Bone cement with induction and degradation characteristics and preparation method of bone cement with induction and degradation characteristics

Abstract

The invention belongs to the field of biological medical materials and particularly relates to bone cement with induction and degradation characteristics and a preparation method of the bone cement with the induction and degradation characteristics. The bone cement is made by powder and solidification liquid according to a ratio of 1:(0.3-1.2); the powder is prepared from, by mass, 30%-70% of calcium sulfate salt, 20%-60% of calcium phosphate salt, 0.1%-5% of inorganic additives, 0.1%-5% of organic additives and 0%-20% of DBM bone powder; the solidification liquid is phosphate solution. The bone cement is excellent in compressive strength, biocompatibility, bone conductivity and bone inductivity, and degradation speed of the bone cement is equivalent to bone growth speed. The bone cement can be made into different dosage forms by control of a liquid-solid ratio, injection products can be used for minimal invasive surgery and are great in collapse resistance, and paste products can be shaped arbitrarily to meet various demands of patients.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a bone cement with inductive degradation properties and a preparation method thereof. Background technique [0002] Worldwide, bone transplantation is the second most common tissue transplant after blood transfusion. At present, the three materials used to treat bone defects are mainly autologous bone, allogeneic bone and artificial bone. Among them, autologous bone has always been the gold standard for bone transplantation, and has the best therapeutic effect, but the operation process is relatively complicated, and bone needs to be taken from the patient's body, resulting in postoperative pain and complications; allogeneic bone, such as demineralized bone matrix (DBM) , although it will not cause additional pain to people, and has good osteoinductivity and promotes the growth of osteoblasts, but the source of materials is insufficient; therefore, compared with a...

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Problems solved by technology

However, calcium sulfate bone cement also has disadvantages such as short injectable time, fast degradation time, and lack of osteoinductive activity.

In order to overcome the rapid degradation of calcium sulfate bone cement and the disadvantage of not being osteoinductive, Wright Corporation of the United States has developed a bone cement product with α-calcium sulfate hemihydrate, β-TCP and DBM as the main raw materials. It has a good bone formation effect, but this product, like the related products of the British Biocomposites company, must rely on medical grade α-calcium sulfate hemihydrate, otherwise its mechanical properties and degradation properties will be affected to a certain extent. At the same time, β-TCP does not It can self-cure, so it only plays the role of slowing down the degradation rate and providing calcium source and phosphorus source, so when calcium sulfate is degraded, it is difficult for bone cement to play the role of mechanical support

[0004] Calcium phosphate has good bioactivity, biocompatibility and injectability, and can provide calcium ions and phosphate ions required for human bone formation; however, calcium phosphate bone cement has poor degradability and hinders the growth of bone tissue; and The common way to solve this shortcoming is to make porous bioceramics, which is conducive to the growth and adsorption of osteoblasts and growth factors, but these products have poor mechanical strength and are difficult to meet the requirements of minimally invasive treatment.

[0005] Due to the defects of its own material, the artificial bone prepared from a single material is often difficult to meet various requirements.

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