105 results about "Whooping cough" patented technology

Provided are compositions and methods for treating lung or respiratory disorders or conditions characterized by airflow obstruction or limitation, or a symptom thereof (e.g., asthma, rhinitis, allergic rhinitis, and chronic obstructive pulmonary disease (COPD) and COPD-associated conditions (e.g., bronchitis, emphysema, asthma), emphysema, pneumonia, bronchitis, influenza, SARS, tuberculosis, and whooping cough (pertussis), and the like) in a subject in need thereof by administering a therapeutic composition comprising at least one electrokinetically altered fluid (gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures as disclosed herein. In certain aspects, the methods comprise regulating intracellular signal transduction by modulation of at least one of cellular membranes, membrane potential, membrane proteins (e.g., membrane receptors, (e.g., to G protein coupled receptors, and intercellular junctions)). Additional aspects include therapeutic compositions, and combination treatment methods comprising administration of electrokinetically generated fluid in combination with at least one additional therapeutic agent.

Provided are compositions and methods for treating or preventing lung or respiratory disorders or conditions characterized by airflow obstruction or limitation, or a symptom thereof (e.g., asthma, rhinitis, allergic rhinitis (e.g. nose respiratory tract), and chronic obstructive pulmonary disease (COPD) and COPD-associated conditions (e.g., bronchitis, emphysema, asthma), emphysema, pneumonia, bronchitis, influenza, SARS, tuberculosis, and whooping cough (pertussis), and the like) in a subject in need thereof by administering a therapeutic composition comprising at least one electrokinetically generated fluid (including gas-enriched electrokinetically generated fluids) as disclosed herein, the electrokinetically altered aqueous fluid suitable to alter cellular membrane structure or function sufficient to provide for modulation of intracellular signal transduction, wherein treating a lung disorder or a symptom thereof is thereby afforded. Additional aspects relate to therapeutic compositions, and combination treatment methods comprising administration of at least one electrokinetically generated fluid in combination with at least one additional therapeutic agent.

Provided are compositions and methods for treating lung or respiratory disorders or conditions characterized by airflow obstruction or limitation, or a symptom thereof (e.g., asthma, rhinitis, allergic rhinitis, and chronic obstructive pulmonary disease (COPD) and COPD-associated conditions (e.g., bronchitis, emphysema, asthma), emphysema, pneumonia, bronchitis, influenza, SARS, tuberculosis, and whooping cough (pertussis), and the like) in a subject in need thereof by administering a therapeutic composition comprising at least one electrokinetically altered fluid (gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures as disclosed herein. In certain aspects, the methods comprise regulating intracellular signal transduction by modulation of at least one of cellular membranes, membrane potential and / or conductance, membrane proteins (e.g., membrane receptors, (e.g., to G protein coupled receptors, and intercellular junctions)). Additional aspects include therapeutic compositions, and combination therapies comprising administration of the electrokinetically generated fluids with at least one additional therapeutic agent.

Provided are compositions and methods for treating lung or respiratory disorders or conditions characterized by airflow obstruction or limitation, or symptoms thereof (e g, asthma, rhinitis, allergic rhinitis, and chronic obstructive pulmonary disease (CaPO) and CaPO-associated conditions (e g, bronchitis, emphysema, asthma), emphysema, pneumonia, bronchitis, in-fluenza, SARS, tuberculosis, and whooping cough (pertussis), and the like) comprising administering a therapeutic composition comprising at least one electrokinetically altered fluid comprising an ionic aqueous solution of charge-stabilized oxygen containing nanostructures as disclosed herein, or comprising administering a nonelectrokinetic superoxygenated aqueous solution The methods preferably comprise regulating intracellular signal transduction by modulation of at least one of cellular membranes, membrane potential, membrane proteins (e g, membrane receptors, (e g, G protein-coupled receptors, and intercellular junctions)) Additional aspects include therapeutic compositions, and combination treatment methods comprising administration of electrokinetically generated fluid in combination with at least one additional therapeutic agent (e g, albuterol, etc).

