1410results about How to "Improve regenerative ability" patented technology

An apparatus for accessing a body lumen includes a tubular member including a proximal end, a distal end sized for introduction into a body lumen, and a passage extending along a steerable distal portion of the tubular member. The passage includes a first region extending substantially parallel to a center of modulus of the distal portion and a second region offset from the center of modulus. A steering element is disposed through the passage extending along the distal portion that includes a proximal end disposed adjacent the tubular member proximal end, and a distal end fixed to the tubular member distal end beyond the distal portion. A steering adjustment member is slidable within the passage for selectively directing a portion of the steering element between the first and second regions to vary the steerability of the distal portion.

A porous β-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 μm, preferably 50-125 μm. The porous β-TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. Preferably, the bioactive agent is encapsulated in a biodegradable agent. The invention provides a kit and an implant device comprising the porous β-TCP, and a bioactive agent and a binder. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region, a porous β-TCP material disposed on the surface region and optionally comprising at least a bioactive agent or a binder. Methods of producing the porous β-TCP material and inducing bone formation are also provided.

Biocompatible tissue implants are provided for repairing a tissue injury or defect. The tissue implants comprise a biological tissue slice that serves as a source of viable cells capable of tissue regeneration and / or repair. The biological tissue slice can be harvested from healthy tissue to have a geometry that is suitable for implantation at the site of the injury or defect. The harvested tissue slice is dimensioned to allow the viable cells contained within the tissue slice to migrate out and proliferate and integrate with tissue surrounding the injury or defect site. Methods for repairing a tissue injury or defect using the tissue implants are also provided.

A system delivers cardiac pacing therapy and chemical and / or biological therapy to modulate myocardial tissue growth in a heart after myocardial infarction (MI). The system includes an agent delivery device to release one or more agents to an MI region to modulate myocardial tissue growth in that region, and a cardiac rhythm management (CRM) device to deliver pacing pulses to enhance the effects of the one or more agents by altering myocardial wall stress and cardiac workload. In one embodiment, the system is an implantable system including an implantable agent delivery device and an implantable CRM device.

The invention provides a nano-bionic material for tissue repair and a preparation method thereof. The nano-bionic material comprises a nano-bionic bracket and hydrosol attached to the nano-bionic bracket, wherein one or more cell factors and / or cells are coated in the hydrosol. The preparation method of the nano-bionic material comprises the following steps of: preparing an electrospinning solution and a hydrosol solution containing the cell factors and / or the cells; preparing the nano-bionic bracket by using the electrospinning; printing the hydrosol solution containing the cell factors and / or the cells on the nano-bionic bracket by using a ink-jet printer; and the like, and repeating the electrospinning and the ink jet to obtain the nano-bionic material with different thicknesses. By combining with an electrospinning technology and a biological printing technology, the invention combines specific medicines and / or the cell factors and / or the cells in the nano-bracket and / or the surface of the nano-bracket, thereby greatly enhancing the effects of the nano-bionic material on tissue repair and tissue regeneration; in addition, the invention has broad application prospect.

Data carrying optical signals are subjected to equalization or pulse shaping of the optical signal waveform. A plurality of optical tap signals derived from the optical signal are used to control a modulator operating on an input signal to provide an output signal having the desired waveform. A Mach-Zehnder interferometer having semiconductor optical amplifiers in each arm provides modulation by the effect of cross modulation induced by propagating the respective tap signals through a selected one of the semiconductor optical amplifiers. Various forms of transversal filter are provided by selecting the number of optical taps, assigning positive or negative weights and appropriate delays. The effects of dispersion in optical signals can be mitigated by utilizing optical taps with negative weights to subtract tail portions from the leading and trailing edges of a signal pulse. The invention has application to systems with high bit rates where equalization or pulse shaping in the electrical domain is difficult to implement.

Biocompatible tissue implants are provided for repairing a tissue injury or defect. The tissue implants comprise a biological tissue slice that serves as a source of viable cells capable of tissue regeneration and / or repair. The biological tissue slice can be harvested from healthy tissue to have a geometry that is suitable for implantation at the site of the injury or defect. The harvested tissue slice is dimensioned to allow the viable cells contained within the tissue slice to migrate out and proliferate and integrate with tissue surrounding the injury or defect site. Methods for repairing a tissue injury or defect using the tissue implants are also provided.

