70 results about "Lipofuscin" patented technology

Methods of retarding formation of a lipofuscin pigment in the retina and of treating or ameliorating the effects of a disease characterized by an accumulation of a lipofuscin pigment in a retina are provided. These methods include the step of administering to a patient in need thereof a substituted C20-retinoid in an amount sufficient to reduce accumulation of a lipofuscin pigment in the retina. Further provided are methods of retarding formation of A2E and / or ATR-dimer by replacing an all-frans-retinal (ATR) substrate with a C20-D3-retinal substrate under conditions sufficient to impede the formation of A2E. Compositions for retarding formation of a lipofuscin pigment in the retina containing a substituted C20-retinoid and a pharmaceutically acceptable carrier are also provided.

The invention discloses pleurotus citrinopileatus sing ultrafine power cultured by using ramulus mori stems as major ingredients and a production method of the pleurotus citrinopileatus sing ultrafine power. The production method is characterized in that the ramulus mori stems is adopted as the major ingredients of the pleurotus citrinopileatus sing ultrafine power, 35-55 DEG C low-temperature vacuum drying is carried out for 4 to 5 hours, the crushing is carried out by a 500-1000-mesh sieve ultrafine crushing machine, and the pleurotus citrinopileatus sing ultrafine dry power is obtained. The pleurotus citrinopileatus sing ultrafine power and the production method have the advantages that the original nutrition and health care characteristics of pleurotus citrinopileatus sing can be maintained, the activity of B type monoamine oxidase is inhibited, in addition, the peroxyl lipid content of the liver can be reduced, the lipofuscin content of the heart is reduced, the activity of SOD (super oxygen dehydrogenises) in red blood cells can be improved, good effects of nourishing yin and yang, delaying senescence, preventing and resisting cancer, lowering the blood pressure and the like are realized, in addition, more convenient edible performance and efficient utilization performance of the health care ingredients are realized, and meanwhile, the silkworm industrial chain can be favorably prolonged.

The present invention relates to the use of cyclic oligosaccharides as chemical complexants of lipofuscin bisretinoids (A2E) to prevent and treat eye (i.e., retinal or macular) disease. Monomeric, dimeric, multimeric, or polymeric oligosaccharide rings act as pharmacologic agents to prevent and treat ophthalmologic disorders triggered by the accumulation of lipofuscin in the retinal pigment epithelium (RPE), which occurs as a consequence of either genetic disorders, such as Stargardt Disease (SD) and Best Disease (BD), or aging, such as Age-Related Macular Degeneration (AMD), or other diseases, such as retinitis pigmentosa, and cone-rod dystrophy.

Zeaxanthin, a natural carotenoid, can improve and increase the ability of enzyme inhibitors that can slow down certain enzymes that are contributing to toxic metabolite accumulation in people who suffer from Stargardt's disease or other lipofuscin disorders. Such enzyme inhibitors include retinoid analogs such as isotretinoin, commonly known by the trademark, ACCUTANE. This drug binds to and inhibits at least two retinal enzymes, known as RPE65 and short chain dehydrogenase, which create surplus metabolites that feed into a pathway that eventually creates toxic metabolites in people with Stargardt's disease. However, isotretinoin treatment alone is not highly effective; therefore, use of zeaxanthin as an adjunctive treatment can improve the efficacy and outcomes of such treatments.

Provided is a method of treating or preventing age-related macular degeneration (AMD) in a patient subject to, or symptomatic of the disease, wherein the method comprises restoring normal lysosomal pH (pHL), or acidifying an abnormally elevated pHL, thus decreasing or preventing a damaging accumulation of lipofuscin or waste products in the retinal pigment epithelium (RPE) cells of the eye of the patient. Further, this method is achieved by elevating cAMP by administering or stimulating receptors coupled to a Gs protein in an amount sufficient to decrease the elevated pHL or restore acidity of said lysosomes, specifically by administering or stimulating receptors comprising D1-like dopamine receptors by the use of D1-like dopamine receptor agonists. Methods for selecting and quantifying the effectiveness of drugs to restore pHL and determine outer segment clearance rates is also provided using a high through-put screening protocol.

A method for treating a disease characterized by excessive lipofuscin accumulation in the retina of a mammal afflicted therewith comprising administering to the mammal an effective amount of a transthyretin (TTR) ligand.

