59 results about "Dodecanedioic acid" patented technology

The invention relates to the technical field of epoxy resin, in particular to self-repairing epoxy resin and a preparation method thereof. The self-repairing epoxy resin is prepared from the following raw materials in parts by mass: 80 to 120 parts of bisphenol A type epoxy resin, 20 to 40 parts of bisphenol F type epoxy resin, 5 to 15 parts of 1, 6-hexanediol diglycidyl ether, 1 to 3 parts of 3, 5-dimethylphenylboronic acid, 1 to 5 parts of furyl maleimide, 10 to 20 parts of dodecanedioic acid, 5 to 15 parts of butanetetracarboxylic acid, 1 to 3 parts of catalyst, 10 to 15 parts of nano silicon dioxide, 1 to 2 parts of boron nitride nanosheet and 1 to 2 parts of hyperbranched polyamidoamine. The curing agent is prepared from the following components in parts by weight: 20-30 parts of epoxy resin, 1-2 parts of sulfydryl-terminated polysiloxane, 20-30 parts of amine curing agent, 5-15 parts of reinforcing filler and 0.5 According to the invention, the balance among self-repairing capability, mechanical property and heat resistance is successfully realized; in the microcrack propagation process, fracture and recombination mechanisms of dynamic covalent bonds effectively prevent further propagation of cracks.

The invention provides a high-flexibility low-temperature fast curing powder coating for reinforcing steel bars as well as a preparation method and application thereof, and belongs to the technical field of powder coatings. The powder coating comprises the following components in parts by mass: 180-200 parts of high-toughness epoxy resin, 45-48 parts of a high-toughness phenolic curing agent, 6-8 parts of a flatting agent, 2-4 parts of a brightener, 1-2 parts of benzoin and 55-70 parts of pigment filler. The high-toughness epoxy resin is obtained by polymerizing bisphenol F diglycidyl ether, 1, 10-decanediol, glyceryl monobutyrate, hexamethylene diisocyanate, dodecanedioic acid, triglycidyl p-aminophenol and the like; the high-toughness phenolic curing agent is obtained by polymerizing bisphenol F diglycidyl ether, 1, 4-butanediol diglycidyl ether and bisphenol F. The coating is used for low-temperature rapid curing molding on the surface of the reinforcing steel bar to obtain a coating, and has excellent bending resistance and corrosion resistance.

The invention relates to the field of processing aids and lubricants thereof, in particular to a plastic lubricant and a preparation method and application thereof.The preparation method comprises the following steps that firstly, dodecanedioic acid and pentaerythritol are added into a reaction kettle provided with a stirring device and a heating system; fully and uniformly mixing under the conditions that the temperature is 190-250 DEG C and the stirring speed is 300-500 revolutions per minute, so as to carry out dehydration esterification reaction, and continuously stirring until a chemical balancing state is achieved; and cooling to 150 DEG C, spraying powder and sieving to finally obtain the finished product plastic lubricant. The plastic lubricant disclosed by the invention can keep excellent lubricating property in a high-temperature environment, effectively reduce the viscosity of a plastic melt and remarkably improve the fluidity. Meanwhile, good thermal stability and chemical stability are achieved, it is ensured that no adverse reaction is generated when the coating is in contact with a plastic matrix, the environmental protection requirement is met, and pollution to the environment is avoided.

The invention provides a degradable plastic bag material and a preparation method thereof, and belongs to the field of plastic bag materials. The degradable plastic bag material is prepared from the following chemical components: 40 to 50 parts of polylactic acid, 15 to 25 parts of 3-hydroxybutyrate-co-4-hydroxybutyric acid copolymer, 5 to 15 parts of silane coupling agent modified starch, 3 to 8 parts of acetylated bamboo source nano cellulose, 5 to 15 parts of furan-terminated polylactic acid copolymer, 3 to 8 parts of bismaleimide dodecanedioate, 2 to 6 parts of coffee residue loaded WO3 and TiO2 and 1 to 5 parts of epoxidized soybean oil, the composition comprises the following components in parts by weight: 1-3 parts of sodium alginate microencapsulated lipase, 1-3 parts of quaternary ammonium salt modified hydrophilic kaolin, 0.1-1 part of zinc phenylphosphate and 0.1-0.8 part of polycarbodiimide. According to the application, the balance between the mechanical property and the degradation rate of the plastic bag material is realized through light-enzyme synergistic trigger degradation and dynamic covalent network regulation and control.

