396 results about "Succinimides" patented technology

One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneamine. In a preferred embodiment, the polyalkyleneamine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer. In certain instances, the polyethyleneimine is mixed with a second polymer, such as a polyethylene glycol containing nucleophilic groups. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneamine bearing electrophilic groups with a cross-linking reagent containing nucleophilic groups. In certain instances, the electrophilic groups on the polyalkyleneamine are activated esters, such as N-hydroxy succinimide ester. In certain instances, the compositions used to seal the wound or tissue plane are formed by reacting a polyalkyleneamine bearing photopolymerizable groups with ultraviolet or visibile light. Compositions used to seal the wound which contain PEI or a derivative of PEI are found to adhere tightly to the tissue. Other aspects of the present invention relate to methods of filling a void of a patient or adhering tissue. In certain instances, the methods use a polyalkyleneamine. In a preferred embodiment, the polyalkyleneamine is polyethyleneimine. Another aspect of the present invention relates to a polymeric composition formed by exposing a polyalkyleneamine to an activated polyalkylene glycol. In certain instances, the composition is attached to mammalian tissue.

The present invention provides lubricating oil compositions having excellent anti-wear properties and anti-fatigue properties as well as excellent low temperature fluidity, particularly suitable for automatic transmissions and/or continuously variable transmissions, and internal combustion engines. The compositions comprises (A) a base oil with a kinematic viscosity at 100° C. of 1 to 8 mm²/s, a pour point of −15° C. or lower, an aniline point of 100° C. or higher, the saturates of the base oil containing 40 percent by mass or more of paraffins, 25 percent by mass or less of one ring naphthenes, and 35 percent by mass or less of two to six ring naphthenes, as the main component, and (B) 0.005 to 0.4 percent by mass of a metallic detergent, (C) 0.005 to 0.2 percent by mass in terms of nitrogen of a succinimide-type ashless dispersant, (D) 0.005 to 0.2 percent by mass in terms of phosphorus of a phosphorus-containing anti-wear agent, and (E) 0.01 to 20 percent by mass of a viscosity index improver with a weight average molecular weight (Mw) of 50,000 or greater, on the basis of the total amount of the composition.

Ethers of polyalkyl or polyalkenyl N-hydroxyalkyl succinimides having the formula: or a fuel soluble salt thereof. The compounds of formula I are useful as fuel additives for the prevention and control of engine deposits.

The invention discloses a bio-medical adhesive, which can be cross-linked with a wound in situ, and a preparation method of the bio-medical adhesive. The preparation method is characterized by comprising the steps of first, preparing oxidized sodium alginate by using sodium periodate to oxidize sodium alginate; dissolving the oxidized sodium alginate in an MES (Methyl Ester Sulfonate) buffer solution, dissolving 1-(3-dimethyl aminopropyl)-3-ethyl carbodiimide hydrochloride and N-hydroxyl succinimide in the MES buffer solution as well under nitrogen protection, continuously adding dopamine, carrying out dialyzing and freeze-drying after reacting for 8 to 24 hours, and obtaining A liquid by dissolving a reaction product in a PBS (Phosphate Buffer Solution) or a sodium borate solution; then, dissolving I-shaped collagen in an acid solution, and obtaining B liquid by neutralizing the solution pH (potential of Hydrogen) to be 5 to 8; firstly pre-treating the wound by using hydrogen peroxide or HRP (Horse Radish Peroxidase) before the bio-medical adhesive is used, then immediately coating the wound with the bio-medical adhesive after mixing the A liquid with the B liquid, and forming gel in 30 to 120 s, wherein the gel is firmly adhered to the surface of the wound. The bio-medical adhesive disclosed by the invention has a stronger adhesive force under a moist environment in vivo, integrates filling, sealing and bleeding stopping functions, is good in biocompatibility, is bio-degradable and can be used for promoting wound healing.

A power transmission fluid composition, a power transmission containing the fluid, a method of operating a power transmission with the fluid and method of improving friction durability for a power transmission fluid. The power transmission fluid includes (a) a base oil and (b) an additive composition having therein (i) at least one ashless dispersant; (ii) a metal detergent providing greater than about 100 ppm metal in the power transmission fluid composition; (iii) a friction modifying amount of an imidazoline; (iv) a succinimide friction modifier; and (v) a non-hydroxy tertiary amine friction modifier other than (iii).

