effectively improves the model's ability to jointly represent the complex morphological structure and multidimensional clinical semantics of bone tumor lesions, significantly enhances the segmentation accuracy of bone tumors under conditions of blurred lesion boundaries and scarce samples, and exhibits excellent generalization performance in independent validation set tests. This method achieves a Dessian similarity coefficient of 0.87 on bone tumor datasets, making it suitable for bone tumor assisted localization and surgical planning needs.

The invention discloses an internal expansion sheathing canal for a bone tumor operation, and relates to the technical field of medical instruments. In order to solve the problems that the operation space is narrow, the operation is limited and the operation space is influenced by the traction of muscular tissues due to non-natural cavities such as muscles when a bone surface tumor is treated by the existing minimally invasive surgery technology, the following technical scheme is provided: the internal expansion sheathing canal for the bone tumor operation comprises a sheathing canal body, the sheathing canal body comprises an inner sheath and an outer sheath which are in threaded connection, and the inner sheath and the outer sheath rotate relatively to adjust the length of the sheathing canal body; a supporting piece is arranged at the end, away from the threads, of the inner sheath and comprises a plurality of supporting walls capable of being elastically deformed, and a locking end cover is arranged at the end, away from the supporting piece, of the outer sheath and used for locking and fixing an instrument inserted into the sheathing canal body. A stable operation space can be actively and minimally invasively established, the length is adjustable, locking is reliable, smoke can be prevented from overflowing through the sealing piece, and the safety and convenience of an operation are improved.

The invention belongs to the technical field of medical biological materials, and discloses a drug-loaded porous pure zinc scaffold as well as a preparation method and application thereof. The drug-loaded porous pure zinc scaffold comprises a porous pure zinc scaffold, the porous pure zinc scaffold is loaded with a traditional Chinese medicine composition; the porous pure zinc scaffold is of a periodic straight rod lattice structure, the rod diameter is 300 microns, and the pore diameter is 400 microns; the traditional Chinese medicine composition comprises eucommia ulmoides, dragon's blood, fructus psoraleae, scorpio, rhizoma drynariae and prepared rehmannia root. According to the drug-loaded porous pure zinc scaffold, mechanical supporting and bone conduction are achieved through structural bionic design, pure zinc is degraded to release zinc ions to achieve the osteogenesis, anti-inflammatory and antibacterial effects, the traditional Chinese medicine composition regulates bone metabolism and the microenvironment in a multi-target mode, and the three components cooperate to construct a scaffold-ion-drug three-in-one bone repair system; the method is especially suitable for bone defects caused by osteoporosis, osteoarthritis, bone tumors, traumatic fractures and the like, and has a wide clinical application prospect.

The application provides a beta-TCP / PLGA support sustained-release body loaded with Cu-based nanoscale enzyme and a preparation method, a 3D model of a microstructure of a bone defect is established by measuring bone structure parameters, and a personalized beta-TCP / PLGA support is printed by using beta-TCP / PLGA printing materials through a 3D bioprinter technology. The beta-TCP / PLGA support is immersed in a Cu-HCF nanoscale enzyme solution, so that the beta-TCP / PLGA support is loaded with Cu-HCF nanoscale enzyme, thereby preparing a Cu-HCF nanoscale enzyme beta-TCP / PLGA sustained-release support. In a tumor and inflammatory microenvironment, the enzyme reaction can selectively kill tumor and inflammatory cells, and can protect normal tissues, reduce the possibility of recurrence of bone tumors and inflammation at the bone defect, and avoid possible side effects of drugs on the human body. As a kind of bionic bone support, the beta-TCP / PLGA sustained-release support has good mechanical strength and biodegradability, and also has the effect of keeping a long-acting and stable drug release, can improve the directionality and reduce the toxic side effects. The material cost of the beta-TCP / PLGA sustained-release support is moderate and relatively easy to prepare, and has good mass production prospects and economic applicability.

The application relates to a bone cement material and a preparation method and application thereof, and belongs to the technical field of bone tumor treatment medical devices. The preparation method comprises the following steps: 1) preparing a hydroxyapatite suspension liquid and mixing with an adriamycin diluent, adding ammonia water to adjust the pH value to be not less than 8.5, stirring uniformly after adding an adhesive to obtain component A; 2) preparing a coupling reaction of 4-bromomethyl phenyl boronic acid and a third-generation polyamidoamine dendritic polymer to obtain G3-PBA, adding quercetin into the G3-PBA solution, and obtaining component B after ultrasonic dissolution; and 3) preparing calcium phosphate powder, mixing with component B, stirring uniformly, and then manually stirring uniformly after adding component A to obtain the bone cement material. The quercetin in the bone cement material can be quickly released, effectively antibacterial, and conducive to early bone healing by regulating immunity, and the adriamycin can be long-acting released and has no long-term residue, so that the bone cement material also has a long-acting bone tumor treatment effect.