The invention relates to an exhaled air condensate metabolite composition, a kit and a method for predicting invasive lung adenocarcinoma. The expired gas condensate metabolite composition for predicting the invasive lung adenocarcinoma comprises lysyl-valine, lysophosphatidyl glycerol (19: 0), vanillyl-glucose, hydroxyproline-threonine, phenylalanine, dihydroxy benzophenone, palmitoyl glycine, triglyceride (43: 0), monobutyl phthalate, hydroxyphenyl propionic acid, oleoyl glycine and dodecanedioic acid. The preparation method comprises the following steps: adding 4-chlorophenylalanine and The kit for predicting the invasive lung adenocarcinoma comprises an internal standard substance required for detecting the metabolite combination. The combined marker provided by the invention has the characteristics of high sensitivity and high specificity on the diagnosis of the invasive lung adenocarcinoma.

The invention provides a blood marker for distinguishing lung cancer and non-lung cancer diseases and application of the blood marker, and belongs to the technical field of biomarkers. The blood marker for distinguishing lung cancer and non-lung cancer diseases comprises at least five metabolites as follows: phosphatidylethanolamine (36: 4), lysophosphatidylcholine 18: 1e, phosphatidylethanolamine 38: 7e, sphingomyelin d38: 5, dodecanedioic acid, N-acetylputrescine, L-glutamyl-L-glutamine, hippuric acid, trans-cyclohexane-1, 3, 4-triazole-1, 3, 4-triazole-1, 3, 4-triazole-1, 3, 4-triazole-1, 3, 4-triazole-1, 3, 4-triazole-1, 3-triazole-1, 3, 4- The compound is prepared from 1, 2-dicarboxylic acid, glycochenodeoxycholic acid, allantoic acid, L-valine, methyleucine and 4-guanidinobutyric acid. A diagnosis model is constructed based on the blood marker, and the area under curve (AUC) is greater than 0.77, which indicates that the diagnosis result is accurate and reliable. The invention provides an effective marker for diagnosis of lung cancer and differential diagnosis of lung cancer and non-lung cancer diseases, greatly simplifies experimental operation, and has important clinical diagnosis significance.

Provided is an engineered bacterium for inhibiting the synthesis of dodecanedioic acid. The expression of a related redox gene is knocked out or down-regulated in the genome of the engineered bacterium. The engineered bacterium can effectively reduce the production of the by-product dodecanedioic acid and prevent the peroxidation of 12-hydroxydodecanoic acid during the synthesis of nylon 12 monomer. Further provided is a method for constructing an engineered bacterium for inhibiting the synthesis of dodecanedioic acid. The method involves synthesizing nylon 12 monomer in Escherichia coli by using a quorum-sensing system in Vibrio fischeri. The established Escherichia coli containing a self-induction system can produce the nylon 12 monomer from glucose, and the generation of the by-product dodecanedioic acid can be effectively reduced. After fermentation in a shake flask for 72 h, the yield of the nylon 12 monomer is more than 100 mg / L, and the yield of the by-product dodecanedioic acid is reduced to less than 200 mg / L (the proportion in the product is less than 20%).

The invention discloses semi-aromatic bio-based polyamide and a preparation method thereof, and belongs to the technical field of macromolecular organic materials. Monomers 2, 5-furan dimethylamine, dodecanedioic acid, undecanedioic acid and sebacic acid are used as raw materials, and the disclosed semi-aromatic bio-based polyamide has rigidity of aromatic rings and flexibility of aliphatic chains and has good thermodynamic properties and mechanical properties. The oxygen permeability of the semi-aromatic bio-based polyamide protected by the invention is 0.005 ml / m < 2 > / 24h, the semi-aromatic bio-based polyamide has excellent gas barrier property, the degradation initial temperature is 348.6 DEG C, the maximum degradation temperature is 373.2 DEG C, the crystal melting point (Tm) of a polymer is 226.4 DEG C, the glass transition temperature (Tg) is 169.5 DEG C, the thermal stability is high, the thermal transition temperature is low, and the semi-aromatic bio-based polyamide has good processability.

