11 results about "Lethargy" patented technology

This invention provides the use of Yigongsan in the treatment of myelodysplastic syndrome (MDS). Specifically, this invention has found that Yigongsan improves ineffective hematopoiesis in MDS patients and significantly alleviates traditional Chinese medicine symptoms of MDS, such as fatigue, lethargy, lack of thirst, and sallow complexion. Furthermore, it has been discovered that Yigongsan regulates hematopoietic function in MDS through the S100A9-TLR4-NF-κB signaling pathway. This invention also provides a treatment method for MDS.

This invention discloses a warming and dispersing medicinal and edible composition and its preparation method. This invention relates to the field of traditional Chinese medicine health food technology. The active ingredients of the composition are extracted from the following medicinal and edible materials: 3-10 parts by weight of dried ginger, 2-8 parts by weight of cinnamon, 5-15 parts by weight of Allium macrostemon, and 10-30 parts by weight of Astragalus membranaceus. Small molecule extract particles are prepared through processes such as β-cyclodextrin inclusion and wet granulation, significantly improving the dissolution rate and bioavailability of the active ingredients. The product is also convenient to prepare, easy to carry, and suitable for long-term use. In terms of safety, all raw materials are medicinal and edible substances. Clinical trials have proven that the overall effective rate for symptoms of Yang deficiency such as aversion to cold, cold limbs, lethargy, and loose stools is over 94%, with no obvious toxic side effects. It can be safely used for daily health maintenance and auxiliary conditioning of those with Yang deficiency and cold constitution. Pure coconut powder is used as a flavoring material, resulting in a rich aroma and good taste.

This invention provides a treatment for patients with developmental and epileptic encephalopathy (DEE) that addresses behavioral problems in addition to seizures, without causing undesirable side effects such as somnolence, lethargy, withdrawal, and sedation. [Solution] A method is provided for treating behavioral problems and seizures in a subject having DEE, comprising administering an effective amount of cannabidiol (CBD) transdermally to the subject, wherein the behavioral problems are treated in the subject.

A cyclic olefin derivative having an orexin 2 receptor (OX2R) agonistic activity. In particular, the present invention relates to a compound as represented by general formula (I), a stereoisomer thereof, a tautomer thereof, a pharmaceutically acceptable salt thereof, and pharmaceutically acceptable salts of the stereoisomer and tautomer. The present invention also relates to a pharmaceutical composition containing the compound, a preparation method therefor, and the use thereof as an orexin 2 receptor (OX2R) agonist for preventing or treating diseases related to the agonistic effect of an orexin 2 receptor (OX2R), such as narcolepsy, lethargy, sleep apnea, anesthesia recovery or respiratory inhibition improvement. Each substituent in general formula (I) is the same as that defined in the description.

The present invention addresses the problem of providing a composition for increasing vigor / vitality or a composition for improving lethargy / lassitude.　Provided is a composition for increasing vigor / vitality or a composition for improving lethargy / lassitude that contains an agrimol. Provided is a composition for increasing vigor / vitality or a composition for improving lethargy / lassitude that contains an agrimony extract as an agrimol. The present invention makes it possible to provide a composition for increasing vigor / vitality or a composition for improving lethargy / lassitude.

The system according to the embodiment aims to detect resident slacking or lethargy and improve their motivation. [Solution] A system according to an embodiment includes a collection unit, a determination unit, and a provision unit. The collection unit collects the resident's smartphone usage history or the operation status of home appliances. The determination unit analyzes the data collected by the collection unit and determines whether the resident is "slacking" or "lethargic." The provision unit provides words to improve motivation based on the determination result obtained by the determination unit.

This invention provides a hemp seed protein peptide that enhances immunity and serum protein levels, along with its preparation method and applications, belonging to the field of hemp seed protein peptide technology. The preparation method includes: pulverizing defatted hemp seed meal and sequentially subjecting it to hydrolysis by a complex polysaccharide enzyme, a protease, and an amidase to obtain an enzymatic hydrolysate. This hydrolysate is then processed to obtain the hemp seed protein peptide. The complex polysaccharide enzyme is a combination of cellulase, pectinase, and xylanase; the protease is pepsin; and the amidase is PNGase F. The hemp seed protein peptide of this invention has the following significant effects: 1. Significantly improves serum albumin, immunoglobulin, prealbumin, and total protein levels and immunity in middle-aged and elderly individuals, those with weak constitutions / poor nutritional status, and those recovering from illness / surgery; 2. Rapidly improves fatigue symptoms in these individuals, such as emaciation, weakness, lethargy, and poor sleep, boosting energy and relieving limb heaviness and soreness.

The invention discloses application of rubber tree seed oil in preparation of a product for improving or treating kidney-yang deficiency, and belongs to the technical field of medicines. The hevea brasiliensis seed oil can improve the levels of serum adrenocorticotropin releasing hormone, adrenocorticotropin and corticosterone by adjusting the hypothalamus-pituitary-adrenal axis function so as to improve the related signs of kidney-yang deficiency, such as intolerance of cold and liking warm, cold limbs, lassitude, reduced autonomous activity and the like. The invention further discloses a composition containing the hevea brasiliensis seed oil. The composition can be prepared into medicines, health-care foods or functional foods. The invention provides a new choice which is single in component, clear in mechanism, safe and effective for the treatment of kidney-yang deficiency.

The present invention relates to dosing regimens and methods of using LY3154207, also described as 2-(2,6-dichlorophenyl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-3,4-dihydroisoquinolin-2 (1H)-yllethanone, and / or pharmaceutical compositions thereof, for treatment of dopaminergic central nervous system disorders. Dopaminergic CNS disorders of the present dosing regimen methods include Parkinson's Disease, Alzheimer's Disease, Lewy body dementia (LBD), Vascular Dementia, Schizophrenia, ADHD, Depression, Autism, chronic musculoskeletal pain, fibromyalgia, cognitive impairment disorders, sleep disorders, excessive daytime sleepiness, narcolepsy, shift work disorder, traumatic brain injury, chronic traumatic encephalopathy, obesity and appetite regulation, mood disorders, lethargy, apathy, and addiction disorders.

This invention provides a hemp seed protein peptide for improving mental and physical fatigue, its preparation method, and its applications. It belongs to the field of hemp seed protein peptide technology. The method includes extracting hemp seed protein solution using an alkali-soluble acid precipitation method; performing three-step enzymatic hydrolysis steps using Serratia marcescens, thermophilic protease, and flavor protease to obtain the final hydrolysate; and performing post-treatment and drying to obtain the final product. Clinical studies of the hemp seed protein peptide prepared by this invention have shown that: 1. It significantly relieves mental fatigue: promotes nitric oxide production, increases brain oxygen and blood supply; rapidly boosts spirits within 15 minutes, improves concentration and reaction time; and maintains energy levels for a long time, improving lethargy. 2. It significantly relieves physical fatigue: rapidly reduces lactic acid and urea nitrogen accumulation, relieves muscle soreness; increases energy reserves, provides sustained anti-fatigue, extends endurance by 2-4 hours, and maintains physical strength; significantly shortens the recovery period after excessive fatigue, improves postoperative limb heaviness and soreness, and promotes immune recovery.

Methods and formulations for treating autism with neurotensin RI agonists without causing significant lethargy in a subject.