The present invention relates to a building block of ecological slope protection vegetation, a fabrication method and a construction technique. The building block is composed of a growing bed body, a lath crib, planting troughs, a vegetation layer and a plant, the lath crib wraps the circumference of the growing bed body, the upper plane of the growing bed body is lower than the upper plane of the lath crib and concave, the vegetation layer is formed on the growing bed body, which matches the inner walls of the sectional area of the lath crib to form an integral building block, and more than one planting troughs are arranged on and run through the growing bed body. The design of the present invention is scientific, the structure is reasonable, the restoration of water ecology can reduce the operating cost, environment is improved, ecology is reinstated, harmonious natural beauty is enhanced, and the present invention is suitable for the nidification of small living creatures and the habitation and the survival of aquatic fishes, so that the cutting-off continuity of water and land regions is restored. The present invention is widely applied to channel slope protection, levee slopes, roadsides, airports, parks, public lands, household lawns, sports grounds, etc. The present invention is suitable for cold regions, damp regions, warm and damp intermediate zone, etc.

A biomimetic biosynthetic nerve implant (BNI) that uses a hydrogel-based, transparent, multi-channel matrix as a 3-D substrate for nerve repair is disclosed. Novel scaffold-casting devices were designed for reproducible fabrication of grafts containing several micro-conduits, and further tested in vivo using a sciatic nerve animal model and repair of the adult hemitransected spinal cord. At 16 weeks post-injury of the sciatic nerve, empty tubes formed a single nerve cable. In sharp contrast, animals that received the multi-luminal BNI showed multiple nerve cables within the available microchannels, better resembling the multi-fascicular anatomy and ultra structure of the normal nerve. In the injured spinal cord, the BNI loaded with genetically engineered Schwann cells were able to demonstrate survival of the grafted cells inside the BNI, and robust axonal regeneration through the implant up to 45 days after repair.

The present invention relates to methods and medicaments used for treating conditions that require axonal regeneration, e.g. in mammals affected by injury or disease of the central or peripheral nervous system. The medicaments used in these methods facilitate axonal regeneration by inhibition of the complement system. Conditions requiring axonal regeneration that may be treated in accordance with the invention include physical injuries as well as neurodegenerative disorders of the peripheral or central nervous system.

An exhaust gas purifying apparatus is provided which includes a honeycomb structure used as a filter to capture particulates in exhaust gas from an internal combustion engine such as diesel engine and as a carrier of a catalyst to convert the exhaust gas. The honeycomb structure is formed from a composite material comprising ceramic particles and crystalline silicon. The particulates captured by the honeycomb structure are removed by combustion at a temperature of 250 to 800° C., thereby, even if a relatively low temperature is distributed or a heat cycle has been repeated from a long term, thermal stress is prevented from being stored, cracking is prevented and thermal shock resistance is thus improved.

A vehicle or watercraft regeneration system includes at least one electric motor capable of generating electricity and a controller for the at least one motor; wherein the controller to optimize the efficiency of the regeneration. The controller can optimize efficiency by including comprises circuitry for biasing the electric motor during regeneration. Also provided is a regeneration system that further comprises an electricity storage device such as a battery, a capacitor, an electrolysis unit that generates hydrogen from water, and a flywheel. In addition, an efficiency enhancing system for a watercraft or vehicle includes at least one electric motor capable of generating electricity; a controller for the at least one motor; and an electrical connection between the at least one motor and the controller, where in the controller adjust one or more magnetic fields of the electric motor during regeneration to optimize the efficiency of the regeneration. Methods for increasing efficiency of regeneration of a watercraft of vehicle powered by at least one electric motor are also disclosed.

The present invention discloses a regeneration type artificial blood vessel based on an in-situ self stem cell technology and a preparation method thereof. The artificial blood vessel is a structure composed of at least three connected bionic support layers, wherein the bionic support layer is prepared by nanometer bionic supports and hydrosol attached to the nanometer bionic supports; the structure is a concentric circle loop and has an inner layer, an insulating layer and an outer layer outwards; the hydrosol of the inner layer and the outer layer are packaged with one or more specificity antibodies and / or cytokines and / or adhered short peptides and / or medicaments. The preparation method includes preparing the inner layer by an electrostatic spinning; preparing the insulating layer on an external surface of the inner layer; preparing the outer layer on an external surface of the insulating layer. The artificial blood vessel of the invention may be degraded safely and automatically during a wound surface repair process, and defect blood vessel is repaired completely during the degradation process, thus a regenerative process and a normal differentiation process are identical, and a good repairing effect will be obtained.