The present application relates to a kind of cement composite for anti-cracking, anti-bending strength mortar, it is first using the component including triethylene glycol, dodecanedioic acid, polypropylene glycol, 2-naphthylamine-1, 5-disulfonic acid, 1, 4-butanediol-2-sodium sulfonate, citric acid, triethanolamine to prepare special toughness structure, hydrophilic polymer polyester resin, then it is fully mixed with cement clinker, gypsum, blast furnace slag and coal gangue powder etc., powder preparation is obtained.The cement product prepared in the present application contains organic polymer polyester resin that can be hydrated and dispersed, the mortar material prepared by using the cement product of the present application not only has excellent anti-cracking performance, but also has high bending strength, which is much better than ordinary cement, and can be used in the field of cement mortar material with high requirements for anti-cracking and bending strength.

The invention provides polyester resin for a self-dusting and high-hardness powder coating as well as a preparation method and application of the polyester resin, and belongs to the technical field of powder coatings. The polyester resin is obtained by mainly polymerizing trimesic acid, N, N-bis (3-aminopropyl) methylamine, 1, 6-hexamethylenediamine, dodecanedioic acid, 2, 5-dimethyl-2, 5-hexanediol, 1, 3-malonic acid, sebacic acid, triethylene glycol, 2, 3-naphthalene dicarboxylic anhydride and the like which are used as main raw materials, and polyester resin 1 and polyester resin 2 which are greatly different in characteristic are respectively prepared by adopting a double-kettle combination mode. And then mixing at high temperature. Good matting and self-frosting effects can be achieved without adding a sand texture agent, and the hardness of a coating film is high.

The invention belongs to the technical field of organic synthesis, and particularly relates to a preparation method of octadecanedioic acid mono-tert-butyl ester. The method specifically comprises the following steps: reacting dodecanedioic acid, dichloromethane and DMF (Dimethyl Formamide), controlling the temperature, dropwise adding an acylation reagent, and performing reduced pressure concentration after reaction to obtain a compound 1; reacting the compound 1, dimethylbenzene, palladium-carbon and organic alkali, carrying out nitrogen displacement, introducing hydrogen at a controlled temperature, carrying out nitrogen displacement after the reaction, and filtering and concentrating to obtain a compound 2; adding tert-butyl acrylate into an acetic acid aqueous solution, dropwise adding the compound 2, reacting, adjusting the pH value, extracting, filtering and concentrating to obtain a compound 3; adding the compound 3 into dichloromethane, controlling the temperature, adding aluminum trichloride, dropwise adding a reducing agent, reacting, filtering, adjusting the pH value, separating liquid, concentrating and recrystallizing to obtain di-tert-butyl octadecanedioate; and reacting the di-tert-butyl octadecanedioate, lithium hydroxide and tert-butyl alcohol, filtering, adjusting the pH value, extracting, concentrating and recrystallizing to obtain the mono-tert-butyl octadecanedioate. The method is low in production cost and high in safety.

The invention belongs to the technical field of high polymer materials, and particularly relates to reactive low-viscosity flexible polyester which is used as an epoxy resin toughening agent and contains an organic silicon short-chain branch and a preparation method of the reactive low-viscosity flexible polyester. Y-type organic silicon dihydric alcohol is introduced into a polycondensation reaction system of dodecanedioic acid, azelaic acid and flexible dihydric alcohol, and meanwhile, an epoxy compound is adopted for blocking, so that the reactive low-viscosity flexible polyester containing the organic silicon short-chain branch and used as the epoxy resin toughening agent is prepared. When the reactive low-viscosity flexible polyester is used as an epoxy resin toughening agent, the impact strength, tensile strength and hydrophobicity of matrix epoxy resin for a composite material can be effectively improved, the transparency of a cured product is kept, and the corrosion resistance and weather resistance of epoxy resin anticorrosive paint can also be effectively improved.