The invention discloses an anti-aging evaluation method based on a model organism caenorhabditis elegans and an application of the method and relates to performance evaluation methods for phytochemicals, anti-aging medicines, healthcare products and the like. In the invention, under non-toxic concentration, the anti-aging effect of the to-be-tested substances is evaluated. With the evaluation method, existence of the anti-aging effect of the to-be-tested substances can be evaluated in a short period, wherein the evaluation is completed mainly through detection on life, heat stress capability,anti-ultraviolet irradiation capability, anti-oxidizing damage capability, reproductive capability, body length and lipofuscin content of the caenorhabditis elegans. The method is advantaged in that the model organism, caenorhabditis elegans, is short in growth period, so that the anti-aging effect can be observed rapidly in several weeks. The method has short experimental period and is convenientto carry out.

Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and / or lipofuscin, and, more specifically, for preventing the formation and / or accumulation of A2E are disclosed.

The invention discloses an application of Chinese angelica polypeptide with effects of resisting oxidization and delaying ageing in preparation of food, particularly of health food, and further discloses a preparation method of the Chinese angelica polypeptide. The preparation method is simple and easy to implement, safe and non-toxic, stable and efficient, and is suitable for industrial production. In vitro, the Chinese angelica polypeptide has a characteristic of a certain hydroxyl radical clearance rate, which means that the Chinese angelica polypeptide has capacity of clearing active oxygen; at an integral animal level, an oxidative stress model and an ageing-associated model are used to perform a test, the test result discloses that the survival time of caenorhabditis elegans under an oxidative stress condition can be remarkably prolonged, the lipofuscin level in the caenorhabditis elegans is reduced, average lifetime of the caenorhabditis elegans is prolonged; under the oxidative stress condition and the ageing condition, the Chinese angelica polypeptide can be used for realizing remarkable anti-oxidization and ageing delaying effects by lowering the reactive oxide species (ROS) in vivo and lowering the content of lipid peroxide.

The invention provides a brown sugar and saussurea involucrate composition. The composition is prepared from, by weight, 35-95 parts of brown sugar, 2-20 parts of jujube extracts, 0.1-12 parts of dried ginger extracts, 0.05-15 parts of longan pulp extracts, 0.01-10 parts of rosa rugosa var plena extracts, 0.01-10 parts of Paeonia ostii T.Hong et extracts, 0.01-5 parts of saussurea involucrate culture, 0.01-5 parts of donkey-hide gelatin and 0.005-5 parts of ginseng (artificially cultivated) extracts. The composition has the effects of warming uterus for dispelling cold, regulating menstruation and dispelling melancholy, eliminating cold to stop pain and benefiting qi and nourishing blood, is high in overall antioxidant capacity, can reduce liver lipofuscin, can easily remove chloasma, and is convenient to drink, delicious in taste, purely natural, purely green, safe, reliable and free of side effects after long-time use.

The invention discloses a Chinese mahonia extracting solution as well as a preparation method and an application thereof. The Chinese mahonia extracting solution prepared by water extraction has good free radical scavenging activity and the effect of inhibiting peroxidation of lipoxygenase and lipid, and due to the characteristics, the Chinese mahonia extracting solution has the effects of scavenging excessive free radicals accumulated in bodies, preventing formation of lipofuscin, protecting cell membranes, maintaining the normal metabolism of cells and prolonging organism senescence; when being applied to cosmetics, the Chinese mahonia extracting solution has remarkable effects of improving facial laxity and reducing generation of wrinkles and black spots.

Cyclodextrin compound therapeutics to reduce age-related non-bisretinoid lipofuscin in a patient having a buildup of same, said method comprising administering 2-hydroxypropyl-β-cyclodextrin, or its derivatives, or β-cyclodextrin or its derivatives, or α-cyclodextrin or its derivatives, or γ-cyclodextrin or its derivatives in an amount effective to reduce non-bisretinoid lipofuscin levels. The methods include treating and / or preventing aging of the skin, muscle and other tissues and organs, which may result in increased life-span or health-span.

The present invention is one kind of health care medicine with functions of delaying senility and regulating immunity. It incldues deer bone powder and some other components. Animal test shows that the medicine can reduce mouse's myocardial lipofuscin content, raise mouse's glutathione peroxidase activity and serum SOD activity; prolong fruit fly's life; and raise mouse's carbon clearance index, macrophage phagocytizing rate and phagocytizing index.

The invention relates to peach blossom porridge with the effects of beautifying and nourishing skin. The technical scheme is that: the peach blossom porridge consists of 60 to 80 percent of glutinous rice, 5 to 8 percent of Chinese yam, 1 to 3 percent of Chinese wolfberry, 5 to 8 percent of brown sugar, 3 to 9 percent of red date, 8 to 12 percent of peach flower flake, 7 to 11 percent of peanut and 15 to 20 percent of red bean. Compared with the conventional porridge, the peach blossom porridge has the advantages that: peach flower flakes are added, so the peach blossom porridge has the effects of dilating blood vessels, dredging meridians, moistening skin, ensuring that the excretion of lipofuscin which can promote human bodies to grow old is accelerated, and preventing and eliminating freckles, chloasma and senile plaque.

