Titanium alloy artificial joint with bio-lubrication surface layer and preparation method thereof

An artificial joint, titanium alloy technology, applied in coating, tissue regeneration, medical science and other directions, can solve problems affecting quality and service life, adverse physiological reactions, artificial joint failure, etc., to achieve large-scale production, excellent mechanical properties , Improve the effect of biological lubricating performance

Active Publication Date: 2019-03-29
NANJING FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, titanium alloys produce high wear and a large amount of wear debris during the sliding friction process. The accumulation of wear debris leads to macrophage phagocytosis, induces adverse physiological reactions, releases a large amount of osteolytic factors, and causes bone resorption by osteoclasts, eventually making the fixation Good artificial joints fail due to aseptic loosening and osteolysis, seriously affecting quality and service life

Method used

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  • Titanium alloy artificial joint with bio-lubrication surface layer and preparation method thereof

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preparation example Construction

[0038] The method for preparing a titanium alloy artificial joint with a biolubricating surface generally adopts the following steps:

[0039] (1) Prepare polyelectrolyte solution: prepare polycation electrolyte solution and polyanion electrolyte solution respectively;

[0040] (2) carrying out hydroxylation treatment on the titanium alloy substrate to form a hydroxylation substrate;

[0041] (3) layer by layer self-assembled polyelectrolyte layer, including the following sub-steps:

[0042](3.1) Soak the hydroxylated substrate in a polycation electrolyte solution to form a polycation electrolyte layer, take it out, clean it and dry it;

[0043] (3.2) Then put it into the polyanion electrolyte solution for soaking to form a polyanion electrolyte layer, take it out, clean it and dry it;

[0044] (3.3) Steps (3.1) and (3.2) are repeated in sequence to form a multilayer polymer electrolyte layer with N layers of polycation electrolyte layers and N layers of polyanion electrolyt...

Embodiment 1

[0056] Preparation of 1# titanium alloy artificial joint with biolubricating surface.

[0057] Prepare 1mg / mL polydiallyldimethylammonium chloride aqueous solution and 1mg / mL polyacrylic acid aqueous solution respectively; carry out oxygen plasma treatment on the titanium alloy substrate for 5min to obtain the hydroxylated substrate; immerse the hydroxylated substrate In the aqueous solution of polydiallyldimethylammonium chloride for 5 minutes, take it out and wash it with deionized water and dry it, then immerse it in the aqueous solution of polyacrylic acid for 5 minutes, take it out and wash it with deionized water and dry it; The solution was submerged five times successively, and a multilayer polymer electrolyte layer with five layers of polycation electrolyte layers and five layers of polyanion electrolyte layers stacked alternately was formed on the titanium alloy substrate. Made 1# titanium alloy artificial joint with biological lubricating surface.

Embodiment 2

[0059] Preparation of 2# titanium alloy artificial joint with biolubricating surface.

[0060] Prepare 2 mg / mL polyacrylamine hydrochloride aqueous solution and 2 mg / mL polymethacrylic acid aqueous solution respectively; treat the titanium alloy substrate with Piranha solution, and keep it in a water bath at 80°C for 60 minutes to obtain a hydroxylated substrate; immerse the hydroxylated substrate in polyhydrochloric acid Acrylamine aqueous solution for 60 minutes, take it out and wash it with deionized water and dry it, then immerse it in polymethacrylic acid aqueous solution for 60 minutes, take it out and wash it with deionized water and blow it dry; A multilayer polymer electrolyte layer with 10 layers of polycation electrolyte layers and 10 layers of polyanion electrolyte layers stacked alternately is formed on the titanium alloy substrate. Made 2# titanium alloy artificial joint with biological lubricating surface.

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Abstract

The invention discloses a titanium alloy artificial joint with a bio-lubrication surface layer, wherein the titanium alloy artificial joint is composed of a titanium alloy substrate and the bio-lubrication surface layer, and the bio-lubrication surface layer is a polymer electrolyte layer prepared by a layer-by-layer self-assembly technology. A preparation method of the joint comprises the following steps: (1) preparing a polycationic electrolyte solution and a polyanionic electrolyte solution; (2) carrying out hydroxylation treatment of the titanium alloy substrate to form a hydroxylated substrate; and (3) carrying out layer-by-layer self-assembly of the polyelectrolyte layer to form the bio-lubrication surface layer; and completing preparation of the titanium alloy artificial joint. Theartificial joint has good lubrication effect, can effectively reduce abrasive debris, improve tribological properties, achieve the effects of osteolysis inhibition and aseptic loosening, and prolong the service life of the artificial joint.

Description

technical field [0001] The invention relates to a titanium alloy artificial joint with a bio-lubricating surface layer and a preparation method thereof, in particular to an artificial joint capable of maintaining good lubricating effect under the action of friction and wear and a preparation method thereof. Background technique [0002] Titanium alloys are widely used as artificial joint materials due to their excellent mechanical properties, fatigue resistance, and biocompatibility. However, titanium alloys produce high wear and a large amount of wear debris during the sliding friction process. The accumulation of wear debris leads to macrophage phagocytosis, induces adverse physiological reactions, releases a large amount of osteolytic factors, and causes bone resorption by osteoclasts, eventually making the fixation Good artificial joints fail due to aseptic loosening and osteolysis, seriously affecting quality and service life. Therefore, improving the lubrication state...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/34A61L27/56
CPCA61L27/06A61L27/34A61L27/56A61L2300/452A61L2300/608A61L2420/08A61L2430/24
Inventor 邓亚玲孙见君于波熊党生
Owner NANJING FORESTRY UNIV
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