The invention relates to a method for preparing a computed tomography (CT)/magnatic resonance imaging (MRI) bimodal imaging contrast agent based on dendrimers. The method comprises the following steps of: (1) adding DOTA-N-hydroxy succinimide (NHS) solution into the fifth generation of poly(amidoamine) (PAMAM) dendrimer solution, adding methoxy poly(ethylene glycol) (mPEG)-COOH solution which is subjected to 1-ethy 1-3-[3-dimethylaminopropyl] carbodiimide hydrochloride (EDC) activation, reacting with stirring, and thus obtaining functionalized dendrimer solution; (2) adding chloroauric acid solution and sodium borohydride solution into the functionalized dendrimer solution, reacting with stirring, adding gadolinium nitrate solution, stirring, adding triethylamine and acetic anhydride, andreacting with stirring for 8 to 24 hours; and (3) dialyzing the solution obtained in the step (2), performing freeze drying treatment, and thus obtaining the contrast agent. The method has a simple preparation process, and experimental conditions are realized at normal temperature and under normal pressure; and the CT/MRI bimodal imaging contrast agent prepared by the method has a good CT/MRI effect, and a favorable foundation is laid for the development of a novel multifunctional contrast agent.

The present invention relates to formulations of asphaltenes' inhibitor-dispersant additives based on oxazolidine derived from polyalkyl or polyalkenyl N-hydroxyalkyl succinimides. Said formulations can contain inert organic solvents, preferably including: toluene, mixtures of xylene, o-xylene, p-xylene, kerosene, turbo-fuel; or inert hydrocarbon solvents having boiling points within the range of gasoline and diesel; or inert hydrocarbon or organic solvents having a boiling point within a range from 75 to 300° C. The ratio in weight of inert organic solvents to additive that prevents and controls the precipitation and deposition of asphaltenes ranges from 1:9 to 9:1, preferably from 1:3 to 3:1.

The invention provides a composite gold nanorod carrier having photo-thermal/photodynamic therapy treatment performance and a preparation method thereof. The composite gold nanorod carrier uses a gold nanorod as a core and uses silicon dioxide as a shell layer, a near infrared fluorescent dye for photodynamic therapy is modified on the outer surface of the shell layer. The preparation method comprises the steps that a chloroauric acid solution and a cetyl trimethyl ammonium bromide solution are mixed, a sodium borohydride ice water mixed solution is added to obtain a nano gold seed solution A; a silver nitrate solution and a chloroauric acid solution are added to a binary surface active agent solution, a hydrochloric acid is added after reaction to obtain a solution B, then ascorbic acid and the solution A are added, and a gold nanorod is obtained after reaction; a tetraethoxysilane methanol solution and an aminopropyl trimethoxy silane methanol solution are added to a gold nanorod solution to obtain composite nanoparticles; 1-(3-dimethyl amino propyl)-3-ethyl carbodiimide hydrochloride is added to the near infrared fluorescent dye, then N-hydroxyl succinimide is added to obtain a solution C; the composite nanoparticle solution is mixed with the solution C to obtain a product.

The present invention relates to methods of using a low sulfur, low phosphorus, low-ash, zinc free consumable lubricating composition in an internal combustion engine equipped with a pilot ignition system, where the composition comprises: an oil of lubricating viscosity; a high TBN succinimide dispersant and where the lubricant composition overall has a sulfated ash value of up to about 0.2, a phosphorus content of up to about 50 to about 800 ppm and a sulfur content of up to about 0.4 percent by weight.

The invention discloses a magnetic nanoparticle biological probe and a test strip for detecting hepatitis B virus (HBV) and a preparation method and a using method of the biological probe. The method for preparing the biological probe comprises the following steps of: performing surface amino functionlization treatment on magnetic nanoparticles with the particle size of 50-300nm, performing carboxylation treatment, mixing and reacting the magnetic nanoparticles subjected to surface carboxylation, carbodiimide and N-hydroxy succinimide in a buffer solution, and washing to obtain a reactant A; mixing and reacting the reactant A and an antibody for a HBV marker in a coupled buffer solution to obtain a reactant B; mixing and reacting the reactant B and a solution of a compound containing amino, and washing to obtain the product. The biological probe is high in specificity, sensitive in signal and high in stability and is suitable for detecting multiple hepatitis B markers according to the selected targeting markers and matched antibodies. According to the test strip, an obtained magnetic signal can be subjected to secondary determination through visual inspection and MAR detection, the personal error can be greatly reduced, and the accuracy is high.