The invention belongs to the technical field of essential oil, and particularly relates to compound essential oil with ginkgo essential oil and effects of resisting oxidation and delaying skin aging.The compound essential oil with the ginkgo essential oil comprises, by weight, 8-15 parts of the ginkgo essential oil, 30-60 parts of grape seed essential oil, 10-30 parts of lavender essential oil, 2-8 parts of tea tree essential oil, 2-8 parts of tea polyphenols and 0.3-3 parts of humectants.The humectants are polyols humectants.The invention further provides a method for preparing the compound essential oil with the ginkgo essential oil and the effects of resisting oxidation and delaying skin aging.The compound essential oil with the ginkgo essential oil and the method have the advantages that the contents of hydroxyproline (HYP) and superoxide dismutase (SOD) in the skins of users can be obviously increased by the compound essential oil with the ginkgo essential oil, malondialdehyde (MDA) and lipofuscin (LF) values can be lowered, and accordingly the compound essential oil has free radical removing, moisture preserving and water locking functions and can be used for delaying skin aging; the compound essential oil with the ginkgo essential oil is difficult to volatilize and is long in shelf life.

The invention provides a skin whitening and freckle removing cosmetic containing a rhodiola rosea extract and an active polypeptide combination. The skin whitening and freckle removing cosmetic comprises the rhodiola rosea extract and the active polypeptide combination as well as a matrix auxiliary material, wherein the active polypeptide combination comprises water, glycerol, 1,2-pentanediol, caprylyl glycol, sodium pyroglutamate, nonapeptide-1 and carnosine. The skin whitening and freckle removing cosmetic provided by the invention has the advantages that the rhodiola rosea extract can delay cell aging and inhibit formation of lipofuscins and active oxygen in cells, nonapeptide-1 can stop tyrosinase from being further activated and no lipofuscin is formed, and carnosine can prevent free radicals produced due to smoking from appearing, so that the cosmetic provided by the invention has the effects of preventing senility of skin and whitening the skin; and active prevention and recuperation of traditional Chinese medicines are combined with passive prevention and treatment of western medicines, so that skin immunity is enhanced while prevention is carried out, irritability is low in a treatment process, and effect is obvious.

The invention provides a traditional Chinese medicinal facial mask containing flowers with five colors. The facial mask is characterized by being prepared from the following raw materials in percentage by weight: 10-30 percent of peach blossom, 10-30 percent of yellow chrysanthemum, 8-26 percent of red rose, 2-20 percent of jasmine, 3-20 percent of lavender, 5-16 percent of honey, 4-15 percent of egg white, 7-6 percent of tea polyphenol, 5-10 percent of L-vitamin C, 1-15 percent of pearl powder, 3-10 percent of isoimperatorin, 5-15 percent of ginsenoside, 2-10 percent of ferulic acid and 8-15 percent of asiaticoside. The facial mask can be used for removing melanin on the surface layer of a human face, enables skin to be bright, white, tender and elastic, and is prepared from flower leaves with an effective skin-nourishing effect, wherein the peach blossom can be used for promoting excretion of lipofuscin pigment causing human senescence and preventing melanin from depositing on skin; the yellow chrysanthemum can be used for strengthening the resistance of blood capillary; the red rose can be easily absorbed by skin because of enriched vegetable protein, and has a certain effect for preventing and treating dry, rough and wrinkled skin; the jasmine contains phenylcarbinol, linalool ester and other organic matters, and has a certain beautifying effect; the adopted traditional Chinese medicinal herbs generate affinity with skin, and respectively infiltrate into skin to play roles in nourishing, removing freckles and acnes, whitening and the like.

The invention relates to a whitening mask and a preparation method thereof. The whitening mask contains lemon juice, pearls, egg white, aloe and honey. The whitening mask has the beauty effects of lightening black spots and freckles and whitening, and is favorable for making skin more refreshed, moisturized and delicate. Aging can be resisted, the formation of lipofuscin can be inhibited, and the skin is smooth, tender, white and fresh. The skin of a female can be prevented from being aged, the whitening mask can be frequently used, the use of any additive is avoided, and the raw materials can be simply obtained.

The invention belongs to the field of medicines and particularly relates to an anti-aging composition containing an IPS cell extract. The anti-aging composition comprises the IPS cell extract, grape procyanindin and beta-carotene. The anti-aging composition has an obvious prolonging effect on half survival time, average lifetime and maximum life of fruit flies. The anti-aging composition is capable of significantly strengthening the content of D-galactose-induced sub-aging model SOD and reducing the content of LPO and lipofuscin. The anti-aging composition is significant in anti-aging effect and is safe and nontoxic.

