Composition with effects of resisting oxidation, brightening and delaying skin saccharification as well as preparation method and application of composition

Abstract

The invention relates to a composition with antioxidant and brightening effects and capable of delaying skin saccharification as well as a preparation method and application of the composition, and belongs to the field of cosmetics. The composition comprises an ormosia henryi bark extract, tetrahydrocurcumin, a mirabilis jalapa extracting solution, a surfactant, polyol, phospholipid and a solvent. The composition provided by the invention has good illumination stability and high-temperature stability, and the composition provided by the invention is high in bioavailability, and has good antioxidant and brightening effects and lipofuscin and RAGE level inhibition effects.

Description

Technical Field

[0001] The present invention relates to the field of cosmetics, and in particular to a composition having antioxidant and brightening effects and delaying skin glycation, as well as a preparation method and application thereof. Background Art

[0002] The receptor for advanced glycation end products (RAGE) is a multiligand member of the type I cell surface immunoglobulin superfamily. It is a pattern recognition receptor expressed in various skin cells, including fibroblasts and keratinocytes.

[0003] Glycation is the process of attaching sugar molecules to proteins or lipids without enzymatic control. When glycation occurs in the skin, advanced glycation end products (AGEs) are produced. These AGEs can directly deposit in skin tissue, causing hyperpigmentation. They can also indirectly contribute to hyperpigmentation by interacting with RAGE, activating melanin-secreting signaling pathways. This increases the expression of related transcription factors and tyrosinase activity, promoting melanin production in melanocytes. The interaction between AGEs and RAGE can also weaken the body's antioxidant defenses, reduce antioxidant capacity, and trigger inflammation. Lipofuscin, a complex of intracellular denatured proteins and lipid peroxides, is deposited in cells due to skin glycation and aging, exacerbating hyperpigmentation and leading to dull skin. To address this issue, we address four key approaches: comprehensively inhibiting AGE production, blocking the AGE-RAGE pathway, eliminating AGE accumulation, and reducing lipofuscin accumulation. This approach reduces and delays glycation, thereby achieving antioxidant and brightening effects.

[0004] Pterocarpus marsupium bark extract is a natural active ingredient extracted from the bark of the Pterocarpus marsupium tree (scientific name: Pterocarpus marsupium). Its core active ingredient is pterostilbene, a polyhydroxystilbene compound. Pterostilbene is a methylated derivative of resveratrol and is known as a "second-generation resveratrol" due to its enhanced bioavailability and stability. This ingredient is widely found in plants such as rosewood and blueberry, but is particularly abundant in Pterocarpus marsupium. This active ingredient occupies glycosylation sites on proteins, competitively binding to them through hydrogen bonds and van der Waals forces, effectively protecting protein structural integrity and inhibiting non-enzymatic glycation. It also reduces glycation by inhibiting the activity of AR and RAGE. Its antioxidant activity can neutralize free radicals, thereby reducing oxidative stress caused by AGEs.

[0005] Tetrahydrocurcumin (THC) is a hydrogenated derivative of curcumin. Formed by reducing the unsaturated double bonds in the curcumin molecule, it possesses enhanced stability and bioactivity. It reduces the accumulation of AGEs, decreases collagen cross-linking, and prevents AGEs from inducing the NF-κB and VEGF pathways, thereby achieving anti-glycation effects. It also synergizes with tamarisk bark extract to enhance its antioxidant capacity, reducing lipofuscin through antioxidant activity and achieving a brightening effect.

[0006] Currently, there are the following difficulties in the application of tetrahydrocurcumin on the market: 1) Low water solubility and fat solubility make it difficult to disperse evenly in cosmetic or drug matrices.

[0007] 2) It is easy to oxidize and discolor. It is easy to oxidize and precipitate when exposed to light or air, resulting in discoloration of the formula (such as yellowing) and loss of activity.

[0008] 3) Low skin permeability, which results in its inability to exert its maximum efficacy and low bioavailability.

[0009] Therefore, there is still an urgent need for a composition for cosmetics that has good stability, antioxidant and brightening effects, and lipofuscin level inhibition effects. Summary of the Invention

[0010] In order to solve the above technical problems, the present invention provides the following technical solutions.

[0011] In a first aspect, the present invention provides a composition.

[0012] A composition comprises: palm tree bark extract, tetrahydrocurcumin, Mirabilis jalapa extract, surfactant, polyol, phospholipid and solvent.

[0013] In some embodiments, the surfactant includes at least one of oleth-20, polyglyceryl-10 stearate, and polyglyceryl-10 oleate, preferably oleth-20, polyglyceryl-10 stearate, and polyglyceryl-10 oleate.

[0014] In some embodiments, the polyol includes at least one of 1,3-butanediol and 1,3-propylene glycol. In some preferred embodiments, the polyol includes 1,3-butanediol and 1,3-propylene glycol.

[0015] In some embodiments, the phospholipid comprises soy lecithin.

[0016] In some embodiments, the solvent comprises water.

[0017] In some embodiments, the Mirabilis jalapa extract comprises a Mirabilis jalapa extract and glycerin. In some embodiments, the Mirabilis jalapa extract comprises 10 wt%-30 wt% or 20 wt% Mirabilis jalapa extract, with the balance being glycerin. In some embodiments, the Mirabilis jalapa extract comprises 10 wt%, 15 wt%, 20 wt%, 25 wt%, or 30 wt% Mirabilis jalapa extract, with the balance being glycerin. In some embodiments, the Mirabilis jalapa extract is at least one of a Mirabilis jalapa flower extract, a Mirabilis jalapa leaf extract, or a Mirabilis jalapa stem extract. In some embodiments, the Mirabilis jalapa extract is a Mirabilis jalapa flower extract.

[0018] In some embodiments, the Mirabilis jalapa extract is Overnight Enhance [MJ+C] Mirabilis jalapa.

[0019] In some embodiments, the surfactant, polyol, and phospholipid form a flexible liposome membrane structure, and the Pterocarpus tatarinowii bark extract and tetrahydrocurcumin are encapsulated in the flexible liposome.

[0020] In some embodiments, the ratio of the total content of the polyol to the total content of the surfactant is 80:3-2: 1. In some embodiments, the ratio of the total content of the polyol to the total content of the surfactant is 80:3, 80:4, 80:5, 80:6, 80:7, 80:8, 80:9, 80:10, 80:11, 80:12, 80:13, 80:14, 80:15, 75:15, 70:15, 70:20, 70:25, 70:30, 70:35 or 2:1.

[0021] In some embodiments, the ratio of the total content of the polyol to the content of the phospholipid is 60: 1-80: 1. In some embodiments, the ratio of the total content of the polyol to the content of the phospholipid is 60: 1, 65: 1, 70: 1, 75: 1 or 80: 1.

[0022] In some embodiments, the ratio of the total content of the polyol to the content of water is 5.1: 1 to 10.5: 1. In some embodiments, the ratio of the total content of the polyol to the content of water is 5.1: 1, 5.6: 1, 8.5: 1, or 10.5: 1.

[0023] In some embodiments, the ratio of the total content of the polyols to the content of the Pterocarpus tatarinowii bark extract is 30: 1 to 160: 1. In some embodiments, the ratio of the total content of the polyols to the content of the Pterocarpus tatarinowii bark extract is 30: 1, 40: 1, 50: 1, 60: 1, 70: 1, 80: 1, 90: 1, 100: 1, 110: 1, 120: 1, 130: 1, 140: 1, 150: 1, or 160: 1.

[0024] In some embodiments, the ratio of the Pterocarpus truncatus bark extract to tetrahydrocurcumin is (0.5-2):(0.1-1). In some preferred embodiments, the ratio of the Pterocarpus truncatus bark extract to tetrahydrocurcumin is (0.5-2):(0.3-0.8). In some embodiments, the ratio of the Pterocarpus truncatus bark extract to tetrahydrocurcumin is 0.5:0.3-0.8:0.3. In some embodiments, the ratio of the Pterocarpus truncatus bark extract to tetrahydrocurcumin is 0.5:0.3, 1:0.5, 0.7:0.3, 2:0.8, or 0.8:0.3.