The three-dimensional structure of crystalline pertussis holotoxin (PT) has been determined by X-ray crystallography. Crystal structures have also been determined for complexes of pertussis toxin with molecules relevant to the biological activity of PT. These three-dimensional structures were analyzed to identify functional amino acids appropriate for modification to alter the biological properties of PT. Similar procedures may be used to predict amino acids which contribute to the toxicity of the holotoxin, to produce immunoprotective, genetically-detoxified analogs of pertussis toxin.

The three-dimensional structure of crystalline pertussis holotoxin (PT) has been determined by X-ray crystallography. Crystal structures have also been determined for complexes of pertussis toxin with molecules relevant to the biological activity of PT. These three-dimensional structures were analyzed to identify functional amino acids appropriate for modification to alter the biological properties of PT. Similar procedures may be used to predict amino acids which contribute to the toxicity of the holotoxin, to produce immunoprotective, genetically-detoxified analogs of pertussis toxin.

The Bordetella pertussis toxin is genetically modified to express a toxin protein which is deficient in target-cell receptor binding and is used in a vaccine for protection against whooping cough.

The invention relates to a medicament for treating pediatric respiratory tract infection and pulmonary infection, which is prepared from campanumaea pilosula, giant knotweed, whiteflower hogfennel root, almond, pummelo peel, willowleaf swallowwort rhizome, indigowoad root, Ningpo yam rhizome, paniculate swallowwort root, Indian trum etflower seed, Chinese magnoliavine fruit, unibract fritillary bulb, pinellia tuber and the like. The medicament has the effects of resisting inflammation, resisting viruses, and relieving cough and asthma, and is used for treating diseases such as acute upper respiratory tract infection (cold and fever), pediatric pneumonia, bronchitis, chronic recurrent trachitis, pulmonary infection, whooping cough and the like. The medicament takes the giant knotweed and the indigowoad root for clearing heat and detoxicating, and cooling blood and disinhibiting throat, the whiteflower hogfennel root for dispelling wind heat of lungs, the almond, the pummelo peel, the willowleaf swallowwort rhizome, the pinellia tuber and the unibract fritillary bulb for eliminating phlegm and relieving cough, the paniculate swallowwort root, the Indian trum etflower seed and the Ningpo yam rhizome for clearing heat and disinhibiting dampness, resisting inflammation, relieving cough, resisting allergic reaction and resisting allergy, and the campanumaea pilosula for tonifying center vitality, strengthening spleen and tonifying lung, supporting right and expelling evil, relieving cough, improving immunity of patients, diffusing lung vitality and clearing phlegm and heat. Medicinal materials such as tatarian aster root and platycodon root are added into the medicament on the basis of the compatibility so as to add the effects of eliminating phlegm and preventing asthma.

The invention discloses a traditional Chinese medicine with functions of eliminating phlegm and stopping cough, and a preparation method thereof. The medicine consists of the following raw materials in portion by weight: 2 to 10 portions of fructus momordicae, 1 to 7 portions of Szechuan-fritillary bulb, 1 to 5 portions of radix isatidis, 1 to 5 portions of scutellaria, 1 to 5 portions of ephedra, and 1 to 5 portions of licorice. The raw materials are prepared into granules, troche, oral liquid and syrups through the processing technique of extracting, condensing, refining and the like. The medicine has the efficacies of clearing away heat and toxic material, freeing lung and eliminating phlegm, and relieving cough and asthma, and is used for symptoms such as fever, cough, yellow sputum, bronchitis, whooping cough, pneumonia and the like caused by infantile phlegm heat in the lung.

The present invention relates to the field of vaccines for protecting against polio, and in particular to combination vaccines for protecting against polio, diphtheria, tetanus, and pertussis diseases. Specifically, vaccines comprising reduced dose inactivated poliovirus are provided

The invention discloses a whooping cough decoction which comprises the following components: 1-3qian of trichosanthes peel, 2-4qian of folium eriobotryae, 2-4qian of tendril-leaved fritillary bulb, 2-4qian of scutellaria baicalensis, 1-2qian of coptis chinensis, 1-3qian of flos farfarae, 1-3qian of almond and 1-3qian of perillaseed. The whooping cough decoction disclosed by the invention is low in price, simple in preparation and obvious in effect and can be used for effectively treating whooping cough of children.

