12 results about "Osteolysis" patented technology

The utility model relates to the technical field of medical instruments, in particular to a positioning device for assisting reduction and fixing acromioclavicular dislocation, which comprises a base plate, an acromion end positioning plate is arranged at one end of the base plate, and a clavicle end positioning block is arranged at the other end of the base plate. Holes are formed in the acromion end positioning plate, acromion end fixing guide needle sleeves are fixedly connected to the positions corresponding to the holes, a plurality of holes are formed in the base plate, and a first coracoshoulder ligament fixing guide needle sleeve, a second coracoshoulder ligament fixing guide needle sleeve and a clavicle end guide needle fixing sleeve are fixedly connected to the positions corresponding to the holes respectively. The positioning device can achieve accurate positioning, damage to blood vessels, nerve tracts and surrounding tissues below the coracoid process is avoided, and operation bleeding is reduced. Due to the fact that the individualized bone tunnel is established, the position where the belt carrier titanium plate is placed is appropriate, the osteolysis phenomenon is reduced, and meanwhile the risk of coracoid fracture is reduced. According to the operation method adopting the positioning device, the operation difficulty is remarkably reduced, the operation time is shortened, and the learning curve of young physicians is reduced.

The invention discloses an RIP3-mediated osteoarthritis animal model as well as a construction method and application thereof. The construction method comprises the following steps: delivering an effective dose of a genetic tool (such as an adenovirus vector) capable of expressing RIP3 protein into a knee joint subchondral bone area of an experimental animal, and realizing continuous overexpression of RIP3 through regular operation, so as to induce pathological characteristics highly similar to human osteoarthritis. The model stably shows typical OA phenotypes such as limb pain sensitization, subchondral bone loss and bone microstructure degeneration, osteoclast number increase and overlying cartilage degeneration. The invention reveals that the natural process of occurrence and development of the osteoarthritis can be directly simulated through specific overexpression of the RIP3 in the subchondral bone for the first time, and a brand-new and valuable tool is provided for researching the pathogenesis of the osteoarthritis and screening and evaluating medicines and therapies for treating the osteoarthritis.

The application discloses a preparation method of a 3D printing hip joint stress relief heat treatment double-gradient bone support, and the method comprises the following steps: acquiring image data by performing three-dimensional scanning on a bone defect by means of a CT scanning device, designing the size and shape of a transplantable bone, designing a concave hexagonal support structure with gradient porosity by means of UG three-dimensional drawing software, and gradually transitioning from a Ti-35Nb-5Ta-7Zr alloy with good biocompatibility and a low elastic modulus to a Co-Cr-Mo alloy with good wear resistance and corrosion resistance, improving metallurgical incompatibility, obtaining better interface combination, minimizing bone resorption and aseptic loosening caused by wear, prolonging the service life of an implant, and performing annealing heat treatment on the functional support after printing to eliminate residual stress and depositing a HA coating to enhance cell activity.

The present application relates to the application of circPDE5A inhibitor in the preparation of drugs for treating aseptic loosening of artificial joints. The present application confirms that circPDE5A has a positive correlation with the occurrence of aseptic loosening. And through RNA Pull-Down experiment and mass spectrometry (MS) analysis, it is confirmed that circPDE5A can affect the regulation of LACC1 signal pathway by interacting with LACC1, and then affect the inflammatory response of macrophages. In addition, through in vivo animal experiments, the results of mouse skull osteolysis model show that the injection of lentivirus for knocking down circPDE5A can reduce the osteolysis induced by Ti particles. In general, the present application provides a new idea and theoretical basis for the research and development of drugs for treating aseptic loosening of artificial joints, and has important clinical value and social significance.

Hollow hydroxyapatite microparticles are provided for sustained delivery of an agent that provides osteoprotegerin anti-osteolytic activity for treatment of post-orthodontic relapse and bone disorders. In particular, methods of using such microparticles for post-orthodontic tooth stabilization and bone regeneration and repair are provided.

The application discloses an acetabular cup for acetabular surgery, which adopts a multilayer structure, namely a first acetabular cup and a second acetabular cup, and the two are connected through an acetabular cup spacer block, the acetabular cup spacer block can prevent the relative movement between the first acetabular cup and the second acetabular cup, improve the stability and wear resistance of the acetabular cup, prolong the service life of the acetabular cup, the first acetabular cup and the second acetabular cup are both trabecular bone structure and are both hollow hemispheres, and have high porosity, so that the biomechanical adaptability of the acetabular cup can be improved, the growth of bone tissue and the fixation of the acetabular cup can be promoted, the stress concentration and osteolysis of the acetabular cup can be reduced, the biocompatibility and corrosion resistance of the acetabular cup can be improved, and a plurality of groups of internal thread base holes are formed in the first acetabular cup, the second acetabular cup and the acetabular cup spacer block, so that the installation and fixation of the acetabular cup are facilitated, and thus the accurate positioning and close connection of the acetabular cup are realized.