[0025] In some embodiments, the composition comprises a ratio of the Pterocarpus truncatus bark extract to the Mirabilis jalapa extract of (0.5-2):(0.1-0.75). In some preferred embodiments, the composition comprises a ratio of the Pterocarpus truncatus bark extract to the Mirabilis jalapa extract of (0.5-2):(0.1-0.5). In some preferred embodiments, the composition comprises a ratio of the Pterocarpus truncatus bark extract to the Mirabilis jalapa extract of 2.5:1-10:1. In some embodiments, the composition comprises a ratio of the Pterocarpus truncatus bark extract to the Mirabilis jalapa extract of 2.5:1, 2.6:1, 2.7:1, 2.8:1, 2.9:1, 3.0:1, 3.5:1, 4.0:1, 4.5:1, 5.0:1, 6.0:1, 7.0:1, 8.0:1, 9.0:1, or 10.0:1.

[0026] In some embodiments, the ratio of any one of the polyols to any one of the surfactants is independently selected from (10-50):(1-10). In some embodiments, the ratio of any one of the polyols to any one of the surfactants is independently selected from 50:1-1:1. In some embodiments, the ratio of any one of the polyols to any one of the surfactants is independently selected from 50:1, 45:1, 40:1, 35:1, 30:1, 25:1, 20:1, 15:1, 40:3, 10:1, 5:1, and 1:1.

[0027] In some embodiments, the ratio of any one of the polyols to the phospholipid is independently selected from (10-50): (0.5-3). In some embodiments, the ratio of any one of the polyols to the phospholipid is independently selected from (10-50): (0.5-1). In some embodiments, the ratio of any one of the polyols to the phospholipid is independently selected from 10:1-100:1. In some embodiments, the ratio of any one of the polyols to the phospholipid is independently selected from 10:1-80:1. In some embodiments, the ratio of any one of the polyols to the phospholipid is independently selected from 10:1, 20:1, 30:1, 40:1, 50:1, 60:1, 70:1, 80:1, 90:1, or 100:1.

[0028] In some embodiments, the ratio of any one of the polyols to water is independently selected from (30-50): (5.7-15.5). In some embodiments, the ratio of any one of the polyols to water is independently selected from (40-50): (5.7-15.5).

[0029] In some embodiments, the content ratio of any one of the polyols to the Pterocarpus tatarinowii bark extract is independently selected from (40-50): (0.5-2).

[0030] In some embodiments, the composition comprises any one of the following: (i) the ratio of the total content of the polyol to the total content of the surfactant is 80:3-2:1, the ratio of the total content of the polyol to the phospholipid is 60:1-80:1, the ratio of the total content of the polyol to the water is 5.1:1-10.5:1, the ratio of the total content of the polyol to the Pterocarpus tatarinowii bark extract is 30:1-160:1, the content ratio of the Pterocarpus tatarinowii bark extract to tetrahydrocurcumin is (0.5-2):(0.3-0.8), and the content ratio of the Pterocarpus tatarinowii bark extract to Mirabilis jalapa extract is (0.5-2):(0.1-0.5); (ii) the ratio of the total content of the polyol to the total content of the surfactant is 80:3-2:1, the ratio of the total content of the polyol to the phospholipid is 60:1-80:1, the ratio of the total content of the polyol to water is 5.1:1-10.5:1, the ratio of the total content of the polyol to the Pterocarpus tatarinowii bark extract is 30:1-160:1, the ratio of the Pterocarpus tatarinowii bark extract to tetrahydrocurcumin is 0.5:0.3-0.8:0.3, and the ratio of the Pterocarpus tatarinowii bark extract to Mirabilis jalapa extract is 2.5:1-10:1; (iii) the ratio of the total content of the polyol to the total content of the surfactant is 80:3-2:1, the ratio of the total content of the polyol to the phospholipid is 60:1-80:1, the ratio of the total content of the polyol to water is 5.1:1-10.5:1, the ratio of the total content of the polyol to the Pterocarpus tatarinowii bark extract is 30:1-160:1, the ratio of the Pterocarpus tatarinowii bark extract to tetrahydrocurcumin is (0.5-2):(0.3-0.8), and the ratio of the Pterocarpus tatarinowii bark extract to Mirabilis jalapa extract is 2.5:1-10:1; (iv) the surfactant comprises oleth-20, polyglyceryl-10 stearate and polyglyceryl-10 oleate; the polyol comprises 1,3-butylene glycol and 1,3-propylene glycol; the ratio of the total content of the polyol to the total content of the surfactant is 80:3-2:1, the ratio of the total content of the polyol to the phospholipid is 60:1-80:1, the ratio of the total content of the polyol to water is 5.1:1-10.5:1, the ratio of the total content of the polyol to the content of the tamarisk bark extract is 30:1-160:1, the content ratio of the tamarisk bark extract to tetrahydrocurcumin is (0.5-2):(0.3-0.8), and the content ratio of the tamarisk bark extract to Mirabilis jalapa extract is 2.5:1-10:1; wherein the content ratio of any one of the polyols to any one of the surfactants is independently selected from (10-50):(1-10); (v) the surfactant comprises oleth-20, polyglyceryl-10 stearate and polyglyceryl-10 oleate; the polyol comprises 1,3-butylene glycol and 1,3-propylene glycol; the ratio of the total content of the polyol to the total content of the surfactant is 80:3-2:1, the ratio of the total content of the polyol to the phospholipid is 60:1-80:1, the ratio of the total content of the polyol to water is 5.1:1-10.5:1, the ratio of the total content of the polyol to the Pterocarpus tataricus bark extract is 30:1-160:1, the ratio of the Pterocarpus tataricus bark extract to tetrahydrocurcumin is 0.5:0.3-0.8:0.3, and the ratio of the Pterocarpus tataricus bark extract to Mirabilis jalapa extract is 2.5:1-10:1; wherein the content ratio of any one of the polyols to any one of the surfactants is independently selected from (10-50):(1-10); (vi) the surfactant comprises oleth-20, polyglyceryl-10 stearate, and polyglyceryl-10 oleate; the polyol comprises 1,3-butylene glycol and 1,3-propylene glycol; the ratio of the total content of the polyol to the total content of the surfactant is 80:3-2:1, the ratio of the total content of the polyol to the phospholipid is 60:1-80:1, the ratio of the total content of the polyol to water is 5.1:1-10.5:1, the ratio of the total content of the polyol to the Pterocarpus tataricus bark extract is 30:1-160:1, the ratio of the Pterocarpus tataricus bark extract to tetrahydrocurcumin is 0.5:0.3-0.8:0.3, and the ratio of the Pterocarpus tataricus bark extract to Mirabilis jalapa extract is 2.5:1-10:1; wherein the content ratio of any one of the polyols to any one of the surfactants is independently selected from 50:1-1:1.

[0031] In some embodiments, the content of the Pterocarpus tatarinowii bark extract is 0.5 wt% to 2 wt% based on the total weight of the composition. In some embodiments, the content of the Pterocarpus tatarinowii bark extract is 0.5 wt%, 0.6 wt%, 0.7 wt%, 0.8 wt%, 0.9 wt%, 1 wt%, 1.5 wt% or 2 wt% based on the total weight of the composition.

[0032] In some embodiments, the content of the tetrahydrocurcumin is 0.1 wt %-1.0 wt % based on the total mass of the composition. In some embodiments, the content of the tetrahydrocurcumin is 0.3 wt %-0.8 wt % based on the total mass of the composition. In some embodiments, the content of the tetrahydrocurcumin is 0.3 wt %, 0.4 wt %, 0.5 wt %, 0.6 wt %, 0.7 wt % or 0.8 wt % based on the total mass of the composition.

[0033] In some embodiments, the content of the Mirabilis jalapa extract is 0.1 wt %-0.5 wt % based on the total mass of the composition. In some embodiments, the content of the Mirabilis jalapa extract is 0.1 wt %, 0.2 wt %, 0.3 wt %, 0.4 wt % or 0.5 wt % based on the total mass of the composition.

[0034] In some embodiments, the total content of the surfactant is 3 wt % to 30 wt % based on the total mass of the composition. In some embodiments, the total content of the surfactant is 3 wt %, 4 wt %, 5 wt %, 6 wt %, 7 wt %, 8 wt %, 9 wt %, 10 wt %, 11 wt %, 12 wt %, 13 wt %, 14 wt %, 15 wt %, 16 wt %, 17 wt %, 18 wt %, 19 wt %, 20 wt %, 21 wt %, 22 wt %, 23 wt %, 24 wt %, 25 wt %, 26 wt %, 27 wt %, 28 wt %, 29 wt % or 30 wt % based on the total mass of the composition.

