113 results about "Bifidobacterium adolescentis" patented technology

The invention belongs to the technical field of biological medicine, and discloses a probiotic agent capable of improving the physiological activity function of vitamin D and maintaining bone health and application of the probiotic agent. The invention provides a probiotic agent composed of bifidobacterium adolescentis and bifidobacterium longum, the probiotic agent can significantly improve the bone mineral density, the bone trabecula thickness, the bone trabecula number, the bone trabecula connectivity and the bone volume fraction of an osteoporosis mouse, and meanwhile, the bone trabecula separation degree of the osteoporosis-removed mouse is significantly reduced; the level of vitamin D metabolites such as 25-hydroxy vitamin D and 1, 25-dihydroxy vitamin D in mouse serum is improved; the content of serum calcium and alkaline phosphatase in serum of mice is reduced, and the level of osteocalcin and type I procollagen amino terminal peptide in the serum is improved. The probiotic agent can relieve bone calcium loss, maintain bone health, repair bone injury, increase osteoblasts and reduce the osteoporosis degree, and can be used for preparing drugs for preventing and / or treating osteoporosis or preparing health care products or food beneficial to improving bone mineral density.

The application belongs to the field of daily chemicals, and discloses a Bifidobacterium adolescentis, the classification name of the Bifidobacterium adolescentis BF23BA001 is Bifidobacterium adolescentis, the preservation number is CGMCC NO.26999, the preservation date is March 31, 2023, the preservation unit is China General Microbiological Culture Collection Center, and the preservation address is No.3, Xibahe Road, Chaoyang District, Beijing City. Compared with other similar bacteria on the market, the bacteria have unique advantages in the production of small molecule peptides and gamma-aminobutyric acid, according to the functional characteristics of the small molecule peptides and gamma-aminobutyric acid, the bacteria have significant anti-wrinkle advantages, and through subsequent functional verification, the bacteria have very important significance for further improving the whitening, brightening, repair and anti-aging effects of yeast fermentation products. In addition, the application also discloses a composition for inhibiting the generation and accumulation of lipofuscin, application based on the composition and cosmetics.

The invention discloses application of bifidobacterium adolescentis CCFM1302 in promoting synthesis of host collagen, and belongs to the technical field of microorganisms and medicines. The metagen of the bifidobacterium adolescentis CCFM1302 disclosed by the invention has a good effect of regulating and controlling synthesis and degradation of collagen, the moisture and elasticity of the skin are improved, the antioxidant capacity of the skin is improved, the inflammation level of an organism is reduced, and the stable state of collagen is maintained. The method specifically comprises the following steps: in vitro promoting the enzyme activity of HSF cell LH1 by a thallus lysate, inhibiting the enzyme activity of MMP-3, increasing the content of COL I and COL III and the enzyme activity of LH1, P4H and LOX from the outside of a fermented supernatant, and inhibiting the enzyme activity of MMP-3; the inactivated thalli are orally taken to increase the collagen content and the enzyme activity of LH1 and inhibit the enzyme activity of MMP-1 and MMP-3; the fermentation supernatant is orally taken to inhibit enzyme activity of MMP-3 and MMP-1 and degradation of collagen, and the content of TGF-beta is increased.

The invention relates to the technical field of microorganisms, and particularly discloses bifidobacterium adolescentis AGE17 capable of promoting growth and development of muscles and bones and application of the bifidobacterium adolescentis AGE17. The bifidobacterium adolescentis AGE17 is separated from excrement of healthy children and is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.33452, and the preservation date is January 17, 2025. The bifidobacterium adolescentis AGE17 has the advantages that the bifidobacterium adolescentis AGE17 can be used for preparing the biological organic fertilizer; animal experiments prove that the bifidobacterium adolescentis strain AGE17 provided by the invention has the function of promoting muscle and skeletal development, has more obvious and prominent effects compared with a model strain bifidobacterium adolescentis ATCC15703, and has important application value in increasing the muscle strength and height of children and adolescents.

