67 results about "Bone tumours" patented technology

The invention discloses a bone tumor rehabilitation process evaluation method and system based on deep learning. The method comprises the following steps: S1, obtaining a preprocessed bone tumor postoperative multi-source rehabilitation data set; s2, generating a high-frequency rehabilitation feature set and a low-frequency rehabilitation feature set; s3, fusion rehabilitation feature representation is formed; s4, obtaining optimized model parameters; s5, using the optimized model parameters to replace corresponding parameters in the bone tumor postoperative rehabilitation trend discrimination model, performing supervised training on the preprocessed bone tumor postoperative multi-source rehabilitation data set, and outputting the trained bone tumor postoperative rehabilitation trend discrimination model; and S6, applying the trained bone tumor postoperative rehabilitation trend discrimination model to fusion rehabilitation feature representation of a patient to be discriminated, and generating a rehabilitation trend prediction result composed of a rehabilitation progress level, a rehabilitation trend curve and a prognosis risk level. The rehabilitation rhythm change and risk trend of the patient can be visually reflected, and a data-driven staging management basis is provided for doctors.

The invention discloses a multi-task collaborative bone tumor CT image segmentation method, system and device, and relates to the technical field of bone tumor CT image segmentation. According to the multi-task collaborative bone tumor CT image segmentation method, a bone tumor CT image segmentation model is adopted to carry out bone tumor segmentation on a target bone tumor CT image; the bone tumor CT image segmentation model is trained and obtained through the following method: obtaining an original bone tumor CT image; according to the original bone tumor CT image, screening through a CT value range to obtain a bone image and a soft tissue image; marking a tumor area and a skeleton area in the bone image and the soft tissue image to form a training sample; constructing a multi-task learning network including a skeleton segmentation task and a tumor segmentation task; and training the multi-task learning network based on at least one group of training samples to obtain a bone tumor CT image segmentation model. According to the invention, the bone tumor can be identified more accurately, and the precision of bone tumor segmentation is improved.

The invention relates to the technical field of focus positioning, and particularly discloses a bone tumor focus positioning method and device based on machine learning, and the method comprises the steps: carrying out the multi-level feature analysis of a bone tumor related CT medical image through employing an image processing method based on machine learning, so as to extract the deep features and shallow features of the medical image, and further, carrying out the positioning of a bone tumor focus. Attention joint perception based on semantic information guidance is carried out on deep features and shallow features of a medical image to realize comprehensive description of an anatomical structure and pathological features of the medical image, so that semantic segmentation and bone tumor focus positioning of a bone tumor related CT medical image are carried out on the basis. By means of the mode, the bone tumor focus positioning efficiency can be effectively improved, dependence on experience and professional knowledge of doctors is reduced, and therefore powerful support is provided for clinical diagnosis and treatment of bone tumors.

The invention relates to a bone tumor repairing method based on three-dimensional reconstruction and a bionic structure. The method comprises the following steps: acquiring multi-modal medical image data of a bone tumor area of a patient to obtain an initial bone tumor three-dimensional model; generating a three-dimensional dynamic bone defect model for describing a bone tumor area based on the geometric structure of the initial bone tumor three-dimensional model; based on the three-dimensional dynamic bone defect model, generating a bionic implant three-dimensional model meeting bone defects; performing space alignment on the bionic implant three-dimensional model and the three-dimensional dynamic bone defect model to obtain a bone tumor repair model; carrying out restoration stability and osseointegration effect verification on the bone tumor restoration model to obtain a verification result; the verification result is used for indicating dynamic adjustment of the bionic implant three-dimensional model, and a final bone tumor repair three-dimensional model is obtained. By adopting the method, the accuracy, reliability and individuation level of bone tumor treatment can be improved.

