165 results about "Bifidobacterium adolescentis" patented technology

The invention relates to the field of microorganisms, in particular to bifidobacterium adolescentis YG3912, inactivated thalli, an extract, a culture, a culture supernatant, a fermentation product and / or a fermentation supernatant of the bifidobacterium adolescentis YG3912, an application of the bifidobacterium adolescentis YG3912 in preparation of a composition for promoting skin repair, reducing skin inflammation or allergy, improving skin quality and improving skin quality. The invention also relates to application of the composition in products for resisting skin aging and enhancing skin immune function. The bifidobacterium adolescentis YG3912 and the related products thereof have the advantages that the bifidobacterium adolescentis YG3912 and the related products of the bifidobacterium adolescentis YG3912 are high in skin cell repairing capacity, skin inflammation relieving, inhibiting or eliminating capacity and remarkable in skin aging resisting capacity, so that the bifidobacterium adolescentis YG3912 and the related products of the bifidobacterium adolescentis YG3912 are expected to be used for skin health care such as skin repairing, inflammation relieving and light aging resisting, and the bifidobacterium adolescentis YG3912 and the related products thereof have remarkable application value and market potential.

The invention relates to a weight-losing enzyme and a preparation method thereof, and belongs to the technical field of biology, and the weight-losing enzyme comprises a fruit enzyme, a vegetable enzyme, a seed enzyme and a lotus leaf extract; the fruit enzyme is obtained by performing enzymolysis on mixed fruit pulp of apples, lemons, grapefruits and haws through pectinase, performing enzymolysis through pepsase and performing co-fermentation through bifidobacterium longum and lactobacillus acidophilus; the vegetable enzyme is obtained by performing enzymolysis on mixed vegetable pulp of wax gourd pulp, celery and spinach through pectinase, performing enzymolysis through pepsin and performing fermentation through lactobacillus plantarum and bifidobacterium adolescentis; the seed enzyme is obtained by carrying out trypsin enzymolysis on mixed powder of semen raphani and phaseolus calcaratus, then carrying out nattokinase enzymolysis and then fermenting with bifidobacterium breve; the lotus leaf extract is obtained by sequentially carrying out enzymolysis on lotus leaves through hemicellulase, snail protease and nattokinase. All the components are matched for use, so that the weight-losing food has the effects of promoting digestion, inhibiting fat absorption, regulating intestinal flora, promoting metabolism and the like, and has a good weight-losing effect.

The invention belongs to the field of daily chemicals, and discloses a strain of bifidobacterium adolescentis, the classification name of the bifidobacterium adolescentis BF23BA001 is bifidobacterium adolescentis, the preservation number is CGMCC NO.26999, and the strain of bifidobacterium adolescentis BF23BA001 is named as bifidobacterium adolescentis BF23BA001. The preservation date is March 31, 2023, and the preservation unit is China General Microbiological Culture Collection Center (CGMCC); the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing. Compared with other commercially available similar bacteria, the strain has unique advantages in the production of small molecule peptides and gamma-aminobutyric acid, has a remarkable anti-wrinkle advantage according to the functional characteristics of the small molecule peptides and gamma-aminobutyric acid, and has a remarkable anti-wrinkle effect through subsequent functional verification. The method is of great significance to further improvement of whitening, brightening, repairing and anti-aging effects of yeast fermentation products. In addition, the invention further discloses a composition for inhibiting generation and accumulation of lipofuscin, application based on the composition and cosmetics.

The invention belongs to the technical field of biological medicine, and discloses a probiotic agent capable of improving the physiological activity function of vitamin D and maintaining bone health and application of the probiotic agent. The invention provides a probiotic agent composed of bifidobacterium adolescentis and bifidobacterium longum, the probiotic agent can significantly improve the bone mineral density, the bone trabecula thickness, the bone trabecula number, the bone trabecula connectivity and the bone volume fraction of an osteoporosis mouse, and meanwhile, the bone trabecula separation degree of the osteoporosis-removed mouse is significantly reduced; the level of vitamin D metabolites such as 25-hydroxy vitamin D and 1, 25-dihydroxy vitamin D in mouse serum is improved; the content of serum calcium and alkaline phosphatase in serum of mice is reduced, and the level of osteocalcin and type I procollagen amino terminal peptide in the serum is improved. The probiotic agent can relieve bone calcium loss, maintain bone health, repair bone injury, increase osteoblasts and reduce the osteoporosis degree, and can be used for preparing drugs for preventing and / or treating osteoporosis or preparing health care products or food beneficial to improving bone mineral density.