The invention discloses a sleep mask with functions of acne treatment and beautifying and a preparation method of the sleep mask. The sleep mask is prepared from peach blossoms, Hylocereus undatus, lycopene, rhizoma dioscoreae and potato juice, aloes, bee propolis, Herba Centellae, vitamin E, green tea extract, kelps, Cortex Dictamni, calendula, pearl powder, tetracycline and tea tree oil. The sleep mask is nonirritant and free of anaphylaxis, the method is convenient to operate, simple and feasible, and cheap raw materials, low cost, low energy consumption and high product added value are realized. The peach blossoms are rich in vegetable proteins and free amino acids easy for skin to absorb, evident effects of prevention and treatment of dry skin, rough skin, wrinkles and the like are realized, blood circulation can be improved, skin nutrition and oxygen supply is promoted, and excretion of lipofuscin which accelerates aging is accelerated. In addition, the raw materials include not only foods and vegetables with the function of acne mark removal but also medicinal materials with the function of acne mark removal, so that effectiveness in acne mark removal is achieved.

A topical composition includes a water soluble extract of an Uncaria species in a concentration range from about 0.1% to 15%, and a dermatologically acceptable medium suitable for topical application. The topical composition can further contain deuterium reduced water which has a deuterium concentration in a range from 0.1 ppm to about 110 ppm. Also disclosed are methods using the topical composition for improving skin cell's resistance to DNA damage and / or enhancing skin cell's DNA repair capacity; for protecting the skin from damage, and / or treating skin damage, caused by exposure to ultraviolet light; for treating and / or preventing skin wrinkles, keratosis and lipofuscin deposit.

The invention provides a dendrobe anti-oxidation preparation which is prepared from the following components in part by mass: 150-220 parts of dendrobe powder, 80-120 parts of notoginseng powder, 15-25 parts of radix astragali extract, 3-6 parts of cornus officinalis extract and 2-5 parts of salvia miltiorrhiza extract. Shown by the result of an animal test, the dendrobe anti-oxidation preparation can obviously reduce the level of a lipid per-oxidation (LPO) in blood and brain tissues of a rat and the lipofuscin content in the brain tissue, and improve the activity of super-oxide dismutase (SOD) in the blood and the brain tissue, and has no influence on the weight of the rat, therefore, the dendrobe anti-oxidation preparation has better anti-oxidation effect and the health-care effect of removing radicals, and has no toxic or side effects.

The invention relates to a skin-care product composition with a senile plaque fading effect. The skin-care product composition is characterized in that a formula is prepared from the following components in percentage by weight: 84%-92% of a skin-care product base material, 3%-7% of glucan, 2%-8% of lepidium sativum extract and 1%-5% of soybean isoflavone. The product provided by the invention can be used for obviously preventing and adjusting the formation of melanin and lipofuscin, is a whitening and plaque fading product with a special remarkable effect, and is particularly suitable for people with senile plaques.

Provided is a method of treating or preventing age-related macular degeneration (AMD) in a patient subject to, or symptomatic of the disease, wherein the method comprises restoring normal lysosomal pH (pHL), or acidifying an abnormally elevated pHL, thus decreasing or preventing a damaging accumulation of lipofuscin or waste products in the retinal pigment epithelium (RPE) cells of the eye of the patient. Further, this method is achieved by modulating the action of the P2X7 and / or P2Y12 receptors of the RPE cells, specifically decreasing the acidity (pHL) of the RPE lysosomes by administering selected receptor antagonists affecting the action of the P2X7 and / or P2Y12 receptors of the RPE. Methods for selecting and quantifying the effectiveness of drugs to restore pHL and determine outer segment clearance rates is also provided using a high through-put screening protocol.

The invention discloses a functional beverage with functions of preventing and resisting ageing. The functional beverage is prepared from, by weight, 10-30 parts of pomegranates, 60-70 parts of water,1-3 parts of folium ginkgo, 0.5-1 part of radix ginseng, 1-3 parts of fructus lycii, 0.5-1 part of lucid ganoderma, 1-5 parts of fructus schizandrae, 1-2 parts of herba gynostemmatis pentaphylli and1-5 parts of rhodiola rosea. According to the functional beverage, the added folium ginkgo and radix ginseng can inhibit the lipid peroxidation of middle-and-old-aged animals, the herba gynostemmatispentaphylli can reduce accumulation of lipofuscin, and alleviate senile symptoms and treat cardiovascular and cerebrovascular diseases, the added rhodiola rosea can prevent senile congestive heart failure, resist fatigue, and improve physical power and headwork functions, and two antioxidant components of anthocyanin and red pomegranate polyphenols in the pomegranates can achieve the good functions of preventing and resisting ageing. Therefore, the green health-care beverage free of addition of chemicals is prepared through multiple natural antioxidant components, and through the mutual effectof the natural antioxidant components, the functions of preventing and resisting ageing of the beverage can be greatly improved.