[0035] In some embodiments, the total content of the polyol is 30 wt%-80 wt% based on the total mass of the composition. In some embodiments, the total content of the polyol is 60 wt%-80 wt% based on the total mass of the composition. In some embodiments, the total content of the polyol is 30 wt%, 35 wt%, 40 wt%, 45 wt%, 50 wt%, 55 wt%, 60 wt%, 65 wt%, 70 wt%, 75 wt% or 80 wt% based on the total mass of the composition.

[0036] In some embodiments, the phospholipid content is 0.5 wt% to 3.0 wt% based on the total weight of the composition. In some embodiments, the phospholipid content is 0.5 wt% to 1.0 wt% based on the total weight of the composition. In some embodiments, the phospholipid content is 0.5 wt%, 1.0 wt%, 1.5 wt%, 2.0 wt%, 2.5 wt%, or 3.0 wt% based on the total weight of the composition.

[0037] In some embodiments, the content of the solvent is 5.7 wt % to 65.8 wt % based on the total mass of the composition. In some embodiments, the content of the solvent is 5.7 wt % to 15.5 wt % based on the total mass of the composition. In some embodiments, the content of the solvent is 5.7 wt %, 6 wt %, 7 wt %, 8 wt %, 9 wt %, 9.1 wt %, 10 wt %, 11 wt %, 12 wt %, 12.4 wt %, 13 wt %, 14 wt %, 15 wt %, or 15.5 wt % based on the total mass of the composition.

[0038] In some embodiments, the content of any one of the surfactants is independently selected from 1.0 wt% to 10.0 wt% based on the total mass of the composition. In some embodiments, the content of any one of the surfactants is independently selected from 1.0 wt%, 2.0 wt%, 3.0 wt%, 4.0 wt%, 5.0 wt%, 6.0 wt%, 7.0 wt%, 8.0 wt%, 9.0 wt% or 10.0 wt% based on the total mass of the composition.

[0039] In some embodiments, based on the total mass of the composition, the content of any one of the polyols is independently selected from 10 wt % to 50 wt %. In some embodiments, based on the total mass of the composition, the content of any one of the polyols is independently selected from 10 wt %, 15 wt %, 20 wt %, 25 wt %, 30 wt %, 35 wt %, 40 wt %, 45 wt % or 50 wt %.

[0040] In some embodiments, the composition includes any one of the following groups: (1) Calculated based on the total mass of the composition, the content of the palmyra palm bark extract is 0.5 wt%-2 wt%, the content of the tetrahydrocurcumin is 0.1 wt%-1.0 wt%, the content of the Mirabilis jalapa extract is 0.1 wt%-0.5 wt%, the total content of the surfactant is 3 wt%-30 wt%, the total content of the polyol is 30 wt%-80 wt%, the content of the phospholipid is 0.5 wt%-3.0 wt%, and the content of the solvent is 5.7 wt%-65.8 wt%; (2) Calculated based on the total mass of the composition, the content of the Pterocarpus dasyphylla bark extract is 0.5 wt%-2 wt%, the content of the tetrahydrocurcumin is 0.3 wt%-0.8 wt%, the content of the Mirabilis jalapa extract is 0.1 wt%-0.5 wt%, the total content of the surfactant is 3 wt%-30 wt%, the total content of the polyol is 60 wt%-80 wt%, the content of the phospholipid is 0.5 wt%-1.0 wt%, and the content of the solvent is 5.7 wt%-15.5 wt%; (3) Calculated based on the total mass of the composition, the content of the Pterocarpus dasyphylla bark extract is 0.5 wt%-2 wt%, the content of the tetrahydrocurcumin is 0.3 wt%-0.8 wt%, the content of the Mirabilis jalapa extract is 0.1 wt%-0.5 wt%, the total content of the surfactant is 3 wt%-30 wt%, the total content of the polyol is 60 wt%-80 wt%, the content of the phospholipid is 0.5 wt%-1.0 wt%, and the content of the solvent is 5.7 wt%-15.5 wt%; (4) The surfactant comprises oleth-20, polyglycerol-10 stearate and polyglycerol-10 oleate; based on the total mass of the composition, the content of the palmyra palm bark extract is 0.5 wt%-2 wt%, the content of the tetrahydrocurcumin is 0.3 wt%-0.8 wt%, the content of the Mirabilis jalapa extract is 0.1 wt%-0.5 wt%, and the total content of the surfactants is 3 wt%-30 wt%, wherein the content of any one of the surfactants is independently selected from 1.0 wt%-10.0 wt%; the total content of the polyol is 60 wt%-80 wt%, the content of the phospholipid is 0.5 wt%-1.0 wt%, and the content of the solvent is 5.7 wt%-15.5 wt%; (5) The surfactant includes oleth-20, polyglycerol-10 stearate and polyglycerol-10 oleate; the polyol includes 1,3-butylene glycol and 1,3-propylene glycol; calculated based on the total mass of the composition, the content of the palm bark extract is 0.5 wt%-2 wt%, the content of the tetrahydrocurcumin is 0.3 wt%-0.8 wt%, the content of the Mirabilis jalapa extract is 0.1 wt%-0.5 wt%, and the total content of the surfactant is 3 wt%-30 wt%; the total content of the polyol is 60 wt%-80 wt%, wherein the content of any one of the polyols is independently selected from 10 wt%-50 wt%; the content of the phospholipid is 0.5 wt%-1.0 wt%, and the content of the solvent is 5.7 wt%-15.5 wt%; (6) The surfactant includes oleth-20, polyglycerol-10 stearate and polyglycerol-10 oleate; the polyol includes 1,3-butylene glycol and 1,3-propylene glycol; calculated based on the total mass of the composition, the content of the palm bark extract is 0.5 wt%-2 wt%, the content of the tetrahydrocurcumin is 0.3 wt%-0.8 wt%, the content of the Mirabilis jalapa extract is 0.1 wt%-0.5 wt%, and the total content of the surfactants is 3 wt%-30 wt%, wherein the content of any one of the surfactants is 1.0 wt%-10.0 wt%; the total content of the polyol is 60 wt%-80 wt%, wherein the content of any one of the polyols is independently selected from 10 wt%-50 wt%; the content of the phospholipid is 0.5 wt%-1.0 wt%, and the content of the solvent is 5.7 wt%-15.5 wt%; (7) The surfactant includes oleth-20, polyglycerol-10 stearate and polyglycerol-10 oleate; the polyol includes 1,3-butylene glycol and 1,3-propylene glycol; calculated based on the total mass of the composition, the content of the palm bark extract is 0.5 wt%-2 wt%, the content of the tetrahydrocurcumin is 0.3 wt%-0.8 wt%, the content of the Mirabilis jalapa extract is 0.1 wt%-0.5 wt%, and the total content of the surfactants is 3 wt%-30 wt%, wherein the content of any one of the surfactants is independently selected from 1.0 wt%-10.0 wt%; the total content of the polyol is 60 wt%-80 wt%, wherein the content of any one of the polyols is independently selected from 10 wt%-50 wt%; the content of the phospholipid is 0.5 wt%-1.0 wt%, and the balance is the solvent; (8) The surfactant includes oleth-20, polyglycerol-10 stearate and polyglycerol-10 oleate; the polyol includes 1,3-butylene glycol and 1,3-propylene glycol; calculated based on the total mass of the composition, the content of the palm bark extract is 0.5wt%, the content of the tetrahydrocurcumin is 0.3wt%, the content of the Mirabilis jalapa extract is 0.2wt%, the total content of the surfactants is 3.0wt%, wherein the content of any one of the surfactants is 1.0wt%; the total content of the polyol is 80wt%, wherein the content of any one of the polyols is 40wt%; the content of the phospholipid is 0.5wt%, and the balance is the solvent; (9) The surfactant includes oleth-20, polyglycerol-10 stearate and polyglycerol-10 oleate; the polyol includes 1,3-butylene glycol and 1,3-propylene glycol; calculated based on the total mass of the composition, the content of the palm bark extract is 0.8wt%, the content of the tetrahydrocurcumin is 0.3wt%, the content of the Mirabilis jalapa extract is 0.3wt%, the total content of the surfactants is 9.0wt%, wherein the content of any one of the surfactants is 3.0wt%; the total content of the polyol is 80wt%, wherein the content of any one of the polyols is 40wt%; the content of the phospholipid is 0.5wt%, and the balance is the solvent; (10) The surfactant includes oleth-20, polyglycerol-10 stearate and polyglycerol-10 oleate; the polyol includes 1,3-butylene glycol and 1,3-propylene glycol; based on the total mass of the composition, the content of the palm bark extract is 1.0 wt%, the content of the tetrahydrocurcumin is 0.5 wt%, the content of the Mirabilis jalapa extract is 0.1 wt%, the total content of the surfactants is 15.0 wt%, wherein the content of any one of the surfactants is 5.0 wt%; the total content of the polyol is 70 wt%, wherein the content of the 1,3-butylene glycol is 50 wt%, the content of the 1,3-propylene glycol is 20 wt%; the content of the phospholipid is 1.0 wt%, and the balance is the solvent; (11) The surfactant includes oleth-20, polyglycerol-10 stearate and polyglycerol-10 oleate; the polyol includes 1,3-butylene glycol and 1,3-propylene glycol; calculated based on the total mass of the composition, the content of the palm bark extract is 2.0 wt%, the content of the tetrahydrocurcumin is 0.8 wt%, the content of the Mirabilis jalapa extract is 0.5 wt%, the total content of the surfactants is 30.0 wt%, wherein the content of any one of the surfactants is 10.0 wt%; the total content of the polyol is 60 wt%, wherein the content of the 1,3-butylene glycol is 50 wt%, the content of the 1,3-propylene glycol is 10 wt%; the content of the phospholipid is 1.0 wt%, and the balance is the solvent.