The invention belongs to the technical field of microorganisms, and particularly relates to a lactobacillus polyactis composition for improving skin as well as a derivative and application of the lactobacillus polyactis composition. The composition comprises a bacterial strain, a pure culture or an inactivated bacterium body of bifidobacterium bifidum Bbifid-1 (CCTCC NO: M2023349), bifidobacterium adolescentis Badol-1 (CCTCC NO: M 20242593), phytobacterium plantarum Lplan-4 (CCTCC NO: M 20242594) and lactobacillus acidophilus (BA05). The invention further relates to a preparation method of the composition. The lactobacillus plantarum derivative composition prepared through treatment modes of splitting decomposition, extraction, fermentation and the like can be used as an active ingredient of a medicine or a cosmetic, has remarkable effects of resisting oxidation and bacteria, especially resisting inflammation and inhibiting skin lipid accumulation aiming at propionibacterium acnes and staphylococcus aureus, is beneficial to fading skin red and swollen, avoids hair follicle blockage, and has a good application prospect. The obvious effect on the acne is realized.

The present invention provides a strain of Bifidobacterium adolescentis with the function of inhibiting α-glucosidase activity and secreting GLP-1 and its application, belonging to the field of functional microbial technology. The present invention isolates a strain of Bifidobacterium adolescentis B24728 from the feces of centenarians in Guangxi. The strain B24728 not only has the function of inhibiting α-glucosidase activity in vitro, but also has the function of high production of GLP-1, and animal experiments show that the strain B24728 has the efficacy of treating diabetes. At the same time, the strain B24728 is a human strain, has no species rejection reaction, and meets the safety requirements. Therefore, the strain B24728 and its culture can be used as food, health products or medicines for lowering blood sugar, and can be used to prepare medicines for the treatment of diabetes.

The application belongs to the field of daily chemicals, and discloses a Bifidobacterium adolescentis, the classification name of the Bifidobacterium adolescentis BF23BA001 is Bifidobacterium adolescentis, the preservation number is CGMCC NO.26999, the preservation date is March 31, 2023, the preservation unit is China General Microbiological Culture Collection Center, and the preservation address is No.3, Xibahe Road, Chaoyang District, Beijing City. Compared with other similar bacteria on the market, the bacteria have unique advantages in the production of small molecule peptides and gamma-aminobutyric acid, according to the functional characteristics of the small molecule peptides and gamma-aminobutyric acid, the bacteria have significant anti-wrinkle advantages, and through subsequent functional verification, the bacteria have very important significance for further improving the whitening, brightening, repair and anti-aging effects of yeast fermentation products. In addition, the application also discloses a composition for inhibiting the generation and accumulation of lipofuscin, application based on the composition and cosmetics.

The invention discloses application of bifidobacterium adolescentis CCFM1302 in promoting synthesis of host collagen, and belongs to the technical field of microorganisms and medicines. The metagen of the bifidobacterium adolescentis CCFM1302 disclosed by the invention has a good effect of regulating and controlling synthesis and degradation of collagen, the moisture and elasticity of the skin are improved, the antioxidant capacity of the skin is improved, the inflammation level of an organism is reduced, and the stable state of collagen is maintained. The method specifically comprises the following steps: in vitro promoting the enzyme activity of HSF cell LH1 by a thallus lysate, inhibiting the enzyme activity of MMP-3, increasing the content of COL I and COL III and the enzyme activity of LH1, P4H and LOX from the outside of a fermented supernatant, and inhibiting the enzyme activity of MMP-3; the inactivated thalli are orally taken to increase the collagen content and the enzyme activity of LH1 and inhibit the enzyme activity of MMP-1 and MMP-3; the fermentation supernatant is orally taken to inhibit enzyme activity of MMP-3 and MMP-1 and degradation of collagen, and the content of TGF-beta is increased.

The invention relates to a bio-based cosmetic composition containing a fermentation product of Bifidobacterium adolescentis and application thereof. The bio-based cosmetic composition disclosed by the invention not only can regulate and maintain skin micro-ecological balance, but also has the effects of relieving skin, resisting wrinkles, tightening skin and the like, compared with a cosmetic with a single effect, the bio-based cosmetic composition can more comprehensively solve skin problems, higher safety and reliability are ensured due to the pure natural characteristic of the bio-based cosmetic composition, and in conclusion, the bio-based cosmetic composition has a very good application prospect. The bio-based cosmetic composition has a good application prospect in the field of cosmetics.