The invention belongs to the technical field of medical instrument disinfection, and particularly relates to a bone tumor interventional therapy device with an auxiliary positioning function, the bone tumor interventional therapy device comprises a main frame, a supporting mechanism, a positioning mechanism, an interventional mechanism and a universal adjusting mechanism, the supporting mechanism is arranged on the side wall of the main frame, and the interventional mechanism is arranged on the universal adjusting mechanism; the universal adjusting mechanism comprises a rotation adjusting mechanism and an angle adjusting mechanism, the rotation adjusting mechanism is arranged at the bottom end of the supporting mechanism, the positioning mechanism is arranged at the bottom end of the rotation adjusting mechanism, and the angle adjusting mechanism is arranged at the bottom end of the positioning mechanism. Through the innovative design of the supporting mechanism, intelligent adjustment of an intervention position is realized, and the operation convenience and the positioning precision are improved; the positioning mechanism can accurately mark the tumor position, and manual judgment errors are avoided; the intervention mechanism can realize automatic fixation and depth calibration of a puncture needle, and the puncture accuracy is improved; the universal adjusting mechanism achieves all-directional and all-angle adjustment of the puncture needle.

The invention discloses a multi-modal bone tumor classification method and system based on blood biochemical text guidance. The method comprises the following steps: acquiring multi-modal data; constructing a blood biochemical text guide factor based on the blood biochemical marker; judging whether a bone tumor image or a pathological section image in the multi-modal data is missing or not, extracting a bone tumor image structure feature or a pathological section image feature when the bone tumor image or the pathological section image is not missing, generating a compensation feature of missing modal data when the bone tumor image or the pathological section image is missing, and compensating an image feature corresponding to the missing modal data; performing cross guide fusion on the bone tumor image structure features and the pathological section image features based on the blood biochemical text guide factors to obtain multi-modal fusion features; and calculating the probability of each bone tumor category according to the multi-modal fusion features through a linear classification layer to obtain a bone tumor classification result. According to the method, effective guidance and supplement of non-image information on image features are realized, and the accuracy and interpretability of a bone tumor classification result are improved.

The invention discloses copper selenide / tricalcium silicate bone cement. The bone cement comprises a liquid phase component and a solid phase component, the liquid phase component is water, and the solid phase component is tricalcium silicate powder and copper selenide nanoparticles. Compared with the existing tricalcium silicate bone cement, the tricalcium silicate bone cement has the advantages that by introducing a trace amount of copper selenide nanoparticles, not only can the hydration and coagulation time of tricalcium silicate be shortened, but also the porosity and degradation rate of the tricalcium silicate after coagulation and solidification can be reduced, the compressive strength can be improved, the stimulation effect on ALP activity of MC3T3-E1 cells can be enhanced, the survival rate of the MC3T3-E1 cells can be improved, and the application prospect is broad. The immunogenic apoptosis of K7M2-wt cells is promoted, and the tumor growth rate is reduced. Besides, the introduction of the copper selenide nanoparticles can also endow the tricalcium silicate bone cement with the performance of temperature rise under near-infrared light, so that in clinical application, the tricalcium silicate bone cement can be further combined with a near-infrared technology to realize ablation of bone tumors, and a new strategy is provided for treatment of the bone tumors.

The invention provides a construction method and application of a transgenic animal model with osteoclast specific deletion, and belongs to the technical field of gene engineering. The invention provides a method for constructing an animal model of an osteoclast expression diphtheria toxin receptor, and particularly provides a method for constructing the animal model of the osteoclast expression diphtheria toxin receptor by using a Cre-loxP method. According to the method, the diphtheria toxin receptor is specifically expressed in the osteoclast, and the osteoclast can be specifically deleted by injecting the diphtheria toxin. The animal model of the osteoclast expression diphtheria toxin receptor prepared by the method can stably inherit after being established, is economical and reliable, can provide important theoretical and practical guidance for bone tumor treatment, also provides powerful animal model support for research of bone tumor growth correlation, and has a wide application prospect. Technical conditions are provided for screening, developing, preventing or treating medicines for bone tumors.