[0041] In a second aspect, the present invention provides a method for preparing the composition described in the first aspect.

[0042] A method for preparing the composition of the first aspect, comprising: (1) mixing a surfactant, a polyol, and a phospholipid, heating and dissolving the mixture, and then adding a safflower oil bark extract and tetrahydrocurcumin to mix and dissolve the mixture to obtain a solution 1; (2) mixing solution 1 with water to obtain solution 2, and then mixing and dissolving solution 2 with Mirabilis jalapa extract to obtain solution 3; (3) Solution 3 is subjected to high-pressure homogenization technology to obtain the composition.

[0043] In some embodiments, the heating and dissolving in step (1) is performed by heating to 65°C-70°C. In some embodiments, the heating and dissolving in step (1) is performed by heating to 65°C, 66°C, 67°C, 68°C, 69°C or 70°C.

[0044] In some embodiments, the mixed dissolution in step (1) is carried out at a temperature of 65° C. to 70° C. In some embodiments, the mixed dissolution in step (1) is carried out at a temperature of 65° C., 66° C., 67° C., 68° C., 69° C., or 70° C.

[0045] In some embodiments, the step (2) of mixing solution 1 with water is to cool solution 1 to 45°C-48°C (such as 45°C, 46°C, 47°C, 48°C).

[0046] In some embodiments, the solution 2 in step (2) is cooled to 30°C-35°C (e.g., 30°C, 31°C, 32°C, 33°C, 34°C, 35°C) before being dissolved with the Mirabilis jalapa extract.

[0047] In some embodiments, the pressure parameter during the high-pressure homogenization process in step (3) is 600 bar-1000 bar (such as 600 bar, 700 bar, 800 bar, 900 bar, 1000 bar).

[0048] In some embodiments, the high pressure homogenization in step (3) is performed 4 times, 5 times, or 6 times.

[0049] In some embodiments, the high-pressure homogenization in step (3) is performed for 3 min to 5 min (eg, 3 min, 4 min, 5 min) per homogenization.

[0050] In a third aspect, the present invention provides a cosmetic.

[0051] A cosmetic comprising the composition of the first aspect or the composition prepared by the preparation method of the second aspect.

[0052] In some embodiments, the cosmetic is selected from the following forms of cosmetics: lotion, emulsion, cream.

[0053] In a fourth aspect, the present invention provides an application of the aforementioned composition or the composition prepared by the aforementioned preparation method.

[0054] A use of the composition of the first aspect or the composition prepared by the preparation method of the second aspect in the preparation of cosmetics.

[0055] In some embodiments, the cosmetics are used for anti-oxidation, brightening skin tone, inhibiting AGEs, inhibiting the receptor for advanced glycation end products, anti-glycation, anti-aging, and inhibiting lipofuscin.

[0056] Beneficial effects Compared with the prior art, a certain embodiment of the present invention has at least one of the following beneficial effects: (1) The composition provided by the present invention has good stability, good skin brightness improvement effect, RAGE inhibition effect and (2) Compared with replacing any of the surfactants in the present invention with other surfactants (such as PEG-40 hydrogenated castor oil, PEG-40 hydrogenated castor oil, PPG-13-decyltetradecyl alcohol polyether-24), the present invention preferably uses oleth-20, polyglyceryl-10 stearate, and polyglyceryl-10 oleate, which is more conducive to improving the appearance stability and content stability of the resulting composition under high temperature, light, and high and low temperature cycling conditions. Replacing any of them with other surfactants will lead to a decrease in appearance stability and content stability. The present invention uses oleth-20, polyglyceryl-10 stearate, and polyglyceryl-10 oleate as surfactants at the same time, which has an unexpected synergistic technical effect.

[0057] (3) Compared with compositions that do not use Pterocarpus truncatus extract, or compositions that use other natural extracts (such as grape seed extract and one of Schisandra chinensis extracts) instead of Pterocarpus truncatus extract or Mirabilis jalapa extract, the compositions prepared by the present invention using Pterocarpus truncatus bark extract and Mirabilis jalapa extract as natural extract active ingredients are significantly better in inhibiting RAGE. In the technical solution provided by the present invention, Pterocarpus truncatus bark extract and Mirabilis jalapa extract as natural extract active ingredients have an unexpected synergistic technical effect.

[0058] (4) Compared with the composition containing only two active ingredients, the composition obtained by the present invention using the palm bark extract, Mirabilis jalapa extract and tetrahydrocurcumin as active ingredients at the same time has a significantly better RAGE inhibition effect than the sum of the RAGE inhibition effects of other compositions containing only a single active ingredient. The technical solution provided by the present invention using the palm bark extract, tetrahydrocurcumin and Mirabilis jalapa extract as active ingredients at the same time has an unexpected synergistic effect.

[0059] (5) Compared with compositions that do not use Pterocarpus ovata extract, or compositions that use other natural extracts (such as grape seed extract and one of Schisandra chinensis extracts) instead of Pterocarpus ovata extract or Mirabilis jalapa extract, the compositions prepared by the present invention using Pterocarpus ovata bark extract and Mirabilis jalapa extract as natural extract active ingredients are significantly better in inhibiting lipofuscin. In the technical solution provided by the present invention, Pterocarpus ovata bark extract and Mirabilis jalapa extract as natural extract active ingredients have an unexpected synergistic technical effect.

[0060] (6) Compared with the composition containing only two active ingredients, the composition obtained by the present invention using the palm bark extract, Mirabilis jalapa extract and tetrahydrocurcumin as active ingredients at the same time has a significantly better lipofuscin inhibition effect than the sum of the lipofuscin inhibition effects of other single active ingredient compositions. The technical solution provided by the present invention using the palm bark extract, tetrahydrocurcumin and Mirabilis jalapa extract as active ingredients at the same time has an unexpected synergistic effect.

[0061] Terminology In the description of the present invention, “plurality” means two or more than two, unless otherwise clearly defined.

[0062] The term "room temperature" means ambient temperature, which refers to a temperature between about 10°C and about 30°C, or between about 20°C and 30°C, or about 25°C.

[0063] The term "wt%" means percentage by mass.

[0064] In the description of this specification, the reference terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" mean that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art can combine and combine different embodiments or examples described in this specification and features of different embodiments or examples without contradiction.

[0065] In the following description, all numerical values ​​disclosed herein are approximate, regardless of whether the word "about" or "approximately" is used. The numerical value of each number may vary by 1%, 2%, 5%, 7%, 8%, 10%, 15%, or 20%. Whenever a number having a value of N is disclosed, any number having a value of N+ / -1%, N+ / -2%, N+ / -3%, N+ / -5%, N+ / -7%, N+ / -8%, N+ / -10%, N+ / -15%, or N+ / -20% is expressly disclosed, where "+ / -" means plus or minus. DETAILED DESCRIPTION

[0066] In order to enable those skilled in the art to better understand the technical solutions of the present invention, some non-limiting embodiments are further disclosed below to further illustrate the present invention in detail.

