25 results about "Bone tumours" patented technology

The present application relates to a kind of self-setting composite bone implants based on gallic acid complex salt and preparation method thereof, belong to bone repair material field.The present application is specifically related to a kind of self-setting composite bone implants, it is characterized in that, component A, component B and component C, the component A is gallic acid and the complex salt of at least two metal elements, wherein the at least two metal elements are the metal element of promoting bone tissue regeneration or the trace metal element required by human body, and the at least two metal elements include calcium, the component B is the complex of calcium / strontium chondroitin sulfate and calcium sulfate, and the component C is magnesium calcium hydrogen phosphate complex.The self-setting composite bone implant of the present application has the characteristics of antibacterial, anti-inflammatory, promoting osteogenesis, instant shaping and all degradation, can meet the clinical needs of bone tumor, bone injury and the like, has wide application prospect in various bone repair, reconstruction and replacement.

This invention discloses a method for preparing and using a long-acting antitumor organic and inorganic bone binder, which is prepared by polymerization, blending, and freeze-drying of porous calcium phosphate and antioxidant-grafted Tremella fuciformis polysaccharide hydrogel. The porous calcium phosphate is prepared by controlling its porous structure and composition to achieve degradation, thereby slowly releasing calcium ions, improving osteogenic properties, and achieving high bonding strength with human bone at the postoperative bone tumor defect site. Simultaneously, leveraging the high bonding strength and long-acting antitumor properties of the Tremella fuciformis polysaccharide hydrogel grafted with one or two antioxidants such as ascorbic acid, tea polyphenols, flavonoids, and tocopherols, the porous calcium phosphate and antioxidant-grafted Tremella fuciformis polysaccharide hydrogel are combined to form a covalently cross-linked network structure, further improving the bonding strength of the bone binder, promoting osteogenic properties with host bone tissue, and providing a long-lasting antitumor cycle.

The invention discloses a radiopharmaceutical for malignant bone tumors and metastatic bone tumors and a preparation method, and belongs to the technical field of radiopharmaceuticals. The preparation method comprises the following steps: firstly preparing a radionuclide stock solution of terbium and lutetium, then preparing a TP-18C6O3N3 stock solution, mixing the radionuclide stock solution with the TP-18C6O3N3 stock solution, and coordinating the radionuclide with the TP-18C6O3N3 to form a complex of terbium and lutetium labeled TP-18C6O3N3, thereby respectively preparing a terbium labeled complex solution and a lutetium labeled complex solution. And filtering, disinfecting and packaging the solution to obtain the radiopharmaceutical. The natural osteotropism of the phosphonic acid group is utilized, radionuclides are carried to reach a bone tumor focus area, and the radionuclides decay to release energy to kill tumor cells. The preparation process is simple, nuclide falling can be effectively reduced through the strong coordination capacity of the TP-18C6O3N3, the targeting property is remarkably improved, and the drug effect durability is remarkably improved.

The invention discloses an integrated bone marrow microenvironment-bone tumor organoid micro-fluidic chip, and relates to the technical field of bone tumor in-vitro research models, the key points of the technical scheme are as follows: the chip is of a double-layer structure, is separated by a porous membrane in the middle, and is matched with a micro-fluidic structure formed by combining a plurality of cavities; the multiple chambers comprise a tumor organ chamber, a blood vessel communication chamber and a marrow chamber; the bone marrow upper-layer chamber and the bone marrow lower-layer chamber are separated by a porous membrane, the bone marrow upper-layer chamber is a nutrition supply layer, the bone marrow lower-layer chamber is a cell culture layer, and the porous membrane allows gradient diffusion of micromolecule nutrition / cell factors, so that nutrition supply of the bone marrow upper-layer chamber to the bone marrow lower-layer chamber is realized. The chip can reproduce a complex three-dimensional structure of the BMME, realizes dynamic microenvironment control and real-time visual monitoring, and provides a more accurate in-vitro model for research of bone tumor organs.

The application discloses a 3D printing long bone osteotomy guide plate, and belongs to the technical field of orthopedic medical instruments. The 3D printing long bone osteotomy guide plate comprises a guide plate main body, the guide plate main body comprises a tumor fixing part, an osteotomy guiding part and an intermediate connecting part, the tumor fixing part and the osteotomy guiding part are fixedly connected through the intermediate connecting part, the tumor fixing part is in a spherical shape, the inner side of the tumor fixing part is in close contact with the outer surface of a long bone tumor, the osteotomy guiding part is clamped at the connecting position of the long bone and the long bone tumor, and the long bone tumor is cut off from the side of the osteotomy guiding part away from the tumor fixing part. The tumor fixing part is in close contact with the irregular shape of the tumor surface, the edge of the osteotomy guiding part is designed according to the direction of the osteotomy line, the guide plate is stably and closely combined with the bone and the tumor surface, sliding or misplacement is avoided, more accurate surgical positioning is provided for clinical doctors, the structure is simple, the operation is convenient, and the guide plate is suitable for large-scale popularization and application.