The invention discloses a medicament for treating whooping cough, and a preparation method thereof. The medicament is mainly prepared by aristolochia fruit, peppergrass, perilla seed, bryozoatum, tatarian aster root, bitter orange, hogfennel root and dark plum according to a certain weight proportion. The medicament has the functions of regulating Qi, strengthening spleen, expelling phlegm, arresting coughing, nourishing yin and clearing away the lung heat, and is quick in action, good in curative effect and high in cure rate.

The invention relates to the use of an antigen which is a non-toxic double mutant form of pertussis toxin for the manufacture of a vaccine composition for intranasal administration to induce an immune response against B. pertussis infection. The invention also relates to the use of a non-toxic double mutant form of pertussis toxin for the manufacture of an adjuvant composition for stimulating or enhancing a protective immune response of an antigen co-administered therewith. The non-toxic double mutant is preferably one in which the glutamic acid 129 amino acid in the S1 sub-unit has been substituted by glycine and the arginine 9 amino acid has been substituted by lysine.

The invention relates to a method using stain cultivation toxoid to prepare diphtheria, tetanus and pertussis vaccine, which uses modes of ammonium sulfate salting out, density gradient centrifugation and glutaraldehyde detoxification to prepare acellular pertussis raw liquid containing effective antigen of PT and FHA. acellular diphtheria, tetanus and pertussis combined vaccine for preventing diphtheria, tetanus and pertussis can be finally prepared by preparing the pertussis raw liquid and refining and purifying to obtain mixture of diphtheria toxoid and tetanus toxoid.

The invention relates to traditional Chinese medicine for treating children cough and asthma and a preparation thereof, belonging to the field of traditional Chinese medicines. The invention aims at overcoming the defects of the prior art and discloses a medicine has the functions of moistening lung and relieving asthma, relieving cough and reducing sputum according to the dialectical treatment principle of traditional Chinese medicine. The traditional Chinese medicine comprises bulbus fritillariae cirrhosae, balloon flower, stemona root, glehnia root, tussilago farfara, aster, ophiopogon root, earthworm, rhizoma imperatae, arisaema cum bile, reed root, gentian, rhizoma anemarrhenae and bletilla striata, the medicinal materials can be prepared into any one preparation of the pharmacy according to a certain weight portion. The invention has a special formulation, is used for mainly treating diseases of children cough, fullness chest and asthma, nausea and emesis, dysphoria, and the like, has remarkable treatment effect especially on children whooping cough without toxic side effect, and is worth being popularized and used.

The invention discloses a Chinese herbal medicine granule for treating the pertussis and a preparation method thereof. The Chinese herbal medicine granule is prepared from the following raw materials: Chinese herbal medicine and a minor ingredient, wherein the Chinese herbal medicine comprises the following components by weight: 10 g of rhizoma imperatae, 6 g of surf clan shell powder, 5 g of radix physochlainae, 25 g of herb of fragrant marshweed, 10 g of Chinese usnea, 4 g of spinycalyx raspberry, 15 g of ambergris, 6 g of desmodium, 7 g of lophatherum gracile brongn, 3 g of mint, 4 g of semen perillae acutae, 5 g of rheum delavayi franch, 8 g of artocarpus lingnanensis merr, 3 g of goodyera schlechtendaliana, and 9 g of viola chaerophylloides; the minor ingredient comprises the following components by weight: 100 g of powdered sugar, 60 g of dextrin and 20 g of beta-cyclodextrin. The granule is prepared from various natural Chinese herbal medicine, and not only has the advantages of fast curative effect, low relapse rate, convenience for use and the like, but also is slightly sweet in taste, has no side effect, and is easy to be accepted by children and parents.

The present invention describes a neurotoxin associated protein from botulinum neurotoxin complex used as an oral or nasal delivery system for a vaccine. The vaccine is selected from tetanus, diphtheria and pertussis alone or in combination. Further the oral or nasal delivery of tetanus vaccine in combination with other drug molecules.