The invention relates to the technical field of microorganisms, and particularly discloses bifidobacterium adolescentis AGE17 capable of promoting growth and development of muscles and bones and application of the bifidobacterium adolescentis AGE17. The bifidobacterium adolescentis AGE17 is separated from excrement of healthy children and is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.33452, and the preservation date is January 17, 2025. The bifidobacterium adolescentis AGE17 has the advantages that the bifidobacterium adolescentis AGE17 can be used for preparing the biological organic fertilizer; animal experiments prove that the bifidobacterium adolescentis strain AGE17 provided by the invention has the function of promoting muscle and skeletal development, has more obvious and prominent effects compared with a model strain bifidobacterium adolescentis ATCC15703, and has important application value in increasing the muscle strength and height of children and adolescents.

Provided are compositions and methods of using compositions including probiotics for treatment and prevention of a variety of pain disorders, neurological disorders, and / or physiological disorders. The compositions include one or more bacterium capable of producing γ-Aminobutyric acid (GABA). The bacterium is selected from Bifidobacterium adolescentis, Limosilactobacillus reuteri, and Lactiplantibacillus plantarum.

The invention discloses a brain glioma intestinal microbial marker, a product and application of the brain glioma intestinal microbial marker, and belongs to the field of biological medicine. The invention relates to an enteric microbial marker, which is characterized by being prepared from one or more of Eubacter algenti, Prevotella copri, Alistipes finegili, Bifidobacterium adolescentis and Citrobacter sp., and the enteric microbial marker is prepared from one or more of Eubacter algenti, Prevotella copri, Alistipes finegili, Bifidobacterium adolescentis and Citrobacter sp., and the enteric microbial marker is prepared from one or more of Eubacter algenti, Prevotella copri, Alistipes finegili, Bifidobacterium adolescentis and Citrobacter sp. The invention provides a kit which comprises a detection reagent for detecting the relative abundance of the intestinal microbial marker. The invention provides a product for diagnosing brain glioma and a computer program product related to the brain glioma. The product provided by the invention has good feasibility and accuracy, and provides a new tool for clinical diagnosis.

The invention discloses a metagen prepared from bifidobacterium adolescentis and used for promoting synthesis of host collagen, and belongs to the technical field of microorganisms and medicines. The metagen of the bifidobacterium adolescentis CCFM1386 provided by the invention has a good effect of promoting synthesis of host collagen, improves moisture and elasticity of skin, and meanwhile, can improve the antioxidant capacity of the skin and maintain the stable state of collagen. The method specifically comprises the following steps: promoting the enzyme activity of the HSF cell LH1 in vitro by a thallus lysate, and improving the content of COL I and COL III and the enzyme activity of the LH1 in vitro from a fermented supernatant; the bifidobacterium adolescentis has the advantages that the content of collagen is increased by orally taking inactivated thalli, the enzyme activity of LH1, P4H and LOX can be improved by orally taking self-fermentation supernate, the synthesis of the collagen is promoted, and the content of the collagen is increased, so that the bifidobacterium adolescentis has huge application prospects in preparation of oral medicines for promoting the synthesis of host collagen and preparation of foods, health-care products or cosmetics.

The invention relates to the technical field of microorganisms, and discloses Ackermann muciniphila, a combined microbial agent thereof and application of the Ackermann muciniphila in inflammatory enteritis. The invention provides Akkermansia muciniphila AIML-559, and the preservation number of the Akkermansia muciniphila AIML-559 is CGMCC (China General Microbiological Culture Collection Center) No. 34246. The invention relates to a combined microbial agent, which is characterized by comprising Ackermann muciniphila AIML-559 and Bifidobacterium adolescentis AIML-528 (the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.34300). The combined microbial agent is prepared from the following raw materials: Ackermann muciniphila AIML-559 and Bifidobacterium adolescentis AIML-528 The ackermann mucophil combined microbial inoculum is suitable for treatment intervention of inflammatory bowel disease (IBD), and can relieve weight loss, hemolysis, anemia, diarrhea, intestinal bleeding and other symptoms of IBD mice.