The present application relates to a kind of distal anchoring bone cement type prosthesis stem, including stem body, several anchoring blades and piston.The bottom end of the stem body is fixed on prosthesis, top end is inserted into medullary cavity, bone cement channel is provided in the stem body along the axial direction, injection hole is formed on the side wall of the stem body, and the injection hole is communicated with the bone cement channel;The anchoring blade is arranged at the top of the stem body, the bottom of the anchoring blade is rotatably connected with the top end of the stem body, the piston is sleeved in the bone cement channel, and under the driving of bone cement, it slides upward, when the piston slides to the top of the stem body, several anchoring blades are opened, and the anchoring blade is converted from the first state to the second state.The distal anchoring bone cement type prosthesis stem can improve the long-term stability of tumor type prosthesis, reduce the aseptic loosening of prosthesis, and improve the long-term function of limb of patients with malignant bone tumor.

The invention belongs to the field of nuclear medicine imaging agents, and relates to an LAT1 targeted phosphoramidated tyrosine PET molecular probe as well as a preparation method and application thereof. The probe has a structure as shown in a formula I. The LAT1-targeted phosphoramidated tyrosine PET molecular probe provided by the invention can be used for high-specificity uptake of bones, and has excellent in-vivo metabolism performance and bone uptake retention capacity. The targeted PET molecular probe provided by the invention has a clear tumor ratio, can be rapidly metabolized out of a body through a kidney, and has important application value for early and accurate diagnosis of bone tumors and bone metastatic tumors.

The invention relates to the technical field of nano materials, and discloses a composite nano material as well as a preparation method and application thereof. The composite nano material is of a core-shell structure and comprises BiVO4 nano particles as a core; the MnO2 layer is coated on the surfaces of the BiVO4 nano particles; and the alendronate is used for modifying the outer part of the MnO2 layer. The composite nanomaterial can obviously inhibit the growth of bone tumors, has a good analgesic effect on mechanical pain and cold and heat pain, and has no obvious side effect after treatment. The pharmaceutical preparation provided by the invention has the advantages that the raw materials are easy to obtain, and the pharmaceutical preparation has a good application prospect in preparation of drugs with dual effects of resisting tumors and relieving pain.

The application discloses a perspective image analysis method for bionic repair of bone tumors, comprising the following steps: acquiring perspective image data of a bone tumor area; performing cross-modal feature alignment on the data, constructing a three-dimensional bone tumor image model in a three-dimensional voxel space coordinate system, and eliminating image artifacts; performing segmentation processing on the bone tumor through a deep learning segmentation network, identifying a bone tumor infiltration boundary, and acquiring three-dimensional morphological parameters and bone tumor characteristic parameters of the bone tumor area; reconstructing a bionic scaffold structure of a bone defect area through biomechanical modeling, and implanting the bionic scaffold into the bone tumor area; and acquiring bone-scaffold interface fusion rate, stress distribution uniformity and new bone growth depth indexes based on postoperative image data. The application has the advantages that: through the combination of accurate segmentation at the voxel level and a convolutional neural network, the bone tumor area and morphology can be accurately identified and divided, thereby providing reliable support for subsequent tumor infiltration evaluation and bionic scaffold design.

This invention discloses a 3D-printed biodegradable drug-loaded artificial bone repair scaffold, belonging to the field of orthopedic implant technology. The scaffold adopts a gradient porous structure and biodegradable composite material, with internal through-holes and tapered interfaces on the surface, which can load drugs for sustained release. It also has functions of bone induction, anti-infection, mechanical support and prosthesis adaptation, and is suitable for individualized repair of large bone defects after bone tumor resection.