The invention relates to pitcher plant health herbal tea, which mainly comprises 70 to 90 percent of pitcher plant, 1 to 10 percent of black bone tea, 2 to 15 percent of wild tea and 1 to 10 percent of mallotus root, also comprises Chinese medicinal components such as spreading hedyotis herb, salvia miltiorrhiza bunge, grosvener siraitia, desmodium and the like, has main effects of clearing away heat and toxic material, protecting lung and liver, stopping pain and illness, eliminating phlegm and stopping cough, dispelling three fats, dispelling mallnutrition and indigestion syndrome in children, and stimulating the appetite and relieving dyspepsia, and has effects of prevention and adjunct therapy of hypertension, hepatitis with jaundice and hepatocirrhosis; and because the pitcher plant has the effects of moistening lung and stopping cough, clearing heat and promoting dieresis and dispelling calculus, releasing toxin and removing swelling, and treating lung dryness and hemoptysis, cold cough, whooping cough, jaundice, diarrhea, lithangiuria and the like, the pitcher plant can be also used for preventing and treating diseases such as stomach and duodenum ulcer diseases, hypertension, diabetes, boils and sores and carbuncle swelling and the like, and the development of the pitcher plant health herbal tea has important significance.

The invention provides artificially synthesized bear bile, which is characterized by being prepared from several types of animal bile and an aid according to natural biological components and medicinal value of the bear bile. The medicinal value of the artificially synthesized bear bile can be equal to that of the scarce and expensive natural bear bile. The artificially synthesized bear bile is bitter and nontoxic, has the effects of clearing heat, detoxifying, relieving cough and asthma, sterilizing, diminishing inflammation, improving eyesight, expelling parasites, relaxing bowels and the like, and is used for replacing the bear bile to treat pediatric whooping cough, epilepsy, bacillary dysentery, meningitis, flu caused encephalitis, trachitis, cough type asthma, hepatitis B, laryngitis and malignant sores, improve the eyesight, expel the parasites and the like.

The present invention discloses a lemon cream and a preparation method thereof. The preparation method comprises the following steps: A, lemons are put into a salt water with a concentration of 10-15 g / L for soaking and scrubbed for 8-10 hours; B, the surface water of the lemons obtained from the step A is removed by air-drying; C, the lemons obtained from the step B are sliced into lemon slices with a thickness of 2-8 mm and the sliced lemons are seeded; and D, crystal sugar is added into the seeded lemon slices obtained from the step C, the mixture is put into a stewing pot and stewed for 10-12 hours to obtain the lemon cream, and the use amount of the crystal sugar is twice the weight of lemons used in the step C. The lemon cream can relieve throat inflammation, cough with a lot of phlegm, pediatric pertussis and other diseases and has efficacies of whitening skin and lightening speckles, and nourishing yin and moistening lungs at the same time. At the same time, the crystal sugar can be replaced with coarse salt and the lemon cream is suitable for a variety of population to consume.

The invention relates to a pertussis genetic-engineering fused subunit vaccine, which is fused protein produced by connecting pertussis toxin S1 subunit mutant with a peptide Fs. The invention also relates to a preparation method of bordetella pertussis double-subunit genetic engineering vaccine. The invention, which overcomes a variety of deficiencies of the traditional vaccine and the traditional preparation method, has the advantages of mass production potential, easy operation, high security, small side effect and no reverse mutation.

A garlicin injection for preventing and treating acute and chronic bacillary dysentery and enteritis, pertussis, fungus infection of lung and digestive tract, etc is prepared through ultrasonic treating to garlicin and tween-80, mixing with alcohol, ultrafiltration, pouring it in containers containing N2 in dark condition, sterilizing, and lamp examining.