The invention discloses an environment-friendly water-based synthetic cutting fluid. The environment-friendly water-based synthetic cutting fluid contains the following components in percentage by weight: 20-30% of antirust agent, 10-20% of lubricating agent, 2-8% of surfactant, 1-3% of chelating agent, 2-4% of bactericide, 0.05-0.2% of defoamer and the balance of water, wherein the antirust agent is one or a mixture of triethanolamine borate and O-(N-succinimide)-1,1,3,3-tetramethyluronium tetrafluoroborate. The environment-friendly water-based synthetic cutting fluid disclosed by the invention has favorable lubricating, cooling and cleaning effects and a particularly favorable antirust effect, and can form a protective film on the surface of metal so as to prevent a machine took, a workpiece and a cutter from being corroded by surrounding mediums.

The invention relates to a method for covalently coupling amino-containing molecules to microspheres. According to the method, a reaction mixture is simultaneously in contact with carbodiimide and N-hydroxy succinimide (or N-hydroxy thiosuccimide)to carry out a covalent coupling reaction. A reagent prepared by utilizing the method disclosed by the invention can be used for effectively improving the self polymerization of the amino-containing molecules in a coupling process and has better linearity when a standard curve is drawn.

The invention provides a method for preparing acrylamide complete antigen. The method is as follows: amine uncoupling reaction is directly carried out between N-acryloyloxy succinimide and the surface amino group of carrier protein molecule in a neutral or weakly alkaline phosphate buffer solution, thereby forming acrylamide complete antigen. Polyclonal antibody capable of realizing specificity identification of acrylamide is obtained through a complete antigen immune animal, so as to establish an enzyme immunoassay method suitable for measuring the content of acrylamide in an aqueous solution or food and to provide a corresponding reagent box. The method has simple operation and does not need other reaction reagent, thereby furthest maintaining the structural integrity of acrylamide; moreover, the method ensures that a coupling position is at a maximum distance from a feature group so as to fully expose the feature structure of acrylamide molecule. The established enzyme immunoassay method of acrylamide and the reagent box have strong specificity, high sensitivity and convenient operation, and are suitable to realize massive sample detection which has low cost and is quick and simple.

A lubricant oil composition which is excellent in deposition resistance, corrosion resistance and wear resistance, despite its low phosphorus content and low sulfuric acid ash content, is provided by using a succinimide compound in combination with at least one selected from specific sulfur-containing compounds, specific heterocyclic compounds and reaction products thereof.

The invention discloses a vehicle fuel oil environmentally-friendly and energy-saving agent which comprises the following components in parts by weight: 10-12 parts of solvent oil; 8-10 parts of oil calcium sulfonate; 5-7 parts of ethyl acetate; 5-6 parts of C9 alkylphenol polyoxyethylene ether; 10-15 parts of isooctyl nitrate; 15-17 parts of sulfonated fatty acid isooctyl sodium salt; 10-15 parts of naphthenate; 8-12 parts of diesel/petrol; 15-17 parts of sodium bis-(2-ethylhexyl) sulfosuccinate, 3-5 parts of dicyclopentadiene; and 3-5 parts of succinimide. The environmentally-friendly and energy-saving agent can improve the vehicle dynamic property, reduce the oil consumption and the vehicle operation cost and also reduce the emission of pollutants in motor vehicle waste gas, effectively improve the gasoline quality, gasoline octane number and the flammability, and completely combust along with the fuel without generating sediments or residues and has oil saving ratio, no side effects and no adverse effects on other properties of fuel oil.

The invention discloses an in-tube solid-phase micro-extraction column and a preparation method thereof, and belongs to the technical field of analytic chemistry sample pretreatment. The in-tube solid-phase micro extraction column is composed of a quartz capillary tube and a graphene oxide coating layer, wherein the graphene oxide coating layer is fixed on the inner wall of the quartz capillary tube through chemical bonding. During preparation, the inner wall of the quartz capillary tube is successively washed with an acid, washed with an alkali and blown to dry by nitrogen, a toluene solution containing 3-aminopropyltriethoxysilane (APTES) is poured into the capillary tube, the capillary tube has both ends sealed and is placed in a water bath for reaction, then a graphene oxide aqueous solution activated by 1-ethyl-3-(3-dimethylaminopropyl)-carbide diimine/N-hydroxy succinimide (EDC/NHS) is poured into the capillary tube, the capillary tube has the both ends sealed and is subjected to a reaction in the water bath, the graphene oxide is allowed to be bonded to the quartz capillary tube wall, and the in-tube solid-phase micro-extraction column is obtained. The in-tube solid-phase micro-extraction column has simple and rapid preparation method, allows the graphene coating layer to have good chemical property, mechanical property and thermal stability, has high extraction capacity and long service life, and has broad application prospects in the analytic chemistry and environmental analysis fields.

