Oral care product containing propolis alcohol extract and having anti-Hp (helicobacter pylori) efficacy

An anti-Helicobacter pylori and oral care technology, which is applied in the field of daily chemicals, can solve the problems of recurrent disease, loss, and unsatisfactory antibacterial effect, etc., and achieve the effect of simple extraction method, stable dosage and composition, and improved antioxidant activity

Active Publication Date: 2015-10-28
杭州华胄生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of the prior art are: 1. Kill a large number of beneficial bacteria, which easily leads to repeated outbreaks of the disease. 2. The taking of large doses of multiple antibiotics increases the drug resistance of Helicobacter pylori, and the drug resistance of the bacteria makes the original effective antibiotics less effective. The treatment effect is reduced or lost, which increases the difficulty of treatment and medical costs for patients
Although there are some Chinese herbal health care toothpastes on the market, the antibacterial effect is not ideal enough, especially it does not have the effect of killing Helicobacter pylori

Method used

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  • Oral care product containing propolis alcohol extract and having anti-Hp (helicobacter pylori) efficacy
  • Oral care product containing propolis alcohol extract and having anti-Hp (helicobacter pylori) efficacy
  • Oral care product containing propolis alcohol extract and having anti-Hp (helicobacter pylori) efficacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The toothpaste containing propolis alcohol extraction with anti-Helicobacter pylori effect is composed of the following components in parts by weight: 90 parts of calcium hydrogen phosphate, 25 parts of water, 7 parts of sorbitol, 3 parts of hydrated silica, polyethylene glycol- 8 3 parts, 4 parts of propylene glycol, 2 parts of sodium lauryl sulfate, 3 parts of cellulose gum, 3 parts of hydroxyethyl cellulose, 3 parts of essence, 3 parts of sodium benzoate, 3 parts of sodium saccharin, 3 parts of propolis alcohol extract .

[0026] Wherein, propolis ethanol extract adopts following method to prepare:

[0027] 1) Freeze natural propolis glue at -20°C, after it becomes hard and brittle, beat it with a wooden hammer to remove impurities and obtain propolis powder;

[0028] 2) Add 1000mL of 60% ethanol to 50g of propolis powder according to the material-to-liquid ratio of 1:20 (g / mL), and extract under reflux at 60°C for 4 hours to obtain the extract;

[0029] 3) The ext...

Embodiment 2

[0034] The mouthwash containing propolis alcohol extract with anti-Helicobacter pylori effect is composed of the following components in parts by weight: 95 parts of water, 15 parts of sorbitol, 7 parts of propylene glycol, 8 parts of xylitol, PEG-400 polyethylene 8 parts of glycol, 3 parts of dimethyl glycyrrhizinate, 3 parts of sodium benzoate, 2 parts of essence, 3 parts of propolis alcohol extract.

[0035] The preparation method of propolis ethanol extract is the same as in Example 1.

Embodiment 3

[0037] The chewing gum containing propolis alcohol extract with anti-Helicobacter pylori effect is composed of the following components in parts by weight: 35 parts of xylitol, 25 parts of gum base, 17 parts of sorbitol, 17 parts of maltitol liquid, D-mannose 8 parts of sugar alcohol, 170 parts of citric acid, 110 parts of phospholipids, 35 parts of aspartame, 35 parts of essence, 3 parts of propolis alcohol extract.

[0038] The preparation method of propolis ethanol extract is the same as in Example 1.

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Abstract

The invention discloses an oral care product containing propolis alcohol extract and having anti-Hp (helicobacter pylori) efficacy. The oral care product is characterized by containing the propolis alcohol extract. The invention provides a kind of traditional Chinese medicine oral care products, a medicine extracting method is simple, dosage and ingredients are stable, and the products can go deep into an oral cavity directly. The oral care product cannot cause internal environment disturbance of the oral cavity when used for a long time and has no side effects. Propolis contains a large quantity of flavonoid, aromatic acid, fatty acid and terpene compounds and has a broad-spectrum antibacterial function. The oral care product not only has similar functions including halitosis removal, oral ulcer treatment, resistance to common pathogenic bacteria in the oral cavity and inflammation diminishing to the conventional oral care products such as Chinese herbal medicine health care toothpaste and the like, but also has the functions of Hp killing and effective prevention of oral transmission of Hp. Natural propolis is applied to the oral care products such as the toothpaste and the like, the oxidation resistance of the products is improved, and the shelf life is prolonged.

Description

technical field [0001] The invention belongs to the technical field of daily chemicals, and in particular relates to an oral care product containing propolis alcohol extract and having the effect of resisting Helicobacter pylori. Background technique [0002] Helicobacter pylori, English name Helicobacter pylori, referred to as Hp. Helicobacter pylori is a highly infectious pathogenic bacteria. In 1983, Australian scholars Barry J.Marshall and Robin Warren J.Robin Warren first isolated and detected Helicobacter pylori in gastric mucosal biopsies of gastritis patients. In 1989, Australian scholar Krajden detected HP from the dental plaque of the oral teeth of patients with gastritis, and confirmed that it was the same as Hp in the stomach from the molecular level. Hp is an orally transmitted infectious disease, and oral Hp is an important reservoir of gastric Hp. The damage of Helicobacter pylori to human health is significant: it is the first carcinogen that induces gastr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/98A61Q11/00A61P31/04A61P1/02A61K35/644A23G3/36A23G4/12
Inventor 严杰林世恩葛玉梅
Owner 杭州华胄生物科技有限公司
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