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Bioactive surface coating of biomedical degradable magnesium alloy and preparation method thereof

A surface coating and bioactive technology, which is applied in the field of bioactive surface coating and preparation of biomedical degradable magnesium alloys, can solve the problems of low bioactivity and lack of the ability of surrounding bone tissue to grow, and is conducive to recovery, The effect of improving the success rate of implantation and increasing the rate of new bone formation

Inactive Publication Date: 2013-05-29
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Coatings prepared on the surface of degradable magnesium alloys by the above methods often have low biological activity and lack the ability to promote the growth of surrounding bone tissue
There is no report on the introduction of strontium element into the surface coating of degradable magnesium alloy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] First prepare strontium-containing deposition solution, its composition is: 40g / L Ca(NO 3 ) 2 4H 2 O, 16g / LNa 2 HPO 4 2H 2 O, 5g / L Sr(NO 3 ) 2 . Fully dissolve the solution, then immerse pure magnesium with a purity of 99.99% into the deposition solution, and treat it at 70° C. for 5 minutes. After the sample was taken out, the residual solution on the surface of the sample was rinsed with tap water and distilled water, dried and stored at room temperature for later use.

[0018] The coating prepared in this example is mainly composed of magnesium phosphate, calcium phosphate and magnesium oxide. According to energy spectrum analysis, strontium element enters the coating with a content of 2.3 at.%, and the thickness of the coating is 20 μm.

[0019] After surface modification of pure magnesium by the above method, in simulated body fluid at 37°C, at 1.25cm 2 After immersion at the / mL ratio for 3 days, the pH value of the simulated body fluid was 8.3, while the...

Embodiment 2

[0021] The surface coating containing strontium was prepared by electrochemical deposition on AZ31 (magnesium-aluminum series) magnesium alloy, and the composition of the electrolyte was as follows: Ca(NO 3 ) 2 :0.0042M;NH 4 PO 4 :0.0025M;Sr(NO 3 ) 2 : 3g / L, adjust the pH to 3~6 with phosphoric acid. Electrodeposit on the surface of AZ31B alloy for 2~30min under the conditions of electrolyte temperature of 25~90℃ and voltage of 0.1~0.5V. After the sample was taken out, the residual solution on the surface of the sample was rinsed with tap water and distilled water, dried and stored at room temperature for later use.

[0022] The elemental components of the coating prepared in this example are Mg, O, P, Ca and Sr, wherein the Sr content is 1.07 at.%, and the thickness is 15 μm.

[0023] After the coated AZ31 magnesium alloy was soaked in simulated body fluid at 37°C for 3 days, a new CaP layer was observed on the surface under an electron microscope, indicating that the s...

Embodiment 3

[0025] The Sr-containing coating was prepared on the surface of ZK60 (Mg-Zn-Zr series) magnesium alloy by micro-arc oxidation. Among them, the composition of micro-arc oxidation electrolyte is: 1~5g / L NaOH; 10~40g / L NaOH 2 SiO 3 ; 10~15g / LKF; 0.5~5g / L Sr(OH) 2 ; the rest is water. The voltage used for micro-arc oxidation is 450V, the frequency is 800Hz, and the oxidation time is 10min.

[0026] The main components of the coating prepared by this method are magnesium oxide, magnesium silicate and magnesium fluoride. Energy spectrum analysis shows that Sr element enters the coating with a content of 1.57 at.%. The coating thickness is 25 μm.

[0027] The hemolysis test method stipulated in the national standard is used to test the magnesium alloy. The hemolysis rate of the magnesium alloy implant with micro-arc oxygen coating is 1%, which meets the requirements of the national standard (less than 5%), without coating protection. The hemolysis rate of magnesium alloy is 5.7%...

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Abstract

The invention provides a bioactive surface coating of a biomedical degradable magnesium alloy and a preparation method thereof. The bioactive surface coating is characterized in that strontium (Sr) is introduced as an active element of the coating. The preparation method of the coating containing strontium provided by the invention relates to the methods of chemical deposition, electrochemical deposition and micro-arc oxidation. The bioactive surface coating not only can control the degradation rate of magnesium alloy, but also can be used for improving the surface bioactivity of a magnesium alloy implantation device, by the release of strontium, the coating has a certain bone induction effect and inhibition on osteolysis, thus promoting the repair of bone tissues around the implantation device, and improving the implantation success rate of a magnesium alloy device. The bioactive surface coating provided by the invention aims at further improving the bioactivity of a biodegradable magnesium alloy surface coating.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and is particularly suitable for the field of surface modification of biomedical materials; in particular, it relates to a bioactive surface coating and its preparation for a biomedical degradable magnesium alloy. Background technique [0002] In recent years, magnesium alloys have attracted great attention due to their good biomechanical properties, biocompatibility and in vivo degradability, and are expected to become a new generation of degradable implant materials. Magnesium alloys have high specific strength and specific stiffness, the highest strength of which exceeds 200MPa; the density of pure magnesium is 1.74g / cm 3 About, and the compact bone density of human bone (1.75g / cm 3 ) is equivalent; the Young's modulus of magnesium alloy is about 45GPa, which is closer to the elastic modulus of human bone (about 20GPa) than other medical metals, which can significantly reduce the stress ...

Claims

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Application Information

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IPC IPC(8): A61L27/30
Inventor 林潇谭丽丽杨柯万鹏于晓明
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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