95results about How to "Accelerate the degradation rate" patented technology

The integral engineering rack of interface osteochondro tissue with bionic interface includes from the top to the bottom one cartilage layer, one calcified layer and one bone layer below cartilage connected organically. The cartilage layer consists of type II collagen and chitosan connected in covalent bond; the calcified layer consists of type II collagen and hydroxyapatite connected in covalent bond; the bone layer below cartilage consists of type I collagen and hydroxyapatite connected in covalent bond; and each of the cartilage layer and the bone layer below cartilage has at least one pore of 100-500 micron size. The integral engineering rack of the present invention has excellent biocompatibility, excellent degradability, sufficient mechanical first and bionic interface function.

The city sewage treatment process includes the following steps: utilizing grile and desilting basin to pretreat sewage, adding coagulating agent to make the phosphorus, heavy metal and orgnaic matters existed as colloid and suspended substances feed into anaerobic reactor in the form of sludge to make organic matter convert into impure methane, making the supernatant fluid pass through the next aerobic treatment reactor to remove organic matter and convert the ammoniacal nitrogen into nitric nitrogen, mixing anaerobic discharged water and aerobic discharged water, and making the mixture waterundergo the process of anaerobic treatment to make denitrifcation, finally utilizing secondary aeration and precipitation to completely remove organic matters from sewage so as to attain the goal of cleaning the sewage.

The invention relates to a hyaluronic-acid-based double-targeting nano-composite medicament and a preparation method thereof. Hydrophobic group ursodeoxycholic acid is included in a hyaluronic acid nano-polymer structure and can form an amphipathic polymer and automatically generate micelles in an aqueous solution, and polyethylene glycol can be introduced into the micelles to improve the dispersity and stability of a composite. An anti-tumor medicament can enter a nano-carrier through electrostatic adsorption or physical inclusion to generate a nano-medicament composite, wherein the nano-medicament composite is selectively concentrated in a tumor cell under an active targeting effect of hyaluronic acid and a surface CD44 receptor of a tumor cell, and promotes a tumor tissue to absorb the nano medicament-carrying composite by using a passive osmotic accumulation effect (EPR) at the same time. After an anti-tumor medicament is wrapped by a modified hyaluronic acid polymer, the anti-tumor medicament has the advantages of improving the bioavailability of the medicament, improving the targeting property, reducing the toxic and side effects, prolonging the half-life period of the medicament, being stably stored and the like, so that the tumor targeting therapy efficiency is improved in many ways.

The invention aims to provide a biodegradable composite film material of controllable degradation rate with good mechanical property, faster and more through degradation and no environmental harm, and a preparation method thereof. The material comprises the following components in parts by weight: 100 parts of matrix resin, 0-40 parts of other biodegradable polymers, 0.5-1.5 parts of heat stabilizer, 0.3-5 parts of nucleating agent, 1-5 parts of compatilizer, 2-15 parts of plasticizer and 0.3-5 parts of opener. The matrix resin is obtained by mixing poly lactic acid (PLA) and 3-hydroxybutyrate-3-hydroxy acid copolyester (PHBH) with each 20-80 parts by weight. The other biodegradable polymers are poly butylenes succinate (PBS), poly propylene carbonate (PPC), 3-hydroxybutyrate-3-hydroxyvalerate copolyester (PHBV) and terephthalic acid-butanediol-adipic acid copolyester (PBAT).

The invention relates to the field of tissue engineering, in particular to a preparation method of a composite nanometer fiber small-diameter intravascular tissue engineering stent material. The technical scheme is achieved as follows: formic acid is used as a common solvent; RGD-recombinant spider silk protein, polycaprolactone and chitosan are mixed in a mass ratio of 1:8:1 according to the requirements of an intravascular stent to prepare a spinning solution with the concentration of 20-30 percent (w/v); electrospinning process parameters are as follows: the diameter of a cross section of acylindrical rotating shaft is 3-6 mm, the rotating speed is 1,500-3,000rpm, the curing distance is 15-30 cm, the voltage is 50-150kV, the extrusion speed is 3-7ml/h and the temperature is 45-50 DEG C. The small-diameter intravascular stent has favorable cell adhesion-promoting capability, anticoagulant property and mechanical property for resisting physiological environment and can be clinicallyapplied as a small-diameter intravascular tissue engineering stent.

