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A kind of preparation method and application of pda supramolecular gel

A technology of supramolecular gels and gelling factors, which is applied in the field of preparation of PDA supramolecular gels, can solve the problems of difficult synthesis of diacetylene derivatives of gelling factors and few applications involved

Active Publication Date: 2021-08-27
ANHUI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the synthesis of diacetylene derivatives of gelling factor is difficult, and its application is rarely involved.

Method used

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  • A kind of preparation method and application of pda supramolecular gel
  • A kind of preparation method and application of pda supramolecular gel
  • A kind of preparation method and application of pda supramolecular gel

Examples

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Effect test

Embodiment 1

[0040] A preparation method of PDA supramolecular gel, comprising the following steps:

[0041] Step 1: Dissolve 1.0 g of dodecanedioic acid in 40 mL of anhydrous dichloromethane CH 2 Cl 2 After being completely dissolved, add 1.2g N-hydroxysuccinimide NHS and 2.0g 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride EDC to the solution in turn, ultrasonic Dissolve for 5 minutes, then place it in a water bath at 30°C and stir it magnetically for 12 hours. After the stirring is completed, use anhydrous dichloromethane CH with a volume ratio of 1:1 2 Cl 2 Extract with a mixed solvent of saturated saline to obtain an organic phase, and dry the organic phase by rotary evaporation to obtain a white solid M for use;

[0042] Step 2: Dissolve the white solid M obtained in Step 1 in 20 mL of N,N-dimethylformamide DMF, and after complete dissolution, add 0.8 g of histamine dihydrochloride and 1 mL of triethylamine TEA to the solution, Then place it in a water bath at 30°C fo...

Embodiment 2

[0056] A preparation method of PDA supramolecular gel, comprising the following steps:

[0057] Step 1: Dissolve 1.0 g of dodecanedioic acid in 20 mL of anhydrous dichloromethane CH 2 Cl 2 After being completely dissolved, add 1.2g N-hydroxysuccinimide NHS and 2.0g 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride EDC to the solution in turn, ultrasonic Dissolve for 5 minutes, then place it in a water bath at 28°C and stir it magnetically for 12 hours. After stirring, use anhydrous dichloromethane CH with a volume ratio of 1:1 2 Cl 2 Extract with a mixed solvent of saturated saline to obtain an organic phase, and dry the organic phase by rotary evaporation to obtain a white solid M for use;

[0058] Step 2: Dissolve the white solid M obtained in Step 1 in 40 mL of N,N-dimethylformamide DMF, and after it is completely dissolved, add 0.8 g of histamine dihydrochloride and 1 mL of triethylamine TEA to the solution, Then place it in a water bath at 28°C for 12 hours ...

Embodiment 3

[0062] A preparation method of PDA supramolecular gel, comprising the following steps:

[0063] Step 1: Dissolve 1.0 g of dodecanedioic acid in 20 mL of anhydrous dichloromethane CH 2 Cl 2 After being completely dissolved, add 1.2g N-hydroxysuccinimide NHS and 2.0g 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride EDC to the solution in turn, ultrasonic Dissolve for 5 minutes, then place it in a water bath at 30°C and stir it magnetically for 12 hours. After the stirring is completed, use anhydrous dichloromethane CH with a volume ratio of 1:1 2 Cl 2 Extract with a mixed solvent of saturated saline to obtain an organic phase, and dry the organic phase by rotary evaporation to obtain a white solid M for use;

[0064] Step 2: Dissolve the white solid M obtained in Step 1 in 40 mL of N,N-dimethylformamide DMF, and after it is completely dissolved, add 0.8 g of histamine dihydrochloride and 1 mL of triethylamine TEA to the solution, Then place it in a water bath at 3...

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Abstract

The invention provides a kind of preparation method of polydiacetylene PDA supramolecular gel and has detected its response to temperature, solvent and pH, and the preparation process of this gel is: dodecanedioic acid is mixed in 1-(3- Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride EDC and N-hydroxysuccinimide (NHS) system activation, and then with histamine hydrochloride in N,N-dimethyl Adding triethylamine TEA to formamide DMF, esterification reaction under alkaline to synthesize gel factor with imidazole group, and assemble with 10,12-pentacosadiynoic acid PCDA through non-covalent bond in organic solvent Form a gel. The gel prepared by the present invention can exist stably in various organic solvents, and undergoes topological polymerization to form a blue gel when irradiated with 254nm ultraviolet light, and can respond to temperature, solvent and pH and undergo a color transition from blue to red , making it into a test paper, the response to pH is simple and clear.

Description

technical field [0001] The invention belongs to the field of supramolecular gels, and in particular relates to a preparation method and application of PDA supramolecular gels. Background technique [0002] Supramolecular gelation refers to the self-assembly of low-molecular-weight molecules to fix water or solvents through weak interactions such as hydrogen bonds, electrostatic reactions, and п-п stacking to form entangled nanostructures. As an important smart soft material, supramolecular gels have many unique properties and functions, making them ideal for applications in the fields of sensors, optical switches, supramolecular catalysis, biomaterials, and controlled drug release. Especially with the introduction of some environmental stimuli, supramolecular gels may undergo some physical or chemical changes and exhibit multi-stimuli responses, illustrating its promising application in biochemical sensing. Yang Xin et al reported "multiple stimuli-responsive stigmasterol d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G83/00G01N21/80
CPCC08G83/008G01N21/80G01N2021/7759
Inventor 宇海银许洋洋付素雅
Owner ANHUI NORMAL UNIV
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