202 results about "Dysphoria" patented technology

The invention discloses a Chinese medicine composition for treating headache and a preparation method thereof. The Chinese medicine composition is mainly formed by the following raw medicine materials: angelica root, Ligusticum wallichii, storax, snowbell, Rhizoma acori Graminei, holy basil, rheum officinale, Chinese angelica, white paeony root, red paeony root, immature bitter orange, rhizoma cyperi, notopterygium root, agilawood, dalbergia wood, Salvia miltiorrhiza Bunge, peach kernel, safflower, motherwort herb, pangolin scale and the like. The Chinese medicine composition of the invention can be prepared into any kind of common oral preparation according to the conventional Chinese medicine preparation method. The invention has the advantages that symptoms such as headache, parietal headache, medial headache and migraine, facial neuralgia, dysphoria, emotional instability, anxiety, insomnia, amnesia and the like are obviously improved, the clinical curative effect is exact, the curative effect is obvious and the rapid effect is obtained. Moreover, the Chinese medicine composition is basically combined by homologous plant food medicines regulated in National Formulary, thereby having the advantages of low cost, basically no toxic side effect and the like.

One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine, serotonin, or norepinephrine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, analgesia, schizophrenia, Parkinson's disease, restless leg syndrome, sleeping disorders, attention deficit hyperactivity disorder, irritable bowel syndrome, premature ejaculation, menstrual dysphoria syndrome, urinary incontinence, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.

The present invention relates to a preparation mainly for preventing and curing the diseases of tonicity, dysphoria, lassitude, light-headedness, hypomnesis and female premenstrual syndrome. It is characterized by that said preparation contains gamma-aminobutyric acid and theanine. Besides, in said preparation the medicinal plant, amino acid, vitamin, mineral and auxiliary material which can be used as additive in food or medicine also can be added.

The invention discloses a traditional Chinese medicinal composition having functions of enriching yin and nourishing kidney as well as a preparation method and application of the traditional Chinese medicinal composition. The active ingredient of the traditional Chinese medicinal composition is prepared from the following raw materials in parts by weight: 1-5 parts of fruit of Chinese wolfberry, 1-5 parts of black sesame, 1-5 parts of mulberry, 1-5 parts of rhizoma polygonati and 1-7 parts of Chinese yam. The method comprises the steps of weighing the raw materials and decocting the raw materials together with water. According to the traditional Chinese medicinal composition disclosed by the invention, the various components take mutual synergic effect so as to achieve the functions of enriching yin and nourishing kidney, and the traditional Chinese medicinal composition is especially suitable for conditioning the deficiency of kidney and yin causing sub-health status; meanwhile, the traditional Chinese medicinal composition can be also used for relieving dizziness, headache, soreness and weakness of waist and knees, dry mouth and throat, dysphoria in chestpalms-soles and other symptoms; and in addition, since various components are prepared from both medicinal and dietary plants, the composition is sufficient in source, free from any toxic and side effects, and suitable for being taken for a long term.

The invention discloses a medicine for alleviating nervousness and taking care of sub-health. Materials of rhizome polygonati, meldar, jujube, mulberry, perilla, bergamot, citron, malt, Poria cocos, lily, lotus plumule, spine date seed are decocted according to a certain weight proportion, and then extracted so as to obtain the medicine which can be prepared into any common oral dosage form. With the functions of soothing the liver and resolving depression, relaxing the chest and regulating qi, nourishing the heart and calming the nerves, as well as tonifying qi and blood, the medicine is of obvious effect in treating sub-health syndromes of chest distress and dysphoria, nervousness, insecurity, insomnia, forgetfulness, inefficiency, lassitude, inappetence and the like, with rapid effect and little toxic side-effect.

A fluoric isoflavone derivative and its preparing process are disclosed. Said derivative can be used to prepare the medicines for treating cancer, hypertension, hyperglycemia, dysphoria and bacterialand viral diseases. Its advantages are high curative effect and low poison.