The invention discloses a Zn-Ge-X ternary biomedical material and a preparation method thereof. The Zn-Ge-X ternary biomedical material comprises the following components in percentage by mass: 0.5-6wt% of Ge, 0.1-1wt% of X and the balance of Zn, wherein X is selected from at least one of Mg, Cu, Mn, Sr, Fe, Ca, Ag and Ti. The ternary Zn-Ge-X biomedical material prepared by adopting traditional casting and deformation treatment as the preparation method and through optimizing deformation treatment and the components of the ternary material has excellent mechanical properties, good cell compatibility and suitable biodegradability, and is expected to become a potential degradable biomedical material.

The invention relates to the technical fields of preparation and application of a novel massive carbon material with an ordered mesoporous structure, and particularly discloses a preparation method and application of an ordered mesoporous carbon-activated carbon fibrofelt composite material. The ordered mesoporous carbon-activated carbon fibrofelt (OMC-ACF) composite material disclosed by the invention is a novel massive carbon material with an ordered mesoporous structure, and is prepared by taking phenolic resin as a carbon source and F127 as a structure directing agent, coating the phenolic resin and the F127 on the surface of an ACF at the same time according to a certain proportion, and performing intermolecular self-assembly, thermal polymerization and calcination under the protection of an inert gas; and the composite material is large in specific area, high in pore volume and large in bore diameter, so that the composite material can be used as a novel electrode material. The novel massive carbon material prepared by the method has the advantages of high catalytic degradation activity, high stability and the like in a test of cathode diffusion oxygen degradation dye wastewater through electro-Fenton reaction; and the novel massive carbon material is simple in production process and low in cost, and can be easily industrialized.

The invention discloses a hydrophilic poly-beta-hydroxybutyrate (PHB) fiber, which is prepared by blending and spinning the following raw materials in percentage by mass: 10 to 20 percent of hydrophilic polymer, 0 to 45 percent of polylactic acid (PLLA) and 40 to 80 percent of PHB, wherein the hydrophilic polymer is methacrylic acid copolymer, polyacrylic acid, polyacrylamide, polyethylene glycol, polyoxyethylene, polyvinyl alcohol or polyvinyl pyrrolidone. In addition, the invention also discloses a preparation method for the hydrophilic PHB fiber. By blending and spinning the PHB and the hydrophilic polymer, the brittleness of the PHB is overcome, the problems of poor hydrophilic property and long degrading period of the PHB fiber are solved, the toughness of the PHB fiber is improved, and the processing range of the PHB is widened. The preparation method is easy and convenient, the process conditions are simple and easy to control, and the tensile strength of the prepared hydrophilic PHB fiber at break can reach over 6.1cN/dtex.

The invention relates to a polylactic-acid-modified magnesium alloy medical composite material and a preparation method thereof. The method comprises: 1) performing micro arc oxidation treatment on a surface of a magnesium alloy substrate, and performing coupling treatment to obtain a silicane coupling substrate; 2) adding a surfactant to a chitosan solution, and performing uniform mixing to obtain a chitosan mixed liquid, and dissolving polylactic acid in trichloromethane to prepare a polylactic acid solution, and adding the polylactic acid solution in the chitosan mixed liquid while performing stirring, and performing high speed emulsification to obtain a film-casting liquid; and 3) coating the surface of the silicane coupling substrate with the film-casting liquid, removing the solvent and the surfactant to obtain a dry film layer, and performing thermal insulation at 80-90 DEG C to obtain the composite material. The composite material is excellent in biological compatibility, surface activity and mechanical properties. The degradation rate of the material can be controlled by adjusting the thickness of a polylactic acid and chitosan film layer. After the material is implanted to a human body, the degradation product can be absorbed by the human body or excreted outside the body with metabolism, so that secondary operation is not required.