[0067] The reagents used in the present invention can be purchased from the market or prepared by the method described in the present invention.

[0068] 1. The sources or preparation methods of some reagents used in the embodiments or comparative examples of the present invention are as follows: Palmyra chinensis bark extract: purchased from Guangzhou Qingnang Biotechnology Co., Ltd., item number 23121401, product name Palmyra chinensis bark extract; contains 100% pterostilbene.

[0069] Mirabilis jalapa extract: purchased from Naolys; contains 20wt% Mirabilis jalapa extract and 80wt% glycerin; product name Overnight Enhance [MJ+C] Repair and Rejuvenate Mirabilis jalapa.

[0070] Grape seed extract: purchased from Hunan Langlin Biological Resources Co., Ltd., product name grape seed extract; Langlin number: NAT-117.

[0071] Schisandra chinensis extract: purchased from Hunan Langlin Biological Resources Co., Ltd., product name Schisandra chinensis extract; Langlin number: NAT-103.

[0072] 2. Tetrahydrocurcumin encapsulation efficiency test method The flexible liposomes and the unencapsulated free active composition were separated by ultrafiltration centrifugation, and the operation was as follows: Accurately measure 0.5 g of sample and place it in an ultrafiltration centrifuge tube (molecular weight cutoff of 10 kDa). Centrifuge at 10,000 r / min for 30 min. Take the filtrate after centrifugation and transfer it to a 5 mL volumetric flask. Add methanol to dissolve and dilute to the scale and shake well. After filtering with a 0.45 μm microporous filter membrane, inject it into the liquid chromatograph and calculate the free drug content (i.e., tetrahydrocurcumin content) in the supernatant by the external standard method based on the main peak area.

[0073] Encapsulation efficiency % = (weight of drug in feed - weight of free drug in supernatant) / weight of drug in feed × 100% Feed drug quality: The tetrahydrocurcumin content was measured after the flexible liposomes were completely destroyed by sonication with methanol for 5 min.

[0074] Free drug mass in supernatant: the tetrahydrocurcumin content in the supernatant measured by the above-mentioned ultrafiltration centrifugation method.

[0075] Example 1-Example 4: Preparation of composition Recipe: See Table 1.

[0076] Table 1: Formulation of the composition

[0077] Preparation method: (1) Mixing a surfactant, a polyol, and a phospholipid, heating to 65°C-70°C to dissolve, then adding a safflower bark extract and tetrahydrocurcumin and mixing and dissolving at 65°C-70°C to obtain a solution 1; (2) Cooling solution 1 to 45-48°C and then mixing it with water at 45-48°C to obtain solution 2, cooling it to 30-35°C, and then mixing and dissolving solution 2 with Mirabilis jalapa extract to obtain solution 3; (3) Solution 3 was subjected to high-pressure homogenization technology (600 bar, 4 times, 3 minutes each time) to obtain the composition.

[0078] Comparative Example 1-Comparative Example 3: Investigation of surfactants Comparative Example 1: The difference from Example 1 is that polyglyceryl-10 stearate is replaced with hydrogenated castor oil 40, and the other conditions are the same as Example 1.

[0079] Comparative Example 2: The difference from Example 1 is that polyglycerol-10 oleate is replaced with hydrogenated castor oil 60, and the other conditions are the same as Example 1.

[0080] Comparative Example 3: The difference from Example 1 is that oleth-20 is replaced by PPG-13-decyltetradecyl alcohol polyether-24, and the other conditions are the same as Example 1.

[0081] Comparative Examples 4-6: Investigation of Extracts Comparative Example 4: The difference from Example 1 is that the extract from the bark of Pterocarpus ovata is not added, and the water in step (2) is adaptively increased to make up the total content of the composition to 100 wt %. The other conditions are the same as those in Example 1.

[0082] Comparative Example 5: The difference from Example 1 is that the Pterocarpus tatarinowii bark extract is replaced by grape seed extract, and the other conditions are the same as Example 1.

[0083] Comparative Example 6: The difference from Example 3 is that the Mirabilis jalapa extract is replaced by Schisandra chinensis extract, and the other conditions are the same as Example 3.

[0084] Comparative Examples 7-10: Investigation of No Active Ingredient and Single Active Ingredient Comparative Example 7 (no active ingredient): The difference from Example 4 is that no palm tree bark extract, tetrahydrocurcumin and Mirabilis jalapa extract are added, wherein the Mirabilis jalapa extract is replaced with glycerol, and the water content is adaptively increased. The increased water content corresponds to the content of palm tree bark extract and tetrahydrocurcumin in Example 4. Other conditions are the same as Example 4.

[0085] Comparative Example 8 (active ingredient only Palmyra truncatula bark extract): The difference from Example 4 is that tetrahydrocurcumin and Mirabilis jalapa extract are not added, wherein the Mirabilis jalapa extract is replaced with glycerol, and the water content is adaptively increased. The increased water content corresponds to the content of tetrahydrocurcumin in Example 4. Other conditions are the same as Example 4.

[0086] Comparative Example 9 (active ingredient only tetrahydrocurcumin): The difference from Example 4 is that the Pterocarpus tatarinowii bark extract and the Mirabilis jalapa extract are not added, wherein the Mirabilis jalapa extract is replaced with glycerol, and the water content is adaptively increased. The increased water content corresponds to the content of the Pterocarpus tatarinowii bark extract in Example 4. Other conditions are the same as Example 4.

[0087] Comparative Example 10 (active ingredient only Mirabilis jalapa extract): The difference from Example 4 is that no Pterocarpus tatarinowii bark extract and tetrahydrocurcumin are added, and the water content is adaptively increased. The increased water content corresponds to the content of Pterocarpus tatarinowii bark extract and tetrahydrocurcumin in Example 4. Other conditions are the same as Example 4.

[0088] Comparative Examples 11-13: Investigation of Dual Active Ingredients Comparative Example 11 (active ingredients: only Pterocarpus dahurica bark extract and tetrahydrocurcumin): The difference from Example 4 is that the Mirabilis jalapa extract is replaced by glycerol, and other conditions are the same as Example 4.

[0089] Comparative Example 12 (active ingredients only: Palmyra truncatula bark extract and Mirabilis jalapa extract): The difference from Example 4 is that tetrahydrocurcumin is not added, and the water content is adaptively increased. The increased water content corresponds to the tetrahydrocurcumin content in Example 4. Other conditions are the same as Example 4.

[0090] Comparative Example 13 (active ingredients only tetrahydrocurcumin and Mirabilis jalapa extract): The difference from Example 4 is that no Pterocarpus tatarinowii bark extract is added, and the water content is adaptively increased. The increased water content corresponds to the content of Pterocarpus tatarinowii bark extract in Example 4. Other conditions are the same as Example 4.

[0091] Test Example 2: Stability Investigation High-Temperature Stability: The products obtained in the above examples and investigational examples were placed at 50°C for three months to test their stability (appearance, pH, and tetrahydrocurcumin encapsulation efficiency). The results are shown in Tables 2, 3, and 4.

[0092] Strong light irradiation test: The products obtained in each of the above examples or comparative examples were placed in a transparent container and placed in a light box under an illumination of 4500 lx ± 500 lx for 10 days. Samples were taken on the 5th and 10th days for testing. The results are shown in Tables 2, 3, and 4.

[0093] High-low temperature cycling: Place the sample in a high-low temperature cycling chamber. The conditions are: 45°C for 24 hours, then return to room temperature for 12 hours, then 15°C for 24 hours, then return to room temperature for another 12 hours. This constitutes one high-low temperature cycle. Each sample is tested for six cycles to observe its stability.

[0094] Table 2: pH results of stability study

[0095] Table 3: Appearance properties of stability test results

[0096] Table 4: Encapsulation efficiency results of stability study

[0097] Result analysis: (1) Compared with replacing any of the surfactants in the present invention with other surfactants (such as PEG-40 hydrogenated castor oil, PEG-40 hydrogenated castor oil, PPG-13-decyltetradecyl alcohol polyether-24), the present invention preferably uses oleth-20, polyglyceryl-10 stearate, and polyglyceryl-10 oleate, which is more conducive to improving the appearance stability and content stability of the resulting composition under high temperature, light, and high and low temperature cycling conditions. Replacing any of them with other surfactants will lead to a decrease in appearance stability and content stability. The present invention uses oleth-20, polyglyceryl-10 stearate, and polyglyceryl-10 oleate as surfactants at the same time, which has an unexpected synergistic technical effect.

