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Preparation method of PDA supramolecular gel and application thereof

A technique of supramolecular gel and gelling factor, which is applied in the field of preparation of PDA supramolecular gel, can solve the problems of difficulty in synthesis of butadiyne derivatives of gelling factor and few applications involved.

Active Publication Date: 2019-08-02
ANHUI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the synthesis of diacetylene derivatives of gelling factor is difficult, and its application is rarely involved.

Method used

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  • Preparation method of PDA supramolecular gel and application thereof
  • Preparation method of PDA supramolecular gel and application thereof
  • Preparation method of PDA supramolecular gel and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0040] A preparation method of PDA supramolecular gel includes the following steps:

[0041] Step 1: Dissolve 1.0g of dodecanedioic acid in 40mL of anhydrous dichloromethane CH 2 Cl 2 After completely dissolving, add 1.2g N-hydroxysuccinimide NHS and 2.0g 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride EDC to the solution in sequence, and ultrasonic Dissolve for 5min, then place it in a 30℃ water bath and magnetically stir for 12h. After stirring, use anhydrous dichloromethane CH with a volume ratio of 1:1 2 Cl 2 Extract with a mixed solvent of saturated brine to obtain an organic phase, and dry the organic phase by rotary evaporation to obtain a white solid M, ready for use;

[0042] Step 2: Dissolve the white solid M obtained in step 1 in 20mL N,N-dimethylformamide DMF, and add 0.8g histamine dihydrochloride and 1mL triethylamine TEA to the solution after it is completely dissolved. Then place it in a 30℃ water bath and magnetically stir for 12 hours. After stirring, ...

Embodiment 2

[0056] A preparation method of PDA supramolecular gel includes the following steps:

[0057] Step 1: Dissolve 1.0g of dodecanedioic acid in 20mL of anhydrous dichloromethane CH 2 Cl 2 After completely dissolving, add 1.2g N-hydroxysuccinimide NHS and 2.0g 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride EDC to the solution in sequence, and ultrasonic Dissolve for 5min, then place it in a 28℃ water bath and magnetically stir for 12h. After stirring, use anhydrous dichloromethane CH with a volume ratio of 1:1 2 Cl 2 Extract with a mixed solvent of saturated brine to obtain an organic phase, and dry the organic phase by rotary evaporation to obtain a white solid M, ready for use;

[0058] Step 2: Dissolve the white solid M obtained in step 1 in 40mL N,N-dimethylformamide DMF, and add 0.8g histamine dihydrochloride and 1mL triethylamine TEA to the solution after it is completely dissolved. Then place it in a 28℃ water bath and magnetically stir for 12 hours. After stirring, ...

Embodiment 3

[0062] A preparation method of PDA supramolecular gel includes the following steps:

[0063] Step 1: Dissolve 1.0g of dodecanedioic acid in 20mL of anhydrous dichloromethane CH 2 Cl 2 After completely dissolving, add 1.2g N-hydroxysuccinimide NHS and 2.0g 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride EDC to the solution in sequence, and ultrasonic Dissolve for 5min, then place it in a 30℃ water bath and magnetically stir for 12h. After stirring, use anhydrous dichloromethane CH with a volume ratio of 1:1 2 Cl 2 Extract with a mixed solvent of saturated brine to obtain an organic phase, and dry the organic phase by rotary evaporation to obtain a white solid M, ready for use;

[0064] Step 2: Dissolve the white solid M obtained in step 1 in 40mL N,N-dimethylformamide DMF, and add 0.8g histamine dihydrochloride and 1mL triethylamine TEA to the solution after it is completely dissolved. Then place it in a 30℃ water bath and magnetically stir for 12 hours. After stirring, ...

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Abstract

The invention provides a preparation method of a polydiacetylene PDA supramolecular gel, and detects response thereof to temperature, a solvent and pH. The preparation process of the gel is as follows: activating dodecanedioic acid in a system of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride EDC and N-hydroxy succinimide (NHS), then adding triethylamine TEA, together with histamine hydrochloride, into N,N-dimethyl formamide DMF, synthesizing a gelator with an imidazole group through an esterification reaction under an alkaline condition, and assembling with 10,12-pentacosadiynoicacid PCDA through a non-covalent bond in an organic solvent to form the gel. The gel prepared according to the preparation method provided by the invention can stably exist in a variety of organic solvents, is topologically polymerized to form a blue gel when irradiated with 254 nm ultraviolet light, and can respond to the temperature, the solvent and the pH and change the color from blue to red;the gel is prepared into test paper which has simple and clear response to the pH.

Description

Technical field [0001] The invention belongs to the field of supramolecular gels, and specifically relates to a preparation method and application of PDA supramolecular gels. Background technique [0002] Supramolecular gelation means that low-molecular-weight molecules fix water or solvent through non-covalent bonds such as hydrogen bonds, electrostatic reactions and п-п stacking and other weak interaction forces, and self-assemble to form entangled nanostructures. As an important intelligent soft material, supramolecular gel has many unique characteristics and functions, making it an ideal choice in the fields of sensors, optical switches, supramolecular catalysis, biological materials and controlled drug release. Especially with the introduction of some environmental stimuli, supramolecular gels may undergo some physical or chemical changes and exhibit multiple stimulus responses, indicating their application prospects in biochemical sensing. Yang Xin et al. reported "Multipl...

Claims

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Application Information

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IPC IPC(8): C08G83/00G01N21/80
CPCC08G83/008G01N21/80G01N2021/7759
Inventor 宇海银许洋洋付素雅
Owner ANHUI NORMAL UNIV
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