The invention relates to the technical field of a traditional Chinese medicine preparation, and discloses a traditional Chinese medicine enema for treating exogenous fever of infants. The enema is prepared by taking radix scutellariae, honeysuckle, forsythia, dandelion, gypsum and rhizoma anemarrhenae as raw materials through the steps of soaking, decocting and filtering. The invention is characterized in that each dose of enema is prepared from the following raw materials in proportioning by weight: 2-5g of radix scutellariae, 5-8g of honeysuckle, 2-5g of forsythia, 5-8g of dandelion, 9-12g of gypsum and 2-5g of rhizoma anemarrhenae. The enema has the functions of clearing away heat and toxic material, diminishing inflammation and allaying the fever, and is a preferred medicament for allaying the exogenous fever of infants. Compared with the existing treatment method, the enema disclosed by the invention can be quickly absorbed through rectal administration, has a good treatment effect, reduces the 'first pass effect' of general medicaments, has high bioavailability and low price, is convenient and easy to implement, does not have toxic side effects, has an obvious effect on allaying the fever, and also solves the problem that infants are afraid of needles and medicaments. Observed by 200 clinical cases, the antipyretic effective rate within 36 hours is 100%.