The invention relates to the technical field of thermal ablation, and particularly discloses a bone tumor thermal ablation treatment control device combined with machine learning, which is characterized in that image definition is enhanced by performing filtering noise reduction and contrast enhancement processing on image data in a thermal ablation operation, and an image processing technology based on deep learning is further introduced. Characteristic dominant modeling based on combined guidance of space-semantic double-domain context information is performed on enhanced image data in thermal ablation, so that key features of a tumor area and peripheral tissues thereof are highlighted, and interference of non-key information is inhibited; therefore, ablation boundary segmentation in the bone tumor thermal ablation treatment process is realized on the basis. By means of the mode, the feature expression distinction degree and ablation boundary segmentation accuracy of image data in the thermal ablation operation can be remarkably improved, efficient thermal ablation treatment control can be achieved, and powerful tool support is provided for minimally invasive treatment of bone tumors.

The present application relates to a kind of self-setting composite bone implants based on gallic acid complex salt and preparation method thereof, belong to bone repair material field.The present application is specifically related to a kind of self-setting composite bone implants, it is characterized in that, component A, component B and component C, the component A is gallic acid and the complex salt of at least two metal elements, wherein the at least two metal elements are the metal element of promoting bone tissue regeneration or the trace metal element required by human body, and the at least two metal elements include calcium, the component B is the complex of calcium / strontium chondroitin sulfate and calcium sulfate, and the component C is magnesium calcium hydrogen phosphate complex.The self-setting composite bone implant of the present application has the characteristics of antibacterial, anti-inflammatory, promoting osteogenesis, instant shaping and all degradation, can meet the clinical needs of bone tumor, bone injury and the like, has wide application prospect in various bone repair, reconstruction and replacement.

The utility model relates to the technical field of pathological specimen manufacturing, and discloses a bone tumor pathological specimen sampling adjustable fixator which comprises a base, a fixing plate is fixedly connected to the base, at least one evenly-arranged slide making groove is formed in the fixing plate, a stroke through groove is formed in the position, above the slide making groove, in the fixing plate, and the stroke through groove is communicated with the slide making groove. A long moving rod is slidably arranged in the stroke through groove, holding plates matched with the sheet making grooves are fixedly connected to the long moving rod, electric push rods are arranged in the holding plates, pressing plates matched with the upper glass sheet are fixedly connected to the lower ends of the electric push rods, and limiting moving plates are fixedly connected to the two ends of the long moving rod; and fixed limiting plates are fixedly connected to the two sides of the base correspondingly, plate body stroke grooves matched with the limiting moving plates are formed in the fixed limiting plates correspondingly, and sliding rods are fixedly connected to the fixed limiting plates correspondingly. Compared with the prior art, the upper glass fixing device has the advantage that upper glass of different sizes can be fixed.

The invention relates to a decision-making auxiliary system for a resection range of a bone tumor degradation region. The decision-making auxiliary system is used for modeling biological characteristics of metabolic activity, blood perfusion and tissue permeability reflected in different image modalities including PET / MRI (Positron Emission Tomography / Magnetic Resonance Imaging); using a space coupling modeling method to generate a functional activity gradient map in the degradation area, and mapping three layers of areas including a central focus, a diffusion boundary and a latent erosion zone; constructing a dynamic interval label mechanism, and forming a variable removal range space; dividing a gradient map generated based on an image into a plurality of different areas, performing joint modeling on each area and corresponding functional positioning parameters and pathological risk parameters, layering tissue structures of cortical bones, cancellous bones, marrow cavities and soft tissue boundaries, and generating a local resection profile cluster according to an anatomical axis; each section cluster is hooked with a single function / risk factor weight, and the whole excision body is re-simulated by adjusting excision target parameters; the excision boundary has the form adaptive capacity in the space, and personalized operation strategy customization and dynamic adjustment are achieved.

