Biocompatible in situ hydrogel

一种水凝胶、生理性的技术，应用在生物相容性原位水凝胶领域，能够解决医疗费用增加、操作困难、风险高等问题

Active Publication Date: 2015-12-30
THE HONG KONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Rapid gelation may lead to sticking of the microcatheter to the embolic material; therefore, the procedure must be performed carefully by experienced radiologists and vascular surgeons
In addition, Onyx is non-adhesive to vessel walls, which creates a high risk of gel migration during and after surgery
Side effects, operational difficulties, and possible complications all lead to increased medical costs and less than ideal results
[0007] A potential disadvantage of forming chemically crosslinked in situ hydrogels for some applications is the fragility of the gels

Method used

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Examples

Experimental program
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Effect test

example 1

[0115] Example 1: Chemical condensation of polymers containing multiple vinylsulfones and polymers containing multiple nucleophiles gelation trigger

[0116] Vinylsulfonated dextran (dex-VS) with a molecular weight (MW) of 70 kDa and a degree of modification (DM) of 8% (dex-VS) and sulfylated dextran with a MW of 70 kDa and a DM of 8% (dex-SH) were dissolved at a concentration of 25% in water or saline. The pH of the water or saline in this area (Hong Kong) is about 5.3 to 5.5. The polymer solution was mixed and loaded into a syringe. A 30-gauge needle was attached to the syringe, and the solution was injected into PBS. A gel formed shortly after the polymer solution was exposed to PBS.

example 2

[0117] Example 2: Chemical condensation of polymers containing multiple vinylsulfones and polymers containing multiple nucleophiles gelation trigger

[0118] dex-VS with MW of 70 kDa and DM of 8% and dex-SH with MW of 70 kDa and DM of 8% were dissolved in water or saline at a concentration of 25%. The pH of the water or saline in this area (Hong Kong) is about 5.3 to 5.5. The polymer solution was mixed and loaded into a syringe. A 30-gauge needle was attached to the syringe, and the solution was injected into 0.1 M phosphate buffer (PB). Hydrogels formed shortly after the polymer solution came into contact with PB.

[0119] In another example, HA-VS with a MW of 29 kDa and a DM of 20% was dissolved in a pH 7 buffer at a concentration of 10% w / v, and HA-VS with a MW of 29 kDa, 20% DM of HA-SH was dissolved in a pH 7.8 buffer. The two polymers were cooled on ice and mixed on ice. The solution was injected into PBS at 37°C. A gel formed shortly after the solution came i...

example 3

[0120] Example 3: Chemical condensation of polymers containing multiple vinylsulfones and polymers containing multiple nucleophiles gelation trigger

[0121] dex-VS with MW of 70 kDa and DM of 8% and dex-SH with MW of 70 kDa and DM of 8% were dissolved in water or saline at a concentration of 25%. The pH of the water or saline in this area (Hong Kong) is about 5.3 to 5.5. The polymer solution was mixed and loaded into a syringe. A 30-gauge needle was attached to the syringe, and the solution was injected into rabbit blood. A gel formed shortly after the polymer solution came into contact with blood.

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Abstract

The present invention provides compositions, and related kits and methods, for formation of hydrogels. The compositions comprise one or more chemically crosslinkable agents dissolved in an aqueous solution to form a precursor solution. The chemically crosslinkable agents useful in the present invention are selected from polymers modified with a molecule selected from acrylate, maleimide, vinylsulfone, N-hydroxy succinimide, aldehyde, ketone, carbodiimide, carbonate, iodoacetyl, mercaptonicotinamide, quinone, thiol, amine, and combinations thereof. The precursor solution is characterized as being in an aqueous form at a non-physiologic physical-chemical condition and undergoing gelation when in contact with another fluid or body at a physiologic physical-chemical condition.

Description

[0001] related application [0002] This application claims priority to US Provisional Patent Application 61 / 854,108, filed April 18, 2013, which is hereby incorporated by reference in its entirety, including all tables, figures, and drawings. technical field [0003] The present invention generally relates to materials capable of forming hydrogels after injection into a space in the body and their use. Background technique [0004] A hydrogel is a material composed of a cross-linked polymer network impregnated with water. One of the most important characteristics of this type of material is its hydrophilicity, a property that makes many varieties of this material compatible with the body. In addition, the physical and chemical properties of hydrogel systems can be well controlled, including but not limited to: mechanical properties, volume change behavior, controlled drug release behavior, functionalization of chemical groups, and gel-body interactions . Therefore, hydr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K47/48C08B37/00C08J3/075A61L27/52
CPCA61K9/0019A61K47/36A61K47/61A61K49/0442A61L27/52A61L2400/06C08B15/005C08B37/0012C08B37/0021C08B37/0072C08B37/0084C08L1/286C08L5/02C08L5/04C08L5/08C08L5/16C08L2205/02A61K9/0024A61K49/0438
Inventor 周迎余渝钟洁莹
Owner THE HONG KONG UNIV OF SCI & TECH
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