The invention discloses a brain glioma intestinal microbial marker, a product and application of the brain glioma intestinal microbial marker, and belongs to the field of biological medicine. The invention relates to an enteric microbial marker, which is characterized by being prepared from one or more of Eubacter algenti, Prevotella copri, Alistipes finegili, Bifidobacterium adolescentis and Citrobacter sp., and the enteric microbial marker is prepared from one or more of Eubacter algenti, Prevotella copri, Alistipes finegili, Bifidobacterium adolescentis and Citrobacter sp., and the enteric microbial marker is prepared from one or more of Eubacter algenti, Prevotella copri, Alistipes finegili, Bifidobacterium adolescentis and Citrobacter sp. The invention provides a kit which comprises a detection reagent for detecting the relative abundance of the intestinal microbial marker. The invention provides a product for diagnosing brain glioma and a computer program product related to the brain glioma. The product provided by the invention has good feasibility and accuracy, and provides a new tool for clinical diagnosis.

The invention discloses a metagen prepared from bifidobacterium adolescentis and used for promoting synthesis of host collagen, and belongs to the technical field of microorganisms and medicines. The metagen of the bifidobacterium adolescentis CCFM1386 provided by the invention has a good effect of promoting synthesis of host collagen, improves moisture and elasticity of skin, and meanwhile, can improve the antioxidant capacity of the skin and maintain the stable state of collagen. The method specifically comprises the following steps: promoting the enzyme activity of the HSF cell LH1 in vitro by a thallus lysate, and improving the content of COL I and COL III and the enzyme activity of the LH1 in vitro from a fermented supernatant; the bifidobacterium adolescentis has the advantages that the content of collagen is increased by orally taking inactivated thalli, the enzyme activity of LH1, P4H and LOX can be improved by orally taking self-fermentation supernate, the synthesis of the collagen is promoted, and the content of the collagen is increased, so that the bifidobacterium adolescentis has huge application prospects in preparation of oral medicines for promoting the synthesis of host collagen and preparation of foods, health-care products or cosmetics.

The invention relates to the technical field of microorganisms, and discloses Ackermann muciniphila, a combined microbial agent thereof and application of the Ackermann muciniphila in inflammatory enteritis. The invention provides Akkermansia muciniphila AIML-559, and the preservation number of the Akkermansia muciniphila AIML-559 is CGMCC (China General Microbiological Culture Collection Center) No. 34246. The invention relates to a combined microbial agent, which is characterized by comprising Ackermann muciniphila AIML-559 and Bifidobacterium adolescentis AIML-528 (the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.34300). The combined microbial agent is prepared from the following raw materials: Ackermann muciniphila AIML-559 and Bifidobacterium adolescentis AIML-528 The ackermann mucophil combined microbial inoculum is suitable for treatment intervention of inflammatory bowel disease (IBD), and can relieve weight loss, hemolysis, anemia, diarrhea, intestinal bleeding and other symptoms of IBD mice.

The invention relates to the technical field of biological medicine, and discloses bifidobacterium adolescentis YF-01 and application thereof in fermented milk. The bifidobacterium adolescentis YF-01 is separated from adult excrement and is preserved in the China Center for Type Culture Collection, and the preservation number is CCTCC NO: M 20251308. Experiments prove that the bifidobacterium adolescentis YF-01 has good gastrointestinal fluid tolerance, the survival rate of the bifidobacterium adolescentis YF-01 can reach 90.1% after simulated gastric fluid treatment for 3 h, and the survival rate of the bifidobacterium adolescentis YF-01 can reach 72% after simulated intestinal fluid treatment for 4 h The strain has the self-aggregation rate of 88.83% and the hydrophobicity of 79.41%, has remarkable scavenging capacity on DPPH free radicals and hydroxyl free radicals, shows good antioxidant activity and adhesion capacity, and provides a theoretical basis for application of the strain in fermented milk. The strain and metabolites thereof can be used for preparing food, medicines or health care products capable of regulating intestinal flora and enhancing oxidation resistance, and have remarkable application potential in development of functional fermented milk products.