This invention discloses a method for preparing and using a long-acting antitumor organic and inorganic bone binder, which is prepared by polymerization, blending, and freeze-drying of porous calcium phosphate and antioxidant-grafted Tremella fuciformis polysaccharide hydrogel. The porous calcium phosphate is prepared by controlling its porous structure and composition to achieve degradation, thereby slowly releasing calcium ions, improving osteogenic properties, and achieving high bonding strength with human bone at the postoperative bone tumor defect site. Simultaneously, leveraging the high bonding strength and long-acting antitumor properties of the Tremella fuciformis polysaccharide hydrogel grafted with one or two antioxidants such as ascorbic acid, tea polyphenols, flavonoids, and tocopherols, the porous calcium phosphate and antioxidant-grafted Tremella fuciformis polysaccharide hydrogel are combined to form a covalently cross-linked network structure, further improving the bonding strength of the bone binder, promoting osteogenic properties with host bone tissue, and providing a long-lasting antitumor cycle.

The utility model relates to a bone tumor puncture sampling anti-leakage device which is characterized in that the bone tumor puncture sampling anti-leakage device comprises a soft tissue protection sleeve used for conducting blunt separation on muscular gaps and a tumor sampling plugging device used for building a sampling closed area in a sampling cavity, and an inner cavity channel used for containing the tumor sampling plugging device is arranged at the far end of the soft tissue protection sleeve. The tumor sampling plugging device is detachably connected with the soft tissue protection sleeve, and the tumor sampling plugging device is internally provided with a plugging channel which is used for injecting bone cement after sampling to implement plugging and prevent bone tumor diffusion caused by tissue fluid leakage. And an annular space is formed between the periphery of the partial section of the tumor sampling plugging device and the inner cavity channel of the soft tissue protection sleeve. According to the utility model, the wound is small, the tumor tissue fluid can be prevented from overflowing in the sampling process, and the tumor tissue fluid can be effectively blocked after sampling.

The application provides a bone tumor classification model training method, a classification method and a system based on multi-view fusion, relates to the technical field of image data processing, and comprises the following steps: a training set containing bone tumor frontal and lateral images is constructed; a three-branch model containing a frontal prediction branch, a lateral prediction branch and a frontal-lateral fusion prediction branch is designed, single-view specific features are extracted through a single-view feature extraction module, and a cross attention mechanism is introduced through a double-view feature extraction module to fuse double-view features; the single-view feature extraction module and the double-view feature extraction module are independently optimized first, then the parameters thereof are fixed, only the classification head is fine-tuned, the classification loss and the consistency loss of the three branches are jointly optimized, and a bone tumor classification model is obtained, so that the benign and malignant classification of bone tumors can be obtained based on the frontal and lateral images of the bone tumors. The application can comprehensively capture the spatial features of bone tumors, deeply fuse the correlation information between multiple views, capture local dependency relationships and improve the classification accuracy.

The invention discloses a radiopharmaceutical for malignant bone tumors and metastatic bone tumors and a preparation method, and belongs to the technical field of radiopharmaceuticals. The preparation method comprises the following steps: firstly preparing a radionuclide stock solution of terbium and lutetium, then preparing a TP-18C6O3N3 stock solution, mixing the radionuclide stock solution with the TP-18C6O3N3 stock solution, and coordinating the radionuclide with the TP-18C6O3N3 to form a complex of terbium and lutetium labeled TP-18C6O3N3, thereby respectively preparing a terbium labeled complex solution and a lutetium labeled complex solution. And filtering, disinfecting and packaging the solution to obtain the radiopharmaceutical. The natural osteotropism of the phosphonic acid group is utilized, radionuclides are carried to reach a bone tumor focus area, and the radionuclides decay to release energy to kill tumor cells. The preparation process is simple, nuclide falling can be effectively reduced through the strong coordination capacity of the TP-18C6O3N3, the targeting property is remarkably improved, and the drug effect durability is remarkably improved.