The invention relates to the field of Chinese medicines, in particular to a preparation method of total flavonoids in albizia julibrissin durazz and a medicinal composition thereof. The total flavonoids in albizia julibrissin durazz is prepared by using dry inflorescence or flower buds of albizia julibrissin durazz which is a plant of leguminous family as a raw material, extracting with water or aqueous solution of ethanol, concentrating the extract to a proper volume, and extracting the obtained extract with ethyl acetate, wherein the total flavonoid content accounts for over 50 weight percent of the total extract and the content of the main ingredient is measured. The extract and the medical composition containing the extract can be used for preparing medicines for preventing and treating nervous disorder diseases such as depression, dysphoria, Parkinson, senile dementia and the like. The preparation method has the advantages that: the medicinally active ingredients, namely total flavonoids, in albizia julibrissin durazz are obtained; and new medicinal resources are provided for preventing and treating nervous disorder diseases such as depression, dysphoria, Parkinson, senile dementia and the like.

The invention relates to a mixture for treating panasthenia, which comprises the following raw material medicaments in part by weight: 13 to 17 parts of tuber fleeceflower stem, 13 to 17 parts of silktree albizzia bark, 1 to 5 parts of grassleaf sweelflag rhizome, 13 to 17 parts of hairyvein agrimonia herb and bud, 13 to 17 parts of coral ardisia root, 13 to 17 parts of fragrant solomonseal rhizome, 13 to 17 parts of young leonurus and 13 to 17 parts of spanishneedles herb. The invention also provides the application of the mixture for treating the panasthenia. The mixture has the advantages that: the compatibility is based on the principle of 'monarch, minister, assistant and guide' of traditional Chinese medicine; pharmacodynamic experiments prove that the mixture has the obvious effect of nourishing heart blood, tranquilizing mind, relieving dysphoria, dispelling melancholy and inducing resuscitation; the mixture is mainly used for the neurasthenia, insomnia, dreaminess, dysphoria and amnesia; and the mixture has no obvious adverse effect, small toxic and side effect, a small medicament number and a good curative effect, is suitable for long-term administration, and is safe and effective.

The invention provides a ninefold processed anti-aging tea, pertaining to the healthcare drink; the tea is produced by glossy privet fruit, astragalus, liquorice, Chinese date, medlar, prepared rhizome of rehmannia, chrysanthemum, cassia seed and so on, and can be drinked after brewing, having functions of Qi-tonifying and Yin-nourishing, essence-filling and marrow-benefiting, life gate tonifying and kidney reinforcing. The tea can be used for treatment of waist and knee soreness, kidney deficiency, talalgia and dizziness caused by middle-aged liver and kidney deficiency, treatment of dim-sight, tinnitus, heart-throb, amnesia, thirst, dysphoria, testiness, nocturia and dribbling caused by liver-blood deficiency; the tea can also be used for prevention and treatment of fatty liver, hyperlipoidemia and adiposity caused by improper diet; the tea has remarkable healthcare function, convenient drinking and low production cost. The invention has simple process, few procedures and high productivity, is suitable for industrial mass production; the invention not only fully utilizes the medicinal value of glossy privet fruit, but also enlarges its application range and increases its usage.

The invention relates to a Chinese medicinal preparation for treating chronic cerebral circulation insufficiency. The Chinese medicinal preparation is prepared from the following traditional Chinese medicines: 30 grams of astragalus, 15 grams of kudzuvine root, 15 grams of Chinese taxillus twig, 30 grams of root of red-rooted salvia, 9 grams of raw fructus crataegi, 9 grams of szechuan lovage rhizome, 10 grams of cassia twig, 12 grams of dwarf lilyturf root, 6 grams of Chinese magnoliavine fruit and 15 grams of fried date kernel. A preparation method of the Chinese medicinal preparation comprises the following steps of: adding 1,000 ml of water into the Chinese medicinal herbs subjected to processing for decocting; concentrating the decoction to 200 ml; and extracting residues and filtering to obtain a decoction. The Chinese medicinal preparation is taken once every day, and each treatment course lasts for two weeks. The Chinese medicinal preparation has the effects of replenishing qi, enriching the blood, relaxing muscles and joints, activating the channels, remarkably improving heart and brain circulation, enhancing mechanism immunity, resisting inflammation, delaying senility, treating both principal and secondary aspects of a disease, and the like, has reasonable compatibility, and can be used for effectively relieving symptoms such as dizziness, head heaviness, headache, dysphoria, tinnitus, irritability, insomnia, dreaminess, hypomnesia, inattention, fatigue, and the like of a patient suffering from chronic cerebral circulation insufficiency.

