Application of carbonized cuttlebones in orthopaedics

A cuttlefish bone and bone defect technology, which is applied in medical science, prosthesis and other directions to achieve the effect of promoting osteogenic differentiation, promoting fusion, good microporous structure and biocompatibility

Inactive Publication Date: 2011-01-05
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no literature report on whether cuttlefish bone can be used as an orthopedic medical material

Method used

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  • Application of carbonized cuttlebones in orthopaedics
  • Application of carbonized cuttlebones in orthopaedics
  • Application of carbonized cuttlebones in orthopaedics

Examples

Experimental program
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Effect test

Embodiment 1

[0016] I. Materials and Methods

[0017] (1) Materials and equipment needed for this experiment

[0018] Materials: Fresh and live cuttlefish were purchased and frozen at -80°C for 72 hours for a short period of time. DMEM medium (GIBCO, USA), trypsin (SIGMA, USA), fetal bovine serum (HYCLON, USA), and other reagents were commercially available for analysis. Pure reagents.

[0019] Instruments: Galanz G8023YSP-BM1 microwave oven (800W per kilometer, 23L volume, China), ultra-clean bench (BIO-HAZARD, VCM-420, Taiwan, China), electronic analytical balance (METTLER TOLEDO, AB204-E, Switzerland), electromagnetic stirring Machine (STUART, SM24, UK), cryogenic centrifuge (UNIVERSAL, 32R, HETTICH, Germany), scanning electron microscope (SEM, JEOL, JSM-6260LV, Japan).

[0020] material handling

[0021] Take out the cuttlefish bone from the fresh frozen cuttlefish, soak it in hydrogen peroxide for 30 minutes, rinse it with distilled water, soak it in alcohol for storage, remove the...

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Abstract

The invention relates to new use of carbonized cuttlebones, in particular to application of carbonized cuttlebones in preparation of medical materials for treating diseases of bone defect, bone tumor and cyst. The medical materials can be bone tissue engineering scaffold materials or bone grafting substitution materials. The invention has the advantages that: the carbonized cuttlebones have excellent microporous structure and biocompatibility, is beneficial to osteoblast adherence growth and promotes bone differentiation to a certain extent. The microwave carbonized cuttlebones can be used as the bone tissue engineering scaffold materials or bone grafting substitution materials, therefore, the invention is hopeful to be used for clinical treatment and repairing of dead space after the cutting of bone defect, bone tumor and cyst, promotes combination of vertebral column and joints, and can be used as a cell carrier to construct tissue-engineered bones in vitro in a compounding way.

Description

【Technical field】 [0001] The invention relates to the technical field of medical material application, in particular to the application of carbonized cuttlebone in orthopedics. 【Background technique】 [0002] Bone transplantation is a common tissue transplant after blood transfusion in clinical practice. It is widely used in orthopedics to fill bone defects caused by infection, tumor, trauma, fracture nonunion, joint and spinal fusion. Autologous bone grafting is the gold standard for the treatment of bone defects, but its source is limited and it will cause complications at the donor site. Therefore, finding new bone graft substitutes or using tissue engineering technology to repair bone defects is the current research at home and abroad. Hotspots and main directions of attack. Among the three major elements of bone tissue engineering, cells, carriers and growth factors, biomaterial scaffolds undoubtedly play a key role as carriers of cells and factors. [0003] Cuttlebon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/02A61L27/56
Inventor 彭兆祥李亚屏汤亭亭许海平李星
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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