The invention provides application of bifidobacterium adolescentis B-201 in preparation of products for relieving asthenopia and protecting eyesight, and belongs to the field of microbial fermentation. The bifidobacterium adolescentis B-201 provided by the invention has the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.27234, and is preserved in the China General Microbiological Culture Collection Center (CGMCC) on April 27, 2023. The strain is subjected to culture fermentation and freeze drying to obtain bacterial powder, after auxiliary materials are added, the bacterial powder can be used for improving eye symptoms, increasing tear secretion amount, reducing ocular surface disease index scores and prolonging short-distance continuous eye using time, and the strain can be used for preparing products for relieving asthenopia and protecting eyesight.

The invention provides an oxidoreductase composition as well as a preparation method and application thereof, and belongs to the technical field of biology. The composition contains various complex enzymes, acetyl hexapeptide-8, a centella asiatica extract, an aesculus chinensis extract, ceramide NP and other components. The centella asiatica extract is obtained by performing common enzymolysis on centella asiatica through cellulase, pectinase and papain, then performing fermentation through lactobacillus plantarum and bifidobacterium adolescentis and performing purification; the aesculus chinensis extract is obtained by fermenting mature aesculus chinensis seeds with lactobacillus reuteri and lactobacillus bulgaricus and purifying. All the components are matched for use, and meanwhile, the composition has the effects of resisting sugar, diminishing swelling, resisting aging, tightening and smoothing skin, brightening and dissolving fat, and is safe and efficient.

The invention relates to the technical field of biological medicine, and discloses bifidobacterium adolescentis YF-01 and application thereof in fermented milk. The bifidobacterium adolescentis YF-01 is separated from adult excrement and is preserved in the China Center for Type Culture Collection, and the preservation number is CCTCC NO: M 20251308. Experiments prove that the bifidobacterium adolescentis YF-01 has good gastrointestinal fluid tolerance, the survival rate of the bifidobacterium adolescentis YF-01 can reach 90.1% after simulated gastric fluid treatment for 3 h, and the survival rate of the bifidobacterium adolescentis YF-01 can reach 72% after simulated intestinal fluid treatment for 4 h The strain has the self-aggregation rate of 88.83% and the hydrophobicity of 79.41%, has remarkable scavenging capacity on DPPH free radicals and hydroxyl free radicals, shows good antioxidant activity and adhesion capacity, and provides a theoretical basis for application of the strain in fermented milk. The strain and metabolites thereof can be used for preparing food, medicines or health care products capable of regulating intestinal flora and enhancing oxidation resistance, and have remarkable application potential in development of functional fermented milk products.

The invention discloses a meningioma enteric microbial marker, a product and application of the meningioma enteric microbial marker, and belongs to the field of biological medicine. The invention relates to an enteric microbial marker, which is characterized by being prepared from one or more of the following components: parabacteroides dissoni, prevotella copri, bifidobacterium adolescentis and streptococcus salivarius, and is characterized in that the enteric microbial marker comprises one or more of the following components: parabacteroides dissoni, prevotella copri, bifidobacterium adolescentis and streptococcus salivarius, and the enteric microbial marker comprises one or more of parabacteroides dissoni, prevotella copri, bifidobacterium adolescentis and streptococcus salivarius. The invention provides a kit which comprises a detection reagent for detecting the relative abundance of the intestinal microbial marker. The invention provides a product for diagnosing meningioma and a computer program product related to meningioma. The product provided by the invention has good feasibility and accuracy, can effectively evaluate the risk of meningioma, and provides a new tool for clinical diagnosis.

The invention relates to a polygonatum sibiricum probiotic compound preparation with an aging delaying effect and application thereof. The compound preparation comprises a polygonatum sibiricum extract and a probiotic composition, the bacterial strains in the probiotic composition comprise a combination of a bifidobacterium animalis subsp. Lactis BLa36 bacterial strain, a bifidobacterium longum BL21 bacterial strain, a bifidobacterium adolescentis BAC30 bacterial strain, a lactobacillus plantarum Lp90 bacterial strain, a lactobacillus casei LC89 bacterial strain, a bifidobacterium breve BBr60 bacterial strain and a pediococcus acidilactici CCFM7902 bacterial strain. After the rhizoma polygonati component and the probiotic component are combined for use, the rhizoma polygonati component and the probiotic component have potential synergistic effects in the aspects of improving the intestinal flora structure, regulating the intestinal environment, delaying senescence, reducing inflammation-related symptoms and the like. Moreover, further, various probiotic strains are compounded and combined for use, so that the capability of a related compound preparation in the aspect of delaying various symptoms of senescence can also be improved in a combined manner.