The invention relates to the technical field of preparation and application of carbon materials, in particular to a preparation method of a municipal sludge derived self-doped iron and nitrogen species carbon material electrode and application of the municipal sludge derived self-doped iron and nitrogen species carbon material electrode as a cathode material to electro-Peroxone reaction to degradetoxic organic pollutants. Municipal sludge serves as a carbon material precursor, after one-step pyrolysis, an obtained carbon material is washed, filtered and dried, the carbon material, acetylene black powder and polytetrafluoroethylene dispersion liquid are mixed and dissolved in an ethanol solvent according to a certain proportion, ultrasonic treatment, stirring, drying and pressing are carried out to form a film, a titanium mesh serves as a carrier for compounding, and the electrode is prepared. The material is self-doped with iron and nitrogen species, iron and nitrogen sources do not need to be additionally added, the preparation method is simple, the cost is relatively low, and the obtained product is more environmentally friendly. And when being used as a cathode material in degradation of toxic organic pollutants by an electric-Peroxone reaction, the composite material shows excellent catalytic degradation activity and degradation rate, and the efficiency of the composite material is far higher than that of a common carbon-based material.

Provided are degradation-controllable magnesium phosphate cement and a preparation method and application thereof.The degradation-controllable magnesium phosphate cement is characterized by being prepared from, by mass, 35%-65% of magnesia powder, 15%-40% of monopotassium phosphate, 2%-7% of borax, 10%-25% of deionized water, 0%-1% of chitosan and 0%-1% of hydroxypropyl methyl cellulose.Compared with an existing material, the degradation-controllable magnesium phosphate cement is high in strength, good in biological activity and controllable in degradation rate and has a good application prospect in the field of biomedical materials by serving as a bone repair material.

The invention relates to the technical field of modification treatment of urea formaldehyde used for slow-release fertilizers, and in particular relates to a urea formaldehyde modifier as well as a preparation method and application thereof. According to the method provided by the invention, an organic acid prepared by fermentation of starch is adopted as the urea formaldehyde modifier, and the organic acid is used for modification treatment of urea formaldehyde, wherein the organic acid makes nitrogen of the urea formaldehyde released quickly, makes the modified urea formaldehyde more suitable for the production of the slow-release fertilizers, and improves the quality of the slow-release fertilizers; and the added organic acid is obtained by fermentation of biomass components, a plurality of the biomass components are compounded in the organic acid, and after entering soil, the organic acid can effectively improve the soil and provide nutrients for crops.

The invention provides a preparation method for a nano-TiO2 modified micro-channel reactor. The preparation method comprises the following steps: preparing a micro-channel reactor made of a transparent material, and cleaning the micro-channel reactor for later use; adding a titanium source in an acidic water solution or ammonia water to obtain a mixture, and stirring the mixture to form nano-TiO2 sol; injecting the nano-TiO2 sol in a channel of the later-use micro-channel reactor, staying for 5-30 min, and injecting deionized water in the channel of the micro-channel reactor for cleaning to obtain a nano-TiO2 sol particle modified micro-channel reactor; placing the nano-TiO2 sol particle modified micro-channel reactor in a 500-1,000 W infrared source to be illuminated, ultrasonically cleaning the passage with an acidic cleaning solution and deionized water in sequence, and obtaining the nano-TiO2 modified micro-channel reactor. The preparation method has the characteristics of being simple in preparation process, and easy to achieve industrial production; the micro-channel reactor, prepared according to the preparation method, has the characteristics of being high in density, convenient and high in efficiency.