[0098] Test Example 2: Human efficacy evaluation experiment (1) Human skin chromaticity L test Thirty eligible volunteers, half male and half female, aged 23 to 47, were selected for the study. Test sites were marked on the left and right sides of each volunteer's face (the left side received the test sample (containing the composition of Example 2), while the right side remained untreated). The test lotion was applied twice daily, at 9:00 AM and 8:00 PM. During the study, the volunteers were prohibited from applying any other cosmetics to the test sites. After using the test lotion for one month, the volunteers washed the applied areas with water on days 7, 14, 21, and 28. The skin color L value of the applied areas was measured using a spectrophotometer. The skin color L value indicates skin brightness; a higher L value indicates more radiant skin. The test results are shown in Table 5.

[0099] Table 5: Human skin chromaticity L value test results

[0100] Result analysis: From the human efficacy test results in Table 5, it can be seen that the skin L value of the subjects was significantly improved compared with the baseline value after continuous use of the test sample product containing the composition for 14 and 28 days, indicating that the test sample has the effect of improving skin brightness.

[0101] (2) RAGE inhibition Logarithmically growing human dermal fibroblasts (HSF) were digested with 0.25% trypsin and centrifuged. A cell suspension at an appropriate density (1.0 x 105 cells / mL) was prepared in complete culture medium. 1 mL of the prepared cell suspension was seeded into each well of a 12-well culture plate and incubated in a 37°C, 5% CO2 incubator for 24 ± 2 hours. The culture medium in the cell plate was discarded and dosing was performed. Serum-free culture medium was added to the blank wells. Serum-free culture medium containing 0.5 mM MGO and 0.1 wt% (based on the total weight of the test composition) of the test composition was added to the test wells. Serum-free culture medium containing 0.5 mM MGO was added to the model wells. Serum-free culture medium containing 0.5 mM MGO and 0.5 mM aminoguanidine hydrochloride was added to the positive control wells. 1 mL of culture medium was added to each well of the 12-well plate (aminoguanidine hydrochloride was the positive control drug). The plates were incubated in a CO2 incubator for 4 hours ± 15 minutes. After incubation, the culture medium in the cell culture plate was discarded, and each well was washed once with 1 mL of DPBS. RNA was collected and the concentration was determined according to the kit instructions. The test results are shown in Table 6.

[0102] Table 6: RAGE inhibition rate results

[0103] Result analysis: (1) Compared with compositions not using Pterocarpus truncatus extract, or compositions using other natural extracts (such as grape seed extract or one of Schisandra chinensis extracts) instead of Pterocarpus truncatus extract or Mirabilis jalapa extract (Comparative Examples 4-6), the compositions prepared by using Pterocarpus truncatus bark extract and Mirabilis jalapa extract as natural extract active ingredients (Examples 1-4) of the present invention are significantly better in inhibiting RAGE. In the technical solution provided by the present invention, Pterocarpus truncatus bark extract and Mirabilis jalapa extract as natural extract active ingredients have an unexpected synergistic technical effect.

[0104] (2) Compared with the compositions containing only two active ingredients (Comparative Examples 11-13), the compositions obtained by the present invention using the Pterocarpus chinensis bark extract, Mirabilis jalapa extract and tetrahydrocurcumin as active ingredients at the same time (Examples 1-4) are significantly better than the sum of the improvements in the RAGE inhibition effect of the compositions containing other single active ingredients (Comparative Examples 8-10) in inhibiting RAGE. The technical solution provided by the present invention using the Pterocarpus chinensis bark extract, tetrahydrocurcumin and Mirabilis jalapa extract as active ingredients at the same time has an unexpected synergistic effect.

[0105] (3) Lipofuscin inhibition Logarithmically growing human dermal fibroblasts (HSF) were digested with 0.25% trypsin and centrifuged. A cell suspension at an appropriate density (1.0 x 105 cells / mL) was prepared in complete culture medium. 0.5 mL of the prepared cell suspension was seeded into a 24-well culture plate and incubated in a 37°C, 5% CO2 incubator for 24 ± 2 hours. The culture medium in the cell plate was discarded and dosing was performed. Serum-free culture medium was added to the blank wells. Serum-free culture medium containing 0.5 mM MGO (methylglyoxal) and 0.1 wt% (based on the total weight of the test composition) of the test composition was added to the test wells. Serum-free culture medium containing 0.5 mM MGO was added to the model wells. Serum-free culture medium containing 0.5 mM MGO and 0.5 mM aminoguanidine hydrochloride (aminoguanidine hydrochloride was the positive control drug) was added to the positive control wells. 0.5 mL of the culture medium was added to each well of the 24-well plate. The plates were incubated in a CO2 incubator for 4 hours ± 15 minutes. After incubation, discard the culture medium and wash once with DPBS (Dulbecco's phosphate-buffered saline). Add 0.5 ml of 4% paraformaldehyde to each well to fix the cells at room temperature for 30 minutes. Wash three times with DPBS and add 0.2 ml of Oil Red O staining solution to each well and incubate at room temperature for 60 minutes. After incubation, discard the staining solution and gently rinse the cells 2-3 times with PBS (phosphate-buffered saline). Observe and photograph under a microscope and measure absorbance using a microplate reader. The test results are shown in Table 7.

[0106] Table 7: Lipofuscin inhibition rate results

[0107] Result analysis: (1) Compared with compositions not using Pterocarpus truncatus extract, or compositions using other natural extracts (such as grape seed extract or one of Schisandra chinensis extracts) instead of Pterocarpus truncatus extract or Mirabilis jalapa extract (Comparative Examples 4-6), the compositions prepared by using Pterocarpus truncatus bark extract and Mirabilis jalapa extract as natural extract active ingredients (Examples 1-4) of the present invention are significantly better in inhibiting lipofuscin. In the technical solution provided by the present invention, Pterocarpus truncatus bark extract and Mirabilis jalapa extract as natural extract active ingredients have an unexpected synergistic technical effect.

[0108] (2) Compared with the compositions containing only two active ingredients (Comparative Examples 11-13), the compositions obtained by the present invention using the Pterocarpus ovata bark extract, Mirabilis jalapa extract and tetrahydrocurcumin as active ingredients at the same time (Examples 1-4) are significantly better than the sum of the improvements in the lipofuscin inhibition effect of the compositions containing other single active ingredients (Comparative Examples 8-10). The technical solution provided by the present invention has an unexpected synergistic effect when the Pterocarpus ovata bark extract, tetrahydrocurcumin and Mirabilis jalapa extract are used as active ingredients at the same time.

[0109] The methods of the present invention have been described through preferred embodiments. It is apparent that those skilled in the art will be able to modify or appropriately alter and combine the methods and applications described herein within the scope, spirit, and spirit of the present invention to implement and apply the technology of the present invention. Those skilled in the art may refer to the disclosure herein and appropriately modify the process parameters to achieve the desired effect. It is particularly important to note that all similar substitutions and modifications apparent to those skilled in the art are considered encompassed by the present invention.

Claims

1. A composition, characterized in that include: Palmyra tamarind bark extract, tetrahydrocurcumin, Mirabilis jalapa extract, surfactants, polyols, phospholipids and solvents.

2. The composition according to claim 1, characterized in that The surfactant comprises at least one of oleth-20, polyglyceryl-10 stearate, and polyglyceryl-10 oleate, preferably oleth-20, polyglyceryl-10 stearate, and polyglyceryl-10 oleate; and / or The polyol comprises at least one of 1,3-butanediol and 1,3-propylene glycol, preferably 1,3-butanediol and 1,3-propylene glycol; and / or The phospholipids include soy lecithin; and / or The solvent comprises water; and / or The Mirabilis jalapa extract comprises Mirabilis jalapa extract and glycerin; and / or The Mirabilis jalapa extract comprises 10 wt%-30 wt% or 20 wt% of Mirabilis jalapa extract, and the balance is glycerol.

3. The composition according to any one of claims 1 to 2, wherein the surfactant, polyol and phospholipid form a flexible liposome membrane structure, and the Pterocarpus tatarinowii bark extract and tetrahydrocurcumin are encapsulated in the flexible liposome.