This invention discloses a multi-level semantically guided bone tumor image segmentation method, belonging to the field of medical image processing technology. The method first completes the spatial alignment and coordinate unification of CT and MR images through affine registration and spatial resampling based on mutual information, and simultaneously performs image preprocessing by enhancing the CT and MR image data. A 3D SwinUNETR encoder is used to extract multi-scale spatial features from the registered and aligned bone tumor CT and MR images, and a 3D bidirectional cross-attention fusion mechanism is used to achieve complementary fusion of multimodal features within the same lesion region. Simultaneously, a multi-level semantic guidance path is constructed, embedding class-level and case-level textual semantics into a dynamic controller, which, together with the multimodal image fusion features, is input into a multilayer perceptron to predict and generate dynamic convolutional kernel parameters with strong semantic directionality. This enables adaptive weighting and region focusing of the decoded feature map of the CT image, and finally outputs a semantically guided corrected bone tumor prediction mask. Experimental results show that this invention effectively improves the model's ability to jointly represent the complex morphological structure and multidimensional clinical semantics of bone tumor lesions, significantly enhances the segmentation accuracy of bone tumors under conditions of blurred lesion boundaries and scarce samples, and exhibits excellent generalization performance in independent validation set tests. This method achieves a Dessian similarity coefficient of 0.87 on bone tumor datasets, making it suitable for bone tumor assisted localization and surgical planning needs.

The invention belongs to the technical field of medical biological materials, and discloses a drug-loaded porous pure zinc scaffold as well as a preparation method and application thereof. The drug-loaded porous pure zinc scaffold comprises a porous pure zinc scaffold, the porous pure zinc scaffold is loaded with a traditional Chinese medicine composition; the porous pure zinc scaffold is of a periodic straight rod lattice structure, the rod diameter is 300 microns, and the pore diameter is 400 microns; the traditional Chinese medicine composition comprises eucommia ulmoides, dragon's blood, fructus psoraleae, scorpio, rhizoma drynariae and prepared rehmannia root. According to the drug-loaded porous pure zinc scaffold, mechanical supporting and bone conduction are achieved through structural bionic design, pure zinc is degraded to release zinc ions to achieve the osteogenesis, anti-inflammatory and antibacterial effects, the traditional Chinese medicine composition regulates bone metabolism and the microenvironment in a multi-target mode, and the three components cooperate to construct a scaffold-ion-drug three-in-one bone repair system; the method is especially suitable for bone defects caused by osteoporosis, osteoarthritis, bone tumors, traumatic fractures and the like, and has a wide clinical application prospect.

The application provides a beta-TCP / PLGA support sustained-release body loaded with Cu-based nanoscale enzyme and a preparation method, a 3D model of a microstructure of a bone defect is established by measuring bone structure parameters, and a personalized beta-TCP / PLGA support is printed by using beta-TCP / PLGA printing materials through a 3D bioprinter technology. The beta-TCP / PLGA support is immersed in a Cu-HCF nanoscale enzyme solution, so that the beta-TCP / PLGA support is loaded with Cu-HCF nanoscale enzyme, thereby preparing a Cu-HCF nanoscale enzyme beta-TCP / PLGA sustained-release support. In a tumor and inflammatory microenvironment, the enzyme reaction can selectively kill tumor and inflammatory cells, and can protect normal tissues, reduce the possibility of recurrence of bone tumors and inflammation at the bone defect, and avoid possible side effects of drugs on the human body. As a kind of bionic bone support, the beta-TCP / PLGA sustained-release support has good mechanical strength and biodegradability, and also has the effect of keeping a long-acting and stable drug release, can improve the directionality and reduce the toxic side effects. The material cost of the beta-TCP / PLGA sustained-release support is moderate and relatively easy to prepare, and has good mass production prospects and economic applicability.

The application relates to a bone cement material and a preparation method and application thereof, and belongs to the technical field of bone tumor treatment medical devices. The preparation method comprises the following steps: 1) preparing a hydroxyapatite suspension liquid and mixing with an adriamycin diluent, adding ammonia water to adjust the pH value to be not less than 8.5, stirring uniformly after adding an adhesive to obtain component A; 2) preparing a coupling reaction of 4-bromomethyl phenyl boronic acid and a third-generation polyamidoamine dendritic polymer to obtain G3-PBA, adding quercetin into the G3-PBA solution, and obtaining component B after ultrasonic dissolution; and 3) preparing calcium phosphate powder, mixing with component B, stirring uniformly, and then manually stirring uniformly after adding component A to obtain the bone cement material. The quercetin in the bone cement material can be quickly released, effectively antibacterial, and conducive to early bone healing by regulating immunity, and the adriamycin can be long-acting released and has no long-term residue, so that the bone cement material also has a long-acting bone tumor treatment effect.