The invention discloses a human leukemia cell targeted cell-penetrating peptide modified enzyme sensitive PDC type PROTAC as well as a preparation method and application thereof, and belongs to the technical field of tumor targeted therapy. The PDC type PROTAC is formed by connecting a hypoxia inducible factor 1 alpha (HIF-1alpha) protein fragment and imatinib through dodecanedioic acid, and is further modified through a human leukemia cell targeted cell-penetrating peptide Cyclo-C9C-R and a cathepsin B sensitive sequence GFLG. The modified PDC type PROTAC can release original drugs under the catalysis of cathepsin B, has small influence on THP1 cell activity, but can effectively inhibit proliferation of K562 cells and KU812 cells, degrade target proteins, induce cell apoptosis and influence cell cycles, so that the PDC type PROTAC has remarkable advantages in the aspect of preparation of antitumor drugs, and has broad application prospects. Particularly, the compound shows a good application prospect in the development of drugs for targeting human chronic myelogenous leukemia cells and human peripheral blood basophilic leukemia cells, and opens up a new field for the development of PROTAC drugs.

The invention discloses a high-lubricity cutting fluid and a preparation method thereof in the technical field of metal processing lubricants, and the cutting fluid is based on deionized water and comprises triethanolamine, an antirust agent, dodecanedioic acid, polyether and a defoaming agent. And two key inorganic modified additives: surface amino functionalized fluorinated hexagonal boron nitride and zinc ion intercalation modified graphite phase carbon nitride. The preparation method comprises the following steps: firstly preparing a premixed solution containing water, triethanolamine, the antirust agent, dodecanedioic acid and polyether, then adding the two inorganic modified additives, performing ultrasonic treatment and uniform dispersion, and finally adding the defoaming agent and filtering to obtain a finished product. Through the synergistic effect of two uniquely designed inorganic compounds, the cutting fluid has excellent lubricity, long-acting antibacterial property and broad-spectrum corrosion inhibition at the same time, is especially suitable for precise and high-speed processing of various materials, and is environment-friendly and easy to process.

The invention discloses an extraction agent as well as a preparation method and application thereof. The extraction agent comprises a phosphorus or phosphine compound extraction agent and an extraction inhibitor, the extraction inhibitor is a weak acid compound selected from nonyl phenol, octyl phenol, 3, 5-di-tert-butyl catechol, 4-tert-butyl catechol, 4-butyl catechol, capryloyl salicylic acid, azelaic acid, sebacic acid, dodecanedioic acid, 2-hexyldecanoic acid, lauric acid, decanoic acid, 2, 2 '-(1, 4-phenylene bis (oxy)) dibutyric acid, 2, 2'-(1, 4-phenylene bis (oxy)) divaleric acid, 2, 2 '-(1, 4-phenylene bis (oxy)) divaleric acid, 2, 2'-(1, 4-phenylene bis (oxy)) dibutyric acid, 2, 2 '-(1, 4-phenylene bis (oxy)) dibutyric acid, 2, 2'-( the organic solvent is at least one of 2, 2 '-(1, 4-phenylene bis (oxy)) dihexanoic acid, neodecanoic acid, 2, 2'-(1, 4-phenylene bis (oxy)) diheptanoic acid or 2, 2 '-(1, 4-phenylene bis (oxy)) dioctanoic acid. The extraction agent provided by the invention can effectively prevent an extraction system from generating emulsification or three phases, and can effectively improve the reverse extraction efficiency. In addition, the extraction agent can be designed and adjusted, the composition of the extraction agent can be adjusted according to the composition, element concentration and the like of the solution, and then efficient separation of metal elements is achieved.

The invention provides an environment-friendly wind power gear oil composition and a preparation method thereof, and relates to the technical field of high-performance lubricants, the environment-friendly wind power gear oil composition comprises the following components by mass: 85%-95% of synthetic ester base oil, 1.5%-2.5% of a composite extreme pressure anti-wear agent, 0.5%-5% of an anti-foaming agent, 0.5%-5% of a demulsifier, and 0.1%-1% of an environment-friendly antioxidant; wherein the synthetic ester type base oil comprises a mixture of pentaerythritol ester and diester, the composite extreme pressure anti-wear agent comprises a composition of sulfurized isobutylene, molybdate and boric acid ester, and the diester is obtained through a reaction of dimethyl dodecanedioic acid and C8-C10 Guerbet alcohol. The wind power gear oil composition disclosed by the invention is good in environmental protection performance, excellent in wear resistance and relatively good in oxidation stability, the biodegradation rate is greater than or equal to 90%, the physical and chemical stability is improved, and the effects of functional additives are fully exerted.