The present invention relates to a carbon material filling connection member for bone defect repair and, more specifically, to a carbon material filling connection member for bone defect repair, which connects bones that have been cut to each other when bones are removed due to bone tumors or trauma. The carbon material filling connection member for bone defect repair according to the present invention is a filling connection member for bone defect repair which connects bones spaced apart from each other due to a bone defect, characterized by comprising: a hollow column-shaped spacer which is disposed between an upper bone and a lower bone which are cut and spaced apart from each other and has a through-hole formed therein; two or more supports which are arranged in the lateral direction of the upper bone, the spacer, and the lower bone; and a fastening member for coupling the supports to the upper bone, the spacer, and the lower bone, wherein the spacer is made of a carbon fiber material, the through-hole communicates with the upper bone and the lower bone, and the length of the spacer can be changed in the longitudinal direction in which the upper bone and the lower bone are arranged.

The present invention discloses a photothermal bone tumor scaffold with controlled drug release, as well as its preparation method and application. The scaffold has two sets of curved, independently connected channels, with the outer channel being open and connected, and the inner channel being closed and connected. The scaffold is made of a Ca2MgSi2O7 / ZTA composite ceramic material. The preparation process involves adding ceramic slurry to a photocuring printing device, performing photocuring printing based on a photothermal bone tumor scaffold model to produce a ceramic blank, performing secondary curing on the blank to produce a ceramic green body, and sintering the green body to obtain the photothermal bone tumor scaffold. The scaffold provided by the present invention has high porosity and strength, possesses an independent dual-channel structure, and integrates multiple functions: osteogenesis, controlled release of chemotherapy drugs, and photothermal killing of bone tumor cells.

The invention relates to the field of bone repair, and discloses a 3D printing bone-imitating biological scaffold and a preparation method thereof.The preparation method comprises the steps that firstly, ammonium bromide is added into a mixture of deionized water and absolute ethyl alcohol, and an ammonium bromide solution is obtained; sequentially adding an ammonia solution, tetraethoxysilane, triethyl phosphate, calcium nitrate and sodium vanadate, continuously stirring, centrifuging, and collecting a precipitate; washing, aging, heating, cooling, grinding, crushing, and screening to obtain V-MBG powder; preparing a TA solution and a V-MBG solution, mixing and putting the TA solution and the V-MBG solution, and freeze-drying to obtain TA-coated V-MBG powder; preparing a trichloromethane solution of PLGA (poly (lactic-co-glycolic acid)), adding the V-MBG powder, fully stirring, and pumping out the trichloromethane solution to obtain solid slurry; printing an inner-layer stent and a hollow-tube outer-layer stent to obtain a bone-imitating biological stent, and soaking the bone-imitating biological stent in a TA solution to obtain a PLGA / TA-V-MBG composite stent; the problems that in the prior art, the bone repairing effect is poor, the bone-like cell proliferation and differentiation effect is poor, and bone defect repairing caused by bone tumor treatment cannot be achieved are solved.

The application discloses a kind of multi-modal bone tumor classification method and system based on blood biochemical text guide, the method includes the following steps: obtaining multi-modal data;Blood biochemical markers are used to construct blood biochemical text guide factor;Determine whether the bone tumor image or pathological section image in multi-modal data is missing, when not missing, the bone tumor image structure feature or pathological section image feature is extracted, when missing, the compensation feature of missing modal data is generated, and the image feature corresponding to the compensation of missing modal data is extracted;Blood biochemical text guide factor is used to cross guide fusion on bone tumor image structure feature and pathological section image feature, and multi-modal fusion feature is obtained;The probability of each bone tumor category is calculated by linear classification layer to multi-modal fusion feature, and bone tumor classification result is obtained.The application realizes the effective guidance and supplement of non-image information to image feature, and improves the accuracy and explainability of bone tumor classification result.

The invention discloses an integrated bone marrow microenvironment-bone tumor organoid micro-fluidic chip, and relates to the technical field of bone tumor in-vitro research models, the key points of the technical scheme are as follows: the chip is of a double-layer structure, is separated by a porous membrane in the middle, and is matched with a micro-fluidic structure formed by combining a plurality of cavities; the multiple chambers comprise a tumor organ chamber, a blood vessel communication chamber and a marrow chamber; the bone marrow upper-layer chamber and the bone marrow lower-layer chamber are separated by a porous membrane, the bone marrow upper-layer chamber is a nutrition supply layer, the bone marrow lower-layer chamber is a cell culture layer, and the porous membrane allows gradient diffusion of micromolecule nutrition / cell factors, so that nutrition supply of the bone marrow upper-layer chamber to the bone marrow lower-layer chamber is realized. The chip can reproduce a complex three-dimensional structure of the BMME, realizes dynamic microenvironment control and real-time visual monitoring, and provides a more accurate in-vitro model for research of bone tumor organs.