The present invention relates to a human pancreatic glucagons sample peptide-1 compound and its preparation method. The human pancreatic glucagons sample peptide-1 in said compound is human pancreatic glucagons sample peptide-1(7-37) or human pancreatic glucagons sample peptide-1(7-36)Nh2. Said compound is formed from human pancreatic glucagons sample peptide-1 and monomethoxy polyglycol containing active group activated by succinimide, namely said compound is mPEG-GLP-1.

The present disclosure is directed to a fuel composition comprising a deposit-modifying effective amount of a hydrocarbyl-substituted succinimide; a detergent; and a fuel. A method for reducing deposit formation is also disclosed.

The invention relates to a copolymer based on environmental response and a preparation method thereof, wherein the copolymer has specific three blocks which are sequentially a hydrophobic block, a hydrophilic environmental response block and a ploy-N-methylacryloyl succinimide (PNAS) chain with reactivity. The preparation method of the copolymer comprises the following steps of: connecting the hydrophobic block with a micromolecular chain transfer agent to prepare a macroinitiator; performing primary polymerization on the hydrophilic environmental response block and the macroinitiator; and performing secondary polymerization on an N-methylacryloyl succinimide (NAS) monomer and a product of the first step, so as to obtain the copolymer based on environmental response. The copolymer has the advantages that the copolymer based on environmental response has a controllable structure, and the hydrophobic block, the hydrophilic environmental response block and the PNAS chain are independent from one another; and the copolymer based on environmental response has a clear specific structure, and can fully play the performances of all the chain segments.

Hydrophobic nanoparticle compositions include silica nanoparticles capped with asphaltene succinimide alkoxy silane (ASAS). The nanoparticles can have a particle size ranging from about 20 nm to about 10000 μm. The nanoparticle compositions can be used as a coating for raw sand to provide a super-hydrophobic sand. The nanoparticle compositions can be used as a coating for a polyurethane (PU) sponge to provide a super-hydrophobic sponge. The super-hydrophobic sand and/or super-hydrophobic sponge can be used to collect crude oil deposited in aquatic environments as a result of petroleum crude oil spills.

The invention provides a microalbuminuria (mAlb) detection kit, which is based on a latex enhanced turbidimetric immunoassay method, is a liquid double reagent, namely reagent R1 and reagent R2, wherein the reagent R1 is a reactant and the reagent R2 is a solution containing albumin immuno latex particles, and the detection kit is characterized by crosslinking by applying a chemical process, and covalently crosslinking a goat anti-human albumin antibody (also called goat anti-human mAlb antibody) with carboxylated polystyrene latex through water-soluble carbodiimide (EDC) and H-hydroxy succinimide (NHS), so as to form an mAlb antibody latex reagent. The reagent has the advantages of high sensitivity, strong specificity and simple preparation, and is worthy of further promotion.

The invention provides a preparation method of a polydiacetylene PDA supramolecular gel, and detects response thereof to temperature, a solvent and pH. The preparation process of the gel is as follows: activating dodecanedioic acid in a system of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride EDC and N-hydroxy succinimide (NHS), then adding triethylamine TEA, together with histamine hydrochloride, into N,N-dimethyl formamide DMF, synthesizing a gelator with an imidazole group through an esterification reaction under an alkaline condition, and assembling with 10,12-pentacosadiynoicacid PCDA through a non-covalent bond in an organic solvent to form the gel. The gel prepared according to the preparation method provided by the invention can stably exist in a variety of organic solvents, is topologically polymerized to form a blue gel when irradiated with 254 nm ultraviolet light, and can respond to the temperature, the solvent and the pH and change the color from blue to red;the gel is prepared into test paper which has simple and clear response to the pH.