This invention is directed in part to novel doses, dosage formulations, and routes of administration of such doses and dose formulations, said dose and dose formulations containing one or more copper chelators, for example, one or more trientine active agents, including trientine analogues, trientine salts, trientine prodrugs, and trientine derivatives, useful in the treatment of diseases, disorders and conditions, including in indications where copper may play a role.

The present invention relates to methods and medicaments used for treating conditions that require axonal regeneration, e.g. in mammals affected by injury or disease of the central or peripheral nervous system. The medicaments used in these methods facilitate axonal regeneration by inhibition of the complement system. Conditions requiring axonal regeneration that may be treated in accordance with the invention include physical injuries as well as neurodegenerative disorders of the peripheral or central nervous system.

A device for utilizing waste heat from a heat engine comprises a Rankine cycle including a pump, a heating device, an expansion device, and a condenser device, and a controller for controlling an operation of the Rankine cycle. The controller calculates an optimum heat collection amount (Qho) as a heat value to be collected from waste heat of the engine, wherein the heat collection amount (Qho) is calculated as an optimum amount in relation to a potential maximum heat radiation amount (Qco) to be radiated at the condenser device. The controller calculates an optimum flow amount (G) of refrigerant corresponding to the optimum heat collection amount (Qho), so that a maximum driving power (L) is generated at the expansion device.

Methods and compositions are provided for the treatment of articular cartilage defects and disease involving the combination of tissue, such as osteochondral grafts, with active growth factor. The active growth factor is preferably a composition containing at least one bone morphogenetic protein and a suitable carrier. The method results in the regeneration and / or functional repair of articular cartilage tissue.

Healing of wounds in mammalian tissue may be enhanced by the application of certain neuropeptides, optionally in combination with known growth promoting hormones. Exemplary neuropeptides include tachykinins, such as Substance P, Substance K, and the like, as well as calcitonin gene-related peptides. The compositions may further include a polymeric delivery carrier and are utilized by applying to the site of the wound. Wounds may be vascular or avascular wounds. The compositions promote elaboration of cellular matrices and development of cellular attachment mechanisms in addition to stimulating cellular proliferation.

A method for operating an internal combustion engine for variable engine out NOx control talking into account the age of the SCR.

A porous β-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 μm, preferably 50-125 μm. The porous β-TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. Preferably, the bioactive agent is encapsulated in a biodegradable agent. The invention provides a kit and an implant device comprising the porous β-TCP, and a bioactive agent and a binder. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region, a porous β-TCP material disposed on the surface region and optionally comprising at least a bioactive agent or a binder. Methods of producing the porous β-TCP material and inducing bone formation are also provided.

A biomimetic biosynthetic nerve implant (BNI) that uses a hydrogel-based, transparent, multi-channel matrix as a 3-D substrate for nerve repair is disclosed. Novel scaffold-casting devices were designed for reproducible fabrication of grafts containing several micro-conduits, and further tested in vivo using a sciatic nerve animal model and repair of the adult hemitransected spinal cord. At 16 weeks post-injury of the sciatic nerve, empty tubes formed a single nerve cable. In sharp contrast, animals that received the multi-luminal BNI showed multiple nerve cables within the available microchannels, better resembling the multi-fascicular anatomy and ultra structure of the normal nerve. In the injured spinal cord, the BNI loaded with genetically engineered Schwann cells were able to demonstrate survival of the grafted cells inside the BNI, and robust axonal regeneration through the implant up to 45 days after repair.

A composition for the treatment, prevention or management of a condition in primates, especially humans comprising a phenolic antioxidant-chromium complex.

The present invention relates to one kind of catalyst for liquid phase alkylation of ethylene to prepare ethylbenzene and aims at raising the stability and regeneration performance of catalyst. The present invention adops beta-zeolite molecular sieve with SiO2 / Al2O3 molar ratio of 10-50 as catalyst, and the catalyst is processed first with high temperature steam and then with organic acid before use, and this raises the stability and regeneration performance of catalyst. The present invention may be used in the industrial production of liquid phase alkylation to prepare ethylbenzene.