4. The composition according to any one of claims 1 to 2, wherein the ratio of the total content of the polyol to the total content of the surfactant is 80:3-2:1; and / or The ratio of the total content of the polyol to the content of the phospholipid is 60:1-80:1; and / or The ratio of the total content of the polyol to the content of water is 5.1:1-10.5:1, or 5.1:1, 5.6:1, 8.5:1, 10.5:1; and / or The ratio of the total content of the polyol to the content of the Pterocarpus tatarinowii bark extract is 30:1-160:1 or 30:1, 70:1, 100:1, or 160:1; and / or The content ratio of the palm tree bark extract and tetrahydrocurcumin is (0.5-2): (0.1-1); preferably (0.5-2): (0.3-0.8), or 0.5:0.3, 0.8:0.3, 1:0.5, 2:0.8; and / or In the composition, the content ratio of the palmyra palm bark extract and the Mirabilis jalapa extract is (0.5-2): (0.1-0.75); preferably (0.5-2): (0.1-0.5) or 2.5:1-10:1, or 2.5:1, 2.6:1, 2.7:1, 2.8:1, 2.9:1, 3.0:1, 3.5:1, 4.0:1, 4.5:1, 5.0:1, 6.0:1, 7.0:1, 8.0:1, 9.0:1 or 10.0:1; and / or The content ratio of any one of the polyols to any one of the surfactants is independently selected from (10-50): (1-10); and / or The content ratio of any one of the polyols to the phospholipid is independently selected from (10-50): (0.5-3), (10-50): (0.5-1), 10:1-100:1 or 10:1-80:1; and / or The content ratio of any one of the polyols to water is independently selected from (30-50): (5.7-15.5) or (40-50): (5.7-15.5); and / or The content ratio of any one of the polyols to the Pterocarpus tatarinowii bark extract is independently selected from (40-50): (0.5-2); and / or The composition includes any one of the following groups: (i) the ratio of the total content of the polyol to the total content of the surfactant is 80:3-2:1, the ratio of the total content of the polyol to the phospholipid is 60:1-80:1, the ratio of the total content of the polyol to the water is 5.1:1-10.5:1, the ratio of the total content of the polyol to the Pterocarpus tatarinowii bark extract is 30:1-160:1, the content ratio of the Pterocarpus tatarinowii bark extract to tetrahydrocurcumin is (0.5-2):(0.3-0.8), and the content ratio of the Pterocarpus tatarinowii bark extract to Mirabilis jalapa extract is (0.5-2):(0.1-0.5); (ii) the ratio of the total content of the polyol to the total content of the surfactant is 80:3-2:1, the ratio of the total content of the polyol to the phospholipid is 60:1-80:1, the ratio of the total content of the polyol to water is 5.1:1-10.5:1, the ratio of the total content of the polyol to the Pterocarpus tatarinowii bark extract is 30:1-160:1, the ratio of the Pterocarpus tatarinowii bark extract to tetrahydrocurcumin is 0.5:0.3-0.8:0.3, and the ratio of the Pterocarpus tatarinowii bark extract to Mirabilis jalapa extract is 2.5:1-10:1; (iii) the ratio of the total content of the polyol to the total content of the surfactant is 80:3-2:1, the ratio of the total content of the polyol to the phospholipid is 60:1-80:1, the ratio of the total content of the polyol to water is 5.1:1-10.5:1, the ratio of the total content of the polyol to the Pterocarpus tatarinowii bark extract is 30:1-160:1, the ratio of the Pterocarpus tatarinowii bark extract to tetrahydrocurcumin is (0.5-2):(0.3-0.8), and the ratio of the Pterocarpus tatarinowii bark extract to Mirabilis jalapa extract is 2.5:1-10:1; (iv) The surfactant includes oleth-20, polyglyceryl-10 stearate and polyglyceryl-10 oleate; the polyol includes 1,3-butylene glycol and 1,3-propylene glycol; the ratio of the total content of the polyol to the total content of the surfactant is 80:3-2:1, the ratio of the total content of the polyol to the phospholipid is 60:1-80:1, the ratio of the total content of the polyol to water is 5.1:1-10.5:1, the ratio of the total content of the polyol to the content of the tamarisk bark extract is 30:1-160:1, the content ratio of the tamarisk bark extract to tetrahydrocurcumin is (0.5-2):(0.3-0.8), and the content ratio of the tamarisk bark extract to Mirabilis jalapa extract is 2.5:1-10:1; wherein, The content ratio of any one of the polyols to any one of the surfactants is independently selected from (10-50): (1-10); (v) The surfactant includes oleyl polyether-20, polyglyceryl-10 stearate, and polyglyceryl-10 oleate; the polyol includes 1,3-butanediol and 1,3-propanediol; the content ratio of the total content of the polyol to the total content of the surfactant is 80:3 - 2:1, the content ratio of the total content of the polyol to the content of phospholipid is 60:1 - 80:1, the content ratio of the total content of the polyol to the content of water is 5.1:1 - 10.5:1, the content ratio of the total content of the polyol to the extract of Ormosia henryi bark is 30:1 - 160:1, the content ratio of the extract of Ormosia henryi bark to tetrahydrocurcumin is 0.5:0.3 - 0.8:0.3, and the content ratio of the extract of Ormosia henryi bark to the extract of Mirabilis jalapa is 2.5:1 - 10:1; wherein, the content ratio of any one of the polyols to any one of the surfactants is independently selected from (10 - 50):(1 - 10); (vi) The surfactant includes oleyl polyether-20, polyglyceryl-10 stearate, and polyglyceryl-10 oleate; the polyol includes 1,3-butanediol and 1,3-propanediol; the content ratio of the total content of the polyol to the total content of the surfactant is 80:3 - 2:1, the content ratio of the total content of the polyol to the content of phospholipid is 60:1 - 80:1, the content ratio of the total content of the polyol to the content of water is 5.1:1 - 10.5:1, the content ratio of the total content of the polyol to the extract of Ormosia henryi bark is 30:1 - 160:1, the content ratio of the extract of Ormosia henryi bark to tetrahydrocurcumin is 0.5:0.3 - 0.8:0.3, and the content ratio of the extract of Ormosia henryi bark to the extract of Mirabilis jalapa is 2.5:1 - 10:1; wherein, the content ratio of any one of the polyols to any one of the surfactants is independently selected from 50:1 - 1:

1.

5. The composition according to any one of claims 1 - 4, calculated based on the total mass of the composition, the content of the extract of Ormosia henryi bark is 0.5 wt% - 2 wt%; and / or Calculated based on the total mass of the composition, the content of tetrahydrocurcumin is 0.1 wt% - 1.0 wt% or 0.3 wt% - 0.8 wt%; and / or Calculated based on the total mass of the composition, the content of the extract of Mirabilis jalapa is 0.1 wt% - 0.5 wt%; and / or Calculated based on the total mass of the composition, the total content of the surfactant is 3.0 wt% - 30.0 wt%; and / or Calculated based on the total mass of the composition, the total content of the polyol is 30 wt% - 80 wt% or 60 wt% - 80 wt%; and / or Calculated based on the total mass of the composition, the content of the phospholipid is 0.5 wt% - 3.0 wt% or 0.5 wt% - 1.0 wt%; and / or Calculated based on the total mass of the composition, the content of the solvent is 5.7 wt% - 65.8 wt% or 5.7 wt% - 15.5 wt%; and / or The content of any one of the surfactants is independently selected from 1.0 wt% to 10.0 wt% based on the total mass of the composition; and / or Based on the total mass of the composition, the content of any one of the polyols is independently selected from 10 wt % to 50 wt %.

