105 results about "Whooping cough" patented technology

Provided are compositions and methods for treating lung or respiratory disorders or conditions characterized by airflow obstruction or limitation, or a symptom thereof (e.g., asthma, rhinitis, allergic rhinitis, and chronic obstructive pulmonary disease (COPD) and COPD-associated conditions (e.g., bronchitis, emphysema, asthma), emphysema, pneumonia, bronchitis, influenza, SARS, tuberculosis, and whooping cough (pertussis), and the like) in a subject in need thereof by administering a therapeutic composition comprising at least one electrokinetically altered fluid (gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures as disclosed herein. In certain aspects, the methods comprise regulating intracellular signal transduction by modulation of at least one of cellular membranes, membrane potential, membrane proteins (e.g., membrane receptors, (e.g., to G protein coupled receptors, and intercellular junctions)). Additional aspects include therapeutic compositions, and combination treatment methods comprising administration of electrokinetically generated fluid in combination with at least one additional therapeutic agent.

Provided are compositions and methods for treating or preventing lung or respiratory disorders or conditions characterized by airflow obstruction or limitation, or a symptom thereof (e.g., asthma, rhinitis, allergic rhinitis (e.g. nose respiratory tract), and chronic obstructive pulmonary disease (COPD) and COPD-associated conditions (e.g., bronchitis, emphysema, asthma), emphysema, pneumonia, bronchitis, influenza, SARS, tuberculosis, and whooping cough (pertussis), and the like) in a subject in need thereof by administering a therapeutic composition comprising at least one electrokinetically generated fluid (including gas-enriched electrokinetically generated fluids) as disclosed herein, the electrokinetically altered aqueous fluid suitable to alter cellular membrane structure or function sufficient to provide for modulation of intracellular signal transduction, wherein treating a lung disorder or a symptom thereof is thereby afforded. Additional aspects relate to therapeutic compositions, and combination treatment methods comprising administration of at least one electrokinetically generated fluid in combination with at least one additional therapeutic agent.

Provided are compositions and methods for treating lung or respiratory disorders or conditions characterized by airflow obstruction or limitation, or a symptom thereof (e.g., asthma, rhinitis, allergic rhinitis, and chronic obstructive pulmonary disease (COPD) and COPD-associated conditions (e.g., bronchitis, emphysema, asthma), emphysema, pneumonia, bronchitis, influenza, SARS, tuberculosis, and whooping cough (pertussis), and the like) in a subject in need thereof by administering a therapeutic composition comprising at least one electrokinetically altered fluid (gas-enriched (e.g., oxygen-enriched) electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures as disclosed herein. In certain aspects, the methods comprise regulating intracellular signal transduction by modulation of at least one of cellular membranes, membrane potential and / or conductance, membrane proteins (e.g., membrane receptors, (e.g., to G protein coupled receptors, and intercellular junctions)). Additional aspects include therapeutic compositions, and combination therapies comprising administration of the electrokinetically generated fluids with at least one additional therapeutic agent.

The three-dimensional structure of crystalline pertussis holotoxin (PT) has been determined by X-ray crystallography. Crystal structures have also been determined for complexes of pertussis toxin with molecules relevant to the biological activity of PT. These three-dimensional structures were analyzed to identify functional amino acids appropriate for modification to alter the biological properties of PT. Similar procedures may be used to predict amino acids which contribute to the toxicity of the holotoxin, to produce immunoprotective, genetically-detoxified analogs of pertussis toxin.

The three-dimensional structure of crystalline pertussis holotoxin (PT) has been determined by X-ray crystallography. Crystal structures have also been determined for complexes of pertussis toxin with molecules relevant to the biological activity of PT. These three-dimensional structures were analyzed to identify functional amino acids appropriate for modification to alter the biological properties of PT. Similar procedures may be used to predict amino acids which contribute to the toxicity of the holotoxin, to produce immunoprotective, genetically-detoxified analogs of pertussis toxin.

The Bordetella pertussis toxin is genetically modified to express a toxin protein which is deficient in target-cell receptor binding and is used in a vaccine for protection against whooping cough.

The invention relates to a medicament for treating pediatric respiratory tract infection and pulmonary infection, which is prepared from campanumaea pilosula, giant knotweed, whiteflower hogfennel root, almond, pummelo peel, willowleaf swallowwort rhizome, indigowoad root, Ningpo yam rhizome, paniculate swallowwort root, Indian trum etflower seed, Chinese magnoliavine fruit, unibract fritillary bulb, pinellia tuber and the like. The medicament has the effects of resisting inflammation, resisting viruses, and relieving cough and asthma, and is used for treating diseases such as acute upper respiratory tract infection (cold and fever), pediatric pneumonia, bronchitis, chronic recurrent trachitis, pulmonary infection, whooping cough and the like. The medicament takes the giant knotweed and the indigowoad root for clearing heat and detoxicating, and cooling blood and disinhibiting throat, the whiteflower hogfennel root for dispelling wind heat of lungs, the almond, the pummelo peel, the willowleaf swallowwort rhizome, the pinellia tuber and the unibract fritillary bulb for eliminating phlegm and relieving cough, the paniculate swallowwort root, the Indian trum etflower seed and the Ningpo yam rhizome for clearing heat and disinhibiting dampness, resisting inflammation, relieving cough, resisting allergic reaction and resisting allergy, and the campanumaea pilosula for tonifying center vitality, strengthening spleen and tonifying lung, supporting right and expelling evil, relieving cough, improving immunity of patients, diffusing lung vitality and clearing phlegm and heat. Medicinal materials such as tatarian aster root and platycodon root are added into the medicament on the basis of the compatibility so as to add the effects of eliminating phlegm and preventing asthma.