This invention discloses a method and prosthesis for connecting a porous surface structure and a substrate using a thermoplastic material. A layer of thermoplastic polymer material is placed in the gap between the porous surface structure and the substrate, allowing the porous surface structure to be tightly bonded to the porous structure on which the substrate is located or to a pre-connected porous structure on the substrate. This improves stress shielding and solves the problem of postoperative osteolysis. The prosthesis of this invention has excellent bone ingrowth performance, ensuring that the strength of the substrate is not substantially affected, guaranteeing the basic strength of the connection structure, and optimizing the overall composite structure stiffness, effectively reducing the risk of stress shielding.

The application discloses a knee joint prosthesis system and a preparation method, wherein the femoral condyle prosthesis, the tibial plateau pad prosthesis, the tibial plateau prosthesis and the patellar prosthesis are made of zirconium niobium alloy, so that the sliding friction contact surfaces of the tibial plateau pad prosthesis, the patellar prosthesis and the femoral condyle prosthesis are metal ceramic interfaces formed by oxidation of zirconium niobium surfaces, the wear rate is lower, the active wear of the joint prosthesis can be effectively reduced, the service life of the joint prosthesis is prolonged and the failure rate is reduced, meanwhile, the risk of osteolysis caused by debris generated by wear of a traditional prosthesis due to an ultra-high molecular weight polyethylene tibial plateau pad prosthesis, and further triggering the risk of loosening of the prosthesis, can be avoided. Moreover, the bone integration interfaces of the femoral condyle prosthesis, the tibial plateau prosthesis and the patellar prosthesis are zirconium niobium alloy trabecular structures, so that the zirconium niobium alloy trabecular structures have excellent biocompatibility, are convenient to combine with the bone tissue of a patient and can improve the bone integration efficiency of the frame body and the bone tissue.

The invention discloses an automatic identification method for osteolysis around a prosthesis after total hip replacement, and belongs to the technical field of medical image processing.The method is achieved through an osteolysis focus identification and prediction model, in the model, image data of a patient after total hip replacement is converted and mapped, and an image matrix is obtained; obtaining an initial partition map of the image matrix through the anatomical partition template; determining a weight matrix of the initial partition map according to preset weights of different anatomical partitions, multiplying the weight matrix by the image matrix to obtain a partition guide enhanced image matrix, inputting the partition guide enhanced image matrix into a feature extraction module, inputting extracted micro texture features and macro features into a Sigmoid gating dynamic fusion module, and outputting the Sigmoid gating dynamic fusion module. And a target bounding box and target confidence are obtained through the fusion features, the intermediate layer feature map and the YOLOv8 recognition module, a staging result is obtained based on the fusion features, clinical data and a staging prediction module, and visual recognition information is further obtained.

This application relates to the field of orthopedic artificial joint design and manufacturing technology, and in particular to a metal-ceramic total shoulder joint prosthesis system and its preparation method. The metal-ceramic total shoulder joint prosthesis system includes a humeral stem prosthesis, a tapered adapter prosthesis, a humeral head prosthesis, and a glenoid fossa prosthesis connected sequentially. The humeral head prosthesis and the tapered adapter prosthesis are both formed using 3D zirconium-niobium metal printing or forging. The humeral stem prosthesis and the glenoid fossa prosthesis are integrally formed using 3D printed zirconium-niobium alloy. A metal-ceramic interface layer formed by the oxidation of the zirconium-niobium surface is provided at the relative motion contact surface of the humeral head prosthesis and the glenoid fossa prosthesis. The metal-ceramic total shoulder joint prosthesis system provided by this application has advantages such as longer service life, high wear resistance, low wear rate, no osteolysis, and no prosthesis loosening.

The present invention relates to uses of a combination therapy of bone morphogenetic protein-2 and denosumab in spinal fusion surgery. When bone morphogenetic protein-2 and denosumab are used in combination during spinal fusion surgery as in the present invention, side effects frequently occurring due to spinal fusion surgery, such as osteolysis, inflammation, wound dehiscence, and bleeding, can be effectively prevented and treated.

The application discloses a new use of table berberine and an experimental method for inhibiting breast cancer cell-induced osteoclast differentiation. The application proves for the first time that table berberine does not inhibit the proliferation of osteoclast precursor cells at a higher concentration (25 μM), and has higher biological safety. In addition, table berberine has a significant inhibitory effect on breast cancer-induced osteoclast formation and metastatic breast cancer-induced osteolysis.