The invention discloses a meningioma enteric microbial marker, a product and application of the meningioma enteric microbial marker, and belongs to the field of biological medicine. The invention relates to an enteric microbial marker, which is characterized by being prepared from one or more of the following components: parabacteroides dissoni, prevotella copri, bifidobacterium adolescentis and streptococcus salivarius, and is characterized in that the enteric microbial marker comprises one or more of the following components: parabacteroides dissoni, prevotella copri, bifidobacterium adolescentis and streptococcus salivarius, and the enteric microbial marker comprises one or more of parabacteroides dissoni, prevotella copri, bifidobacterium adolescentis and streptococcus salivarius. The invention provides a kit which comprises a detection reagent for detecting the relative abundance of the intestinal microbial marker. The invention provides a product for diagnosing meningioma and a computer program product related to meningioma. The product provided by the invention has good feasibility and accuracy, can effectively evaluate the risk of meningioma, and provides a new tool for clinical diagnosis.

The invention relates to a polygonatum sibiricum probiotic compound preparation with an aging delaying effect and application thereof. The compound preparation comprises a polygonatum sibiricum extract and a probiotic composition, the bacterial strains in the probiotic composition comprise a combination of a bifidobacterium animalis subsp. Lactis BLa36 bacterial strain, a bifidobacterium longum BL21 bacterial strain, a bifidobacterium adolescentis BAC30 bacterial strain, a lactobacillus plantarum Lp90 bacterial strain, a lactobacillus casei LC89 bacterial strain, a bifidobacterium breve BBr60 bacterial strain and a pediococcus acidilactici CCFM7902 bacterial strain. After the rhizoma polygonati component and the probiotic component are combined for use, the rhizoma polygonati component and the probiotic component have potential synergistic effects in the aspects of improving the intestinal flora structure, regulating the intestinal environment, delaying senescence, reducing inflammation-related symptoms and the like. Moreover, further, various probiotic strains are compounded and combined for use, so that the capability of a related compound preparation in the aspect of delaying various symptoms of senescence can also be improved in a combined manner.

The invention discloses combined probiotics for improving sarcopenia as well as a preparation method and application of the combined probiotics, and belongs to the field of probiotics. The invention relates to a combined probiotic for improving sarcopenia. The combined probiotic comprises a lactobacillus reuteri body, a lactobacillus johnsonii body, a lactobacillus fermentum body and a bifidobacterium adolescentis body. The combined probiotics disclosed by the invention can be used for remarkably improving the overall symptoms of sarcopenia model mice, including inhibiting weight loss, constipation symptoms and colonic mucosa destruction, prolonging load swimming time, improving muscle endurance, improving skeletal muscle atrophy, improving the expression of I-type slow muscle fiber protein MyHC I and promoting slow muscle fiber repair, and has the effects of preventing and treating sarcopenia. The invention discloses a probiotic intervention method for treating sarcopenia, which comprises the following steps of: preparing probiotics for treating sarcopenia, reducing the content of inflammatory cytokines in muscular tissues, increasing the content of hepatic glycogen, improving systematic metabolism of mice with sarcopenia and damaged serum markers, including lactic acid, lactic dehydrogenase, creatine kinase, creatinine, alanine transaminase ALT and aspartate transaminase AST, providing a new scheme for probiotic intervention for sarcopenia, and being used for preparing related functional products or intervention means.

The invention provides a bacterial strain for preventing and / or treating ulcerative colitis, mixed probiotics and application of the bacterial strain and the mixed probiotics, and belongs to the technical field of microorganisms. The bacterial strain disclosed by the invention is Bifidobacterium longum ZJUCH (Bifidobacterium longum), and the preservation number of the bacterial strain is CCTCC (China Center for Type Culture Collection) NO: M 2025583. Experiments prove that the strain has the effect of improving the symptoms of ulcerative colitis. Meanwhile, mixed probiotics prepared by combining the bifidobacterium longum ZJUCH with bifidobacterium adolescentis and bifidobacterium pseudocatenuicola improve weight loss, DAI score increase and colon shortening caused by molding, and have the effect of preventing and / or treating ulcerative colitis.

