Treatment of methylmalonic aciduria, isovaleric aciduria, and other organic acidurias with tocotrienol quinones

a technology of tocotrienol quinones and methylmalonic aciduria, which is applied in the direction of biocide, drug composition, metabolic disorder, etc., can solve the problems of kidney failure, kidney failure, pancreatitis, seizures, and possible death, and achieve seizures and death. coma, possible death, and the effect of reducing the risk of coma
US20150057363A1Inactive Publication Date: 2015-02-26BIOELECTRON TECH CORP
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
BIOELECTRON TECH CORP
Publication Date
2015-02-26
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to methods of treating methylmalonic aciduria and other organic acidurias with tocotrienol quinones, including alpha-tocotrienol quinone, in order to alleviate symptoms of the disease.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims priority benefit of U.S. provisional patent application No. 61 / 505,051, filed Jul. 6, 2011. The entire contents of that application are incorporated by reference herein.TECHNICAL FIELD OF THE INVENTION

[0002] The present invention relates to a method of treating methylmalonic aciduria, isovaleric aciduria, and other organic acidurias with tocotrienol quinones (including tocotrienol hydroquinones), for example, alpha-tocotrienol quinone.BACKGROUND OF THE INVENTION

[0003] Organic acidurias (also known as organic acidemias) are a set of disorders caused by defects in amino acid metabolism, resulting in an abnormal accumulation of acids in the body. See Rezvani I., “Defects in metabolism of amino acids,” in: Kliegman R M, Behrman R E, Jenson H B, Stanton B F, eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, Pa.: Saunders Elsevier; 2007, Chap 85.

[0004] Methylmalonic aciduria (methylmalonic acidemia, MMA) is caused ...

Claims

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