The invention discloses a broiler chicken breeding method and special feed traditional Chinese medicine addition agents thereof. According to the breeding method, during the age of 1-10 days of broiler chickens, the feed traditional Chinese medicine addition agents improving immunity of the broiler chickens are added to feeding feed; during the age of 11-19 days of the broiler chickens, the feed traditional Chinese medicine addition agents preventing respiratory diseases of the broiler chickens are added to the feeding feed; during the age of 20-29 days of the broiler chickens, the anti-virus feed traditional Chinese medicine addition agents are added to the feeding feed; during the age of 30-42 days of the broiler chickens, the feed traditional Chinese medicine addition agents promoting growth of the broiler chickens are added to the feeding feed; and adding proportion of the addition agents in the feeding feed is 0.3-1% of the total weight of the feed. The broiler chicken breeding method and the special feed traditional Chinese medicine addition agents thereof have the advantages of using the traditional Chinese medicine feed in the whole process, improving disease-resistant capacity of the broiler chickens, promoting growth and development of the broiler chickens, and being low in production cost, simple to produce and use, remarkable in use effect, and free from drug residue and adverse effect.

A porous β-tricalcium phosphate material for bone implantation is provided. The multiple pores in the porous TCP body are separate discrete voids and are not interconnected. The pore size diameter is in the range of 20-500 μm, preferably 50-125 μm. The porous β-TCP material provides a carrier matrix for bioactive agents and can form a moldable putty composition upon the addition of a binder. Preferably, the bioactive agent is encapsulated in a biodegradable agent. The invention provides a kit and an implant device comprising the porous β-TCP, and a bioactive agent and a binder. The invention also provides an implantable prosthetic device comprising a prosthetic implant having a surface region, a porous β-TCP material disposed on the surface region and optionally comprising at least a bioactive agent or a binder. Methods of producing the porous β-TCP material and inducing bone formation are also provided.

The present invention relates to the regeneration of adsorbent matrices that are used for the purification of substances from aqueous liquid samples derived from biological material. The method is adapted to adsorbent matrices that are sensitive to hydrolysis either because of a sensitive base matrix or a sensitive ligand including also a sensitive spacer a n d is characterized in contacting at least one regeneration solution with the adsorbent matrix which comprises an organic solvent which is water-miscible and has a pH value ≦4, preferably ≦3 (acid solution) or ≧10 but <13 (alkaline solution).

Methods and systems are provided for opportunistic regeneration of a diesel particulate filter based on cloud based traffic information and navigation information. In one example, a method may include determining initiation of regeneration, termination of regeneration and a degree of regeneration based on information from a lead vehicular network and navigation information in order to reduce a regeneration fuel penalty.

A biomimetic biosynthetic nerve implant (BNI) casting device includes a matrix casting tube; a matrix casting tube protective shield comprising a male coupling portion joinable to a female coupling portion, wherein the joined portions encase the matrix casting tube; microchannel forming fibers; a fixing point for holding one end of the microchannel forming fibers; loading fiber guideholes for placement of the microchannel forming fibers; one or more ports for injection of matrix material into the casting tube; and a cell suspension loading well in fluid communication with the matrix casting tube when the device is fully assembled such that removing the fibers from the formed implant can draw fluid containing cells and / or other agents into the microchannels.

A regenerating braking system is provided, which includes: a synchronous motor with field coil excitation including a cylindrical stator coil, an inverter electrically connected to the stator coil, a battery electrically connected to the inverter, a rotor coil provided in an internal space of the stator coil, a two-way switch electrically connected to the rotor coil, and a capacitor electrically connected to the two-way switch; and a controller, wherein when the first differential calculus of acceleration of a load on the synchronous motor becomes negative, the controller stores regenerative power regenerated in the rotor coil from the stator coil, in the capacitor through the two-way switch, and wherein the controller supplies the regenerative power stored in the capacitor to the rotor coil through the two-way switch.

The invention relates to a guided tissue regeneration membrane, which comprises a compact coating and a loose coating, wherein the compact coating is composed of collagen-I or collagen-I composite hyaluronic acid; and the loose coating is composed of collagen-I or collagen-I composite calcium salt. A preparation method of the guided tissue regeneration membrane comprises the following steps of: preparing a collagen solution or a collagen and hyaluronic acid mixed solution by the use of acetic acid; injecting the solution into a self-made die, and drying it in the air to prepare the compact coating; injecting the collagen solution or a mixed liquor of the collagen solution and calcium salt onto the compact coating, and uniformly spreading; precooling the die at ultralow temperature, followed by freeze-drying to prepare the guided membrane with the compact coating and loose coating structure; carrying out vacuum high-temperature crosslinking and chemical crosslinking; and finally cleaning. The regeneration membrane has good histocompatibility and mechanical strength, low antigenicity and strong guided tissue regeneration capability. Its degradation rate in vivo is 3-8 months. The method is easy to operate, is suitable for automatic and continuous large-scale production, and solves the problems of large size of collagen membrane and material uniformity during industrial production.