The invention discloses anti-fatigue mood adjusting beauty health wine and a preparation method for the same. The health wine is prepared by impregnating the following raw materials: 3,000 to 5,000 grams of fresh grapes, 240 to 300 grams of red wolfberries, 240 to 300 grams of cocos, 240 to 300 grams of hawthorns, 1,400 to 1,600 grams of lily, 1,400 to 1,600 grams of jujubes, 240 to 300 grams of raw licorice, 240 to 300 grams of tangerine peel, 240 to 300 grams of sweet osmanthus, 240 to 300 grams of dried longan pulp, 240 to 300 grams of gardenia, 1,400 to 1,600 grams of polygonatum, 240 to 300 grams of ginger and 150 to 200 liters of white spirit. The health wine is researched and prepared after the exploration of many years, has the effects of regulating and tonifying qi and blood, adjusting the mood, resisting fatigue, stabilizing internal organs and enhancing the disease resistance of a human body, has good curative effects on subhealthy populations with the symptoms of dim, gaunt and lusterless complexions, spiritual fatigue, bad mood, sleeping difficulty, inappetence, alopecia, dysphoria, weakness, hyposexuality and the like, which are caused by working pressure, and also has good curative effects on lusterless and sallow complexions, insomnia, amnesia, deficiency of qi and blood and listlessness, which are caused by heart-liver blood deficiency.