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Ultra-high-molecular-weight-polyethylene and drug complexes artificial joint material and its preparation method, and artificial joint prepared therefrom

An ultra-high molecular weight, artificial joint technology, applied in the field of hip joints, artificial joint materials and their preparation, can solve problems such as artificial joint prosthesis loosening, achieve the effects of overcoming low bioavailability of treatment, reducing revisions, and achieving obvious results

Inactive Publication Date: 2007-08-01
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This new type of medical device has two main benefits: it helps control damaging substances from being absorbed into our body while also promoting healing processes within weaker tissues like arthritis; it releases medicine slowly throughout its lifespan without causing any harmful compounds during use. Overall, these technical improvements make them more efficient than existing treatments used alone.

Problems solved by technology

This patents discusses the use of certain compounds called diphenol monomers, abbreviated DMPS hereinafter referred to as dinoproterins, including dimerized triazole derivatives like Dinacostimulatory Compound 21(DNZ)-AMB12-4012) and other related chemical agents commonly found in natural products. Diodecyl sulfide (DSMS) was discovered earlier but its mechanism remains unclear until now. Additionally, current treatment options involve surgery involving total shoulder reconstruction, revision surgeries, and spine fusion procedures.

Method used

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  • Ultra-high-molecular-weight-polyethylene and drug complexes artificial joint material and its preparation method, and artificial joint prepared therefrom

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Add 0.5 parts of estradiol to 99.5 parts of ultra-high molecular weight polyethylene powder with a diameter of 60 μm to 270 μm and a molecular weight of 2.50±500,000, and mix evenly to obtain a powdery composite artificial joint material.

Embodiment 2

[0029] Take 10 parts of estradiol and add it to its solvent - acetone, then add 90 parts of ultra-high molecular weight polyethylene powder with a molecular weight of 4.50±500,000 and a diameter of 60 μm to 270 μm, mix evenly to form a suspension, and vacuum dry it. A composite material in powder form is obtained.

Embodiment 3

[0031] Take 6 parts of estradiol alendronate sodium and dissolve in distilled water, then add 94 parts of ultra-high molecular weight polyethylene powder with a molecular weight of 3.50±500,000 and a diameter of 60 μm to 270 μm, and mix evenly to form a suspension. After vacuum drying, a uniformly dispersed mixture is made, and then put into a hot press mold for hot pressing. After four stages of pre-pressing, heating, heat preservation, and cooling, the mold is taken out to obtain a shaped solid composite material.

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Abstract

The invention disclosed a kind of super high molecular weight polyethylene/medicine compounded artificial joint as well as the preparing method and the prepared coax joint. The materials of the invention include 99.5-90 shares (by weight) of super high molecular weight polyethylene and 0.5-10 shares of medicine that can restrain osteolysis. After implanting the invention in human bodies, it can prevent the ostelysis of artificial hip joint and total knee prosthesis under common conditions; it can also prevent the cinch of prosth, prolong the service life of artificial joints, and ease the pain and burden of patients.

Description

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Claims

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Application Information

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Owner SOUTHWEST JIAOTONG UNIV
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