The application discloses a preparation method of a dual-response copper death nanoparticle material, and belongs to the technical field of nanometer materials.The method comprises the following steps: dissolving BSA to obtain solution A, mixing a sodium citrate solution and CuCl2 to obtain solution B, dropping the solution B into the solution A, dropping Na2S*9H2O, stirring and reacting, dialyzing and freeze-drying to obtain Cu2S@BSA; dissolving TEA, CTAB and NaSal to obtain solution C, then dropping a mixture of TEOS and BTESPTS into the solution C, removing a template after reaction to obtain MSN; mixing and stirring the MSN and the Cu2S@BSA to load, to obtain MSN@Cu2S; dissolving dextran into deionized water, adding sodium periodate, stirring and reacting in the dark, then adding glycerol to stop oxidation to obtain oDEX; and (5) dissolving the MSN@Cu2S, adding the oDEX to carry out capping treatment to obtain MD@Cu2S. The application also discloses the MD@Cu2S obtained by the preparation method and application of the MD@Cu2S in preparation of a drug for bone tumor or bone repair.

The present application relates to a kind of degradable cationic polymer with bone targeting function and its preparation method and application, specifically, the degradable cationic polymer with bone targeting function provided in the present application can effectively load nucleic acid (such as mRNA, miRNA, DNA), and the encapsulation efficiency is more than 90%, and stable nanoparticles are formed by electrostatic interaction, protect nucleic acid from degradation, while having the characteristics of slowing down particle positive electricity.This carrier shows better stability compared with LNP, supports long-term storage at low temperature.Its bone targeting is clear, promotes the accurate delivery of nucleic acid to bone tissue, enhances the efficacy and reduces side effects, while showing biocompatibility for osteoblasts without toxicity.The application range is wide, covering osteoporosis, osteoarthritis, bone tumor treatment and gene and stem cell therapy.Experiments have verified that the nanoparticles formed by the carrier and eGFP mRNA have high transfection efficiency, and the combination with miRNA effectively inhibits breast cancer bone metastasis, highlighting its therapeutic potential.

The application relates to a preparation method and application of a bionic scaffold with bone repair and anti-osteosarcoma functions, and the specific steps are as follows: firstly, polydopamine nanoparticles are added into a curcumin ethanol solution, room temperature stirring reaction is carried out, and a polydopamine nanoparticle solution loaded with curcumin is obtained; secondly, freeze-dried silk fibroin is dissolved in hexafluoroisopropanol to form a silk fibroin solution, acetone is added to crosslink the solution into a gel, ammonium bicarbonate is added, hydroxyapatite nanoparticles are added, and mixing is uniformly carried out, and a porous fiber scaffold is synthesized through supercritical CO2 assisted phase separation; finally, the porous fiber scaffold is added into the polydopamine nanoparticle solution loaded with curcumin, room temperature stirring reaction is carried out, and then freeze-drying is carried out, so that the silk fibroin scaffold is obtained. The silk fibroin scaffold provided by the application has the anti-osteosarcoma function, can simulate the composition and structure of bone and induce new bone formation, can simultaneously meet the purposes of treating bone tumors and repairing bone defects, and has important clinical value and scientific significance.

The present application relates to the technical field of biomedical materials, and particularly relates to a modified LDH composite material and application thereof in bone regeneration and treatment of bone tumors. The modified LDH composite material is prepared by the following steps: firstly, zinc-calcium-molybdenum hydrotalcite nanosheets are synthesized by a coprecipitation method; then the hydrotalcite nanosheets are subjected to alkali etching; yeast is loaded on the etched zinc-calcium-molybdenum nanosheets to induce intracellular mineralization of hydroxyapatite nanoparticles and promote bone regeneration; meanwhile, the strength of collagen fiber gel is enhanced in situ, and the bone mineralization process is simulated; the yeast can destroy the glycolysis of tumor cells, consume glucose and lactic acid, and combine with efficient SDT to induce ICD, destroy the immunosuppressive microenvironment in the tumor area, and activate T cells; and the yeast has excellent anti-tumor and bone repair performance.

The utility model provides an osteotome, which belongs to the technical field of medical instruments and comprises an osteotome structure, the osteotome structure comprises a drill rod and a drill bit, the drill rod is movably connected with the drill bit, one end of the drill rod is a handle, the other end of the drill rod is a threaded head of a conical structure, and the threaded head penetrates through an opening on one side of the drill bit. According to the bone chisel, in the process of treating a bone tumor patient, medical staff can rapidly cut bone blocks from bone substances, obtain needed samples and conduct detection, operation steps are optimized, more labor is saved, convenience is achieved, operation efficiency is improved, the size of the bone chisel can be designed according to needs, the bone chisel can be applied to large animal bone defect modeling, the structure is simple, and operation is convenient. 3D printing equipment can be used for manufacturing, and the cost is low.