The invention discloses a high-strength biomedical Mg-Zn-Zr-Fe alloy material with rapid biodegradability, and a preparation method thereof. The magnesium alloy is prepared from the components in percentage by mass: 5.0 to 6.0 percent of Zn, 0.5 to 1.0 percent of Zr, 0.01 to 0.09 percent of Fe, and the balance Mg and inevitable impurities. The preparation method comprises the concrete steps of smelting, carrying out casting homogenization treatment, hot-extruding and carrying out artificial aging treatment, so that biomedical magnesium alloy sheets, rods and wires meeting the service requirement of the biological fluid environment are obtained. According to the high-strength biomedical Mg-Zn-Zr-Fe alloy material with rapid biodegradability provided by the invention, the alloy elements harmless to a human body are added into the magnesium alloy, so that the alloy has no any toxicity on the human body after being degraded in vivo, and has excellent mechanical property, favorable mechanical property and processability, and appropriate corrosion rate. The high-strength degradable biomedical Mg-Zn-Zr-Fe alloy material provided by the invention has the tensile strength being larger thanor equal to 360MPa and the yield strength being larger than or equal to 320MPa, and is suitable for preparing medical materials such as bone nails.

The invention relates to the technical field of poly (lactic acid) polymer materials, in particular to a preparation method and application of a humin acid based poly (lactic acid) crystallization nucleating agent and a poly (lactic acid) composite material. The humin acid based poly (lactic acid) crystallization nucleating agent is prepared from the humin acid, carbonyl diimidazole, hydrochloricacid, pyridine and amines. With the humin acid based poly (lactic acid) crystallization nucleating agent, mechanical property, heat resistance, crystallization performance and degradation velocity ofthe poly (lactic acid) composite material are obviously improved, the poly (lactic acid) composite material is excellent in mechanical property, heat resistance, crystallization performance and high in degradation velocity, and the application range of the poly (lactic acid) composite material can be well expanded due to the good mechanical property, degradation performance and heat resistance; the poly (lactic acid) composite material is prepared by using twin-screw extrusion equipment, so that simpleness in technology, short production circle and low production cost are achieved.

A cytostromatic protein bioscaffold material for tissue engineering is prepared through using the buffering acetic acid solution to extract the cytostromatic protein, depositing with inorganic salt, and using the inorganic salt with different gradient to remove the III-type collagen from the cytostromatic protein, resulting in purified cytostromatic protein. Its advantages are high stability, purity and adhesion and no toxic by-effect.

The invention relates to a biological material for bone injury repair. A hydroxyapatite/polyurethane porous bone repair material with shape memory is mainly prepared by a gas foaming method. The porous bone repair material with the shape memory function is prepared from polycaprolactone and polytetrahydrofuran which are equal in mass and hydroxyapatite in different proportions. The bone repair material shows a good shape memory effect at 37 DEG C, the shape recovery rate of the bone repair material can reach 100%, the bone repair material can change the shape in an extremely short time to fill a defect part, and the material can adapt to and gradually degrade along with repair closing of tissue growth. In addition, the bone repair material also has the advantages of high porosity, good biocompatibility, non-toxic and harmless degradation products and the like, the preparation method is simple, the cost is low, and an effective and feasible way is provided for preparing the hydroxyapatite/polyurethane porous bone repair material with shape memory for the field of biological materials.

The invention belongs to the field of biological medical materials and particularly relates to bone cement with induction and degradation characteristics and a preparation method of the bone cement with the induction and degradation characteristics. The bone cement is made by powder and solidification liquid according to a ratio of 1:(0.3-1.2); the powder is prepared from, by mass, 30%-70% of calcium sulfate salt, 20%-60% of calcium phosphate salt, 0.1%-5% of inorganic additives, 0.1%-5% of organic additives and 0%-20% of DBM bone powder; the solidification liquid is phosphate solution. The bone cement is excellent in compressive strength, biocompatibility, bone conductivity and bone inductivity, and degradation speed of the bone cement is equivalent to bone growth speed. The bone cement can be made into different dosage forms by control of a liquid-solid ratio, injection products can be used for minimal invasive surgery and are great in collapse resistance, and paste products can be shaped arbitrarily to meet various demands of patients.