The invention relates to the technical field of medical instruments, and discloses a bone tumor pathological tissue sampling device integrated with a cutting function, which comprises a left side shell and a right side shell which are connected through a screw, and also comprises a cutting assembly and a tumor sampling assembly, the front ends of the left side shell and the right side shell are connected with end covers through screws, the end faces of the end covers are fixedly connected with sleeves, and the outer walls of the sleeves are fixedly connected with lug blocks and side blocks. Sampling and cutting functions are ingeniously combined, after cutting is completed, a buckle plate is pulled to drive a string, a micro winch and other parts, so that a biting block rotates around a vertical shaft to be close to a cutting blade, the biting block and the cutting blade are matched to bite tumor pathological tissue, and sawteeth on the side edge of the biting block facilitate easy sampling; by means of the integrated design, the sampling process of bone tumor pathological tissue is effectively simplified, the tedious step of switching multiple tools in traditional operation is avoided, and the sampling efficiency is greatly improved.

The application discloses a 3D printing long bone osteotomy guide plate, and belongs to the technical field of orthopedic medical instruments. The 3D printing long bone osteotomy guide plate comprises a guide plate main body, the guide plate main body comprises a tumor fixing part, an osteotomy guiding part and an intermediate connecting part, the tumor fixing part and the osteotomy guiding part are fixedly connected through the intermediate connecting part, the tumor fixing part is in a spherical shape, the inner side of the tumor fixing part is in close contact with the outer surface of a long bone tumor, the osteotomy guiding part is clamped at the connecting position of the long bone and the long bone tumor, and the long bone tumor is cut off from the side of the osteotomy guiding part away from the tumor fixing part. The tumor fixing part is in close contact with the irregular shape of the tumor surface, the edge of the osteotomy guiding part is designed according to the direction of the osteotomy line, the guide plate is stably and closely combined with the bone and the tumor surface, sliding or misplacement is avoided, more accurate surgical positioning is provided for clinical doctors, the structure is simple, the operation is convenient, and the guide plate is suitable for large-scale popularization and application.

The present application relates to a kind of distal anchoring bone cement type prosthesis stem, including stem body, several anchoring blades and piston.The bottom end of the stem body is fixed on prosthesis, top end is inserted into medullary cavity, bone cement channel is provided in the stem body along the axial direction, injection hole is formed on the side wall of the stem body, and the injection hole is communicated with the bone cement channel;The anchoring blade is arranged at the top of the stem body, the bottom of the anchoring blade is rotatably connected with the top end of the stem body, the piston is sleeved in the bone cement channel, and under the driving of bone cement, it slides upward, when the piston slides to the top of the stem body, several anchoring blades are opened, and the anchoring blade is converted from the first state to the second state.The distal anchoring bone cement type prosthesis stem can improve the long-term stability of tumor type prosthesis, reduce the aseptic loosening of prosthesis, and improve the long-term function of limb of patients with malignant bone tumor.

The invention relates to the technical field of bone tumor sample collection and diagnosis, in particular to a bone tumor patient diagnosis sample collection integrated structure which comprises a diagnosis mechanism and a collection mechanism. The diagnosis mechanism comprises a guide assembly, an adjusting assembly, a uniformizing assembly, a detection assembly, a sample feeding assembly and a cover plate assembly, the adjusting assembly is fixedly connected to the inner side of the guide assembly, the uniformizing assembly is fixedly connected to the bottom of the inner side of the guide assembly, and the detection assembly is clamped to the front side of the inner side of the adjusting assembly. The bone tumor patient diagnosis sample collection integrated structure provided by the invention has the advantages that the sample needing to be collected can be quantitatively collected in real time, so that the sample needing to be collected can be quantitatively collected in real time, the accuracy of sample collection is improved, the collected sample can be immediately subjected to preliminary diagnosis, and the accuracy of sample collection is improved. And a sample can be immediately subjected to preliminary diagnosis, so that the bone tumor diagnosis efficiency is improved.