The invention discloses a method for synthesizing alpha-arbutin through biotransformation, and belongs to the technical field of biochemistry. A gene cloning technology is utilized, sucrose phosphorylase Spase in leuconostoc mesenteroides and sucrose phosphorylase gtfa in bifidobacterium adolescentis are screened and found through a Deep Molecules and DLKcat algorithm on a Uniprot database, novopro is utilized for codon optimization, then the sucrose phosphorylase Spase and the sucrose phosphorylase gtfa are expressed on a plasmid vector PET-28a and are converted into an escherichia coli BL21 (DE3) strain, and the sucrose phosphorylase Spase and the sucrose phosphorylase gtfa in the bifidobacterium adolescentis are obtained. An engineering strain for heterologous expression of the gene is constructed by taking the gene as a chassis cell. According to the process, sucrose and hydroquinone are taken as co-substrates, and bioconversion is carried out under the action of sucrose phosphorylase from different sources to obtain alpha-arbutin.

The invention discloses bifidobacterium adolescentis for relieving estrogen-related metabolic disorder and obesity and application thereof, and belongs to the technical field of microorganisms. The bifidobacterium adolescentis CCFM1506 screened by the invention can effectively improve ovariectomized individual estrogen disorder symptoms, obviously slow down the weight increase speed and weight increment of estrogen disorder individuals, increase the expression quantity of serum estradiol, CYP11A1 and ERalpha in adrenal gland and the high-density lipoprotein content in serum, reduce the total cholesterol and glucose level and improve the ovariectomized ovariectomized ovariectomized ovariectomized ovariectomized ovariectomized ovariectomized ovariectomized ovariectomized abnormal glucose and lipid metabolism is adjusted; the invention has the advantages of simple preparation method and wide application prospect, can be used for preparing medicines for relieving or treating estrogen-related metabolic disorders and obesity, and can be used for preparing health-care products beneficial to controlling in-vivo fat and maintaining the health level of blood fat, and has obvious physiological effects and wide application prospects, and can be used for preparing the medicines for relieving or treating the estrogen-related metabolic disorders and obesity and preparing health-care products beneficial to controlling in-vivo fat and maintaining the health level of blood fat. A new thought and a new basis are provided for developing functional foods or medicines based on the probiotics.

The application belongs to the technical field of microorganisms and particularly relates to a Bifidobacterium adolescentis beneficial to skin, a derivative of the Bifidobacterium adolescentis and application of the Bifidobacterium adolescentis and the derivative. The derivative of the Bifidobacterium adolescentis has significant antioxidant and anti-inflammatory effects, can inhibit pathogenic bacteria of acne and other common skin infections such as Propionibacterium acnes, Staphylococcus aureus and Malassezia furfur, can eliminate pathogenic bacteria, can inhibit skin lipid accumulation, can avoid follicle blockage, and can improve skin problems in multiple directions, especially acne skin problems.

Provided is a composition for maintaining, improving or ameliorating a cognitive function, the composition containing cells of Bifidobacterium adolescentis JCM 7045 strain or a treated product of the cells.

The invention relates to an anti-aging and whitening ligustroside-rich composition and a preparation method and application thereof.The preparation method of the composition comprises the following steps that 1, dried osmanthus fragrans flowers and flaxseeds are smashed and then sieved, obtained osmanthus fragrans flower powder and obtained flaxseed powder are mixed according to the mass ratio of 10: (1-3), and mixed powder is obtained; (2) adding deionized water into the mixed powder, and sterilizing to obtain a mixed material; (3) inoculating bifidobacterium adolescentis and saccharomyces cerevisiae into the mixed material for anaerobic fermentation, and sterilizing to obtain an anaerobic fermentation product; and (4) inoculating bacillus coagulans into the anaerobic fermentation product to carry out aerobic fermentation, sterilizing, filtering and drying to obtain the anti-aging and whitening composition rich in ligustrum glycoside. The composition provided by the invention has excellent whitening and anti-aging effects.