The invention discloses combined probiotics for improving sarcopenia as well as a preparation method and application of the combined probiotics, and belongs to the field of probiotics. The invention relates to a combined probiotic for improving sarcopenia. The combined probiotic comprises a lactobacillus reuteri body, a lactobacillus johnsonii body, a lactobacillus fermentum body and a bifidobacterium adolescentis body. The combined probiotics disclosed by the invention can be used for remarkably improving the overall symptoms of sarcopenia model mice, including inhibiting weight loss, constipation symptoms and colonic mucosa destruction, prolonging load swimming time, improving muscle endurance, improving skeletal muscle atrophy, improving the expression of I-type slow muscle fiber protein MyHC I and promoting slow muscle fiber repair, and has the effects of preventing and treating sarcopenia. The invention discloses a probiotic intervention method for treating sarcopenia, which comprises the following steps of: preparing probiotics for treating sarcopenia, reducing the content of inflammatory cytokines in muscular tissues, increasing the content of hepatic glycogen, improving systematic metabolism of mice with sarcopenia and damaged serum markers, including lactic acid, lactic dehydrogenase, creatine kinase, creatinine, alanine transaminase ALT and aspartate transaminase AST, providing a new scheme for probiotic intervention for sarcopenia, and being used for preparing related functional products or intervention means.

The invention discloses bifidobacterium adolescentis from longevity dogs and cats and application thereof, and belongs to the technical field of microorganisms. Bifidobacterium adolescentis with the effect of prolonging the life of mice is separated from fresh feces of longevity dogs and cats, and after mutagenesis, the bifidobacterium adolescentis for dogs and cats, which is more suitable for gastrointestinal environments of dogs and cats, is bred by taking growth speed, gastrointestinal digestion resistance and oxygen resistance as indexes. The mutant strain is preserved in the China Center for Type Culture Collection (CCTCC) on August 5, 2024, and the preservation number of the mutant strain is CCTCC NO: M20241747 and the preservation number of the mutant strain is CCTCC NO: M20241746. The bifidobacterium adolescentis disclosed by the invention can be applied to food (feed) of dogs and cats, and has the effects of reducing the food change stress rate of the dogs and the cats and improving the senescence index (NAD < + >).

The invention discloses a metagen which is prepared from bifidobacterium adolescentis CCFM1404 and has the effect of improving skin health, and belongs to the technical field of microorganisms and medicines. The metagen (especially the thallus lysate) of the bifidobacterium adolescentis CCFM1404, provided by the invention, has a good skin barrier repairing effect, which is specifically shown in that the cell viability of keratinocytes after injury and the expression of FLG, IVL and LOR gene levels can be improved by externally applying the thallus lysate of the bifidobacterium adolescentis CCFM1404; the DNFB-induced mouse skin barrier injury can be relieved in the aspects of apparent TEWL and epidermis thickness, up-regulation of epidermis and basal layer protein and the like by oral administration of metabiotics (including thallus lysate and fermentation supernatant) of bifidobacterium adolescentis. Therefore, the bifidobacterium adolescentis has a huge application prospect in preparation of external or oral medicines for repairing the skin barrier and preparation of food, health care products or cosmetics.

The invention belongs to the field of gene engineering and enzyme engineering, and discloses a phosphoketolase mutant derived from bifidobacterium adolescentis and application of the phosphoketolase mutant in production of metabolites. By adopting a site-specific mutagenesis method, histidine at the 480th site of the phosphoketolase PKT from bifidobacterium adolescentis is mutated into lysine, so that the enzyme activity of the phosphoketolase is remarkably improved, and the problem that the existing phosphoketolase has relatively low catalytic performance on 6-phosphofructose is effectively solved; the strain is successfully applied to fermentation production of bacitracin, ectoine and gamma-aminobutyric acid, and a new thought is provided for improving the production level of metabolites.

The invention provides a bacterial strain for preventing and / or treating ulcerative colitis, mixed probiotics and application of the bacterial strain and the mixed probiotics, and belongs to the technical field of microorganisms. The bacterial strain disclosed by the invention is Bifidobacterium longum ZJUCH (Bifidobacterium longum), and the preservation number of the bacterial strain is CCTCC (China Center for Type Culture Collection) NO: M 2025583. Experiments prove that the strain has the effect of improving the symptoms of ulcerative colitis. Meanwhile, mixed probiotics prepared by combining the bifidobacterium longum ZJUCH with bifidobacterium adolescentis and bifidobacterium pseudocatenuicola improve weight loss, DAI score increase and colon shortening caused by molding, and have the effect of preventing and / or treating ulcerative colitis.

