Multifunctional injectable hydrogel for tumor photo-thermal treatment and bone tissue repair and preparation method

Abstract

The invention discloses multifunctional injectable hydrogel for tumor photo-thermal treatment and bone tissue repair and a preparation method, and belongs to the field of biomedical materials. The preparation method comprises the following steps of firstly, synthesizing micro-nano carbon spheres by adopting a hydrothermal carbonization method; secondly, adding the micro-nano carbon spheres into achitosan solution, and performing uniform stirring to obtain a solution A; thirdly, simultaneously dissolving beta-sodium glycerophosphate and sodium hyaluronate in deionized water, and performing sufficient stirring to obtain a solution B; and finally, in an ice bath environment, adding the solution B into the solution A, uniformly stirring the solutions, and performing sterilizing and disinfection for 24 hours by using an ultraviolet lamp to obtain the injectable composite hydrogel. The injectable hydrogel has good biocompatibility; the injectable hydrogel is in a liquid state at the room temperature, can be directly injected into a bone tumor focus, and can rapidly form gel in situ in an environment with the body temperature of 37 DEG C, so that effective fixation of a photothermal agent and rapid filling of bone defects are realized; and bone tumor cells can be killed through local photo-thermal treatment, meanwhile bone tissue repair can be effectively promoted, and all-dimensional treatment of bone tumors is achieved.

Description

Technical field [0001] The invention belongs to the field of biomedical materials, and more specifically, relates to a multifunctional injectable hydrogel used for tumor photothermal treatment and bone tissue repair and a preparation method thereof. Background technique [0002] Bone tumors are tumors that occur in the bones or their accessory tissues, which cause abnormal growth of human tissues. Malignant bone tumors have a high incidence and are usually difficult to cure. It is worth noting that most malignant tumors such as lung cancer, prostate cancer, breast cancer and kidney cancer are prone to cancer metastasis in their development process, and bone tissue is the main metastasis site of the above tumors, which leads to the formation of metastatic bone tumors. Bone tumors are usually accompanied by serious complications such as bone pain, osteolysis, fractures, and bone deformities. These complications bring great pain to the patient, reduce the quality of life, and caus...

AI Technical Summary

Problems solved by technology

However, photothermal therapy for the treatment of bone tumors is still in further research, and some significant problems need to be resolved urgently

For example, as an important photothermal conversion material for photothermal therapy of tumors, nano-photothermal agents have a significant impact on the effect of photothermal therapy, and the enrichment rate of photothermal agents is low when delivered to tumor sites through intravenous injection. to photothermal therapeutic effect

Although in situ injection of nano photothermal agent can enhance the local photothermal treatment temperature, due to human metabolism and blood circulation, the residence time of photothermal agent in the tumor site is short, which greatly affects the long-term curative effect of the tumor.

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