The present invention addresses the problem of providing: a stress-relieving composition that can relieve stress, and is excellent in stability and safety; and food and drink, medicine, and feed that contain the stress-relieving composition.　Provided are: a stress-relieving composition characterized by containing Bifidobacterium adolescentis as an active ingredient; and food and drink, stress-relieving medicine, and stress-relieving feed that are characterized by containing the stress-relieving composition.

The present invention discloses a fusion strain of Lactobacillus paracasei and Bifidobacterium adolescentis, as well as its preparation method and application, belonging to the field of strain breeding technology. A fusion strain of Lactobacillus paracasei and Bifidobacterium adolescentis was successfully prepared using the method provided by the present invention. The prepared fusion strain has a new morphology, a broadened carbon source utilization range, and significantly improved inhibitory effects on three pathogens. Furthermore, it is resistant to both vancomycin and mupirocin lithium salts. It also has good fermentation characteristics, with a pH of 4.05 and a titer of 114°T after 28 days of storage, and the viable cell count can still be maintained at 1×10 7 The protoplasts have a CFU / mL value of above 2260 mPa·s, a viscosity value of 37.462 g, a hardness of 37.462 g, and a consistency of 282.04 g·s, and can be used for the development and application of dairy products. The preparation method provided provides protoplasts with strong regeneration ability, high vitality, and high fusion rate, providing support for the selection of excellent lactic acid bacteria strains using protoplast fusion technology.

The invention discloses a probiotic agent for relieving prediabetic action and application thereof, and belongs to the technical field of microorganisms. Experiments prove that bifidobacterium longum CCFM1113 and bifidobacterium adolescentis CCFM1386 composite probiotics can relieve the prediabetic stage, which is specifically embodied in reducing weight gain of mice in the prediabetic stage, regulating blood sugar metabolism, improving sugar tolerance and insulin resistance, protecting liver and pancreas tissues, being beneficial to increasing the diversity of intestinal flora, recovering the structure of the intestinal flora, and improving the immunity of the mice in the prediabetic stage. The invention also provides a preparation method of the bifidobacterium longum CCFM1113 and bifidobacterium adolescentis CCFM1386 composite probiotics. The bifidobacterium longum CCFM1113 and bifidobacterium adolescentis CCFM1386 composite probiotics. And the growth of beneficial bacteria related to metabolic disorder is enriched and regulated. The invention provides an important basis for developing a dietary formula suitable for prediabetic patients, and provides a new method for prevention and management of diabetes mellitus.

The application discloses a kind of poria cocos rehmannia enzyme health drinks preparation method and product, belong to poria cocos rehmannia health food field.The poria cocos rehmannia enzyme health drinks include the following raw materials according to weight parts: 45-55 portions of poria cocos, 45-55 portions of rehmannia glutinosa, 7-10 portions of red date, 5-6 portions of Chinese wolfberry and 18-22 portions of compound bacterial liquid;The compound bacterial liquid is made by mixing lactobacillus reuteri bacterial liquid and bifidobacterium adolescentis bacterial liquid according to volume ratio (1-1.5) :1;The preservation number of lactobacillus reuteri is CICC 6118, and the preservation number of bifidobacterium adolescentis is CICC 6178.Poria cocos and rehmannia are used as main raw materials, supplemented with a small amount of red date and Chinese wolfberry to enhance the taste and health care effect of the beverage, and the raw materials are safe and healthy, non-toxic and side effects;Synergistic effect between components, with the effects of improving intestinal tract, regulating intestinal flora and improving sleep.