The invention discloses a Chinese herbal medicine for treating pertussis. The Chinese herbal medicine is prepared from the following medicines in parts by weight: 5-15 parts of platycodon grandiflorus, 5-15 parts of radix stemonae, 5-15 parts of willowleaf swallowwort rhizome, 5-15 parts of exocarpium citri rubrum, 6-18 parts of radix asteris, 6-18 parts of honeysuckle, 6-18 parts of thunberg fritillary bulb, 6-18 parts of radix scutellariae, 6-18 parts of almond, 6-18 parts of root of straight ladybell, 6-18 parts of radix peucedani and 10-20 parts of radix isatidis. The Chinese herbal medicine is prepared by adding 1000 parts by weight of water to a crockery, after the water is boiled, decocting the medicines with slow fire for 20-30 minutes, filtering the decoction and collecting the supernatant, adding 1000 parts by weight of water and decocting the supernatant three times, bottling and uniformly mixing the supernatant decocted three times and then sterilizing the supernatant under a high temperature for later use. Platycodon grandiflorus is taken as the monarch, radix stemonae and willowleaf swallowwort rhizome are taken as the ministers, exocarpium citri rubrum, radix asteris, honeysuckle and thunberg fritillary bulb are taken as the assistants, and radix scutellariae, almond, root of straight ladybell, radix peucedani and radix isatidis are taken as the guides. The Chinese herbal medicine has the following beneficial effects: the Chinese herbal medicine is convenient to prepare and use, is safe, does not have side effects, has low treatment cost and is an ideal medicine for treating pertussis.

The invention relates to a herbal oral care preparation, and relates to the field of oral care. The herbal oral care preparation is prepared from the following raw materials: herba sarcandrae, cortexmoutan radicis, licorice root, fructus momordicae, radix zanthoxyli, herba portulacae, semen sterculiae lychnophorae, a fermented material, folium eriobotryae, fructus cnidii, herba rabdosiae rubescentis, flos jasmini nudiflori, flos osmanthi fragrans, glossy privet leaves, radix sophorae flavescentis, marigold root, flos lonicerae, fructus hyperici chinense, radix isatidis, cortex pericarpii granati, akebia stem, flos rosae rugosae, jasminum officinale root, and radix scutellariae. The herbal oral care preparation provided by the invention has the beneficial effects that the above herbal plants which are non-toxic and suitable for oral care are used as raw materials for efficacy, is purely natural, does not contain various additives and added materials, does not contain chemical components, can clear heat, detoxify, reduce swelling, reduce inflammation, slake thirst and help produce saliva, remove heat from the lung to relieve cough, remove heat to coll blood, harmonize the stomach and promote diuresis, diminish inflammation and relieve pain, is favorable for treating acute laryngitis, acute tonsillitis, tumor, diminishing inflammation, treating bronchitis, whooping cough, stomatitis, and dental ulcers, and relieving toothache.

A traditional Chinese medicine for curing cholestatic hepatitis belongs to a traditional Chinese medicine of curing hepatitis. The components contain: 50g of christina loosestrife, 8g of natural indigo, 15g of giant knotweed rhizome, 15g of turmeric root tuber, 15g of oriental waterplantain rhizome, 15g of polyporus, 20g of virgate wormwood herb, 20g of chinese date, 20g of isatis root, 12g of Chinese thorowax root and 10g of rhubarb; the invention has the auxiliary prescriptions that: for severe abdominal distension, 25g of immature orange fruit, 25g of malt and 25g of parched hawthorn fruit are added; for aversion to cold with fever, 15g of honeysuckle flower, 15g of dandelion and 15g of golden thread are added; for vomiting, 20g of villous amomum fruit, 20g of perilla leaf and 20g of endothelium corneum gigeriae galli are added. The substances in the prescription are made from natural traditional Chinese medicine plus traditional preparing methods. The materials are easy to collect, the prescription and the preparation methods are simple, and the cost of medicine preparation is low. The compatibility of the traditional Chinese medicine is simple; the medicine used in the prescription is fully natural herbal medicine, which is easy to collect and use; the preparation method is simple; the effects for taking and curing are good; the cost of the medicine is low, and the medicine is in particular suitable for the people living in remote villages far from towns; the cost is low for curing the people suffering from whooping cough, which solves the problem that the local area lacks medical conditions to cure the disease because of low household income and poor living condition.