The invention belongs to the technical field of microorganisms, and particularly relates to bifidobacterium adolescentis beneficial to skin as well as a derivative and application of the bifidobacterium adolescentis. The derivative of bifidobacterium adolescentis has remarkable antioxidant and anti-inflammatory effects, can inhibit acne and other common pathogenic bacteria infected by skin, such as propionibacterium acnes, staphylococcus aureus and malassezia furfur, can eliminate induced pathogenic bacteria, can also inhibit skin lipid accumulation, avoids hair follicle blockage, and has a good anti-inflammatory effect. The skin problem, especially the acne skin problem, is improved in multiple aspects.

The invention provides bifidobacterium adolescentis B-201, a metagen containing the bifidobacterium adolescentis B-201 and rich in active substances and application, and belongs to the technical field of probiotics. The bifidobacterium adolescentis B-201 is separated from healthy breast milk, and is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC No.31756. The bifidobacterium adolescentis B-201 metabolite is rich in functional active substances such as amino acid and metabolite thereof, benzene and derivative thereof, organic acid alcohol, flavone, hormone and hormone related substances, alkaloid, organic acid and derivative thereof, heterocyclic compound and fatty acyl thereof, has broad-spectrum antibacterial activity, and can effectively inhibit pathogenic bacteria and food-borne putrefying bacteria. The invention provides a brand new thought for deep research and utilization of the probiotic postbiotics with functional active substances, and has great research and application values.

The invention discloses a method for synthesizing alpha-arbutin through biotransformation, and belongs to the technical field of biochemistry. A gene cloning technology is utilized, sucrose phosphorylase Spase in leuconostoc mesenteroides and sucrose phosphorylase gtfa in bifidobacterium adolescentis are screened and found through a Deep Molecules and DLKcat algorithm on a Uniprot database, novopro is utilized for codon optimization, then the sucrose phosphorylase Spase and the sucrose phosphorylase gtfa are expressed on a plasmid vector PET-28a and are converted into an escherichia coli BL21 (DE3) strain, and the sucrose phosphorylase Spase and the sucrose phosphorylase gtfa in the bifidobacterium adolescentis are obtained. An engineering strain for heterologous expression of the gene is constructed by taking the gene as a chassis cell. According to the process, sucrose and hydroquinone are taken as co-substrates, and bioconversion is carried out under the action of sucrose phosphorylase from different sources to obtain alpha-arbutin.

The invention discloses bifidobacterium adolescentis for relieving estrogen-related metabolic disorder and obesity and application thereof, and belongs to the technical field of microorganisms. The bifidobacterium adolescentis CCFM1506 screened by the invention can effectively improve ovariectomized individual estrogen disorder symptoms, obviously slow down the weight increase speed and weight increment of estrogen disorder individuals, increase the expression quantity of serum estradiol, CYP11A1 and ERalpha in adrenal gland and the high-density lipoprotein content in serum, reduce the total cholesterol and glucose level and improve the ovariectomized ovariectomized ovariectomized ovariectomized ovariectomized ovariectomized ovariectomized ovariectomized ovariectomized abnormal glucose and lipid metabolism is adjusted; the invention has the advantages of simple preparation method and wide application prospect, can be used for preparing medicines for relieving or treating estrogen-related metabolic disorders and obesity, and can be used for preparing health-care products beneficial to controlling in-vivo fat and maintaining the health level of blood fat, and has obvious physiological effects and wide application prospects, and can be used for preparing the medicines for relieving or treating the estrogen-related metabolic disorders and obesity and preparing health-care products beneficial to controlling in-vivo fat and maintaining the health level of blood fat. A new thought and a new basis are provided for developing functional foods or medicines based on the probiotics.

The application belongs to the technical field of microorganisms and particularly relates to a Bifidobacterium adolescentis beneficial to skin, a derivative of the Bifidobacterium adolescentis and application of the Bifidobacterium adolescentis and the derivative. The derivative of the Bifidobacterium adolescentis has significant antioxidant and anti-inflammatory effects, can inhibit pathogenic bacteria of acne and other common skin infections such as Propionibacterium acnes, Staphylococcus aureus and Malassezia furfur, can eliminate pathogenic bacteria, can inhibit skin lipid accumulation, can avoid follicle blockage, and can improve skin problems in multiple directions, especially acne skin problems.

Provided is a composition for maintaining, improving or ameliorating a cognitive function, the composition containing cells of Bifidobacterium adolescentis JCM 7045 strain or a treated product of the cells.