The invention discloses a Chinese medicinal preparation for treating insomnia depression, which is characterized by comprising the following raw materials by weight: 9 to 11g of fossilia ossis mastoid, 9 to 11g of oyster shell, 9 to 11g of Chinese thorowax root, 9 to 11g of pinellia tuber, 9 to 11g of radix curcumae, 14 to 16g of baical skullcap root, 14 to 16g of szechwon tangshen root, 14 to 16g of spina date seed and 9 to 11g of grassleaf sweelflag rhizome. The Chinese medicinal preparation can relieve phenomena of dysphoria and foodintake reduction, so that people are calm and smooth and have steady sleep.

The invention relates to a Chinese medicinal preparation for treating chronic cerebral circulation insufficiency. The Chinese medicinal preparation is prepared from the following traditional Chinese medicines: 30 grams of astragalus, 15 grams of kudzuvine root, 15 grams of Chinese taxillus twig, 30 grams of root of red-rooted salvia, 9 grams of raw fructus crataegi, 9 grams of szechuan lovage rhizome, 10 grams of cassia twig, 12 grams of dwarf lilyturf root, 6 grams of Chinese magnoliavine fruit and 15 grams of fried date kernel. A preparation method of the Chinese medicinal preparation comprises the following steps of: adding 1,000 ml of water into the Chinese medicinal herbs subjected to processing for decocting; concentrating the decoction to 200 ml; and extracting residues and filtering to obtain a decoction. The Chinese medicinal preparation is taken once every day, and each treatment course lasts for two weeks. The Chinese medicinal preparation has the effects of replenishing qi, enriching the blood, relaxing muscles and joints, activating the channels, remarkably improving heart and brain circulation, enhancing mechanism immunity, resisting inflammation, delaying senility, treating both principal and secondary aspects of a disease, and the like, has reasonable compatibility, and can be used for effectively relieving symptoms such as dizziness, head heaviness, headache, dysphoria, tinnitus, irritability, insomnia, dreaminess, hypomnesia, inattention, fatigue, and the like of a patient suffering from chronic cerebral circulation insufficiency.

The invention provides a capsule for nourishing liver and kidney and reducing blood pressure, comprising the raw materials with the following parts by weight: 1 part of dogbane leaf, each 0.5-1.2 parts of holly leaf, earthworm and radix curcumae, each 0.5-2 parts of achyranthes and uncaria, 0.5-0.8 part of Salvia miltiorrhiza, 0.3-0.8 part of szechuan lovage rhizome, 0.5-1.5 parts of selfheal, each 0.5-1 part of sophora flower and kudzu-vine root, 0.1-0.5 part of borneol, 0.5-1 part of rhizoma cibotii, each 0.3-0.8 part of eucommia bark and dogwood, and each 0.5-1 part of Semen Cuscutae, spinadate seed and epimedium. The capsule is characterized by nourishing the liver and the kidney, improving the activity of human stem cell, calming the liver and detoxifying, being capable of obviouslyreducing the viscosity of blood, stabilizing the blood pressure, removing blood stasis and relieving pain, removing pathogenic heat from blood, nourishing Yin and nourishing the blood, and being capable of effectively curing hypertension, and symptoms such as headache and reel, pyreticosis and coma, obstruction of the circulation of vital energy and swoon, yin asthenia generating intrinsic heat, body fluid deficiency and thirst, dysphoria wakefulness, pavor and dreaminess, lassitude in waist and knees, etc.

The invention discloses a traditional Chinese medicine for improving sleep, which is composed of Chinese jujube seed 10-30 parts, ginseng 5-20 parts and poria cocos 20-40 parts. This prescription uses Suanzaoren to suppress sweat, ginseng to nourish lung qi, and poria cocos to soothe the nerves. It is used for spontaneous sweating and night sweats due to physical deficiency. Because the three can nourish the heart and calm the nerves, it can also be used for insomnia due to fatigue.