The application discloses a modified mixed solution suitable for cement construction waste material regeneration, a cement construction waste material regeneration product and a preparation method thereof, and belongs to the technical field of solid waste utilization. The modified mixed solution for regeneration in the application comprises the following components in parts by weight: 5-8 parts of dodecanedioic acid solution and 15-20 parts of Lewis acid catalyst solution. Through the synergistic effect of "chemical grafting modification-catalytic strengthening bonding-physical compaction forming", the regenerated product with high compactness and excellent compressive strength can be prepared without additional traditional cementing materials such as cement and lime.

The invention discloses a cleaning agent for cleaning a nickel-plated battery shell and a preparation method of the cleaning agent, and belongs to the technical field of cleaning agents. The cleaning agent is prepared by compounding 30-80 parts by mass of a hydrocarbon solvent, 10-30 parts by mass of an alcohol ether solvent, 2-10 parts by mass of a surfactant, 1-5 parts by mass of a penetrant and 0.2-3 parts by mass of a self-made auxiliary agent. Wherein the self-made auxiliary agent is prepared from isooctyl alcohol, cyclohexanol, triethanolamine, dodecanedioic acid and dipropylene glycol butyl ether according to a specific proportion and a reaction process, and organic amine salt with surface activity and a corrosion inhibition function is generated in a system. The cleaning agent can synchronously and efficiently remove polar and non-polar pollutants on the surface of a nickel-plated battery shell through the synergistic effect of all the components, and can deeply penetrate into micropore gaps to complete precise cleaning by means of the ultralow surface tension of the fluorocarbon penetrant, meanwhile, a protective film is formed on the surface of a nickel-plated layer, and zero damage in the cleaning process is achieved. The product is good in stability, high in environmental protection property, simple and convenient in preparation method and suitable for industrial production.

The present invention relates to a method for preparing hydrocarbon double acids using a cyclic hydrocarbon oxidation catalyst, wherein adipic acid and dodecanedioic acid may be produced with high yield while solving the problem of environmental pollution, the adipic acid and the dodecanedioic acid being prepared by using an oxidation reaction of a cyclohexane-cyclohexanone mixture and an oxidation reaction of a cyclododecane-cyclododecanone mixture, respectively, in the presence of a vanadium phosphate oxide-based catalyst and / or a cobalt-manganese oxide-based catalyst.

The invention relates to the technical field of high polymer materials, in particular to a nylon composition, application thereof and a foaming material. The nylon composition disclosed by the invention is prepared by carrying out condensation polymerization reaction on polymeric monomers, wherein the polymeric monomers comprise caprolactam, hexamethylenediamine, decamethylene diamine, sebacic acid and dodecanedioic acid. The nylon composition disclosed by the invention is prepared through condensation polymerization reaction of polymeric monomers including caprolactam, hexamethylenediamine, decamethylene diamine, sebacic acid and dodecanedioic acid, has relatively high hardness, can be used as an additive of a foaming material, and forms a microscopic skeleton in a foamed product after foaming, so that the foaming performance of the foaming product is improved, and the service life of the foaming product is prolonged. The volume weight of a foamed product is reduced, and the foamed product still has excellent hardness.

The invention belongs to the technical field of sewage treatment, and particularly relates to a reverse osmosis scale inhibitor and a preparation method and application thereof. The reverse osmosis scale inhibitor is prepared from the following components in percentage by mass: 15 to 30 percent of polyepoxysuccinic acid, 10 to 25 percent of 2-acrylamide-2-methylpropanesulfonic acid / hydroxypropyl acrylate copolymer, 5 to 15 percent of polyaspartic acid, 3 to 8 percent of dodecanedioic acid and the balance of deionized water. The reverse osmosis scale inhibitor has the beneficial effects that the strong polarity of the AMPS in the reverse osmosis scale inhibitor and the sulfonic acid group provide excellent dispersity and calcium ion tolerance; the PASP and the DDA enhance the chelation and lattice distortion effects; bTA provides copper material corrosion inhibition protection, and corrosion of metal parts of a membrane system is prevented; the PESA, the AMPS / HPA copolymer, the PASP and the DDA are synergistically compounded, so that the calcium sulfate scale inhibitor has ultrahigh inhibition capability on calcium sulfate scale, and the scale inhibition effect of the calcium sulfate scale inhibitor is far better than that of a single component; the preparation process of the reverse osmosis scale inhibitor is physical mixing, conditions are mild, high-temperature and high-pressure or complex polymerization reaction is not needed, energy consumption is low, and industrial production is easy to achieve.