A modulated immune response to an antigen is achieved by coadministering the antigen and a genetically-detoxified pertussis holotoxin, particularly one retaining its immunogenicity, to a host. The modulated immune response enables immunogenic compositions, including multivalent pediatric vaccines such as DTP, to be provided which produce a modulated immune response in the absence of extrinsic adjuvants such as alum. The adjuvanting effect achieved by the genetically-detoxified pertussis holotoxin enables at least the same level of adjuvanting effect to be achieved as previously attained by alum, without the undesirable side effects thereof.

The present invention relates to the field of vaccines for protecting against polio, and in particular to combination vaccines for protecting against polio, diphtheria, tetanus, and pertussis diseases. Specifically, vaccines comprising reduced dose inactivated poliovirus are provided

The invention relates to a method using stain cultivation toxoid to prepare diphtheria, tetanus and pertussis vaccine, which uses modes of ammonium sulfate salting out, density gradient centrifugation and glutaraldehyde detoxification to prepare acellular pertussis raw liquid containing effective antigen of PT and FHA. acellular diphtheria, tetanus and pertussis combined vaccine for preventing diphtheria, tetanus and pertussis can be finally prepared by preparing the pertussis raw liquid and refining and purifying to obtain mixture of diphtheria toxoid and tetanus toxoid.

The invention relates to traditional Chinese medicine for treating children cough and asthma and a preparation thereof, belonging to the field of traditional Chinese medicines. The invention aims at overcoming the defects of the prior art and discloses a medicine has the functions of moistening lung and relieving asthma, relieving cough and reducing sputum according to the dialectical treatment principle of traditional Chinese medicine. The traditional Chinese medicine comprises bulbus fritillariae cirrhosae, balloon flower, stemona root, glehnia root, tussilago farfara, aster, ophiopogon root, earthworm, rhizoma imperatae, arisaema cum bile, reed root, gentian, rhizoma anemarrhenae and bletilla striata, the medicinal materials can be prepared into any one preparation of the pharmacy according to a certain weight portion. The invention has a special formulation, is used for mainly treating diseases of children cough, fullness chest and asthma, nausea and emesis, dysphoria, and the like, has remarkable treatment effect especially on children whooping cough without toxic side effect, and is worth being popularized and used.

A traditional Chinese medicine for curing cholestatic hepatitis belongs to a traditional Chinese medicine of curing hepatitis. The components contain: 50g of christina loosestrife, 8g of natural indigo, 15g of giant knotweed rhizome, 15g of turmeric root tuber, 15g of oriental waterplantain rhizome, 15g of polyporus, 20g of virgate wormwood herb, 20g of chinese date, 20g of isatis root, 12g of Chinese thorowax root and 10g of rhubarb; the invention has the auxiliary prescriptions that: for severe abdominal distension, 25g of immature orange fruit, 25g of malt and 25g of parched hawthorn fruit are added; for aversion to cold with fever, 15g of honeysuckle flower, 15g of dandelion and 15g of golden thread are added; for vomiting, 20g of villous amomum fruit, 20g of perilla leaf and 20g of endothelium corneum gigeriae galli are added. The substances in the prescription are made from natural traditional Chinese medicine plus traditional preparing methods. The materials are easy to collect, the prescription and the preparation methods are simple, and the cost of medicine preparation is low. The compatibility of the traditional Chinese medicine is simple; the medicine used in the prescription is fully natural herbal medicine, which is easy to collect and use; the preparation method is simple; the effects for taking and curing are good; the cost of the medicine is low, and the medicine is in particular suitable for the people living in remote villages far from towns; the cost is low for curing the people suffering from whooping cough, which solves the problem that the local area lacks medical conditions to cure the disease because of low household income and poor living condition.

The present invention belongs to the field of natural medicine, in the concrete, it relates to a medicinal application of peucedanum praeruptorum total coumarin extract. It can be used for preparing medicine for curing the diseases of respiratory tract, such as acute and chronic bronchitis, pneumonitis, brochinal asthma, allergic asthma and whooping cough, etc.

The invention relates to a traditional Chinese medicine preparation for the treatment of whooping cough, which comprises daphne genkwa, bulbus fritillaria thunbergii, perillaseed, nodus nelumbinis rhizomatis, earthworm, tabasheer, loquat leaf, bile arisaema, centipede, inula flower, adenophora stricta, magnetite, radix paeoniae alba, radix peucedani, semen lepidii, flos imperatae, pericarpium citri reticulatae, periostracum cicada, bryozoatum and perfoliote knotweed herb. The traditional Chinese medicine preparation disclosed by the invention has the effects of purging excessive fluid, clearing away the lung-heat, dispersing blood stasis, depressing qi, causing laxation, promoting transportation, tonifying the spleen and stomach, removing heat from the liver, realizing spasmolysis, preventing phlegm from forming, stopping coughing, clearing heat, dissolving phlegm, depressing qi, relieving asthma, and the like. The traditional Chinese medicine preparation can restore the toxicant elimination and detoxification functions of the liver and kidney, and fundamentally eliminate phlegm and improve the circulation of the respiratory system and the digestive system, so that the self-regulating function of the respiratory system is restored. Through comprehensive treatment, the symptoms such as cough, shortness of breath, rhinorrhoea, phlegm and the like can be thoroughly relieved, and finally, the effects of balancing Yin and Yang, improving microcirculation, and adjusting endocrine dysfunction are achieved, thereby achieving the purpose of completely curing whooping cough.