6. The composition according to any one of claims 1 to 5, comprising any one of the following groups: (1) Calculated based on the total mass of the composition, the content of the palmyra palm bark extract is 0.5 wt%-2 wt%, the content of the tetrahydrocurcumin is 0.1 wt%-1.0 wt%, the content of the Mirabilis jalapa extract is 0.1 wt%-0.5 wt%, the total content of the surfactant is 3 wt%-30 wt%, the total content of the polyol is 30 wt%-80 wt%, the content of the phospholipid is 0.5 wt%-3.0 wt%, and the content of the solvent is 5.7 wt%-65.8 wt%; (2) Calculated based on the total mass of the composition, the content of the palmyra palm bark extract is 0.5 wt%-2 wt%, the content of the tetrahydrocurcumin is 0.3 wt%-0.8 wt%, the content of the Mirabilis jalapa extract is 0.1 wt%-0.5 wt%, the total content of the surfactant is 3 wt%-30 wt%, the total content of the polyol is 60 wt%-80 wt%, the content of the phospholipid is 0.5 wt%-1.0 wt%, and the content of the solvent is 5.7 wt%-15.5 wt%; (3) Calculated based on the total mass of the composition, the content of the palm bark extract is 0.5 wt%-2 wt%, the content of the tetrahydrocurcumin is 0.3 wt%-0.8 wt%, the content of the Mirabilis jalapa extract is 0.1 wt%-0.5 wt%, the total content of the surfactant is 3 wt%-30 wt%, the total content of the polyol is 60 wt%-80 wt%, the content of the phospholipid is 0.5 wt%-1.0 wt%, and the content of the solvent is 5.7 wt%-15.5 wt%; (4) The surfactant comprises oleth-20, polyglycerol-10 stearate and polyglycerol-10 oleate; based on the total mass of the composition, the content of the palmyra palm bark extract is 0.5 wt%-2 wt%, the content of the tetrahydrocurcumin is 0.3 wt%-0.8 wt%, the content of the Mirabilis jalapa extract is 0.1 wt%-0.5 wt%, and the total content of the surfactants is 3 wt%-30 wt%, wherein the content of any one of the surfactants is independently selected from 1.0 wt%-10.0 wt%; the total content of the polyol is 60 wt%-80 wt%, the content of the phospholipid is 0.5 wt%-1.0 wt%, and the content of the solvent is 5.7 wt%-15.5 wt%; (5) The surfactant includes oleth-20, polyglycerol-10 stearate and polyglycerol-10 oleate; the polyol includes 1,3-butylene glycol and 1,3-propylene glycol; calculated based on the total mass of the composition, the content of the palm bark extract is 0.5 wt%-2 wt%, the content of the tetrahydrocurcumin is 0.3 wt%-0.8 wt%, the content of the Mirabilis jalapa extract is 0.1 wt%-0.5 wt%, and the total content of the surfactant is 3 wt%-30 wt%; the total content of the polyol is 60 wt%-80 wt%, wherein the content of any one of the polyols is independently selected from 10 wt%-50 wt%; the content of the phospholipid is 0.5 wt%-1.0 wt%, and the content of the solvent is 5.7 wt%-15.5 wt%; (6) The surfactant includes oleth-20, polyglycerol-10 stearate and polyglycerol-10 oleate; the polyol includes 1,3-butylene glycol and 1,3-propylene glycol; calculated based on the total mass of the composition, the content of the palm bark extract is 0.5 wt%-2 wt%, the content of the tetrahydrocurcumin is 0.3 wt%-0.8 wt%, the content of the Mirabilis jalapa extract is 0.1 wt%-0.5 wt%, and the total content of the surfactants is 3 wt%-30 wt%, wherein the content of any one of the surfactants is 1.0 wt%-10.0 wt%; the total content of the polyol is 60 wt%-80 wt%, wherein the content of any one of the polyols is independently selected from 10 wt%-50 wt%; the content of the phospholipid is 0.5 wt%-1.0 wt%, and the content of the solvent is 5.7 wt%-15.5 wt%; (7) The surfactant includes oleth-20, polyglycerol-10 stearate and polyglycerol-10 oleate; the polyol includes 1,3-butylene glycol and 1,3-propylene glycol; calculated based on the total mass of the composition, the content of the palm bark extract is 0.5 wt%-2 wt%, the content of the tetrahydrocurcumin is 0.3 wt%-0.8 wt%, the content of the Mirabilis jalapa extract is 0.1 wt%-0.5 wt%, and the total content of the surfactants is 3 wt%-30 wt%, wherein the content of any one of the surfactants is independently selected from 1.0 wt%-10.0 wt%; the total content of the polyol is 60 wt%-80 wt%, wherein the content of any one of the polyols is independently selected from 10 wt%-50 wt%; the content of the phospholipid is 0.5 wt%-1.0 wt%, and the balance is the solvent; (8) The surfactant includes oleth-20, polyglycerol-10 stearate and polyglycerol-10 oleate; the polyol includes 1,3-butylene glycol and 1,3-propylene glycol; calculated based on the total mass of the composition, the content of the palm bark extract is 0.5wt%, the content of the tetrahydrocurcumin is 0.3wt%, the content of the Mirabilis jalapa extract is 0.2wt%, the total content of the surfactants is 3.0wt%, wherein the content of any one of the surfactants is 1.0wt%; the total content of the polyol is 80wt%, wherein the content of any one of the polyols is 40wt%; the content of the phospholipid is 0.5wt%, and the balance is the solvent; (9) The surfactant includes oleth-20, polyglycerol-10 stearate and polyglycerol-10 oleate; the polyol includes 1,3-butylene glycol and 1,3-propylene glycol; calculated based on the total mass of the composition, the content of the palm bark extract is 0.8wt%, the content of the tetrahydrocurcumin is 0.3wt%, the content of the Mirabilis jalapa extract is 0.3wt%, the total content of the surfactants is 9.0wt%, wherein the content of any one of the surfactants is 3.0wt%; the total content of the polyol is 80wt%, wherein the content of any one of the polyols is 40wt%; the content of the phospholipid is 0.5wt%, and the balance is the solvent; (10) The surfactant includes oleth-20, polyglycerol-10 stearate and polyglycerol-10 oleate; the polyol includes 1,3-butylene glycol and 1,3-propylene glycol; based on the total mass of the composition, the content of the palm bark extract is 1.0 wt%, the content of the tetrahydrocurcumin is 0.5 wt%, the content of the Mirabilis jalapa extract is 0.1 wt%, the total content of the surfactants is 15.0 wt%, wherein the content of any one of the surfactants is 5.0 wt%; the total content of the polyol is 70 wt%, wherein the content of the 1,3-butylene glycol is 50 wt%, the content of the 1,3-propylene glycol is 20 wt%; the content of the phospholipid is 1.0 wt%, and the balance is the solvent; (11) The surfactant includes oleth-20, polyglycerol-10 stearate and polyglycerol-10 oleate; the polyol includes 1,3-butylene glycol and 1,3-propylene glycol; calculated based on the total mass of the composition, the content of the palm bark extract is 2.0 wt%, the content of the tetrahydrocurcumin is 0.8 wt%, the content of the Mirabilis jalapa extract is 0.5 wt%, the total content of the surfactants is 30.0 wt%, wherein the content of any one of the surfactants is 10.0 wt%; the total content of the polyol is 60 wt%, wherein the content of the 1,3-butylene glycol is 50 wt%, the content of the 1,3-propylene glycol is 10 wt%; the content of the phospholipid is 1.0 wt%, and the balance is the solvent.

7. A method for preparing the composition according to any one of claims 1 to 6, characterized in that: include: (1) mixing a surfactant, a polyol, and a phospholipid, heating and dissolving the mixture, and then adding a safflower oil bark extract and tetrahydrocurcumin to mix and dissolve the mixture to obtain a solution 1; (2) mixing solution 1 with water to obtain solution 2, and then mixing and dissolving solution 2 with Mirabilis jalapa extract to obtain solution 3; (3) Solution 3 is subjected to high-pressure homogenization technology to obtain the composition.

8. The preparation method according to claim 7, wherein the heating and dissolving in step (1) is performed by heating to 65°C-70°C for dissolving; and / or The mixed dissolution in step (1) is carried out at a temperature of 65°C-70°C; and / or The step (2) of mixing the solution 1 with water is to cool the solution 1 to 45°C-48°C; and / or In step (2), the solution 2 is cooled to 30°C-35°C before dissolving with the Mirabilis jalapa extract; and / or The pressure parameter during the high-pressure homogenization process in step (3) is 600 bar-1000 bar; and / or The number of high pressure homogenization in step (3) is 4, 5 or 6 times; and / or The high-pressure homogenization in step (3) takes 3-5 minutes for each homogenization.

9. A cosmetic, characterized in that: A composition comprising the composition according to any one of claims 1 to 5 or a composition prepared by the preparation method according to any one of claims 6 to 7; Optionally, the cosmetic is selected from the following forms of cosmetics: lotion, emulsion, cream.

10. Use of the composition according to any one of claims 1 to 5 or the composition prepared by the preparation method according to any one of claims 7 to 8 in the preparation of cosmetics; Optionally, the cosmetic is used for anti-oxidation, skin lightening, AGEs inhibition, advanced glycation end product receptor inhibition, anti-glycation, anti-aging, and lipofuscin inhibition.

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