The invention belongs to the field of traditional Chinese medicine, and discloses herbal decoction for treating insomnia. The herbal decoction is prepared from the following TCM raw materials in parts by weight: 10-20 parts of prepared rhizome of rehmannia, 15-25 parts of Chinese yam, 5-15 parts of Indian buead, 5-15 parts of alisma, 10-20 parts of Chinese angelica, 10-15 parts of rhizoma anemarrhenae, 20-40 parts of spina date seed, 10-20 parts of cortex albiziae, 10-20 parts of tuber fleeceflower stem, 15-25 parts of mistletoe, 20-40 parts of drgonsbones, 10-20 parts of polygala tenuifolia, 15-25 parts of curcuma aromatica, 5-10 parts of coptis chinensis, 5-10 parts of liquorice, 10-20 parts of astragali radix, 5-15 parts of rhizome pinelliae preparatum, 10-15 parts of dried orange peel, 5-15 parts of rosa rugosa, 5-15 parts of tree peony bark, 10-20 parts of radix achyranthis bidentatae, 10-20 parts of polygonum multiflorum, 10-20 parts of shelled cedar seed and 10-20 parts of radix paeoniae alba. The herbal decoction prepared by dialectical compatibility of the traditional Chinese medicines obviously improves the difficulty in falling asleep, difficulty in maintaining sleep, dysphoria, soreness and weakness of waist and knees, mental and physical fatigue and other symptoms of a patient.

The invention relates to a pharmaceutical composition capable of improving sleep as well as a preparation and application thereof. The pharmaceutical composition comprises the following components in parts by weight: 5-50 parts of theanine, 5-20 parts of gamma-aminobutyric acid, 50-100 parts of spina date seeds and 50-100 parts of gastrodia elata. A pharmaceutical preparation comprises the previous pharmaceutical composition. The invention further provides application of the pharmaceutical composition in preparation of a medicine with an effect of improving the sleep. According to the pharmaceutical composition in the invention, the theanine has the effects of resisting depression, calming the mind, regulating changes of neurotransmitters in the brain, improving the learning ability and memory and resisting fatigue; the gamma-aminobutyric acid has physiological effects of calming, promoting hypnosis, resisting convulsion and reducing blood pressure; the spina date seeds have the effects of nourishing the liver, calming heart, soothing nerves, arresting sweating, and treating various symptoms such as dysphoria and egersis, palpitation, polydipsia, abnormal sweating and the like; and the gastrodia elata has the effects of calming, resisting convulsions and reducing the blood pressure. According to the synergistic effects of the previous components, the aim of improving the sleep is achieved.

The invention relates to a medicinal pillow capable for relaxing mind and for facilitating sleep when people have a rest, which consists of a pillow case, silk wadding, Chinese herbs such as storax, folium ginkgo, citronella, sandalwood, cypress and lavender and a Chinese medicine bag, wherein the silk wadding has a soft and comfort function, the storax has an effect on enlightening, relieving the pain and stimulating twelve meridians, the folium ginkgo can clear away the lung-heat and relieve asthma and pain and can be used for deficiency syndrome of the lung, asthma, high blood pressure, coronary heart disease, cerebral thrombosis and spasm, the citronella can maintain the function of the respiratory tract, can relax the mind and can help people to sleep, the sandalwood can relax the mind, avoid evil spirits, correct the magnetic field and can increase the mediation, the cypress can facilitate the smooth breathing, and the lavender can relieve the dysphoria.

The invention discloses a preparation method of a dendrobium huoshanense wine for improving human body immunity. The dendrobium huoshanense wine is prepared from distilled spirit taking as base liquor and traditional Chinese medicinal materials, wherein the traditional Chinese medicinal materials comprise dendrobium huoshanense, desertliving cistanche, American ginseng, herb of shorthorned epimedium, barbary wolfberry fruit, prepared rehmannia root, pulp of cornus, eucommia bark, Chinese taxillus twig, oriental waterplantain rhizome, cassia bark, tuber onion seed, hippocamp, cornu cervi pantotrichum and licorice. The preparation method comprises the following steps: crushing the medicinal materials into fine powder of 80-120 meshes, adding 5-8 times of the white spirit of 55-60 degrees, mixing and soaking for 8-12 days, and filtering out wine liquid; and adding 3-5 times of the white spirit of 55-60 degrees, soaking for 6-9 days continuously, filtering out wine liquid, combing the wine liquids, and mixing to an appropriate wine degree to obtain the dendrobium huoshanense wine. The dendrobium huoshanense wine disclosed by the invention has the effects of reinforcing kidney to strengthen yang, replenishing qi to strengthen essence and keeping fit, and has very good curative effects on hyposexuality, cold semen weakness, lassitude in loin and legs, dysphoria insomnia, chronic prostatitis and the like caused by insufficiency of kidney-yang and deficiency of qi and blood.