The present invention belongs to the field of natural medicine, in the concrete, it relates to a medicinal application of peucedanum praeruptorum total coumarin extract. It can be used for preparing medicine for curing the diseases of respiratory tract, such as acute and chronic bronchitis, pneumonitis, brochinal asthma, allergic asthma and whooping cough, etc.

The present invention provides a vaccine production strain of Bordetella bronchiseptica that produces a pertussis toxin in high yield. The present invention provides a method for creating a Bordetella bronchiseptica cell line which produces a Bordetella pertussis toxin comprising the steps of introducing a plasmid containing a DNA encoding antibiotic resistance into a Bordetella bronchiseptica strain, selecting for isolates in which the DNA encoding antibiotic resistance is recombinantly incorporated into the chromosome in place of the Bordetella bronchiseptica toxin gene, introducing a plasmid containing DNA encoding subunits of the Bordetella pertussis toxins into the Bordetella bronchiseptica isolates; and, selecting for isolates in which DNA encoding Bordetella pertussis toxin subunit is recombinantly incorporated into the chromosome, the resulting cells producing the Bordetella pertussis toxin. The present invention further provides a method for creating a Bordetella bronchiseptica cell line which produces a Bordetella pertussis toxin and does not express filamentous hemagglutinin.

The invention discloses a Chinese medicament for treating whooping cough, which consists of the following raw material medicaments in part by weight: 10 to 20 parts of sandalwood, 10 to 20 parts of sessile stemona root, 10 to 20 parts of gansui root, 10 to 20 parts of platycodon root, 10 to 20 parts of anemarrhena, 10 to 20 parts of golden thread, 10 to 20 parts of liquoric root, 10 to 20 parts of reed rhizome, 10 to 20 parts of blackberrykiky rhizome, 10 to 20 parts of natural indigo, 3 to 7 parts of heartleaf houttuynia herb, 3 to 7 parts of garden balsam stem, 3 to 7 parts of herba inulae, 3 to 7 parts of medcinal evodia fruit, 3 to 7 parts of pepperweed seed, 3 to 7 parts of radish seed, 3 to 7 parts of knoxia root, 3 to 7 parts of white mustard seed, 3 to 7 parts of bitter almond kernel and 3 to 7 parts of pedate pinallia jackinthepulpit rhizome. The Chinese medicament takes pure Chinese medicinal herbs as raw materials, is scientifically prepared, has the effects of diffusing lung vitality, reducing sputum and relieving cough and asthma, moistening lung and disinhibiting throat, and has the advantages of quick response and cure rate of pediatric whooping cough of 98 percent.

The invention relates to a traditional Chinese medicine preparation for the treatment of whooping cough, which comprises daphne genkwa, bulbus fritillaria thunbergii, perillaseed, nodus nelumbinis rhizomatis, earthworm, tabasheer, loquat leaf, bile arisaema, centipede, inula flower, adenophora stricta, magnetite, radix paeoniae alba, radix peucedani, semen lepidii, flos imperatae, pericarpium citri reticulatae, periostracum cicada, bryozoatum and perfoliote knotweed herb. The traditional Chinese medicine preparation disclosed by the invention has the effects of purging excessive fluid, clearing away the lung-heat, dispersing blood stasis, depressing qi, causing laxation, promoting transportation, tonifying the spleen and stomach, removing heat from the liver, realizing spasmolysis, preventing phlegm from forming, stopping coughing, clearing heat, dissolving phlegm, depressing qi, relieving asthma, and the like. The traditional Chinese medicine preparation can restore the toxicant elimination and detoxification functions of the liver and kidney, and fundamentally eliminate phlegm and improve the circulation of the respiratory system and the digestive system, so that the self-regulating function of the respiratory system is restored. Through comprehensive treatment, the symptoms such as cough, shortness of breath, rhinorrhoea, phlegm and the like can be thoroughly relieved, and finally, the effects of balancing Yin and Yang, improving microcirculation, and adjusting endocrine dysfunction are achieved, thereby achieving the purpose of completely curing whooping cough.