The invention belongs to the field of nuclear medicine imaging agents, and relates to an LAT1 targeted phosphoramidated tyrosine PET molecular probe as well as a preparation method and application thereof. The probe has a structure as shown in a formula I. The LAT1-targeted phosphoramidated tyrosine PET molecular probe provided by the invention can be used for high-specificity uptake of bones, and has excellent in-vivo metabolism performance and bone uptake retention capacity. The targeted PET molecular probe provided by the invention has a clear tumor ratio, can be rapidly metabolized out of a body through a kidney, and has important application value for early and accurate diagnosis of bone tumors and bone metastatic tumors.

The invention discloses a preparation method of a nano immunomodulator, which comprises the following steps: mixing 3-amino-1, 2, 4-triazole and oxalic acid, and sequentially carrying out calcination, grinding, acid treatment, ultrasonic stripping and step-by-step centrifugation to obtain a double-defect nitrogen-rich carbon nitride CNO nanosheet; adding the copper chloride solution into the metal-phase molybdenum disulfide MS nanosheet solution, and stirring for reaction to obtain a surface-atomized copper-chelated metal-phase molybdenum disulfide nanosheet CuMS; and dropwise adding the CuMS solution into the double-defect nitrogen-rich carbon nitride CNO nanosheet solution, and reacting to obtain the nano immunomodulator CNO coated CuMS. The invention also discloses the nano immunomodulator prepared by the preparation method and application of the nano immunomodulator in preparation of medicines for treating bone tumors. According to the nano immunomodulator prepared by the preparation method disclosed by the invention, the tumor immune microenvironment is improved through multi-mode catalysis and cell copper death induction effects of piezoelectric catalysis, sonodynamic catalysis and Fenton-like catalysis, so that efficient treatment of malignant bone tumors is realized.

The invention relates to the technical field of medical equipment, in particular to a rib bone fracture plate, a limiting and fixing assembly and a lock catch assembling method of the limiting and fixing assembly, and is suitable for internal fixation after rib fracture or rib bone tumor excision. The rib bone fracture plate is assembled in a combined mode and can be assembled and used according to the requirements of different patients, the left encircling claw and the right encircling claw reinforce fixation, and the adjustable moving claw is installed according to different positions of the affected bone so that the requirement for fixing the ribs of the patients with comminuted fractures can be met. The movable claw is mainly used for fixing broken bone blocks in rib fracture fixation, the lower plane of the cross beam makes contact with the broken bone blocks and provides a fixing face, and the movable claw fixes the broken bone blocks left and right to achieve the mechanical fixing effect of the broken bone blocks.

The utility model discloses a perioperative nursing turning-over auxiliary device for orthopedic bone tumor patients, and aims to solve the problems that an existing triangular pillow needs to be operated by multiple persons in a matched mode, and the state that the bone tumor patients are almost completely disabled in clinical nursing is difficult to deal with. The device comprises an elastic cushion body, and the elastic cushion body comprises an insertion bucket part used for being inserted into the back of a patient, a pressure-bearing supporting part connected with the insertion bucket part, an abutting part connected with the pressure-bearing supporting part and a plane arranged at the end of the abutting part. According to the utility model, the insertion bucket part is inserted into the back of a patient until the insertion bucket part is exposed, and then the patient is lightly and slowly turned over, due to the existence of the pressure-bearing supporting part, the body of the patient is always supported in the turning-over process, and the abutting part abuts against the body until the patient finishes the turning-over action, so that the patient can turn over more stably. And the whole operation can be completed by one medical worker, so that the working efficiency of the medical worker is greatly improved.