The invention relates to the technical field of medical auxiliary instruments, in particular to a bone tumor patient auxiliary fixing device capable of monitoring and correcting. The auxiliary fixing device for the bone tumor patient can monitor the state of a fixed part in real time, can perform accurate correction according to the monitored state, and can improve the treatment effect. A bone tumor patient auxiliary fixing device capable of monitoring and correcting comprises a first clamping ring, a second clamping ring and the like, and the lower side of the first clamping ring is rotationally connected with the second clamping ring. The limb pressure data is collected in real time through the pressure sensor, when the limb deviates, the pressure sensor monitors the pressure change, the small electric push rod is started, the correction push piece is driven to stretch out and be attached to the limb, dynamic correction is conducted on the deviated part, and therefore the state of the fixed part can be monitored in real time; and accurate correction can be performed according to the monitoring state, so that the treatment effect is improved.

This invention relates to the field of nail surgical instruments, specifically providing an adjustable-depth drilling sampler and its method of use. The sampler includes a head and a drive unit for rotating the drill bit. The outer surface of the drill bit is provided with graduation lines, and the drill bit has a hollow structure. It also includes a negative pressure unit, on which the drill bit is mounted. The negative pressure unit communicates with the hollow area of ​​the drill bit, and can generate negative pressure to extract drilling debris from the hollow area of ​​the drill bit. This invention proposes a drilling tool specifically for surgical nail drilling, which not only allows for neat drilling of the nail but also enables free adjustment of the drilling size and depth by changing the drill bit and the graduation lines on it. It also has a debris absorption and sampling function. It can also be made visually accessible for application in minimally invasive surgeries such as bone tumor sampling and bone cyst surgery.

The invention relates to the technical field of biomedical materials, in particular to a modified LDH composite material and application thereof in bone regeneration and bone tumor treatment. The modified LDH composite material is prepared by the following steps: firstly, synthesizing a zinc-calcium-molybdenum hydrotalcite nanosheet by adopting a coprecipitation method, then carrying out alkali etching on the hydrotalcite nanosheet, loading saccharomycetes on the etched zinc-calcium-molybdenum nanosheet, inducing intracellular mineralization of hydroxyapatite nanoparticles, and promoting bone regeneration; meanwhile, the collagen fiber gel strength is enhanced in situ, and the bone mineralization process is simulated in a bionic manner; the saccharomycetes can destroy glycolysis of tumor cells, consume glucose and lactic acid, induce ICD in combination with efficient SDT, destroy an immunosuppression microenvironment in a tumor area and activate T cell action; the excellent anti-tumor and bone repair performance is realized.

The application discloses a leg thermal therapy device for bone tumor nursing, which comprises an adjusting recliner, a thigh thermal therapy assembly and a lower leg thermal therapy assembly. The thigh thermal therapy assembly comprises a first adjusting plate, an upper thigh clamping seat and a lower thigh clamping seat. The lower leg thermal therapy assembly comprises a second adjusting plate, an upper lower leg clamping seat and a lower lower leg clamping seat. Elastic rubber wire layers are clamped between the upper thigh clamping seat and the lower thigh clamping seat and between the upper lower leg clamping seat and the lower lower leg clamping seat. The elastic rubber wire layers are internally clamped with thermal therapy tubes in the form of spiral discs. The inner sides of the elastic rubber wire layers are attached to the surface of the thighs. The application has the advantages that it can be attached to the legs of patients with different body shapes, and the lying and sitting postures can be switched, which is more humanized.

The invention discloses a bone tumor biopsy positioning device, and relates to the technical field of medical biopsy instruments, the bone tumor biopsy positioning device comprises a biopsy medical bed, the top of the biopsy medical bed is movably provided with a bed plate, and two sides of the biopsy medical bed are fixedly provided with slide rails. After a driving motor at the end of a supporting plate is started, the motor drives a threaded rod to rotate, through the thread meshing effect of the threaded rod and a threaded block, the threaded block is pushed to move in the axial direction of the supporting plate, the height of a positioning frame is adjusted, and then a rotating shaft extending to the side face of an assembling block is rotated; through the meshing effect of a rotating gear at the end of a rotating shaft and a transmission ring in the positioning frame, the transmission ring is driven to rotate around the axis of the transmission ring, then the internal clamping plate is driven to synchronously rotate to be matched with the clamping angle, the clamping plate can flexibly rotate along with the transmission ring, and the clamping angle can be adjusted according to the growth direction of bone tumors and the optimal angle of biopsy puncture; the limitation of fixed-angle clamping is broken through, the biopsy operation requirements of tumors at different anatomical positions are met, and the reasonability of a puncture path is improved.