The application belongs to the field of medicine synthesis, and provides a preparation method of compound II, which comprises the following steps: reacting monomethyl dodecanedioate, N-hydroxysuccinimide and a condensing agent in an aprotic solvent to generate an active ester intermediate; and reacting compound I and an acid binding agent with the active ester intermediate to obtain compound II. Compound III can be prepared from compound II, the starting material of the steps is cheap and easy to obtain, the conditions are mild, the steps are simple, the yield is high, the product has high purity and stable chemical properties, the defects of high preparation cost and easy generation of impurities by column chromatography of compound III in the prior art are overcome, and the method is suitable for industrialized production.

The present invention relates to the technical field of composite materials, specifically a kind of oil and high temperature resistant nylon material based on pipe clamps and its preparation method; in order to improve the high temperature resistance and oil resistance of plastic pipe clamps, the present invention prepares a nylon material with oil and high temperature resistance; first, the present invention uses diphenylmethane diisocyanate as a raw material, mixes it with 1,1,3,3-tetramethyldisiloxane containing a silicon-hydrogen bond for reaction, thereby preparing a silane-modified diisocyanate containing an aromatic benzene ring structure and a silicon-oxygen bond structure. By using the benzene ring and the silicon-oxygen bond, the movement and decomposition of the polyamide molecular chain at high temperature are restricted, and the performance of high temperature resistance and resistance to oil agent erosion is enhanced; on this basis, the present invention also limits the dibasic acid, uses long carbon chain dodecanedioic acid as the dibasic acid for reaction, avoids the problem of excessive rigidity caused by too much aromatic benzene in the silane-modified diamine, and further improves the mechanical performance of the pipe clamp.

The invention relates to the technical field of powder coatings, in particular to a high-adhesion uvioresistant polyester powder coating and a preparation method thereof. The problem that in the prior art, the mechanical property and the anti-ultraviolet property of a polyester powder coating cannot be considered at the same time is solved. The preparation method comprises the following steps: firstly, carrying out esterification and polycondensation on terephthalic acid, isophthalic acid, dodecanedioic acid, neopentyl glycol and trimethylolpropane; in the polycondensation process, hydroxyl-terminated polydimethylsiloxane and reaction type UVA are introduced step by step and covalently bonded to a polyester main chain through a chemical reaction; and finally, carrying out end capping by using trimellitic anhydride to obtain the modified polyester resin. And mixing the epoxy silane coupling agent with HAA, HALS and an inorganic filler pretreated by the epoxy silane coupling agent to obtain the powder coating. According to the coating, through the synergistic effect of the components and the process, the mechanical property is improved, meanwhile, the good anti-ultraviolet performance is kept, the comprehensive durability of the powder coating is remarkably improved, and the powder coating is suitable for high-durability outdoor coating.

The invention provides a shape memory type porous ink direct writing printing implantation intervention type micro medical device product and a preparation method thereof, dodecanedioic acid and glycerol are stirred and reacted under a vacuum condition to prepare a PGD prepolymer, then water-soluble inorganic salt particles are added, and curing is performed to obtain a PGD ink material for printing. The preparation method comprises the following steps: carrying out 3D printing molding by utilizing ink direct writing, curing, removing water-soluble inorganic salt particles, and freeze-drying to prepare an implanted and intervened micro medical device product. According to the preparation method disclosed by the invention, an implantation intervention type micro medical device product is prepared by coupling ink direct writing printing and PGD, and the PGD-based product is endowed with porous structure characteristics and drug loading property by utilizing water-soluble inorganic salt particles for the first time based on a particle percolation method; the effective scheme of the precise adjustment strategy of the mechanical strength and the drug loading characteristic required by clinical healing is realized, and particularly, a new thought is provided for related implantable miniature medical equipment products for intervertebral disc degeneration related research.