One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various mammalian cellular receptors, including G-protein coupled receptors. A third aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for mammalian dopamine, muscarinic or serotonin receptors or transporters. Another aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for mammalian dopamine, muscarinic or serotonin receptors. The compounds of the present invention will also find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, analgesia, schizophrenia, Parkinson's disease, restless leg syndrome, sleeping disorders, attention deficit hyperactivity disorder, irritable bowel syndrome, premature ejaculation, menstrual dysphoria syndrome, urinary incontinence, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, Tourette's syndrome, psychiatric disorders, stroke, senile dementia, peptic ulcers, pulmonary obstruction disorders, and asthma.

The invention discloses a heart and spleen-nourishing colla corii asini composition and a preparation method thereof, and belongs to the technical field of health care food. The heart and spleen-nourishing colla corii asini composition is prepared from the following raw materials in parts by weight: 5 to 10 parts of lily bulb, 5 to 10 parts of poria cocos, 5 to 10 parts of lotus seeds, 17 to 22 parts of roasted malts, 28 to 32 parts of wheat, 5 to 10 parts of oysters, 9 to 12 parts of jasmine flowers, 9 to 12 parts of spina date seeds, 9 to 12 parts of fructus lycii, 5 to 15 parts of red dates, 5 to 15 parts of longan aril, 10 to 20 parts of black sesames, 10 to 20 parts of walnuts, 10 to 70 parts of colla corii asini and 10 to 70 parts of yellow wine. The heart and spleen-nourishing colla corii asini composition has a relatively good treatment effect on dysphoria, agrypnia, thin sloppy stool, dizziness, sallow complexion, inappetence, palpitation, hidrosis, irregular menstruation and soreness and weakness of waist and knees which are caused by insufficiency of heart and spleen, takes a quick response and does not have side effects.

The invention relates to traditional Chinese medicine for treating children cough and asthma and a preparation thereof, belonging to the field of traditional Chinese medicines. The invention aims at overcoming the defects of the prior art and discloses a medicine has the functions of moistening lung and relieving asthma, relieving cough and reducing sputum according to the dialectical treatment principle of traditional Chinese medicine. The traditional Chinese medicine comprises bulbus fritillariae cirrhosae, balloon flower, stemona root, glehnia root, tussilago farfara, aster, ophiopogon root, earthworm, rhizoma imperatae, arisaema cum bile, reed root, gentian, rhizoma anemarrhenae and bletilla striata, the medicinal materials can be prepared into any one preparation of the pharmacy according to a certain weight portion. The invention has a special formulation, is used for mainly treating diseases of children cough, fullness chest and asthma, nausea and emesis, dysphoria, and the like, has remarkable treatment effect especially on children whooping cough without toxic side effect, and is worth being popularized and used.

The invention provides a cola capable of enhancing organism immunity, lowering blood lipid, moisturizing lung and calming nerves, and is characterized by the main components according to the parts by weight: 10-200 of gynostemm, 10-200 of lily, 0.1-0.6 of cola essence, 0.1-2 of caramel pigment, 0.1-2 of phosphoric acid and the balance of flavoring agent, preservative and water. The gynostemm is aleaf of sweetleaf gynostemm of cucurbitaceae, the origin of which is the western area of Hubei province. The gynostemm specially contains trace element selenium. The cola contains trace element selenium, can effectively enhance organism immunity, has significant improving effect to people with dysphoria and fire excess, insomnia and more dreams, and also has significant improving effect on hyperlipidemia symptom.

The invention relates to middle-tempering and qi-tonifying bread, which overcomes the defects that the conventional bread has poor mouthfeel and low rigidity and softness and can only solve the hungry problem and most of nutrient components in the conventional bread cannot be absorbed completely by a human body. The bread is prepared by the following steps of: mixing flour, tangerine peel, ginseng, liquoric root, phellodendron (washing with rice wine), sugar and baking powder and shaping; placing the mixture for 20 to 40 minutes; and putting into an oven for baking. The middle-tempering and qi-tonifying bread has the effects of tempering middle and opening yang, tonifyimg qi and raising the fall, curing heaving body and fatigued limbs, dysphoria and shortness of breath and the like caused by poor qi of middle-Jiao, absorption breakdown, clearness promotion and turbidness demotion and curing qi depression and transformation into heat, dryness of the throat, blurred vision and hot body, and can be used for good food nutrient supply in daily diet; and the nutrient components can be absorbed well.