The refreshing musk preparation for treating ischemic cerebral diseases is prepared with the medicine powder of leech, ground beetle, artificial bezoar, nux vomica seed, pearl, ginseng, natural musk and borneol in certain proportion, and through mixing through stirring in some container and capsulizing or tabletting to make capsule or tablet. By means of the synergistic effects of the medicine components, the refreshing musk preparation can improve body's micro circulation, improve cardiac and cerebral ischemia, anoxia and hemerheological state, increase nourishing blood flow rate, reduce blood fat, lipofuscin, serum urea nitrogen and creatinie effect, eliminate arteriosclerosis block, resist thrombosis and platelet aggregation, and eliminate pathological change damage.

The invention discloses wild ganoderma lucidum fruiting body health-preserving powder concurrently having the effects of oxidation resistance and ageing resistance, and a preparation method of the wild ganoderma lucidum fruiting body health-preserving powder. The wild ganoderma lucidum fruiting body health-preserving powder is obtained by mixing the following materials in parts by mass: main materials including 30-50 parts of wild ganoderma applanatum powder and 15-50 parts of tricholoma lobayense heim powder, and auxiliary materials including 10-20 parts of Chinese yam powder and 10-15 parts of isomaltooligosacharide. The health-preserving powder disclosed by the invention is rich in polysaccharide substances including ganoderma lucidum polysaccharide, tricholoma lobayense heim polysaccharide (TLH-3) and the like, and active components of ganoderic acid and the like, so that the health-preserving powder has distinct anti-ageing effect. Mouse in-vivo anti-ageing experiment indicates that a wild ganoderma applanatum and tricholoma lobayense heim coarse polysaccharide mixture has distinct cooperated alleviating effect on the D-galactose inducing subacute ageing process of mice, and the contents of ageing biomarkers namely lipofuscin (LPF) and advanced-stage glycosylation end products (AGEs) in the mice can be notably reduced.

The invention discloses a preparation method for gynostemma waxberry honey wine. The component of the gynostemma waxberry honey wine includes honey brewed wine, gynostemma leaching solution, waxberrywine and blended white spirit. The method is characterized by acquiring the gynostemma waxberry honey wine by uniformly mixing the following components in parts by weight: 40-60 parts of honey brewedwine, 15-30 parts of gynostemma leaching solution, 10-15 parts of waxberry wine and 20-35 parts of blended white spirit. The wine prepared according to the invention is capable of promoting circulation of Qi and blood, lifting spirit, resisting against cold, accelerating the discharge of various toxins in human body, obviously promoting the immunity of human body, reducing accumulation of lipofuscin in a human body, softening blood vessels, preventing arteriosclerosis, certainly protecting and improving human heart and blood vessels of brain, and reducing blood pressure; the wine is beneficialto the patients suffering from various chronic diseases, such as neurasthenia, insomnia and sexual dysfunction, namely, the wine is capable of maintaining beauty and keeping young, tonifying kidney and nourishing stomach, and promoting metabolism, and the wine also has an ultrahigh anti-ageing function; the wine tastes fragrant, has long-lasting aftertaste, has a mellow flavor and is more popularwith the consumers.

The invention discloses a Chinese patent medicine, comprising the following ingredients: 20-30 weight portions of ginseng, 20-30 weight portions of Radix Astragali, 20-30 weight portions of Chinese angelica, 20-30 weight portions of prepared fleece flower root, 15-25 weight portions of Scutellaria Baicalensis, 15-25 weight portions of honeysuckle flower, 15-25 weight portions of radix curcumae, 15-25 weight portions of wolfberry, 5-15 weight portions of Chinese caterpillar fungus, and 5-15 weight portions of licorice. The medicine disclosed in the invention can treat chloasma, cyasma, malar rash, piebald, hyperlipidemia, atherosclerosis and other symptoms, improve or remove the accumulation of lipofuscins, and improve the immune function, so as to achieve the effect of facial beautification and longevity. The use of the Chinese patent medicine for the treatment has the advantages of obvious curative effect, the cure rate is 92.86 % after a treatment course, and the effectual rate is 100 % after a treatment course.