The application relates to the field of microbial technology, and particularly discloses a Bifidobacterium adolescentis AGE17 for promoting muscle and bone growth and development and an application thereof. Bifidobacterium adolescentis The Bifidobacterium adolescentis AGE17 is isolated from the feces of healthy children, is preserved in the China General Microbiological Culture Collection Center, and has a preservation number of CGMCC No. 33452 and a preservation date of January 17, 2025. Animal experiments prove that the Bifidobacterium adolescentis strain AGE17 provided by the application has the function of promoting muscle and bone development, has more obvious and prominent effects compared with a model strain Bifidobacterium adolescentis ATCC15703, and has important application values in increasing the muscle strength and height of children and teenagers.

The invention provides a strain capable of resisting radiation damage as well as a product and application thereof, and relates to the technical field of probiotics capable of resisting radiation damage. The probiotic strains are separated from healthy breast milk and comprise lactobacillus gasseri LG02, lactococcus lactis LL6 and bifidobacterium adolescentis BA18, and the three probiotic strains can improve the survival rate after ionizing radiation; the LG02 or LL6 strain relieves damage of ionizing radiation to tissue structures of the heart, the liver, the spleen, the lung, the kidney, the stomach, the small intestine, the colon and the femur, the physiological function of an organism is maintained, and recovery of the tissue structures is accelerated; the LG02 or LL6 strain accelerates the body repair after radiotherapy, reduces the side reactions of diarrhea, stomachache, constipation and cough, and reduces the incidence rate of hematochezia and radiation pneumonitis; the LG02 or LL6 strain increases or recovers the number of leukocytes, and improves the hematopoietic ability and immunity of the organism; the LG02 or LL6 strain has the effects of inhibiting harmful bacteria, improving the anti-infection and anti-inflammation capability of the body and improving the resistance; the LG02 or LL6 strain can improve the oxidation resistance of the body and enhance the aging resistance of the body.

The present application relates to a kind of probiotic mixed fermentation of ziziphus mauritiana fruit juice and its preparation method, belong to food field, involve juice processing technical field.The method includes the following steps: ziziphus mauritiana is scalded with hot water, and peeling, kernel is removed, and ziziphus mauritiana pulp is obtained;The ziziphus mauritiana pulp and water, white granulated sugar are mixed, and are coarsely pulverized, and are microjet fine pulverization, sterilization, and ziziphus mauritiana juice is obtained;Bifidobacterium adolescentis and lactobacillus rhamnosus are inoculated to the ziziphus mauritiana juice, and probiotic mixed fermentation ziziphus mauritiana fruit juice is obtained after fermentation.The ziziphus mauritiana fruit juice prepared by two kinds of probiotic mixed fermentation method, not only removes the sour and astringent taste of ziziphus mauritiana initially, but also significantly increases the type and content of volatile aroma component, gives its unique flavor produced by fermentation, while also increasing the polyphenol content, reducing total sugar content and pH value, higher nutritional value, enrich the product form of ziziphus mauritiana.

The invention provides UVB damage repair application of a grease composition containing safflower seed oil and fermented artemisia apiacea oil. The fermented artemisia apiacea oil is prepared by the following steps: (a) carrying out supercritical CO2 extraction on artemisia apiacea medicinal materials; (b) fermenting, namely fermenting by adopting bifidus yeast; (c) separating to obtain fermented artemisia apiacea oil; wherein the bifidobacterium is selected from bifidobacterium adolescentis, bifidobacterium animalis subspecies, bifidobacterium animalis subspecies lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium longum subspecies longum or bifidobacterium longum subspecies infantis. The invention further relates to application of the grease composition containing the safflower seed oil and the fermented artemisia apiacea oil in preparation of a skin external preparation with a UVB damage repairing effect.