The invention discloses a medicine for treating hypertension. The medicine comprises the following raw materials by weight: 10-30g of radix paeoniae alba, 10-30g of fried Eucommia ulmoides, 5-15g of golden cypress, 10-30g of hawthorn, 5-15g of radix rehmanniae preparata, 5-15g of lumbricus and the like, wherein radix rehmanniae preparata, lumbricus, the root of red-rooted salvia, selfheal and apocynum venetum are primary medicines for clearing away the heart-fire, cooling blood and reducing blood press so as to effectively reduce additional diseases such as irritability, insomnia and dysphoria caused by hypertension. Other traditional Chinese medical components prepared into decoctum not only can ensure the effects respectively, but also can supplement each other, draw on each other's strength, promote the vascular vitality, dredge microcirculation, enhance the immunity and prevent complications of hypertension.

The invention discloses a compound which is prepared from the effective compositions of the traditional Chinese medicinal prescription of Danzhi Ease Powder by a predetermined proportion, the compound has the functions of treating depression, dysphoria, sleep-disorder, sub-health state and apocamnosis.

The invention discloses depression-dispelling nerve-soothing granules and a preparation method for an oral solution of the same. The depression-dispelling nerve-soothing granules are prepared by the following components by weight: 180-220 parts of ginseng, 280-320 parts of spina date seed, 180-220 parts of prepared rehmannia root, 90-110 parts of multiflower knotweed vine, 90-110 parts of platycladi seed, 135-165 parts of fushen, 90-110 parts of pearl powder, 85-95 parts of albizia flower, 90-110 parts of polygala tenuifolia, 75-85 parts of lotus plumule, 85-95 parts of radix ophiopogonis, 75-85 parts of rose, 55-65 parts of radix scrophulariae and 45-55 parts of fructus amomi. The depression-dispelling nerve-soothing granules are mainly used for clinically treating the symptoms of dysphoria and insomnia, palpitation and uneasiness, nerve tiredness and amnesia, feverishness in palms and soles, dryness in pharynx and mouth, dry stool, reddened tongue with less moss and thready rapid pulse. The granules achieve a remarkable effect in treatment of insomnia, neurosis and the like. The granules can further improve the memory of the body while soothing the nerves and assisting sleep.

One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian cellular receptors, including dopamine transporters. The compounds of the present invention will find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to addiction, anxiety, depression, sexual dysfunction, hypertension, migraine, Alzheimer's disease, obesity, emesis, psychosis, analgesia, schizophrenia, Parkinson's disease, restless leg syndrome, sleeping disorders, attention deficit hyperactivity disorder, irritable bowel syndrome, premature ejaculation, menstrual dysphoria syndrome, urinary incontinence, inflammatory pain, neuropathic pain, Lesche-Nyhane disease, Wilson's disease, and Tourette's syndrome. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds, and the screening of those libraries for biological activity, e.g., in assays based on dopamine transporters.

The invention discloses a traditional Chinese medicine pill for treating dysphoria and sleeplessness, belonging to the technical field of Chinese patent medicines. The traditional Chinese medicine pill for treating dysphoria and sleeplessness comprises the following traditional Chinese medicines in parts by weight: 3 parts of Rhizome Pinelliae Preparata, 3 parts of radix ophiopogonis, 4 parts of Poria cocos, 9 parts of semen zizyphi spinosae, 2 parts of liquorice, 2 parts of cassia twig, 2 parts of scutellaria baicalensis, 2 parts of polygala tenifolia, 2 parts of rhizoma dioscoreae colletii, 2 parts of suncured ginseng, 2 parts of fresh ginger, 10 parts of husked sorghum and 6 parts of elm tree leaves. The traditional Chinese medicine pill for treating dysphoria and sleeplessness has good curative effects on sleeplessness accompanying with symptoms such as dysphoria, unaware feeling, absent-minded feeling and easy temper losing.

Chronic pain is alleviated in a mammal suffering there from by administering to the mammal a chronic pain alleviating amount of a nontoxic N-methyl-D-aspartate receptor antagonist such as dextromethorphan, dextrorphan, ketamine or pharmaceutically acceptable salt thereof, in combination with a μ-opiate analgesic such as tramadol or an analogously acting molecular entity, and a methylxanthine such as caffeine, and optionally in sustained release dosage form.