The present invention provides a bio-based copolymerized nylon resin and a preparation method thereof, a bio-based copolymerized nylon composite material and a preparation method and application thereof, belonging to the technical field of nylon resin and composite materials thereof. The water absorption of polyamide materials is mainly caused by the interaction between polar amide bonds and water molecules. The dodecanedioic acid used in the present invention has a longer carbon chain and a lower amide group density, so the water absorption rate of the material is lower and the barrier property to moisture is better. At the same time, the longer the carbon chain, the better the toughness of the material, and the puncture resistance and fatigue resistance are both proportional to the toughness of the material. Therefore, the bio-based copolymerized nylon composite material prepared by the present invention has excellent barrier properties, puncture resistance and fatigue resistance, and can be widely used in the field of soft-pack lithium battery films, effectively solving the current industry problem of insufficient pit depth in nylon film materials.

The application provides a hot melt adhesive for low-pressure injection molding and a preparation method thereof, and belongs to the technical field of hot melt adhesive materials for electronic components and circuit packaging. The hot melt adhesive for low-pressure injection molding is prepared from the following raw materials in parts by weight: adipic acid: 0.1-60 parts; dodecanedioic acid: 0.1-60 parts; 2-methylpentanediamine: 0.1-50 parts; dodecanediamine: 0.1-50 parts; caprolactam: 0.5-200 parts; plasticizer: 0.1-20 parts; antioxidant: 0.01-1 part; modifier: 0-10 parts; and flame retardant: 0-20 parts. The hot melt adhesive for low-pressure injection molding has high softening point and high fluidity, and can meet the high requirements of electronic components and battery circuit packaging.

This invention discloses an enzyme-sensitive PDC-type PROTAC modified with a human leukemia cell-targeting transmembrane peptide, its preparation method, and its applications, belonging to the field of tumor targeted therapy technology. This PDC-type PROTAC is composed of a hypoxia-inducible factor 1α (HIF-1α) protein fragment linked to imatinib via dodecanoic acid, and further modified with the human leukemia cell-targeting transmembrane peptide Cyclo-C9C-R and the cathepsin B-sensitive sequence GFLG. The modified PDC-type PROTAC can release the original drug under the catalysis of cathepsin B, with minimal impact on THP1 cell viability, but effectively inhibits the proliferation of K562 and KU812 cells, degrades target proteins, induces apoptosis, and affects the cell cycle. This gives the PDC-type PROTAC significant advantages in the preparation of anti-tumor drugs, particularly showing promising application prospects in the development of drugs targeting human chronic myeloid leukemia cells and human peripheral blood basophilic leukemia cells, opening up a new field for PROTAC drug development.

Provided is Escherichia coli producing dodecanedioic acid. The genotypes of Escherichia coli are tesA::Ptet_luxR-Plux_luxI_UcfatB, adhE::Ptet_luxR-Plux_luxI_UcfatB, fadE::Plux_CYP153A-BM3, pgi::Plux_CYP153A-BM3, pCDF-Plux_paoB_aldB-Plux_puuC_betB-Plux_patD_feaB_gadB. Further provided is a construction method for Escherichia coli producing dodecanedioic acid. By constructing a quorum sensing system of Vibrio fischeri in Escherichia coli and slowing down the synthesis rate of AHL, an engineered strain efficiently producing dodecanedioic acid is obtained, so that self-induced synthesis of dodecanedioic acid can be achieved and cell growth and product synthesis can be balanced. The constructed Escherichia coli can produce dodecanedioic acid from glucose or dodecanedioic acid from 12-hydroxydodecanoic acid.

The invention discloses an analysis method for monobenzyl dodecanedioate and an application thereof. The method of the invention comprises using liquid chromatography to detect a sample to be tested containing monobenzyl dodecanedioate. The method of the invention has high accuracy and precision, good linearity, and extremely low detection limit and quantitative limit, and can be used to monitor the reaction of monobenzyl dodecanedioate and evaluate product quality.