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Silk fibroin/polymer-based tubular stent with three-dimensional ordered and disordered double network structures and preparation and usage methods thereof

A three-dimensional orderly, network-structured technology, applied in medical science, prostheses, tissue regeneration, etc., can solve the problems of limited ability of cells to induce growth and difficulty in forming a three-dimensional pore structure, achieving small structure size, ensuring mechanical support and Flexibility, enhanced structural stability and flexibility effects

Active Publication Date: 2019-09-10
YANCHENG INST OF IND TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen from the above prior art that double-layer tubular scaffolds can be prepared by changing the electrospinning process and the template process, but the double-layer tubular scaffolds prepared by this method are mostly disordered structures, and it is difficult to form relatively ordered three-dimensional pores structure, so the prepared tubular scaffold has limited ability to induce growth of cells

Method used

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  • Silk fibroin/polymer-based tubular stent with three-dimensional ordered and disordered double network structures and preparation and usage methods thereof
  • Silk fibroin/polymer-based tubular stent with three-dimensional ordered and disordered double network structures and preparation and usage methods thereof
  • Silk fibroin/polymer-based tubular stent with three-dimensional ordered and disordered double network structures and preparation and usage methods thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Add polylactic acid PLA into tetrahydrofuran to fully dissolve to obtain a 5g / L polymer solution, inject the polymer solution into a tubular mold with an inner diameter of 15mm, freeze-dry it quickly at -60°C, and then freeze it at -20°C Vacuum freeze-drying for 2 days and demoulding to obtain a polymer porous inner layer scaffold with a wall thickness of 2 mm, wherein the polymer porous inner layer scaffold contains a honeycomb pore structure with a pore size of 20-200 μm.

[0035] (2) The titanium-nickel shape memory alloy with a diameter of 0.2-0.3mm is used to form a metal mesh with a pore size of 0.8-1.5mm. After the inner support surface is covered with a layer of medical rubber, the polymer porous inner layer bracket is covered with medical rubber. On the surface, a tubular scaffold with a polymer porous inner layer supported by a metal mesh is obtained.

[0036] (3) Add silkworm cocoons to 0.05% Na2CO3 solution, the bath ratio is 1:50, after degumming at 100...

Embodiment 2

[0039] (1) Add polycaprolactone PCL to tetrahydrofuran to fully dissolve to obtain a 10g / L polymer solution, inject the polymer solution into a tubular mold with an inner diameter of 35mm, freeze-dry quickly at -80°C, and then dry it at -30 Vacuum freeze-drying at °C for 4 days, demoulding to obtain a polymer porous inner layer scaffold with a wall thickness of 6 mm, wherein the polymer porous inner layer scaffold contains a honeycomb pore structure with a pore size of 20-200 μm.

[0040] (2) A titanium-nickel shape memory alloy with a diameter of 0.3 mm is used to form a metal mesh with a pore size of 1.5 mm. After the inner support surface is covered with a layer of medical rubber, the polymer porous inner layer bracket is placed on the surface of the medical rubber to obtain a metal mesh containing A polymeric porous inner tubular scaffold supported within a metal mesh.

[0041] (3) Add silkworm cocoons to 0.05% Na2CO3 solution, the bath ratio is 1:50, after degumming at 10...

Embodiment 3

[0044] (1) Add polylactic acid-glycolic acid copolymer PLGA into tetrahydrofuran to fully dissolve to obtain a polymer solution of 8 g / L, inject the polymer solution into a tubular mold with an inner diameter of 20 mm, and freeze-dry it quickly at -70 ° C. Vacuum freeze-drying at -25°C for 3 days, demoulding to obtain a polymer porous inner layer scaffold with a wall thickness of 4 mm, wherein the polymer porous inner layer scaffold contains a honeycomb pore structure with a pore size of 20-200 μm.

[0045] (2) A titanium-nickel shape memory alloy with a diameter of 0.25 mm is used to form a metal mesh with a pore size of 1.2 mm. After the inner support surface is covered with a layer of medical rubber, the polymer porous inner layer bracket is placed on the surface of the medical rubber to obtain a metal mesh containing A polymeric porous inner tubular scaffold supported within a metal mesh.

[0046] (3) Add the raw silk to the 0.05% Na2CO3 solution, the bath ratio is 1:50, a...

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Abstract

The invention provides a silk fibroin / polymer-based tubular stent with three-dimensional ordered and disordered double network structures and preparation and usage methods thereof. The tubular stent comprises a polymer porous internal layer tubular stent of inner support of a metal mesh and a silk fibroin porous ordered outer layer tubular stent. The preparation method includes the following steps: adding a polymer to tetrahydrofuran for fully dissolving, injecting into a tubular mold, freeze-drying, and demolding to obtain a polymer porous internal layer stent; after degumming silkworm cocoons or raw silk, then heating and dissolving by a ternary solution and performing dialysis to obtain a silk fibroin solution, adding a cross-linking agent to the silk fibroin solution, and stirring uniformly to form silk fibroin gel; and after sleeving the surface of a tubular nickel-titanium alloy mesh with a layer of medical rubber, then sleeving the polymer porous internal layer stent on the surface of the medical rubber, then through a three-dimensional printing process, allowing the silk fibroin gel to form a three-dimensional ordered porous structure on the surface of a polymer porous tubular skeleton, and freeze-drying to obtain the silk fibroin / polymer-based tubular stent with the three-dimensional ordered and disordered double network structures.

Description

technical field [0001] The invention belongs to the technical field of biological stents, and in particular relates to a silk fibroin / polymer-based tubular stent with a three-dimensional ordered and disordered double network structure and a preparation and use method thereof. Background technique [0002] Human tissues and organs may be abnormal or damaged during use. Simply relying on tissue and organ transplantation to restore their functions is difficult to be widely used, and there will be problems such as exclusion. Therefore, tissue engineering is used to implant scaffold materials loaded with seed cells. After entering the human body, it promotes the proliferation and differentiation of cells, the degradation and absorption of scaffolds, and completes the repair of defective tissues. Therefore, scaffold materials are an essential component of tissue engineering. [0003] Scaffold materials can be divided into natural materials such as collagen, chitosan, and silk fib...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/22A61L27/18A61L27/56
CPCA61L27/18A61L27/227A61L27/56A61L2430/22
Inventor 王曙东樊理山刘华
Owner YANCHENG INST OF IND TECH
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