A multifunctional injectable hydrogel for photothermal therapy of tumors and bone tissue repair and its preparation method

Abstract

The invention discloses a multifunctional injectable hydrogel for tumor photothermal therapy and bone tissue repair and a preparation method thereof, belonging to the field of biomedical materials. The steps are as follows: firstly, micro-nano carbon spheres are synthesized by a hydrothermal carbonization method. Next, add the micro-nano carbon spheres into the chitosan solution and stir evenly to obtain solution A. Again, dissolve sodium β-glycerophosphate and sodium hyaluronate into deionized water at the same time, and stir thoroughly to obtain solution B. Finally, in an ice-bath environment, solution B was added to solution A, stirred evenly, and sterilized by ultraviolet light for 24 hours to obtain an injectable composite hydrogel. The invention has good biocompatibility; it is liquid at room temperature, can be directly injected into bone tumor lesions, and can quickly form a gel in situ at a body temperature of 37°C, realizing effective fixation of photothermal agents and bone defects The rapid filling of bone tumor cells can be achieved through local photothermal therapy, and at the same time, it can effectively promote the repair of bone tissue and realize the comprehensive treatment of bone tumors.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and more specifically relates to a multifunctional injectable hydrogel for photothermal treatment of tumors and bone tissue repair and a preparation method thereof. Background technique [0002] Bone tumors are tumors that develop in the bone or the tissues surrounding it, causing abnormal growth of tissue in the body. Malignant bone tumors have a high incidence and are often difficult to cure. It is worth noting that most malignant tumors such as lung cancer, prostate cancer, breast cancer, and kidney cancer are prone to cancer metastasis during their development, and bone tissue is the main metastatic site of the above tumors, resulting in the formation of metastatic bone tumors. Bone tumors are usually accompanied by serious complications such as bone pain, osteolysis, fracture, and bone deformity. These complications bring great suffering to patients, reduce the quality of life, and caus...

AI Technical Summary

Problems solved by technology

However, photothermal therapy for the treatment of bone tumors is still in further research, and some significant problems need to be resolved urgently

For example, as an important photothermal conversion material for photothermal therapy of tumors, nano-photothermal agents have a significant impact on the effect of photothermal therapy, and the enrichment rate of photothermal agents is low when delivered to tumor sites through intravenous injection. to photothermal therapeutic effect

Although in situ injection of nano photothermal agent can enhance the local photothermal treatment temperature, due to human metabolism and blood circulation, the residence time of photothermal agent in the tumor site is short, which greatly affects the long-term curative effect of the tumor.

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