This invention relates to the field of probiotic screening and application technology, specifically to a Bifidobacterium adolescentis HC2916 that inhibits melanin synthesis, its microbial preparations, and applications. Bifidobacterium adolescentis HC2916 was deposited on May 16, 2023, at the China General Microbiological Culture Collection Center (CGMCC), with accession number CGMCC No. 27352. This strain exhibits excellent antioxidant capacity, capable of scavenging various free radicals and inhibiting lipid peroxidation. Furthermore, its fermentation supernatant and lysate significantly downregulate the protein and mRNA expression of MITF, a core factor in melanin production signaling, and inhibit the expression of its downstream key enzymes TYRP1 and TYRP2. This effectively suppresses UVA-induced increases in melanin content in skin keratinocytes, demonstrating promising application prospects in the field of skin whitening.

This invention relates to the field of probiotics technology, specifically to a Bifidobacterium adolescentis BN18 and its postbiotics for lowering uric acid and improving gout symptoms, and their applications. The Bifidobacterium adolescentis BN18 can promote the degradation of inosine and guanosine, thereby reducing uric acid levels in the blood. The postbiotics for Bifidobacterium adolescentis BN18 are made from carefully selected raw materials such as carrots, winter melon, blueberries, apples, lemons, and fructooligosaccharides as the core components of the composition. Through deep fermentation with BN18, the resulting postbiotics not only reduce the activity of xanthine oxidase and lower uric acid levels in the blood, thus promoting uric acid reduction, but also significantly enhance their antioxidant properties, reducing inflammatory responses, lowering inflammation levels, alleviating joint pain, and improving gout symptoms.

The invention discloses a fermented chicory composition with xanthine oxidase inhibitory activity as well as a preparation method and application of the fermented chicory composition. The composition is prepared by taking chicory roots as a single plant raw material and fermenting the chicory roots with a composite flora consisting of lactobacillus plantarum, lactobacillus rhamnosus, bifidobacterium adolescentis and streptococcus thermophilus in a viable count ratio of 1: 1: 1: 1. The preparation method comprises the steps of culture medium preparation, inoculated fermentation and post-treatment. Through the synergistic fermentation effect of the specific flora and the chicory substrate, the xanthine oxidase inhibitory activity of the product is remarkably enhanced. Metabonomics analysis shows that various active ingredients such as phenolic acids and prebiotic oligosaccharides are remarkably enriched after fermentation, and a dual-action mechanism of directly inhibiting enzyme activity and indirectly regulating intestinal flora is formed. The composition is safe in raw materials and definite in effect, and can be used for preparing medicines, health-care foods or dietary supplements for prevention or adjuvant treatment of hyperuricemia, gout and related diseases.

The invention belongs to the field of daily chemicals, and discloses application of fermented dragon's blood with bifidobacterium adolescentis to preparation of a cosmetic raw material with at least one of skin oxidation resistance, anti-inflammation, anti-wrinkle, skin glossiness improvement and skin compactness improvement. According to the invention, the bifidobacterium adolescentis is adopted to ferment the dragon's blood, so that a fermentation product with at least one obviously improved function of skin oxidation resistance, anti-inflammation, anti-wrinkle, skin glossiness improvement and skin compactness improvement can be obtained; meanwhile, the invention also provides a dragon's blood fermentation product as well as a preparation method and application thereof.

The invention provides bifidobacterium adolescentis for improving urticaria and Alzheimer as well as a product and application thereof. The bifidobacterium adolescentis NHNK-622 disclosed by the invention is preserved in the China Center for Type Culture Collection on December 05, 2024, and the preservation number of the bifidobacterium adolescentis NHNK-622 is CCTCC (China Center for Type Culture Collection) NO: M 20242734. The NHNK-622 has the effects of inhibiting the growth of klebsiella pneumonia and / or generating alcohol, agglutinating klebsiella pneumonia, tolerating 10% alcohol, reducing alcohol-induced damaged skin cutin barrier and inflammation, reducing alcohol-induced damaged brain microvascular barrier and inflammation, improving the klebsiella pneumonia-induced damaged survival rate of brain microvascular endothelial cells, and improving the activity of the brain microvascular endothelial cells. Klebsiella pneumonia induced damage to brain microvascular barriers and inflammation is reduced, and Klebsiella pneumonia induced damage to intestinal barriers and inflammation is reduced.