3results about How to "Enhance detoxification ability" patented technology

The invention relates to the technical field of marine organisms, in particular to a nucleic acid aptamer modified nerve extracellular vesicle and application thereof in prevention and treatment of marine guanamine neurotoxin poisoning. According to the invention, extracellular vesicles (nEVs) and a nucleic acid aptamer (Apt) of tetrodotoxin (TTX) are coupled to construct a guanamine toxoid nano antagonism system Apt-nEVs. According to the present invention, the Apt-nEVs retains the natural Na < + > channel on the nerve cell membrane, can synergistically provide the dual detoxification function of the coupling aptamer and the natural Na < + > channel to identify and trap TTX, can achieve the efficient detoxification of TTX in the non-cell system and the cell level, and can significantly protect the cell oxidative stress injury caused by TTX. In addition, the aptamer coupled extracellular vesicles (Apt-nEVs) obtained in the invention can also provide thought and reference for construction of a more broad-spectrum marine biotoxin antagonism system.

This invention discloses a method for detoxifying chromium corundum, comprising: feeding chromium corundum sequentially into a jaw crusher and a column mill for pulverization; feeding the pulverized chromium corundum into a mixer, spraying a composite reducing agent and mixing the mixture to obtain a homogeneous mixture; subjecting the mixture to gradient heating reduction under an inert atmosphere, followed by cooling; and discharging the cooled mixture into ton bags and allowing it to stand for a period of time to obtain detoxified chromium corundum. This invention improves production efficiency through a simplified process and significantly increases the reduction rate of hexavalent chromium by adding a composite reducing agent with strong penetrating and anti-reoxidation properties, while achieving zero wastewater discharge. This improves the resource utilization rate of detoxified chromium corundum and reduces processing costs. The detoxified chromium corundum can be used as a resource in refractory materials, abrasives, and functional fillers.

The application discloses an antibacterial peptide mutant and application thereof, the amino acid sequence of the mutant is shown in any one of SEQ ID NO:1 or SEQ ID NO:2.The antibacterial peptide has good antibacterial and bacteriostatic performance, and the application thereof in preparing microbial inhibitors and in feed additives is also provided.The feed additive comprises the antibacterial peptide, wherein the antibacterial peptide can replace the growth promoting effect of antibiotics, and the effect is rapid and stable without residue; meanwhile, the feed additive also comprises gamma-aminobutyric acid and vitamin C, which can eliminate the reduction of feed intake caused by high temperature and high humidity, relieve heatstroke symptoms such as no sweating and rapid breathing, resist stress, have a good regulating effect on various physiological and pathological changes, reduce and neutralize toxins, and enhance the detoxification capacity of liver.